公开(公告)号：US06394983B1

公开(公告)日：2002-05-28

申请号：US09181240

申请日：1998-10-28

申请人： Joaquin Mayoral ,  Douglas L. Marriott ,  Richard W. Grabenkort

发明人： Joaquin Mayoral ,  Douglas L. Marriott ,  Richard W. Grabenkort

IPC分类号： A61M532

CPC分类号： A61M39/20 ,  Y10S604/905

摘要： A cap and Luer connector arrangement with an improved external seal is provided for a fluid transfer connector or fitting that has a nozzle with a surrounding annular collar located coaxially within a surrounding sealing lip. The cap includes a structure of resilient material which defines an end wall, an annular, inner sleeve extending from the end wall, and an annular, outer skirt extending from the end wall to define an annular receiving channel between the outer skirt and the inner sleeve. At least a portion of the inner sleeve has an inner surface for sealingly engaging the nozzle. A distal end of the outer skirt includes a seal region having a V-shaped cross-sectional crevice. The Luer connector sealing lip and seal region are distorted when the sealing lip is received into the crevice during initial screwed-on installation of the cap to the Luer connector, forming an external seal. The sealing lip and seal region are heat set during autoclave-sterilization of the cap and Luer connector arrangement, which prevents reinstallation of the cap once removed.

摘要翻译： 提供具有改进的外部密封件的帽和Luer连接器装置，用于具有与周围的密封唇内同轴定位的周围环形套圈的喷嘴的流体传送连接器或配件。 盖包括弹性材料的结构，其限定端壁，从端壁延伸的环形内套筒和从端壁延伸的环形外裙部，以在外裙和内套筒之间限定环形容纳通道 。 内套筒的至少一部分具有用于密封地接合喷嘴的内表面。 外裙部的远端包括具有V形横截面缝隙的密封区域。 当密封唇盖初始螺纹安装到Luer连接器上时，密封唇被接收到缝隙中，Luer连接器密封唇和密封区域变形，形成外部密封。 密封唇和密封区域在盖和Luer连接器装置的高压灭菌灭菌期间被热定形，这防止了一旦拆下盖子的重新安装。

公开(公告)号：US5382229A

公开(公告)日：1995-01-17

申请号：US124734

申请日：1993-09-21

申请人： Richard W. Grabenkort ,  Robert J. Kruger ,  Joaquin Mayoral ,  Sheldon M. Wecker

发明人： Richard W. Grabenkort ,  Robert J. Kruger ,  Joaquin Mayoral ,  Sheldon M. Wecker

IPC分类号： A61M1/00 ,  A61M3/02

CPC分类号： A61M1/0058 ,  A61M2205/7518 ,  A61M2205/7545 ,  A61M3/0229

摘要： An irrigation solution re-circulating system comprises a reservoir of irrigation solution, a solution supply line for joining the reservoir in fluid communication with a surgery site for delivering a controlled volume, pressure, and temperature of the irrigation solution to the surgery site, and a return line for further joining the surgery site in fluid communication with the reservoir. A pump, which is preferably non-hemolyzing, is connected to the return line for returning a controlled volume of the irrigation solution from the surgery site to the reservoir. The system further comprises at least one filter connected to the return line for removing contaminants from the irrigation solution prior to return to the reservoir to permit re-circulation of the solution without impairing endoscopic visualization of the surgery site, while providing solution for expanding the surgery site to permit performance of the attendant surgical procedure.

摘要翻译： 灌溉解决方案循环系统包括灌溉溶液储存器，用于将储存器与手术部位流体连通的溶液供应管线，用于将冲洗溶液的受控体积，压力和温度输送到手术部位，以及 返回线，用于进一步加入与储层流体连通的手术部位。 优选不溶血的泵连接到返回管线，用于将受控体积的冲洗溶液从手术部位返回到储存器。 该系统还包括连接到返回管线的至少一个过滤器，用于在返回到储存器之前从冲洗溶液中除去污染物，以允许溶液的再循环而不损害手术部位的内窥镜可视化，同时提供用于扩大手术的解决方案 允许执行外科手术的现场。

