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    Process and apparatus for producing inhalable medicaments
    4.
    发明授权
    Process and apparatus for producing inhalable medicaments 有权
    生产可吸入药物的方法和设备

    公开(公告)号：US07249599B2

    公开(公告)日：2007-07-31

    申请号：US11173772

    申请日：2005-06-30

    申请人： Joerg Schiewe ,  Bernd Zierenberg

    发明人： Joerg Schiewe ,  Bernd Zierenberg

    IPC分类号： A61M11/00 ,  A61M15/00 ,  A61M9/00

    CPC分类号： B01F13/0071 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0036 ,  B01D9/0063 ,  B01F5/0453 ,  B01F5/046 ,  B01F13/0066 ,  B01F2005/0031 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00984 ,  B01J2219/0245

    摘要： A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exists from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch. Also disclosed is an apparatus for carrying out the method.

    摘要翻译： 一种使物质特别是可吸入药物结晶的方法，包括以下步骤：（a）将所述物质溶解在溶剂中，以产生所述物质的溶液，（b）产生由所述溶液的交替段组成的分段流 的物质和运输介质，（c）将所述分段流引入保持拉伸的第一端，所述保持拉伸具有第一端和第二端，使得所述分段流从所述第一端到所述第二端 所述保留拉伸的端部，并且从保持拉伸的第二端存在，（d）冷却保留拉伸，从而在分段流中在分段流中导致溶液段中物质的结晶，因为所述分段流通过 保留拉伸，和（e）当从分段流离开保留拉伸的第二端时分离材料的晶体。 还公开了一种用于执行该方法的装置。

    Process and apparatus for producing inhalable medicaments
    6.
    发明申请
    Process and apparatus for producing inhalable medicaments 有权
    生产可吸入药物的方法和设备

    公开(公告)号：US20050244314A1

    公开(公告)日：2005-11-03

    申请号：US11173772

    申请日：2005-06-30

    申请人： Joerg Schiewe ,  Bernd Zierenberg

    发明人： Joerg Schiewe ,  Bernd Zierenberg

    IPC分类号： A61J3/02 ,  A61K9/00 ,  A61K9/08 ,  A61K9/12 ,  A61K9/14 ,  A61K9/16 ,  A61K9/72 ,  A61M15/00 ,  B01D9/00 ,  B01F5/04 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00

    CPC分类号： B01F13/0071 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0036 ,  B01D9/0063 ,  B01F5/0453 ,  B01F5/046 ,  B01F13/0066 ,  B01F2005/0031 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00984 ,  B01J2219/0245

    摘要： A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exists from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch. Also disclosed is an apparatus for carrying out the method.

    摘要翻译： 一种使物质特别是可吸入药物结晶的方法，包括以下步骤：（a）将所述物质溶解在溶剂中，以产生所述物质的溶液，（b）产生由所述溶液的交替段组成的分段流 的物质和运输介质，（c）将所述分段流引入保持拉伸的第一端，所述保持拉伸具有第一端和第二端，使得所述分段流从所述第一端到所述第二端 所述保留拉伸的端部，并且从保持拉伸的第二端存在，（d）冷却保留拉伸，从而在分段流中在分段流中导致溶液段中物质的结晶，因为所述分段流通过 保留拉伸，和（e）当从分段流离开保留拉伸的第二端时分离材料的晶体。 还公开了一种用于执行该方法的装置。

    Process and apparatus for producing inhalable medicaments
    7.
    发明授权
    Process and apparatus for producing inhalable medicaments 有权
    生产可吸入药物的方法和设备

    公开(公告)号：US07066171B2

    公开(公告)日：2006-06-27

    申请号：US10340314

    申请日：2003-05-19

    申请人： Joerg Schiewe ,  Bernd Zierenberg

    发明人： Joerg Schiewe ,  Bernd Zierenberg

    IPC分类号： A61M11/00 ,  A61M15/00 ,  A61M9/00

    CPC分类号： B01F13/0071 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0036 ,  B01D9/0063 ,  B01F5/0453 ,  B01F5/046 ,  B01F13/0066 ,  B01F2005/0031 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00984 ,  B01J2219/0245

    摘要： A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exits from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch. Also disclosed is an apparatus for carrying out the method.

