公开(公告)号：US06750962B2

公开(公告)日：2004-06-15

申请号：US09828874

申请日：2001-04-10

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  John M. Gleisner ,  Charles C. Raney ,  David A. Hasker ,  Ryszard Radwanski ,  John Ramirez

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  John M. Gleisner ,  Charles C. Raney ,  David A. Hasker ,  Ryszard Radwanski ,  John Ramirez

IPC分类号： G01N110

CPC分类号： G01N21/8483

摘要： A multi-use assay system accurately docks a removable test strip supporting a reagent-analyte reaction with an optics system including an LED, photodetector, and lenses or light pipes for directing light to and from the test strip. Docking is achieved using alignment fixturing, whereby an optics block holder is relied upon to align the test strip and test pad with the various optical components. Signals from the photodetector indicative of test strip reaction progress are provided to a processor for measuring the analyte.

摘要翻译： 多用分析系统将包含LED，光电检测器和透镜或光管的光学系统的支撑试剂 - 分析物反应的可移除测试条准确地对准，以将光导向和从测试条引导。 使用对准夹具实现对接，由此依靠光学块保持器将测试条和测试垫与各种光学部件对准。 来自光电检测器的指示测试条反应进程的信号被提供给用于测量分析物的处理器。

公开(公告)号：US07018848B2

公开(公告)日：2006-03-28

申请号：US10224875

申请日：2002-08-21

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest

IPC分类号： G01N33/551

CPC分类号： C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  Y10S435/817 ,  Y10S436/805 ,  Y10S436/806

摘要： An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with an analyte to produce a measurable change in potential which can be correlated to the concentration of the analyte in the fluid sample. The test device optionally contains a reference electrode made of an amorphous semiconductor material having a reference material on the reference electrode. The test device electrodes can be constructed on a flexible film substrate, such as a polymeric film or a metal foil coated with a non-conductive coating.

公开(公告)号：US06638772B1

公开(公告)日：2003-10-28

申请号：US08876812

申请日：1997-06-17

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest

IPC分类号： G01N33543

CPC分类号： C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  Y10S435/817 ,  Y10S436/805 ,  Y10S436/806

摘要： An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with an analyte to produce a measurable change in potential which can be correlated to the concentration of the analyte in the fluid sample. The test device optionally contains a reference electrode made of an amorphous semiconductor material having a reference material on the reference electrode. The test device electrodes can be constructed on a flexible film substrate, such as a polymeric film or a metal foil coated with a non-conductive coating.

摘要翻译： 提供电化学测试装置，用于确定含水流体样品中分析物的存在或浓度。 电化学测试装置包括工作电极和由非晶半导体材料制成的对电极。 工作电极与能够与分析物反应的试剂重叠，以产生可测量的电位变化，其可以与流体样品中分析物的浓度相关。 测试装置可选地包含由在参考电极上具有参考材料的非晶半导体材料制成的参考电极。 测试装置电极可以构建在柔性膜基底上，例如聚合物膜或涂有非导电涂层的金属箔。

公开(公告)号：US07115362B2

公开(公告)日：2006-10-03

申请号：US11287522

申请日：2005-11-23

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest

IPC分类号： C12Q1/00

CPC分类号： C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  Y10S435/817 ,  Y10S436/805 ,  Y10S436/806

摘要： An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with an analyte to produce a measurable change in potential which can be correlated to the concentration of the analyte in the fluid sample. The test device optionally contains a reference electrode made of an amorphous semiconductor material having a reference material on the reference electrode. The test device electrodes can be constructed on a flexible film substrate, such as a polymeric film or a metal foil coated with a non-conductive coating.

公开(公告)号：US6001239A

公开(公告)日：1999-12-14

申请号：US164405

申请日：1998-09-30

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  G01N33/487 ,  G01N33/49 ,  G01N33/543 ,  G01N27/26

CPC分类号： C12Q1/001 ,  C12Q1/26 ,  G01N27/3272 ,  G01N33/54386

摘要： An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with an analyte to produce a measurable change in potential which can be correlated to the concentration of the analyte in the fluid sample. The test device optionally contains a reference electrode made of an amorphous semiconductor material having a reference material on the reference electrode.

公开(公告)号：US06582573B2

公开(公告)日：2003-06-24

申请号：US09878774

申请日：2001-06-08

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

IPC分类号： G01N27327

CPC分类号： C12Q1/001 ,  C12Q1/26 ,  G01N27/3272 ,  G01N33/54386

摘要： An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with an analyte to produce a measurable change in potential which can be correlated to the concentration of the analyte in the fluid sample. The test device optionally contains a reference electrode made of an amorphous semiconductor material having a reference material on the reference electrode.

摘要翻译： 提供电化学测试装置，用于确定含水流体样品中分析物的存在或浓度。 电化学测试装置包括工作电极和由非晶半导体材料制成的对电极。 工作电极与能够与分析物反应的试剂重叠，以产生可测量的电位变化，其可以与流体样品中分析物的浓度相关。 测试装置可选地包含由在参考电极上具有参考材料的非晶半导体材料制成的参考电极。

公开(公告)号：US06245215B1

公开(公告)日：2001-06-12

申请号：US09401062

申请日：1999-09-22

申请人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

发明人： Joel S. Douglas ,  Jeffrey N. Roe ,  John H. Priest ,  David A. Hasker

IPC分类号： G01N2726

CPC分类号： C12Q1/001 ,  C12Q1/26 ,  G01N27/3272 ,  G01N33/54386

摘要： An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a counter electrode made of an amorphous semiconductor material. The working electrode is overlaid with a reagent capable of reacting with an analyte to produce a measurable change in potential which can be correlated to the concentration of the analyte in the fluid sample. The test device optionally contains a reference electrode made of an amorphous semiconductor material having a reference material on the reference electrode.