公开(公告)号：US5167816A

公开(公告)日：1992-12-01

申请号：US845106

申请日：1992-03-03

申请人： Robert J. Kruger ,  Joaquin Mayoral

发明人： Robert J. Kruger ,  Joaquin Mayoral

IPC分类号： A61M1/16 ,  A61M1/28 ,  B01D61/02 ,  B01D63/12 ,  C02F1/44

CPC分类号： B01D61/022 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  B01D63/12 ,  C02F1/441 ,  A61M2205/3613

摘要： The present invention is directed to a device for sterile coupling and decoupling of a first solution system to a second solution system. The first system has a resealable member so as to allow access into the system. The device includes a housing for receiving the resealable member so as to provide a fluid tight cooperating engagement with the resealable member. A penetrable barrier is positioned in the housing across from the resealable member. A conduit in flow communication with the second system is adapted for sterile penetration of the barrier and the resealable member. An inlet and outlet duct provides a passageway between the barrier and the resealable member. The inlet is adapted for fluid flow from a source of sterilizing fluid and optionally a sterile rinsing fluid. The outlet duct receives the sterilizing fluid after is passes across and sterilizes the resealable member facing the barrier.

摘要翻译： 本发明涉及一种用于将第一溶液系统无菌耦合和解耦到第二溶液系统的装置。 第一系统具有可重新密封的构件，以允许进入系统。 该装置包括用于接收可再密封构件的壳体，以便提供与可再密封构件的流体密封配合接合。 可穿透的屏障位于外壳的可再密封构件的两侧。 与第二系统流动连通的导管适合于屏障和可再密封构件的无菌穿透。 入口和出口管道在阻挡件和可再密封构件之间提供通道。 入口适于从灭菌流体源和任选的无菌漂洗流体流体流动。 出口管道在通过之后接收灭菌液体，并且使可再密封构件面向屏障消毒。

公开(公告)号：US5951863A

公开(公告)日：1999-09-14

申请号：US262421

申请日：1994-06-20

申请人： Robert J. Kruger ,  Warren P Frederick ,  R. Hayes Helgren ,  Mark E. Larkin ,  Joaquin Mayoral ,  Brad A. Schmolesky ,  Roman W Siczek ,  Kenneth J. Timmons

发明人： Robert J. Kruger ,  Warren P Frederick ,  R. Hayes Helgren ,  Mark E. Larkin ,  Joaquin Mayoral ,  Brad A. Schmolesky ,  Roman W Siczek ,  Kenneth J. Timmons

IPC分类号： A61M1/16 ,  A61M1/28 ,  B01D61/02 ,  B01D63/10 ,  B01D63/12 ,  C02F1/44 ,  B01D61/26 ,  A61M1/34 ,  B01D61/08

CPC分类号： B01D63/106 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  B01D61/022 ,  B01D63/103 ,  B01D63/12 ,  C02F1/441 ,  A61M2205/3613 ,  B01D2311/08 ,  B01D2313/086 ,  B01D2313/143 ,  B01D2313/24

摘要： Medical drug formulation and delivery system includes a reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom. A second reverse osmosis multilayer assembly is also wound on the core and is in fluid communication with the water treatment chemicals to receive the chemically purified water for purification of at least a second portion thereof. The second reserve osmosis multilayer assembly is in fluid communication with the first outlet so as to permit passage of the second portion of purified water therethrough. In one preferred embodiment, the first and second reverse osmosis assemblies are formed integrally in a side by side configuration. In an alternative embodiment, they are rolled about the core in an interleaf configuration.

摘要翻译： 药物制剂和递送系统包括用于净化来自源的水的反渗透装置，包括具有用于使来自源的水通过的入口的壳体，用于从壳体通过净化水的第一出口和用于通过废物的第二出口 净化后剩余水。 第一反渗透多层组件设置在壳体内，与入口流体连通，用于从源净化至少第一部分水。 水处理化学品可以位于卷绕第一储备渗透多层组件的核心中。 处理化学品与第一反渗透多层组件流体连通以接收第一纯化部分的水并且至少从其中去除化学污染物。 第二反渗透多层组件也缠绕在芯上并且与水处理化学品流体连通以接收用于纯化其至少第二部分的化学净化水。 第二储备渗透多层组件与第一出口流体连通，以允许第二部分净化水通过其中。 在一个优选实施例中，第一和第二反渗透组件以并排构造一体地形成。 在替代实施例中，它们以插页配置围绕核心滚动。

