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    GENE SWITCH COMPOSITIONS AND METHODS OF USE
    1.
    发明申请
    GENE SWITCH COMPOSITIONS AND METHODS OF USE 审中-公开
    基因开关组合物和使用方法

    公开(公告)号：US20110287936A1

    公开(公告)日：2011-11-24

    申请号：US13086765

    申请日：2011-04-14

    申请人： Jin Fang ,  William J. Gordon-Kamm ,  Keith S. Lowe ,  Kevin E. McBride ,  Brian McGonigle ,  Carl R. Simmons

    发明人： Jin Fang ,  William J. Gordon-Kamm ,  Keith S. Lowe ,  Kevin E. McBride ,  Brian McGonigle ,  Carl R. Simmons

    IPC分类号： A01N47/34 ,  A01P21/00 ,  A01H5/10 ,  C12N5/10 ,  C12N15/113 ,  A01H5/00

    CPC分类号： C12N15/8217

    摘要： Compositions and methods relating to the use of sulfonylurea-mediated control of gene expression are provided. Compositions include sulfonylurea responsive chemical switches wherein the gene expression is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to regulate expression of a polynucleotide of interest in a cell or organism, and methods to modify a genome, including in a plant or plant cell.

    摘要翻译： 提供了与使用磺酰脲介导的基因表达控制有关的组合物和方法。 组合物包括磺酰脲反应性化学开关，其中基因表达受磺酰脲化合物调节。 组合物还包括编码多肽的多核苷酸以及构建体，载体，原核和真核细胞，以及真核生物，包括包含多核苷酸的植物和种子，和/或由该方法产生的。 还提供了调节细胞或生物体中目的多核苷酸表达的方法，以及修饰基因组（包括植物或植物细胞）的方法。

    Plant prohibition genes and their use
    4.
    发明授权
    Plant prohibition genes and their use 有权
    植物禁食基因及其用途

    公开(公告)号：US06441151B1

    公开(公告)日：2002-08-27

    申请号：US09395674

    申请日：1999-09-14

    申请人： William J. Gordon-Kamm ,  Keith S. Lowe ,  Ramgopal Nadimpalli ,  Carl R. Simmons

    发明人： William J. Gordon-Kamm ,  Keith S. Lowe ,  Ramgopal Nadimpalli ,  Carl R. Simmons

    IPC分类号： C07H2104

    CPC分类号： C07K14/415 ,  C12N15/8279

    摘要： Compositions and methods for modulating cell cycle and cell proliferation are provided. Additionally the compositions find use in enhancing disease resistance and increasing transformation efficiency in plants. The method involves transforming a plant with a sense or antisense prohibitin sequence. The prohibitin sequence acts to regulate cell division in the plant cell. Transformed plants, plant cells, tissues, and seed are also provided having enhanced disease resistance.

    摘要翻译： 提供了调节细胞周期和细胞增殖的组合物和方法。 此外，组合物可用于增强抗病性并提高植物的转化效率。 该方法涉及用有义或反义禁忌蛋白序列转化植物。 禁食序列用于调节植物细胞中的细胞分裂。 还提供了具有增强的抗病性的转化植物，植物细胞，组织和种子。

    Seed-preferred regulatory elements and uses thereof
    6.
    发明授权
    Seed-preferred regulatory elements and uses thereof 失效
    种子优选的调节元件及其用途

    公开(公告)号：US07432418B2

    公开(公告)日：2008-10-07

    申请号：US11519184

    申请日：2006-09-11

    申请人： Shane E. Abbitt ,  William J. Gordon-Kamm ,  Keith S. Lowe

    发明人： Shane E. Abbitt ,  William J. Gordon-Kamm ,  Keith S. Lowe

    IPC分类号： C12N15/29 ,  C12N15/82 ,  A01H5/00 ,  A01H5/10

    CPC分类号： C12Y505/01004 ,  C07K14/415 ,  C12N9/90 ,  C12N15/8234

    摘要： The present invention provides compositions and methods for regulating expression of isolated nucleotide sequences in a plant. The compositions are novel nucleic acid sequences for callus-tissue and seed embryo-preferred regulatory sequences. Methods for expressing an isolated nucleotide sequence in a plant or callus tissue using the regulatory sequences are also provided. The methods comprise transforming a plant cell to contain an isolated nucleotide sequence operably linked to the regulatory sequences of the present invention and regenerating a stably transformed plant or callus tissue from the transformed plant cell.

    摘要翻译： 本发明提供用于调节植物中分离的核苷酸序列表达的组合物和方法。 组合物是用于愈伤组织和种子胚优选调节序列的新型核酸序列。 还提供了使用调节序列在植物或愈伤组织中表达分离的核苷酸序列的方法。 所述方法包括将植物细胞转化成含有与本发明的调控序列可操作地连接的分离的核苷酸序列，并从转化的植物细胞再生稳定转化的植物或愈伤组织。

    METHODS AND COMPOSITIONS FOR TARGETED POLYNUCLEOTIDE MODIFICATION
    10.
    发明申请
    METHODS AND COMPOSITIONS FOR TARGETED POLYNUCLEOTIDE MODIFICATION 有权
    用于靶向多核苷酸修饰的方法和组合物

    公开(公告)号：US20110165679A1

    公开(公告)日：2011-07-07

    申请号：US12982013

    申请日：2010-12-30

    申请人： William J. Gordon-Kamm ,  Keith S. Lowe ,  David J. Peterson ,  Christopher J. Scelonge ,  Grace M. St. Clair ,  Bing-Bing Wang

    发明人： William J. Gordon-Kamm ,  Keith S. Lowe ,  David J. Peterson ,  Christopher J. Scelonge ,  Grace M. St. Clair ,  Bing-Bing Wang

    IPC分类号： C12N15/82 ,  C12N5/10

    CPC分类号： C12N15/8216 ,  C07K14/415 ,  C12N15/8213

    摘要： A variety of methods and compostions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism, methods for integrating polynucleotides of interest, methods to assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the genome of an organism, such as a plant, remove polynucleotides of interest, combine multiple transfer cassettes, invert or excise a polynucleotide, silence a gene, and identify and/or characterize transcriptional regulating regions. The methods involve the introduction of a cell proliferation factor and a double-strand break-inducing enzyme into an organism.

    摘要翻译： 提供了各种方法和组合物，包括用于靶向修饰细胞或生物体中特定靶位点的方法和组合物，用于整合感兴趣的多核苷酸的方法，评估启动子活性的方法，直接选择转化的生物体，最小化或消除产生的表达 从随机整合到生物体如植物的基因组中，去除感兴趣的多核苷酸，组合多个转移盒，反转或切割多核苷酸，使基因沉默，并鉴定和/或表征转录调节区。 该方法涉及将细胞增殖因子和双链断裂诱导酶引入生物体中。