利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.041 秒)

    Photosensitizing compositions
    2.
    发明授权
    Photosensitizing compositions 有权
    光敏组合物

    公开(公告)号：US09026203B2

    公开(公告)日：2015-05-05

    申请号：US13390404

    申请日：2010-08-16

    申请人： Jo Klaveness ,  Anders Hogset

    发明人： Jo Klaveness ,  Anders Hogset

    IPC分类号： A61K31/409 ,  A61M37/00 ,  C07D487/22 ,  A61K41/00

    CPC分类号： A61K41/0071

    摘要： The invention relates to pharmaceutically acceptable salts of amphiphilic photosensitizing agents which have a water solubility of at least 0.5 mg/ml and to their use in methods of photochemical internalization. Such salts may be formed from a pharmaceutically acceptable base, for example an organic amine such as an amino alcohol, or from a pharmaceutically acceptable acid, for example a sulphonic acid or a sulphonic acid derivative. Due to their increased water solubility, such salts are particularly suitable for use in the preparation of parenteral pharmaceutical preparations, e.g. for use as solutions for injection or infusion.

    摘要翻译： 本发明涉及两亲性光敏剂的药学上可接受的盐，它们的水溶解度至少为0.5mg / ml，并且它们在光化学内化方法中的用途。 这样的盐可以由药学上可接受的碱形成，例如有机胺如氨基醇，或由药学上可接受的酸，例如磺酸或磺酸衍生物形成。 由于其水溶性增加，这些盐特别适合用于制备肠胃外药物制剂，例如， 用作注射或输注的溶液。

    PHOTOSENSITIZING COMPOSITIONS
    3.
    发明申请
    PHOTOSENSITIZING COMPOSITIONS 有权
    光敏组合物

    公开(公告)号：US20120226217A1

    公开(公告)日：2012-09-06

    申请号：US13390404

    申请日：2010-08-16

    申请人： Jo Klaveness ,  Anders Hogset

    发明人： Jo Klaveness ,  Anders Hogset

    IPC分类号： A61K31/409 ,  A61M37/00 ,  C07D487/22

    CPC分类号： A61K41/0071

    摘要： The invention relates to pharmaceutically acceptable salts of amphiphilic photosensitizing agents which have a water solubility of at least 0.5 mg/ml and to their use in methods of photochemical internalization. Such salts may be formed from a pharmaceutically acceptable base, for example an organic amine such as an amino alcohol, or from a pharmaceutically acceptable acid, for example a sulphonic acid or a sulphonic acid derivative. Due to their increased water solubility, such salts are particularly suitable for use in the preparation of parenteral pharmaceutical preparations, e.g. for use as solutions for injection or infusion.

    摘要翻译： 本发明涉及两亲性光敏剂的药学上可接受的盐，它们的水溶解度至少为0.5mg / ml，并且它们在光化学内化方法中的用途。 这样的盐可以由药学上可接受的碱形成，例如有机胺如氨基醇，或由药学上可接受的酸例如磺酸或磺酸衍生物形成。 由于其水溶性增加，这些盐特别适合用于制备肠胃外药物制剂，例如， 用作注射或输注的溶液。

    PHOTOCHEMICAL INTERNALIZATION METHOD
    4.
    发明申请
    PHOTOCHEMICAL INTERNALIZATION METHOD 审中-公开
    光化学内在化方法

    公开(公告)号：US20120253264A1

    公开(公告)日：2012-10-04

    申请号：US13390360

    申请日：2010-08-16

    申请人： Jo Klaveness ,  Anders Hogset

    发明人： Jo Klaveness ,  Anders Hogset

    IPC分类号： A61M37/00

    CPC分类号： A61K9/0014 ,  A61K9/0019 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/006 ,  A61K9/107 ,  A61K9/2054 ,  A61K9/4858 ,  A61K41/0071

    摘要： The invention relates to methods of introducing drugs into cells which are located in body cavities. In particular, it provides a photosensitizing agent for use in a method of introducing a drug molecule into the cytosol of a cell located within a body cavity, said method comprising the step of contacting said cell with said photosensitizing agent and said drug molecule, and irradiating the cell with light of a wavelength effective to activate the photosensitizing agent. Such methods are particularly suitable for use in the delivery of cytotoxic drugs in the treatment of cancer, especially bladder cancer, ovarian cancer, cervical cancer, lung cancer, brain cancer, colorectal cancer and cancers of the oral and nasal cavity.

    摘要翻译： 本发明涉及将药物引入位于体腔内的细胞中的方法。 特别地，本发明提供一种用于将药物分子引入体腔内的细胞质的细胞溶质的方法中的光敏剂，所述方法包括使所述细胞与所述光敏剂和所述药物分子接触的步骤，以及照射 具有有效激活光敏剂的波长的光的电池。 这些方法特别适用于递送细胞毒性药物治疗癌症，特别是膀胱癌，卵巢癌，子宫颈癌，肺癌，脑癌，结肠直肠癌和口腔和鼻腔癌。