摘要:
The present invention relates to a melanin concentrating hormone antagonist compound of formula I: (I); or a pharmaceutically acceptable salt, solvate, enantiomer or prodrug thereof useful in the treatment, prevention or amelioration of symptoms associated with obesity and related diseases.
摘要:
This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)
摘要翻译:本申请涉及式(I)化合物或其药学上可接受的盐,其药物组合物及其作为速激肽受体的NK-1亚型的抑制剂的用途,以及其制备方法及其中间体。 (I)其中:D是C 1 -C 3烷烃二基; R 1是苯基,其任选地被一至三个独立地选自卤素,C 1 -C 4烷基的取代基取代, C 1 -C 4烷氧基,氰基,二氟甲基,三氟甲基和三氟甲氧基; (I),(IB),(IC),(ID),(IE),(IF),(IG),(IH)
摘要:
The present invention relates to selective NK-1 receptor antagonists of Formula (I); or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins.
摘要:
The present invention provides monitoring means for monitoring the space and volume within a lower annulus. In particular, the monitoring means monitors the space and volume within the lower annulus 52 located between the inner surface of the 22 intermediate casing string 22 and the outer surface of the inner casing string 32. Furthermore, the monitoring means provides the capability to retrieve and/or introduce fluid(s) into the annular space 52. The monitoring means provides a port, specifically a passageway 100, which extends upwardly from the annular space 52 to an outlet located above the hanger 36 for the intermediate casing string 22. The passageway 100 is provided in a sleeve 102. The monitoring means includes a sensor located above the hanger 36 which means that the fluid in the annular space 52 can be monitored without the need for penetrating a casing in the wellhead.
摘要:
An example photodetector includes a waveguide structure having an active waveguide comprising an absorber for converting photons conveying an optical signal into charge carriers conveying a corresponding electrical signal; a carrier collection layer for transporting the charge carriers conveying the electrical signal; and a secondary waveguide immediately adjacent to the carrier collection layer, for receiving the photons to be detected, and which is evanescently coupled to the active waveguide.
摘要:
A transfer unit is configured for use with a form, fill and seal packaging machine. The transfer unit receives a partially erected carton from a first station in a tubular form, conveys the carton to a second station, and conveys the carton from the second station to a third station. The transfer unit includes a hub defining a longitudinal hub axis and configured for rotational movement about the hub axis. A plurality of car pairs are mounted to the hub for longitudinal movement along the hub. Each of the car pairs includes first and second cars, each of which has first and second mandrels mounted thereto. The mandrels are configured to receive a partially erected carton. Each mandrel has a mandrel axis and is rotational about its respective axis. The mandrel axes are perpendicular and tangential to the hub axis. A drive longitudinally moving the car pairs along the hub and rotationally moves the mandrels about their respective mandrel axes, about 90 degrees, between an untwisted position and a twisted position.
摘要:
An object access system for retrieving objects in response to requests identifying requested objects, the system comprising an access structure consisting of a plurality of tables where each table is identified by a unique table identifier and has a plurality of rows where each row has a plurality of fields and is identified by a unique primary key in one of the fields and where a field may also contain objects; a row index for each table, each row index having entries ordered on the primary key of the rows in the table where each entry points to a row of fields in the table; a table index ordered on the table identifier for the tables, the table index having an entry for each table which point to the row index for that table and access means, responsive to requests for an object having an associated table identifier and primary key, for searching the table index for the requested table identifier and for retrieving from the table index entry for the requested table identifier the pointer to the row index for the requested table identifier, searching the pointed to row index for the requested primary key and retrieving from the row index entry for the requested primary key the pointer to the row of fields and searching the pointed to row of field for the requested object and retrieving the requested object.
摘要:
The CareMed, National Walk-In Medical Clinical Locator provide consumers global access to healthcare provider services regardless of their affiliation or membership to any one caregivers network. A single point of intelligent access removes the need for consumers to submit generic searches or make arbitrary decisions with little if any basis in fact. Additionally, it avoids the need for consumers to register or enroll in any one specific provider care network. The weighted list of provider recommendations utilizes a wide range of propriety decision-based variables to recommend services to the benefit of the consumer and facilitate inter-provider competitiveness thereby increasing the availability of care providers.
摘要:
A wellhead securement arrangement releasably clamps casing strings such that they cannot move in an upwards or downwards longitudinal direction. Prior to being clamped, the securement arrangement secures the casing strings in a first position whereby cement returns are able to flow around the hangers towards the surface. Once cemented, the casing strings are released and moved upwardly, where the securement arrangement clamps the hangers into position, thus creating an axial load on the casing strings while also preventing movement in the upward and downward longitudinal directions.
摘要:
Disclosed is a an electronic system for equities securities lending and financing. In particular, the disclosed system provides a hub for electronic financial transactions such as securities borrowing and lending and facilitates the ability of borrowers and lenders to locate suitable counterparties and engage in direct negotiations in a securities lending transaction.