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    Antimycotically active substituted 2-aminothiazoles
    2.
    发明授权
    Antimycotically active substituted 2-aminothiazoles 失效
    抗微生物活性取代的2-氨基丁酸

    公开(公告)号：US5104879A

    公开(公告)日：1992-04-14

    申请号：US596626

    申请日：1990-10-11

    申请人： Joachim Ippen ,  Bernd Baasner ,  Klaus Schaller ,  Miklos von Bittera

    发明人： Joachim Ippen ,  Bernd Baasner ,  Klaus Schaller ,  Miklos von Bittera

    IPC分类号： A61K31/505 ,  A61P31/04 ,  C07C45/00 ,  C07C45/63 ,  C07C49/80 ,  C07C49/84 ,  C07D417/12 ,  C07D417/14

    CPC分类号： C07D417/12 ,  C07C45/004 ,  C07C45/63 ,  C07C49/80 ,  C07C49/84 ,  C07D417/14

    摘要： Antimicotically active 2-aminothiazoles have been found having the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl andR.sup.2 represents optionally substituted cyclohexyl or phenyl which is substituted by halogen, alkyl, halogenoalkyl, halogenoalkoxy, dioxyhalogenoalkyl or halogenoalkylthio,and their physiologically tolerable acid addition salts,with the exception of the compounds 4-(4-chlorophenyl)-2-[2-(1,4,5,6-tetrahydropyrimidinyl)-amino]thiazole and 4-(2,4-dichlorophenyl)-2-[2-(1,4,5,6-tetrahydropyrimidinyl)-amino]-thiazole and 4-(4-chloro-2-methylphenyl)-2-[2-(1,4,5,6-tetrahydropyrimidinyl)-amino]-thiazole and with the exception of the physiologically tolerable acid addition salts of these compoundshave been found.

    摘要翻译： 已经发现具有式“IMAGE”的反活性2-氨基噻唑，其中R1代表氢或烷基，R2代表任选取代的环己基或被卤素，烷基，卤代烷基，卤代烷氧基，二卤基烷基或卤代烷硫基取代的苯基，以及它们的生理可耐受酸 加成盐，除4-（4-氯苯基）-2- [2-（1,4,5,6-四氢嘧啶基） - 氨基]噻唑和4-（2,4-二氯苯基）-2- [2-（1,4,5,6-四氢嘧啶基） - 氨基] - 噻唑和4-（4-氯-2-甲基苯基）-2- [2-（1,4,5,6-四氢嘧啶基） - 氨基] - 噻唑，除了这些化合物的生理可耐受酸加成盐之外。

    Active compound release systems
    3.
    发明授权
    Active compound release systems 失效
    活性化合物释放系统

    公开(公告)号：US4627852A

    公开(公告)日：1986-12-09

    申请号：US681977

    申请日：1984-12-14

    申请人： Miklos von Bittera ,  Rolf-Volker Meyer

    发明人： Miklos von Bittera ,  Rolf-Volker Meyer

    IPC分类号： A61K9/70 ,  A61F7/02

    CPC分类号： A61K9/7053 ,  A61K9/7076

    摘要： In a therapeutic system such as a plaster for administration of an active compound through the skin and comprising a covering layer which is essentially impermeable to the active compound, an active coupound reservoir layer and a protective layer which can be pulled off and which is essentially impermeable to the active compound, the improvement wherein the reservoir layer contains about 1-30% of active compound in an elastomer mixture comprising a diene rubber which can optionally be copolymerized with an .alpha.-olefin, mixed with from 0 up to about 70% by weight of a polyisobutylene, polybutadiene oil and/or paraffin oil, and a tackifying resin. Thereby the active compound can be released in regulated relatively large quantity over a prolonged period of time.

    摘要翻译： 在诸如用于通过皮肤施用活性化合物的石膏的治疗系统中，包括基本上不可渗透活性化合物的覆盖层，活性偶合储库层和可以被拉出并且基本上不渗透的保护层 对活性化合物的改进，其中储层在弹性体混合物中含有约1-30％的活性化合物，其包含二烯橡胶，其可以任选地与α-烯烃共聚，与0至约70重量％ 的聚异丁烯，聚丁二烯油和/或石蜡油，以及增粘树脂。 因此，活性化合物可以在更长的时间内以相对大的量调节释放。

    Self-adhesive sheet-like structures, process for their preparation and their use
    4.
    发明授权
    Self-adhesive sheet-like structures, process for their preparation and their use 失效
    自粘片状结构，其制备方法及其用途

    公开(公告)号：US4661099A

    公开(公告)日：1987-04-28

    申请号：US669402

    申请日：1984-11-08

    申请人： Miklos von Bittera ,  Dietmar Schapel ,  Ulrich von Gizycki ,  Roland Rupp

    发明人： Miklos von Bittera ,  Dietmar Schapel ,  Ulrich von Gizycki ,  Roland Rupp

    IPC分类号： A61L15/20 ,  A61L15/58 ,  C08G18/08 ,  C09J7/02 ,  C09J175/04 ,  A61F13/02 ,  A61L15/06 ,  C08K5/06 ,  C08L75/04

    CPC分类号： A61F13/063 ,  A61L15/20 ,  A61L15/58 ,  C08G18/08 ,  C09J175/04 ,  C09J7/0207 ,  C08G2220/00 ,  Y10T428/263 ,  Y10T428/2852 ,  Y10T428/2857 ,  Y10T428/2874 ,  Y10T428/2878 ,  Y10T428/2896 ,  Y10T442/2738