摘要翻译： 提供电化学测试装置，用于确定含水流体样品中分析物的存在或浓度。 电化学测试装置包括工作电极和由非晶半导体材料制成的对电极。 工作电极与能够与分析物反应的试剂重叠，以产生可测量的电位变化，其可以与流体样品中分析物的浓度相关。 测试装置可选地包含由在参考电极上具有参考材料的非晶半导体材料制成的参考电极。

公开(公告)号：US20110275916A1

公开(公告)日：2011-11-10

申请号：US11153854

申请日：2005-06-15

申请人： Jeffrey N. Roe ,  Michael E. Hilgers ,  Jay Vinson ,  John H. Priest ,  Steven P. Mecca ,  Thomas C. Rademacher

发明人： Jeffrey N. Roe ,  Michael E. Hilgers ,  Jay Vinson ,  John H. Priest ,  Steven P. Mecca ,  Thomas C. Rademacher

IPC分类号： A61B5/145

CPC分类号： A61B5/157 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15144 ,  A61B5/1519 ,  A61B5/15194 ,  A61B2562/0295 ,  Y10T436/10 ,  Y10T436/102499 ,  Y10T436/103332 ,  Y10T436/104165 ,  Y10T436/104998 ,  Y10T436/105831 ,  Y10T436/106664 ,  Y10T436/109163

摘要： A control solution packet for calibrating a bodily fluid sampling device includes a container, a control solution pressurized within the container, and a membrane for covering and sealing the container. The control solution can be pressurized before or during calibration so as to ensure the appropriate amount of control solution is delivered to the bodily fluid sampling device. The control solution is manufactured to have a viscosity that controls delivery of the control solution to the device. The membrane is permeable by a piercing device of the bodily fluid sampling device and seals around the piercing device during calibration. In another aspect, the container is in the form of a capsule or dosing attachment that contains the control solution along with a sponge-like material.

摘要翻译： 用于校准体液采样装置的控制解决方案包包括容器，在容器内加压的对照溶液以及用于覆盖和密封容器的膜。 在校准之前或期间，可以对对照溶液进行加压，以确保将适当量的对照溶液输送到体液采样装置。 控制解决方案被制造成具有控制控制溶液输送到装置的粘度。 该膜可通过体液采样装置的穿刺装置渗透，并在校准过程中围绕穿刺装置密封。 在另一方面，容器是胶囊或剂量附件的形式，其包含对照溶液以及海绵状材料。

公开(公告)号：US06780651B2

公开(公告)日：2004-08-24

申请号：US09875297

申请日：2001-06-07

申请人： Joel S. Douglas ,  Ryszard Radwanski ,  Brent G. Duchon ,  John H. Priest ,  David A. Hasker ,  John M. Gleisner

发明人： Joel S. Douglas ,  Ryszard Radwanski ,  Brent G. Duchon ,  John H. Priest ,  David A. Hasker ,  John M. Gleisner

IPC分类号： G01N33543

CPC分类号： G01N33/521 ,  B01L3/5023 ,  B01L2200/026 ,  B01L2200/0605 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N33/525 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

摘要： A method of making strip for testing for the presence of an analyte generally comprises providing a support member which includes a spreading layer and a reagent layer, and a capillary in communication with the support layer and spreading layer for transporting a sample of body fluid thereto.

摘要翻译： 制造用于测试分析物存在的条带的方法通常包括提供包括扩散层和试剂层的支撑构件，以及与支撑层连通的毛细管和用于将体液样品输送到其的扩散层。

公开(公告)号：US06242207B1

公开(公告)日：2001-06-05

申请号：US09411237

申请日：1999-10-04

申请人： Joel S. Douglas ,  Karen R. Drexler ,  John M. Gleisner ,  John H. Priest

发明人： Joel S. Douglas ,  Karen R. Drexler ,  John M. Gleisner ,  John H. Priest

IPC分类号： C12Q126

CPC分类号： C12Q1/26 ,  C12Q1/28 ,  C12Q2326/00 ,  C12Q2326/32 ,  G01N33/52 ,  Y10S435/808 ,  Y10S435/814 ,  Y10S435/97

摘要： A dry chemistry reagent matrix composition is provided containing a matrix material and a reagent composition containing 3-methyl-6(sulfonate salt)-benzothiazolinone-(2)-hydrazone (MBTH-S), N-ethyl-N-(3-sulfopropyl)aniline, and an oxidase enzyme or a peroxidase enzyme or a mixture thereof. The dry chemistry reagent matrix composition is useful in reagent test strips for determining the presence or concentration of an analyte in a fluid sample, such as blood.

摘要翻译： 提供了含有基质材料和含有3-甲基-6（磺酸盐） - 苯并噻唑啉酮 - （2） - 腙（MBTH-S），N-乙基-N-（3-磺基丙基） ）苯胺，氧化酶或过氧化物酶或其混合物。 干化学试剂基质组合物可用于试剂测试条，用于确定流体样品（如血液）中分析物的存在或浓度。