公开(公告)号：US5498338A

公开(公告)日：1996-03-12

申请号：US254014

申请日：1994-06-03

申请人： Robert J. Kruger ,  Warren P. Frederick ,  R. Hayes Helgren ,  Mark E. Larkin ,  Joaquin Mayoral ,  Brad A. Schmolesky ,  Roman W. Siczek ,  Kenneth J. Timmons

发明人： Robert J. Kruger ,  Warren P. Frederick ,  R. Hayes Helgren ,  Mark E. Larkin ,  Joaquin Mayoral ,  Brad A. Schmolesky ,  Roman W. Siczek ,  Kenneth J. Timmons

IPC分类号： A61M1/16 ,  A61M1/28 ,  B01D61/02 ,  B01D63/10 ,  B01D63/12 ,  C02F1/44 ,  B01D61/08

CPC分类号： B01D63/106 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  B01D61/022 ,  B01D63/103 ,  B01D63/12 ,  C02F1/441 ,  A61M2205/3613 ,  B01D2311/08 ,  B01D2313/086 ,  B01D2313/143 ,  B01D2313/24

摘要： Medical drug formulation and delivery system includes a reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom. A second reverse osmosis multilayer assembly is also wound on the core and is in fluid communication with the water treatment chemicals to receive the chemically purified water for purification of at least a second portion thereof. The second reserve osmosis multilayer assembly is in fluid communication with the first outlet so as to permit passage of the second portion of purified water therethrough. A method of forming a reverse osmosis device, a peritoneal dialysis treatment system and alternative treatment systems incorporating such a device as well as corresponding methods of treatment are also disclosed.

摘要翻译： 药物制剂和递送系统包括用于净化来自源的水的反渗透装置，包括具有用于使来自源的水通过的入口的壳体，用于从壳体通过净化水的第一出口和用于通过废物的第二出口 净化后剩余水。 第一反渗透多层组件设置在壳体内，与入口流体连通，用于从源净化至少第一部分水。 水处理化学品可以位于卷绕第一储备渗透多层组件的核心中。 处理化学品与第一反渗透多层组件流体连通以接收第一纯化部分的水并且至少从其中去除化学污染物。 第二反渗透多层组件也缠绕在芯上并且与水处理化学品流体连通以接收用于纯化其至少第二部分的化学净化水。 第二储备渗透多层组件与第一出口流体连通，以允许第二部分净化水通过其中。 还公开了形成反渗透装置的方法，腹膜透析治疗系统和包含这种装置的替代治疗系统以及相应的治疗方法。

公开(公告)号：US5352364A

公开(公告)日：1994-10-04

申请号：US990580

申请日：1992-12-15

申请人： Robert J. Kruger ,  Warren P. Frederick ,  Mark E. Larkin ,  Joaquin Mayoral ,  Sheldon M. Wecker

发明人： Robert J. Kruger ,  Warren P. Frederick ,  Mark E. Larkin ,  Joaquin Mayoral ,  Sheldon M. Wecker

IPC分类号： A61M1/16 ,  A61M1/28 ,  B01D61/02 ,  B01D63/10 ,  B01D63/12 ,  C02F1/44 ,  B01D61/08

CPC分类号： B01D63/106 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  B01D61/022 ,  B01D63/103 ,  B01D63/12 ,  C02F1/441 ,  A61M2205/3613 ,  B01D2311/08 ,  B01D2313/086 ,  B01D2313/143 ,  B01D2313/24

摘要： A reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom. A second reverse osmosis multilayer assembly is also wound on the core and is in fluid communication with the water treatment chemicals to receive the chemically purified water for purification of at least a second portion thereof. The second reserve osmosis multilayer assembly is in fluid communication with the first outlet so as to permit passage of the second portion of purified water therethrough.