    摘要： The present disclosure is concerned with self-adhesive sheet-like structures made by adhering an adhesive polyurethane gel material to a supporting substrate and the utilization of such structures in the medical field to adhere materials such as plasters, wound dressings and appliances to the human body, and in other fields to connect articles, such as the parts of a fractured or cracked object, to one another by means of an adhesive bond. The gel is formed by immobilizing a high molecular weight polymeric polyol in the matrix of a covalently crosslinked polyurethane which is prepared by reacting polyisocyanates having an isocyanate functionality of at least 2 with higher molecular weight polyhydroxyl compounds having a hydroxyl functionality of at least 3. These reactants are selected in accordance with the following formula which relates the isocyanate number, K, (isocyanate to hydroxyl equivalents ratio times 100) to the average functionalities of the polyisocyanates (F.sub.I) and of the polyhydroxyl compounds (F.sub.P) as follows: ##EQU1## wherein X is less than or equal to 120. These reactants are also selected to give a weight ratio of matrix to immobilized polymeric polyol of between about 15:85 and 62:38.

    摘要翻译： 本公开涉及通过将粘性聚氨酯凝胶材料粘附到支撑基底而制成的自粘片状结构，并且在医疗领域中利用这种结构将诸如膏药，伤口敷料和器具等材料粘附到人体上 ，并且在其他领域中，通过粘合剂粘合将诸如断裂或裂纹物体的部分的物品彼此连接。 凝胶通过将高分子量聚合物多元醇固定在共价交联的聚氨酯的基质中而形成，该聚合物多羟基化合物通过使具有至少2个异氰酸酯官能度的多异氰酸酯与具有至少3个羟基官能度的较高分子量多羟基化合物反应而制备。 根据以下公式选择反应物：将异氰酸酯数K（异氰酸酯与羟基当量比100倍）相对于多异氰酸酯（FI）和多羟基化合物（FP）的平均官能度如下所述： 其中X小于或等于120.这些反应物也被选择为使基质与固定的聚合多元醇的重量比在约15:85和62:38之间。

    Medicinal plasters
    5.
    发明授权
    Medicinal plasters 失效
    药膏

    公开(公告)号：US4738670A

    公开(公告)日：1988-04-19

    申请号：US72063

    申请日：1987-07-10

    申请人： Miklos von Bittera

    发明人： Miklos von Bittera

    IPC分类号： A61K9/70 ,  A61L15/44 ,  A61L15/06

    CPC分类号： A61K9/7053 ,  A61K9/7076 ,  A61L15/44 ,  A61L2300/41

    摘要： A medicinal plaster comprising a covering layer, a reservior layer for an active compound and a detachable protective layer is disclosed. The covering is a substantially impermeable material comprising a textile sheet-like structure which is longitudinally and transversely elastic and is impregnated or coated with a polymer. Disposed on such a covering layer is a reservior layer comprising 1 to 30% by weight of active compound is an elastomeric mixture comprising a polyisobutylene polymer, a carrier such as a polybutadiene oil or liquid paraffin and a resin such as a polybutadiene oil or liquid paraffin and a resin such as a adhesion-conferring resin. Methods for the formation of such medicinal plaster and the use of such medicinal plaster, especially to apply large dosages of antiinflammatory materials are disclosed.

    摘要翻译： 公开了一种药膏，其包含覆盖层，活性化合物的储液层和可拆卸保护层。 覆盖物是基本上不可渗透的材料，其包括纵向和横向弹性并被聚合物浸渍或涂覆的织物片状结构。 在这样的覆盖层上设置的是含有1〜30重量％的活性化合物的储液层，是包含聚异丁烯聚合物，载体如聚丁二烯油或液体石蜡和树脂如聚丁二烯油或液体石蜡的弹性体混合物 以及树脂如粘合赋予树脂。 公开了形成这种药膏的方法和使用这种药膏，特别是应用大剂量的抗炎材料。

    Active compound release systems
    6.
    发明授权
    Active compound release systems 失效
    活性化合物释放系统

    公开(公告)号：US4661104A

    公开(公告)日：1987-04-28

    申请号：US681976

    申请日：1984-12-14

    申请人： Miklos von Bittera ,  Rolf-Volker Meyer ,  Rolf Dhein

    发明人： Miklos von Bittera ,  Rolf-Volker Meyer ,  Rolf Dhein

    IPC分类号： A61K9/70 ,  A61F7/02 ,  A61F13/02 ,  A61L15/03 ,  A61L15/06

    CPC分类号： A61K9/7053 ,  A61K9/7076 ,  Y10T428/24479

    摘要： In a therapeutic system such as a plaster for administration of an active compound through the skin and comprising a covering layer which is essentially impermeable to the active compound, an active compound reservoir layer and a protective layer which can be pulled off and which is essentially impermeable to the active compound, the improvement wherein the reservoir layer contain about 1-30% of active compound in an elastomer mixture comprising a predominantly amorphous olefinic (co)polymer with a glass transition temperature of

    摘要翻译： 在诸如用于通过皮肤施用活性化合物的石膏的治疗系统中，包括基本上不可渗透活性化合物的覆盖层，活性化合物储存层和可以被拉出并且基本上不渗透的保护层 对活性化合物的改进，其中储层在含有玻璃化转变温度<20℃的主要是无定形烯烃（共）聚合物的弹性体混合物中含有约1-30％的活性化合物，与0混合 至约50重量％的聚异丁烯，聚丁二烯油和/或石蜡油，以及增粘树脂。 因此，活性化合物可以在更长的时间内以相对大的量调节释放。