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公开(公告)号:US08926972B2
公开(公告)日:2015-01-06
申请号:US12727188
申请日:2010-03-18
申请人: Joe Zhou , Jianyang Zhao , Jiuru Sun , Jun Wang , Shaoxiong Wang , Xinxing Ma , Jun Lin
发明人: Joe Zhou , Jianyang Zhao , Jiuru Sun , Jun Wang , Shaoxiong Wang , Xinxing Ma , Jun Lin
CPC分类号: C07K14/71 , A61K38/00 , C07K2319/30
摘要: The disclosure provides a novel anti-angiogenesis fusion protein. The present invention combines a chimeric vascular endothelial cell growth factor (VEGF) receptor or a fragment thereof with a multimerizing component, which have a superior binding capacity with human VEGF and placental growth factor (PIGF). The fusion protein has improved stability, prolonged half-life and the ability to form multivalent interactions with VEGF, and can be used for anti-angiogenesis, treating VEGF related diseases and inhibiting tumor growth.
摘要翻译: 本公开提供了一种新的抗血管生成融合蛋白。 本发明将嵌合血管内皮细胞生长因子(VEGF)受体或其片段与多聚化成分组合,其与人VEGF和胎盘生长因子(PIGF)具有优异的结合能力。 融合蛋白具有改善的稳定性,延长的半衰期和与VEGF形成多价相互作用的能力,并且可用于抗血管生成,治疗VEGF相关疾病和抑制肿瘤生长。
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公开(公告)号:US20100331250A1
公开(公告)日:2010-12-30
申请号:US12727188
申请日:2010-03-18
申请人: Joe ZHOU , Jianyang Zhao , Jiuru Sun , Jun Wang , Shaoxiong Wang , Xinxing Ma , Jun Lin
发明人: Joe ZHOU , Jianyang Zhao , Jiuru Sun , Jun Wang , Shaoxiong Wang , Xinxing Ma , Jun Lin
IPC分类号: A61K38/18 , C12P21/06 , C12N5/10 , C12N1/19 , C12N15/63 , C07K14/705 , C07K16/22 , C07H21/04
CPC分类号: C07K14/71 , A61K38/00 , C07K2319/30
摘要: The disclosure provides a novel anti-angiogenesis fusion protein. The present invention combines a chimeric vascular endothelial cell growth factor (VEGF) receptor or a fragment thereof with a multimerizing component, which have a superior binding capacity with human VEGF and placental growth factor (PIGF). The fusion protein has improved stability, prolonged half-life and the ability to form multivalent interactions with VEGF, and can be used for anti-angiogenesis, treating VEGF related diseases and inhibiting tumor growth.
摘要翻译: 本公开提供了一种新的抗血管生成融合蛋白。 本发明将嵌合血管内皮细胞生长因子(VEGF)受体或其片段与多聚化成分组合,其与人VEGF和胎盘生长因子(PIGF)具有优异的结合能力。 融合蛋白具有改善的稳定性,延长的半衰期和与VEGF形成多价相互作用的能力,并且可用于抗血管生成,治疗VEGF相关疾病和抑制肿瘤生长。
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公开(公告)号:US20210383637A1
公开(公告)日:2021-12-09
申请号:US17152786
申请日:2021-01-19
申请人: Jun Wang , Weijun Zhang
发明人: Jun Wang , Weijun Zhang
IPC分类号: G07F13/04 , G16H20/60 , G06Q30/02 , G01G19/414
摘要: A nutrition tracking system comprises a nutrition tracking server, a plurality of weight-based food offering terminals, and one or more nutrition and meal information inquiry terminals. Multiple weight-based food offering terminals may be equipped on a food service cart. Each weight-based food offering terminal may be initialized to offer a type of food. The weight-based food offering terminal automatically measures the weight of food taken by a customer or for a customer, calculates the cost of food, and shows the weight and the cost on the display in real time. When the food is paid, the weight-based food offering terminal automatically reports the vending information to the nutrition tracking server. The nutrition tracking server maintains a database for customer meal information and a database for customer nutrition information. Customers may inquire their meal history and nutrition information using the nutrition and meal information inquiry terminals.