摘要翻译： 一种用于净化来自源的水的反渗透装置，包括具有用于从源通过水的入口的壳体，用于从壳体通过净化水的第一出口和用于净化后剩余的废水通过的第二出口。 第一反渗透多层组件设置在壳体内，与入口流体连通，用于从源净化至少第一部分水。 水处理化学品可以位于卷绕第一储备渗透多层组件的核心中。 处理化学品与第一反渗透多层组件流体连通以接收第一纯化部分的水并且至少从其中去除化学污染物。 第二反渗透多层组件也缠绕在芯上并且与水处理化学品流体连通以接收用于纯化其至少第二部分的化学净化水。 第二储备渗透多层组件与第一出口流体连通，以允许第二部分净化水通过其中。

公开(公告)号：US5603894A

公开(公告)日：1997-02-18

申请号：US332191

申请日：1994-10-31

申请人： Albert J. Aikus ,  Joaquin Mayoral

发明人： Albert J. Aikus ,  Joaquin Mayoral

IPC分类号： A61L2/00 ,  A61L2/04 ,  A23L3/005

CPC分类号： A61L2/0023 ,  A61L2/04

摘要： The present invention provides a method and apparatus for sterilizing a pharmaceutical composition, the method comprising providing a sterilization system including a heat exchanger for elevating and then lowering the temperature of the fluid in a time period; measuring temperature at an input of the heat exchanger, measuring temperature at an output of the heat exchanger and measuring temperature at least one point in the heat exchanger intermediate to the input and output; calculating a coefficient of heat transfer for the sterilization system using the temperature measurements; calculating a degree of sterilization (F.sub.o) using the coefficient; and adjusting the temperature of the heat exchanger to minimize degradation of the pharmaceutical composition while maintaining an acceptable degree of sterilization.

摘要翻译： 本发明提供一种灭菌药物组合物的方法和装置，该方法包括提供一种灭菌系统，该灭菌系统包括一段时间内升高并降低流体温度的热交换器; 测量热交换器输入端的温度，测量热交换器输出端的温度，并将热交换器中至少一点的温度测量到输入和输出; 使用温度测量计算灭菌系统的传热系数; 使用系数计算灭菌程度（Fo）; 并且调节热交换器的温度以使药物组合物的降解最小化，同时保持可接受的灭菌程度。

公开(公告)号：US5382406A

公开(公告)日：1995-01-17

申请号：US93297

申请日：1993-07-16

申请人： Robert J. Kruger ,  Joaquin Mayoral

发明人： Robert J. Kruger ,  Joaquin Mayoral

IPC分类号： B65B55/10 ,  A61L2/20

CPC分类号： A61L2/20

摘要： The present invention is directed to a method for the on-line sterile filling of a container with a sterile solution from a filling nozzle in a filling head. A container having an open end and a hollow body portion for receiving the sterile solution is provided. The container also includes an access passageway tube having first and second ends and a pierceable septum sealing the passageway at an intermediate position within the tube. The first open end of the access passageway tube is sealed in the open end of the container so as to close the hollow body portion of the container, which is then sterilized. Later, before on line filling, the second end of the access passageway tube is isolated from the surrounding environment by axially advancing and sealably seating the filling head at the second end of the access passageway tube. The isolated end of the access passageway tube is then sterilized for a time period sufficient to reduce the viable micro-organism population present to a predetermined level. Then a filling nozzle is advanced from the filling head through the isolated and sterilized end of the passageway tube and pierces the septum of the tube. After the sterilized hollow body portion is filled with the sterile solution, the access passageway is sealed between the hollow body portion and the filling nozzle.

摘要翻译： 本发明涉及一种用于在填充头中的来自填充喷嘴的无菌溶液的在线无菌填充容器的方法。 提供了一种具有开放端和用于接收无菌溶液的中空主体部分的容器。 容器还包括具有第一和第二端的通路通道管和在管内的中间位置处密封通道的可穿透隔膜。 进入通道管的第一开口端被密封在容器的开口端，以封闭容器的中空主体部分，然后将其消毒。 之后，在线填充之前，进入通道管的第二端通过轴向前进并且将密封地安置在进入通道管的第二端处而与周围环境隔离。 然后将进入通道管的隔离端消毒足以将存活的活微生物种群减少至预定水平的时间。 然后，填充嘴从填充头前进通过隔离和灭菌的通道管的端部并刺穿管的隔膜。 在灭菌的空心体部分填充无菌溶液之后，进入通道被密封在中空本体部分和填充喷嘴之间。

公开(公告)号：US5312547A

公开(公告)日：1994-05-17

申请号：US846184

申请日：1992-03-04

申请人： Robert J. Kruger ,  Warren P. Frederick ,  William J. Hook ,  Mark E. Larkin ,  Joaquin Mayoral ,  Roman W. Siczek ,  Kenneth J. Timmons ,  Sheldon M. Wecker

