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    Method of making lyophilized microbubble compositions useful as contrast agents
    2.
    发明授权
    Method of making lyophilized microbubble compositions useful as contrast agents 失效
    制备用作造影剂的冻干微泡组合物的方法

    公开(公告)号：US06217850B1

    公开(公告)日：2001-04-17

    申请号：US09084105

    申请日：1998-05-26

    申请人： Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Braenden

    发明人： Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Braenden

    IPC分类号： A61B800

    CPC分类号： A61K49/223 ,  A61K49/227 ,  Y10T428/2982

    摘要： Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful both as efficacious contrast agents per se and as intermediates in the preparation of contrast agents wherein the phospholipids are crosslinked or polymerised. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.

    摘要翻译： 由主要包含单独具有整体净电荷的分子的磷脂稳定的微泡分散体表现出有利的稳定性，使得它们作为有效的造影剂本身以及作为制备造影剂的中间体是有用的，其中磷脂是交联或聚合的。 还公开了一种用于制备含微泡的造影剂的改进方法，其包括将由一种或多种形成膜的脂质稳定的气体微泡的水性分散体冻干以产生可在可注射载体液体中重构以产生微泡的干燥产物 含有造影剂。

    Microbubbles surrounded by a monolayer of negatively charged phospholipids as contrast agents
    3.
    发明授权
    Microbubbles surrounded by a monolayer of negatively charged phospholipids as contrast agents 有权
    由单层带负电荷的磷脂包围的微泡作为造影剂

    公开(公告)号：US06221337B1

    公开(公告)日：2001-04-24

    申请号：US09136410

    申请日：1998-08-19

    申请人： Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Brænden

    发明人： Harald Dugstad ,  Jo Klaveness ,  Pål Rongved ,  Roald Skurtveit ,  Jorunn Brænden

    IPC分类号： A61B800

    CPC分类号： A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  Y10T428/2982

    摘要： Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.

    摘要翻译： 主要由包含单独具有整体净电荷的分子的磷脂稳定的微泡分散体显示出有利的稳定性，使其成为有效的造影剂。 还公开了一种用于制备含微泡的造影剂的改进方法，其包括将由一种或多种形成膜的脂质稳定的气体微泡的水性分散体冻干以产生可在可注射载体液体中重构以产生微泡的干燥产物 含有造影剂。

    Polymeric surfactant-encapsulated microbubbles and their use in ultrasound imaging
    9.
    发明授权
    Polymeric surfactant-encapsulated microbubbles and their use in ultrasound imaging 失效
    聚合物表面活性剂包封的微泡及其在超声成像中的应用

    公开(公告)号：US5919434A

    公开(公告)日：1999-07-06

    申请号：US602797

    申请日：1997-03-14

    申请人： Harald Dugstad ,  Per Antonius Foss ,  Jo Klaveness ,  P.ang.l Rongved ,  Roald Skurtveit

    发明人： Harald Dugstad ,  Per Antonius Foss ,  Jo Klaveness ,  P.ang.l Rongved ,  Roald Skurtveit

    IPC分类号： A61K49/00 ,  A61K49/04 ,  A61K49/22 ,  B01F17/00 ,  B01J13/04 ,  C08G63/08 ,  A61K9/16 ,  B01J13/02 ,  B32B5/16

    CPC分类号： B01F17/0028 ,  A61K49/223 ,  Y10T428/2985

    摘要： The present invention relates to polymer-based gas-containing contrast agents in which microbubbles of gas are encapsulated by non-polymerizable wall-forming block or graft copolymer surfactants. The polymer surfactants are preferably biodegradable and include block and graft copolymers containing linkages of formula (I):--(O).sub.m --CO--O--C(R.sup.1 R.sup.2)--O--CO--(O).sub.n --(I)where R.sup.1 and R.sup.2 each represent a hydrogen atom or a carbon-attached monovalent organic group, or R.sup.1 and R.sup.2 together form a carbon-attached divalent organic group and m and n are each zero or 1.

    摘要翻译： PCT No.PCT / GB94 / 01923 Sec。 371日期1997年3月14日 102（e）1997年3月14日PCT PCT 1994年9月5日PCT公布。 第WO95 / 06518号公报 日期：1995年3月9日本发明涉及气体微气泡被不可聚合的壁形成嵌段或接枝共聚物表面活性剂包封的基于聚合物的含气体造影剂。 聚合物表面活性剂优选是可生物降解的，并且包括含有式（I）的键的嵌段和接枝共聚物： - （O）m -CO-OC（R 1 R 2）-O-CO-（O）n - （I），其中R 1和R 2各自 表示氢原子或碳键的一价有机基团，或者R 1和R 2一起形成碳键的二价有机基团，m和n各自为0或1。

    Contrast agents
    10.
    发明申请
    Contrast agents 审中-公开
    对比剂

    公开(公告)号：US20050201942A1

    公开(公告)日：2005-09-15

    申请号：US11073027

    申请日：2005-03-04

    申请人： Harald Dugstad ,  Jo Klaveness ,  Pal Rongved ,  Roald Skurtveit ,  Jorunn Braenden

    发明人： Harald Dugstad ,  Jo Klaveness ,  Pal Rongved ,  Roald Skurtveit ,  Jorunn Braenden

    IPC分类号： A61K49/00 ,  A61K47/24 ,  A61K49/04 ,  A61K49/22

    CPC分类号： A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  Y10T428/2982

    摘要： Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.

    摘要翻译： 主要由包含单独具有整体净电荷的分子的磷脂稳定的微泡分散体显示出有利的稳定性，使其成为有效的造影剂。 还公开了一种用于制备含微泡的造影剂的改进方法，其包括将由一种或多种形成膜的脂质稳定的气体微泡的水性分散体冻干以产生可在可注射载体液体中重构以产生微泡的干燥产物 含有造影剂。