    摘要翻译： 一种使物质特别是可吸入药物结晶的方法，包括以下步骤：（a）将所述物质溶解在溶剂中，以产生所述物质的溶液，（b）产生由所述溶液的交替段组成的分段流 的物质和运输介质，（c）将所述分段流引入保持拉伸的第一端，所述保持拉伸具有第一端和第二端，使得所述分段流从所述第一端到所述第二端 所述保留拉伸的端部并且从保持拉伸的第二端离开，（d）冷却保留拉伸，从而在分段流中导致溶液段中物质的结晶，因为所述分段流通过 保留拉伸，和（e）当从分段流离开保留拉伸的第二端时分离材料的晶体。 还公开了一种用于执行该方法的装置。

    Process and apparatus for producing inhalable medicaments
    8.
    发明授权
    Process and apparatus for producing inhalable medicaments 有权
    生产可吸入药物的方法和设备

    公开(公告)号：US06663848B2

    公开(公告)日：2003-12-16

    申请号：US10125044

    申请日：2002-04-18

    申请人： Joerg Schiewe ,  Bernd Zierenberg

    发明人： Joerg Schiewe ,  Bernd Zierenberg

    IPC分类号： A61K912

    CPC分类号： B01F13/0071 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0036 ,  B01D9/0063 ,  B01F5/0453 ,  B01F5/046 ,  B01F13/0066 ,  B01F2005/0031 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00984 ,  B01J2219/0245

    摘要： A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exits from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch. Also disclosed is an apparatus for carrying out the method.

    摘要翻译： 一种使物质特别是可吸入药物结晶的方法，包括以下步骤：（a）将所述物质溶解在溶剂中，以产生所述物质的溶液，（b）产生由所述溶液的交替段组成的分段流 的物质和运输介质，（c）将所述分段流引入保持拉伸的第一端，所述保持拉伸具有第一端和第二端，使得所述分段流从所述第一端到所述第二端 所述保留拉伸的端部并且从保持拉伸的第二端离开，（d）冷却保留拉伸，从而在分段流中导致溶液段中物质的结晶，因为所述分段流通过 保留拉伸，以及（e）从分段流中的晶体从保留拉伸的第二端离开时也分离。还公开了一种用于承载ou 方法。

    Powder inhaler having a nozzle with a plurality of channels
    9.
    发明申请
    Powder inhaler having a nozzle with a plurality of channels 有权
    具有具有多个通道的喷嘴的粉末吸入器

    公开(公告)号：US20050263151A1

    公开(公告)日：2005-12-01

    申请号：US11072374

    申请日：2005-03-04

    申请人： Dieter Hochrainer ,  Stephen Dunne ,  Georg Boeck ,  Joerg Schiewe

    发明人： Dieter Hochrainer ,  Stephen Dunne ,  Georg Boeck ,  Joerg Schiewe

    IPC分类号： A61M15/00 ,  A61L9/04 ,  A61M11/00

    CPC分类号： A61M15/0028 ,  A61M15/005 ,  A61M15/009 ,  A61M2202/064

    摘要： The invention relates to a powder inhaler (1) with mouthpiece (2) for dispersing pharmaceutical medicament formulations, which comprises an auxiliary energy source in the form of a pressure medium system (3), having a device for supplying (6) a powder formulation (7), while on activation of the pressure medium system a gaseous pressure medium (8) released by the pressure medium system (3) forms an aerosol (9) with the powder formulation (7) such that the powder particles are present in the gaseous pressure medium (8) in dispersed form. This is achieved by means of a powder inhaler (1) comprising a multi-channel nozzle, the channels of which are inclined to one another at an angle such that the aerosol jets flowing through them meet one another downstream behind the nozzle (10).

    摘要翻译： 本发明涉及一种具有用于分散药物制剂的吸嘴（2）的粉末吸入器（1），其包括压力介质系统（3）形式的辅助能量源，其具有用于供应（6）粉末制剂 （7），在压力介质系统激活时，由压力介质系统（3）释放的气体压力介质（8）与粉末制剂（7）形成气溶胶（9），使得粉末颗粒存在于 分散形式的气体压力介质（8）。 这通过包括多通道喷嘴的粉末吸入器（1）来实现，该多通道喷嘴的通道以一定角度彼此倾斜，使得流过它们的气溶胶喷流在喷嘴（10）的下游相交。