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公开(公告)号:US20200153538A1
公开(公告)日:2020-05-14
申请号:US16620129
申请日:2018-06-13
申请人: Xixian CHEN , Jung-Fu CHENG , James Jianfeng WENG , Jun Wang
发明人: Xixian CHEN , Jung-Fu CHENG , James Jianfeng WENG , Jun Wang
IPC分类号: H04L1/00
摘要: There is provided a method performed by a wireless device for handling user data. The method comprises: receiving an index (such as a Transport Block Size (TBS) index) from a network node; determining a TBS based on the received index; determining a modulation order based at least on the determined TBS; and performing one of decoding and encoding the user data based at least on the determined modulation order.
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公开(公告)号:US10171998B2
公开(公告)日:2019-01-01
申请号:US12048883
申请日:2008-03-14
摘要: An authentication server may be adapted to (a) authenticate an authentication peer seeking to establish communications via a first network access node; (b) retrieve user profile information associated with the authentication peer; and/or (c) send the user profile information to a network gateway node that facilitates communication services for the authentication peer. A PMIP network node may be adapted to (a) provide wireless network connectivity to an authentication peer via a first network access node; (b) provide a PMIP key to both ends of a PMIP tunnel between the first network access node and a PMIP network node used to provide communications to the authentication peer; (c) provide the PMIP key to a first authenticator associated the first network access node; (d) receive a request at the PMIP network node from a requesting entity to reroute communications for the authentication peer; and/or (e) verify whether the requesting entity knows the PMIP key.
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公开(公告)号:US09493821B2
公开(公告)日:2016-11-15
申请号:US13989031
申请日:2011-09-21
申请人: Ye Du , Meiru Zhao , Ying Chen , Jinghua Wu , Geng Tian , Jun Wang
发明人: Ye Du , Meiru Zhao , Ying Chen , Jinghua Wu , Geng Tian , Jun Wang
CPC分类号: C12Q1/683 , C12N15/1093 , C12Q1/6869 , C12Q1/6883 , C12Q2521/313 , C12Q2525/191 , C40B50/06
摘要: A DNA library, and a preparing method thereof, a method of determining DNA sequence information, an apparatus and a kit for detecting SNPs, and a method for genotyping may be provided. The method for preparing the DNA library may comprise the steps of: digesting a genomic DNA sample using a restriction endonuclease to obtain a digested product, wherein the restriction endonuclease comprises at least one selected from the group consisting of Mbo II and Tsp 45I; separating the digested product to obtain DNA fragments having a length of 100 bp to 1,000 bp; end-repairing the DNA fragments to obtain an end-repaired DNA fragments; adding a base A to the end of the end-repaired DNA fragments to obtain DNA fragments having a terminal base A; and ligating the DNA fragments having the terminal base A with sequencing adaptors to obtain the DNA library.
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公开(公告)号:US09461447B2
公开(公告)日:2016-10-04
申请号:US13976961
申请日:2011-11-29
申请人: Shufeng Kang , Mingxu Zhang , Fengxiang Shi , Xuebin Wang , Juxuan Jiao , Zhi Gao , Zhongsheng Li , Sanping Geng , Yongjie Su , Jian Li , Jun Wang , Boyan Yao , Ming Chen , Qifeng Song
发明人: Shufeng Kang , Mingxu Zhang , Fengxiang Shi , Xuebin Wang , Juxuan Jiao , Zhi Gao , Zhongsheng Li , Sanping Geng , Yongjie Su , Jian Li , Jun Wang , Boyan Yao , Ming Chen , Qifeng Song
CPC分类号: H02G1/02 , H02G1/04 , Y10T29/53283
摘要: A maintenance tool for an insulator of a direct current transmission line comprises clamping devices and a tensioning device. The clamping devices are mounted at the two sides of the insulator through clamping, and the tensioning device is connected between the clamping devices. The clamping devices comprise a closed clamp (1), a single serial clamping device (2) and a wire end clamping device (30). The clamping device has advantages such as strong overall strength and bearing capacity, small size, light weight, and reliable working, and can be applied to replacement of various insulators on the direct current transmission line, reliably ensuring safe commissioning and regular maintenance of transmission lines.
