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1.发明授权Implantable modular, multi-channel connector system for nerve signal sensing and electrical stimulation applications 失效用于神经信号感测和电刺激应用的可植入模块化多通道连接器系统公开(公告)号：US07303422B2
公开(公告)日：2007-12-04
申请号：US10861323
申请日：2004-06-03
IPC分类号： H01R13/62
CPC分类号： H01R13/5224 , H01R4/2408 , H01R2201/12 , Y10S439/909
摘要： An implantable electrical connector includes a male portion and a female receptacle. The male portion includes a number of wires that terminate in a pattern of conductive areas. The male portion is inserted into a female receptacle and guides in the female receptacle limit the insertion of the male portion to a single direction. A locking mechanism such as a setscrew on the female receptacle forces conductive areas of the exposed conductors onto connecting pins within the female receptacle. The setscrew itself is electrically isolated from the conductive areas. Each pin in the female receptacle is surrounded by a rigid seal that engages a compressible insulating member under compression of the locking mechanism to prevent an electrical connection forming between adjacent pins in the connector.
摘要翻译： 可植入电连接器包括阳部分和阴插座。 阳部分包括以导电区域的图案终止的多根电线。 阳部分插入阴接收器中，并且在阴接收器中引导限制了凸部向单个方向的插入。 凹形插座上的诸如固定螺丝之类的锁定机构迫使暴露的导体的导电区域到母插座内的连接销上。 固定螺丝本身与导电区域电隔离。 阴插座中的每个销都被刚性密封件包围，该刚性密封件在锁定机构的压缩下接合可压缩绝缘构件，以防止在连接器中相邻销之间形成电连接。
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公开(公告)号：US20120233855A1
公开(公告)日：2012-09-20
申请号：US13486864
申请日：2012-06-01
CPC分类号： A61N1/0556 , B29C39/10 , B29C45/14426 , Y10T29/49117
摘要： A nerve cuff comprising a wall band member having an inner surface defining a lumen when the wall band member is in a closed configuration for receiving a nerve therethrough. At least one longitudinal and contiguous conductor extends within the lumen. The conductor is insulated and has at least one exposed portion thereby providing an electrode. When mounting the nerve cuff to a nerve, each electrode is in electrical communication with the nerve. A multi-channel nerve cuff further comprises a plurality of longitudinal ridges formed on the inner surface with each adjacent pair of ridges defining a longitudinal chamber. Each chamber comprises a respective conductor extending therein. When mounting the multi-channel nerve cuff to the nerve, the ridges abut the nerve providing for each chamber to isolate respective longitudinal portions of the nerve. A method and an apparatus for manufacturing such nerve cuffs are also disclosed.
摘要翻译： 一种神经套囊，其包括壁带构件，当所述壁带构件处于用于接收神经的闭合构型时，所述壁带构件具有限定内腔的内表面。 至少一个纵向和相邻导体在管腔内延伸。 导体是绝缘的并且具有至少一个暴露部分，从而提供电极。 将神经袖带安装在神经上时，每个电极与神经电连通。 多通道神经套还包括形成在内表面上的多个纵向脊，每个相邻的脊脊限定纵向腔。 每个室包括在其中延伸的相应导体。 当将多通道神经袖带安装到神经时，脊邻接神经，提供每个腔室以分离神经的各个纵向部分。 还公开了用于制造这种神经箍的方法和装置。
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公开(公告)号：US08428749B2
公开(公告)日：2013-04-23
申请号：US13486864
申请日：2012-06-01
IPC分类号： A61N1/00
CPC分类号： A61N1/0556 , B29C39/10 , B29C45/14426 , Y10T29/49117
摘要： A nerve cuff comprising a wall band member having an inner surface defining a lumen when the wall band member is in a closed configuration for receiving a nerve therethrough. At least one longitudinal and contiguous conductor extends within the lumen. The conductor is insulated and has at least one exposed portion thereby providing an electrode. When mounting the nerve cuff to a nerve, each electrode is in electrical communication with the nerve. A multi-channel nerve cuff further comprises a plurality of longitudinal ridges formed on the inner surface with each adjacent pair of ridges defining a longitudinal chamber. Each chamber comprises a respective conductor extending therein. When mounting the multi-channel nerve cuff to the nerve, the ridges abut the nerve providing for each chamber to isolate respective longitudinal portions of the nerve. A method and an apparatus for manufacturing such nerve cuffs are also disclosed.