发明人： Robert J. Kruger ,  Warren P. Frederick ,  William J. Hook ,  Mark E. Larkin ,  Joaquin Mayoral ,  Roman W. Siczek ,  Kenneth J. Timmons ,  Sheldon M. Wecker

IPC分类号： A61M1/16 ,  A61M1/28 ,  B01D61/02 ,  B01D63/10 ,  B01D63/12 ,  C02F1/44 ,  B01D61/08

CPC分类号： B01D63/106 ,  A61M1/1643 ,  A61M1/1662 ,  A61M1/28 ,  A61M1/281 ,  A61M1/284 ,  B01D61/022 ,  B01D63/103 ,  B01D63/12 ,  C02F1/441 ,  A61M2205/3613 ,  B01D2311/08 ,  B01D2313/086 ,  B01D2313/143 ,  B01D2313/24

摘要： Medical drug formulation and delivery system includes a reverse osmosis device for purifying water from a source comprising a housing having an inlet for passage of water from the source, a first outlet for passage of purified water from the housing and a second outlet for passage of waste water remaining after purification. A first reverse osmosis multilayer assembly is disposed within the housing in fluid communication with the inlet for purification of at least a first portion of the water from the source. Water treatment chemicals can be positioned in a core about which the first reserve osmosis multilayer assembly is wound. The treatment chemicals are in fluid communication with the first reverse osmosis multilayer assembly to receive the first purified portion of water and for removal of at least chemical contaminants therefrom. A second reverse osmosis multilayer assembly is also wound on the core and is in fluid communication with the water treatment chemicals to receive the chemically purified water for purification of at least a second portion thereof. The second reserve osmosis multilayer assembly is in fluid communication with the first outlet so as to permit passage of the second portion of purified water therethrough. In one preferred embodiment, the first and second reverse osmosis assemblies are formed integrally in a side by side configuration. In an alternative embodiment, they are rolled about the core in an interleaf configuration.

摘要翻译： 药物制剂和递送系统包括用于净化来自源的水的反渗透装置，包括具有用于使来自源的水通过的入口的壳体，用于从壳体通过净化水的第一出口和用于通过废物的第二出口 净化后剩余水。 第一反渗透多层组件设置在壳体内，与入口流体连通，用于从源净化至少第一部分水。 水处理化学品可以位于卷绕第一储备渗透多层组件的核心中。 处理化学品与第一反渗透多层组件流体连通以接收第一纯化部分的水并且至少从其中去除化学污染物。 第二反渗透多层组件也缠绕在芯上并且与水处理化学品流体连通以接收用于纯化其至少第二部分的化学净化水。 第二储备渗透多层组件与第一出口流体连通，以允许第二部分净化水通过其中。 在一个优选实施例中，第一和第二反渗透组件以并排构造一体地形成。 在替代实施例中，它们以插页配置围绕核心滚动。

公开(公告)号：US4478770A

公开(公告)日：1984-10-23

申请号：US378655

申请日：1982-05-17

申请人： David Vofsi ,  Shymon Reich ,  Israel Tchoukran ,  Joaquin Mayoral

发明人： David Vofsi ,  Shymon Reich ,  Israel Tchoukran ,  Joaquin Mayoral

IPC分类号： B29C41/14 ,  B29D11/00

CPC分类号： B29D11/00038 ,  B29D11/00942 ,  B29C41/14 ,  Y10S425/808

摘要： The invention relates to a process for the production of a contact lens, which comprises coating a tool made of an inert material, having a curvature corresponding to that of one of the optical surfaces of the lens to be produced, with a layer of solid polymer, and machining the outer surface of said polymer to the desired curvature of the second surface of said lens while supported by said tool, and to a tool for carrying out such process.

摘要翻译： 本发明涉及一种用于制造隐形眼镜的方法，该方法包括使用一层固体聚合物涂覆由惰性材料制成的工具，其具有与待生产的镜片的光学表面的曲率相对应的曲率 并且在由所述工具支撑的同时将所述聚合物的外表面加工成所述透镜的第二表面的期望曲率，以及用于执行这种处理的工具。