摘要翻译: 用于直流传输线的绝缘体的维护工具包括夹紧装置和张紧装置。 夹紧装置通过夹紧安装在绝缘体的两侧,并且张紧装置连接在夹紧装置之间。 夹紧装置包括闭合夹具(1),单个串联夹持装置(2)和线端夹紧装置(30)。 夹紧装置具有整体强度高,承载能力强,体积小,重量轻,工作可靠等优点,可用于直流输电线路上各种绝缘子的更换,可靠地确保安全调试和定期维护输电线路 。
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公开(公告)号:US09448821B2
公开(公告)日:2016-09-20
申请号:US13880418
申请日:2011-08-19
申请人: Jun Wang
发明人: Jun Wang
CPC分类号: G06F9/455 , G06F9/45558 , G06F9/4856 , G06F2009/4557 , H04L61/103 , H04L61/2084 , H04L61/6022
摘要: The present document discloses a method and system for realizing virtual machine mobility, comprising: in a process of establishing communication with a second virtual machine, a first virtual machine subscribing to a media access control (MAC) address change notification of the second virtual machine from an address resolution server (ARS) through a first virtual switch in a physical server where the first virtual machine is located; after the second virtual machine migrates, a second virtual switch in a physical server, to which the second virtual machine migrates, registering a corresponding relationship between an IP address of the second virtual machine and a MAC address of the second virtual switch itself to the ARS; and the ARS updating the MAC address corresponding to the IP address of the second virtual machine, and notifying the first virtual machine of the updated MAC address according to the subscription of the first virtual machine.
摘要翻译: 本文件公开了一种用于实现虚拟机移动性的方法和系统,包括:在与第二虚拟机建立通信的过程中,第一虚拟机订阅第二虚拟机的媒体访问控制(MAC)地址改变通知, 通过第一虚拟机所在物理服务器中的第一虚拟交换机的地址解析服务器(ARS); 在第二虚拟机迁移之后,第二虚拟机迁移到的物理服务器中的第二虚拟交换机将第二虚拟机的IP地址与第二虚拟交换机本身的MAC地址之间的对应关系注册到ARS ; 并且所述ARS更新与所述第二虚拟机的IP地址相对应的MAC地址,并且根据所述第一虚拟机的预约通知所述第一虚拟机所述更新的MAC地址。
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公开(公告)号:US09301950B2
公开(公告)日:2016-04-05
申请号:US13391519
申请日:2010-07-30
申请人: William F. DeGrado , Jun Wang
发明人: William F. DeGrado , Jun Wang
IPC分类号: A61K31/438 , A61K31/439 , C07D209/56 , C07D209/96 , C07D233/61 , A61K31/44 , C07D339/08 , C07D471/08
CPC分类号: A61K31/44 , C07D233/61 , C07D339/08 , C07D471/08
摘要: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
摘要翻译: 提供能够通过与M2跨膜蛋白相互作用来调节甲型流感病毒的活性的化合物。 还提供了用于治疗受甲型流感感染的疾病状态或感染的方法,其包括施用包含已被鉴定为能够与M2蛋白相互作用的一种或多种化合物的组合物。
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公开(公告)号:US09226265B2
公开(公告)日:2015-12-29
申请号:US13445864
申请日:2012-04-12
申请人: Ajay Gupta , Gang Bao , George Cherian , Jun Wang
发明人: Ajay Gupta , Gang Bao , George Cherian , Jun Wang
CPC分类号: H04W72/005 , H04W4/06 , H04W28/08 , H04W64/00
摘要: A method or system for managing demand-based multicast services in a wireless communications system (WCS) capable of both unicast and multicast signaling may include providing content requested by a mobile entity in an area of the WCS via a unicast session, determining that a concurrent demand level for the content exceeds a defined threshold for the area of the WCS, and initiating a multicast session for the content in the area of the WCS, in response to determining the concurrent demand level has exceeded the threshold. The method or system may include more detailed operations or aspects for measuring the concurrent demand level, transitioning signaling between unicast and multicast modes, communicating between network components, or related functions.
摘要翻译: 一种用于在能够同时进行单播和多播信令的无线通信系统(WCS)中管理基于需求的多播服务的方法或系统可以包括经由单播会话在WCS的区域中提供由移动实体请求的内容,确定并发 响应于确定并发需求级别已经超过阈值,内容的需求级别超过WCS区域的定义阈值,并且针对WCS区域中的内容发起多播会话。 该方法或系统可以包括用于测量并发需求级别,在单播和多播模式之间转换信令,网络组件之间的通信或相关功能的更详细的操作或方面。
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