摘要翻译： 一种神经套囊，其包括壁带构件，当所述壁带构件处于用于接收神经的闭合构型时，所述壁带构件具有限定内腔的内表面。 至少一个纵向和相邻导体在管腔内延伸。 导体是绝缘的并且具有至少一个暴露部分，从而提供电极。 将神经袖带安装在神经上时，每个电极与神经电连通。 多通道神经套还包括形成在内表面上的多个纵向脊，每个相邻的脊脊限定纵向腔。 每个室包括在其中延伸的相应导体。 当将多通道神经袖带安装到神经时，脊邻接神经，提供每个腔室以分离神经的各个纵向部分。 还公开了用于制造这种神经箍的方法和装置。
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公开(公告)号：US08214056B2
公开(公告)日：2012-07-03
申请号：US11809934
申请日：2007-06-04
IPC分类号： A61N1/00
CPC分类号： A61N1/0556 , B29C39/10 , B29C45/14426 , Y10T29/49117
摘要： A nerve cuff comprising a wall band member having an inner surface defining a lumen when the wall band member is in a closed configuration for receiving a nerve therethrough. At least one longitudinal and contiguous conductor extends within the lumen. The conductor is insulated and has at least one exposed portion thereby providing an electrode. When mounting the nerve cuff to a nerve, each electrode is in electrical communication with the nerve. A multi-channel nerve cuff further comprises a plurality of longitudinal ridges formed on the inner surface with each adjacent pair of ridges defining a longitudinal chamber. Each chamber comprises a respective conductor extending therein. When mounting the multi-channel nerve cuff to the nerve, the ridges abut the nerve providing for each chamber to isolate respective longitudinal portions of the nerve. A method and an apparatus for manufacturing such nerve cuffs are also disclosed.
摘要翻译： 一种神经套囊，其包括壁带构件，当所述壁带构件处于用于接收神经的闭合构型时，所述壁带构件具有限定内腔的内表面。 至少一个纵向和相邻导体在管腔内延伸。 导体是绝缘的并且具有至少一个暴露部分，从而提供电极。 将神经袖带安装在神经上时，每个电极与神经电连通。 多通道神经套还包括形成在内表面上的多个纵向脊，每个相邻的脊脊限定纵向腔。 每个室包括在其中延伸的相应导体。 当将多通道神经袖带安装到神经时，脊邻接神经，提供每个腔室以分离神经的各个纵向部分。 还公开了用于制造这种神经箍的方法和装置。
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公开(公告)号：US20100276944A1
公开(公告)日：2010-11-04
申请号：US11990165
申请日：2006-08-10
CPC分类号： F03G5/06 , A61F2002/708 , F03G5/00 , H02K7/1853
摘要： Methods and apparatus are disclosed for harvesting energy from motion of one or more joints. Energy harvesters comprise: an energy converter for converting mechanical energy into corresponding electrical energy; one or more sensors for sensing one or more corresponding characteristics associated with motion of the one or more joints; and a controller connected to receive the one or more sensed characteristics and configured to assess, based at least in part on the one or more sensed characteristics, whether motion of the one or more joints is associated with mutualistic conditions or non-mutualistic conditions. If conditions are determined to be mutualistic, energy harvesting is engaged. If conditions ate determined to be non-mutualistic, energy harvesting is disengaged.
摘要翻译： 公开了用于从一个或多个接头的运动中收集能量的方法和装置。 能量收集器包括：用于将机械能转换成相应电能的能量转换器; 用于感测与所述一个或多个关节的运动相关联的一个或多个相应特征的一个或多个传感器; 以及控制器，其被连接以接收所述一个或多个感测到的特征并且被配置为至少部分地基于所述一个或多个感测到的特征来评估所述一个或多个关节的运动是否与互惠状态或非共享条件相关联。 如果确定条件是互惠互利的，那么就能进行能量收集。 如果情况决定为非互惠的，能量收获就会脱离。
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6.发明授权公开(公告)号：US07302296B1
公开(公告)日：2007-11-27
申请号：US10030973
申请日：2000-07-05
IPC分类号： A61N1/34
CPC分类号： A61F2/72 , A61F2002/5061 , A61F2002/5063 , A61F2002/6827 , A61N1/0551 , A61N1/0556 , A61N1/36017 , A61N1/36021 , A61N1/36071 , A61N1/361 , A61N1/37229
摘要： This invention relates to a system and methods for relieving phantomlimb pain in amputees, and for providing an amputee with sensory feedback from a prosthetic limb. The system employs implantable multichannel, multi-chambered interface structures, namely, nerve cuffs. The implanted nerve cuffs have electrodes which transmit electrical signals generated by a signal generator to nerves, recruiting certain neurons to send sensory signals to the cerebral cortex, suggesting sensory sensations to the amputee. Such signals can arise directly from the signal generator, approximating the train of signals seen by the cortex in a normally innervated limb, or can originate from sensors in a prosthetic limb.
摘要翻译： 本发明涉及一种用于缓解截肢者幻影疼痛的系统和方法，以及为假肢提供具有感觉反馈的截肢者。 该系统采用植入式多通道多腔接口结构，即神经袖口。 植入的神经袖口具有将由信号发生器产生的电信号传递给神经的电极，招募某些神经元以向大脑皮层发送感觉信号，提示对截肢者的感觉。 这样的信号可以直接从信号发生器产生，近似于在正常神经支配的肢体中由皮质看到的信号序列，或者可以源于假肢中的传感器。
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公开(公告)号：US08571662B2
公开(公告)日：2013-10-29
申请号：US12524571
申请日：2008-01-29
IPC分类号： A61N1/18
CPC分类号： A61N1/3611 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/3601 , A61N1/36139 , A61N1/36185
摘要： Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
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8.发明授权Fully implantable nerve signal sensing and stimulation device and method for treating foot drop and other neurological disorders 有权完全植入式神经信号感知和刺激装置及治疗脚痛等神经系统疾病的方法公开(公告)号：US07636602B2
公开(公告)日：2009-12-22
申请号：US10817158
申请日：2004-04-02
申请人： Marcelo Daniel Baru Fassio , Joaquin Andres Hoffer , Enric Calderon , Gary Bernhard Jenne , Albert Calderon
发明人： Marcelo Daniel Baru Fassio , Joaquin Andres Hoffer , Enric Calderon , Gary Bernhard Jenne , Albert Calderon
IPC分类号： A61N1/00
CPC分类号： A61B5/112 , A61B5/7207 , A61N1/0556 , A61N1/36003 , A61N1/36067
摘要： A fully implantable nerve stimulation system includes an event-triggered, closed-loop control unit that detects physiological events from nerve signals and delivers stimulation pulses to a nerve to produce a desired physiological response. The stimulation system includes a low-noise, low-power nerve signal amplifier, accelerometers that detect position and a battery powered processor that selectively powers components in the system to detect physiological events and deliver stimulation pulses with a minimum of battery power.
摘要翻译： 完全可植入的神经刺激系统包括事件触发的闭环控制单元，其检测来自神经信号的生理事件并将刺激脉冲传递给神经以产生期望的生理反应。 刺激系统包括低噪声，低功率神经信号放大器，检测位置的加速度计和电池供电的处理器，其选择性地为系统中的组件供电，以检测生理事件并以最小的电池电力递送刺激脉冲。
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公开(公告)号：US20100036451A1
公开(公告)日：2010-02-11
申请号：US12524571
申请日：2008-01-29
CPC分类号： A61N1/3611 , A61N1/05 , A61N1/0551 , A61N1/0558 , A61N1/3601 , A61N1/36139 , A61N1/36185
摘要： Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.
摘要翻译： 用于经血管神经刺激的电极结构将电极与电绝缘背衬层结合。 背衬层增加通过血管内腔中的血液的电路径的电阻抗，从而增加通过周围组织的电流的流动。 可以施加电极结构以刺激神经，例如膈神经，迷走神经，三叉神经，闭孔或其他神经。
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