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    Process and apparatus for producing inhalable medicaments
    4.
    发明授权
    Process and apparatus for producing inhalable medicaments 有权
    生产可吸入药物的方法和设备

    公开(公告)号：US07249599B2

    公开(公告)日：2007-07-31

    申请号：US11173772

    申请日：2005-06-30

    申请人： Joerg Schiewe ,  Bernd Zierenberg

    发明人： Joerg Schiewe ,  Bernd Zierenberg

    IPC分类号： A61M11/00 ,  A61M15/00 ,  A61M9/00

    CPC分类号： B01F13/0071 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0036 ,  B01D9/0063 ,  B01F5/0453 ,  B01F5/046 ,  B01F13/0066 ,  B01F2005/0031 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00984 ,  B01J2219/0245

    摘要： A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exists from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch. Also disclosed is an apparatus for carrying out the method.

    摘要翻译： 一种使物质特别是可吸入药物结晶的方法，包括以下步骤：（a）将所述物质溶解在溶剂中，以产生所述物质的溶液，（b）产生由所述溶液的交替段组成的分段流 的物质和运输介质，（c）将所述分段流引入保持拉伸的第一端，所述保持拉伸具有第一端和第二端，使得所述分段流从所述第一端到所述第二端 所述保留拉伸的端部，并且从保持拉伸的第二端存在，（d）冷却保留拉伸，从而在分段流中在分段流中导致溶液段中物质的结晶，因为所述分段流通过 保留拉伸，和（e）当从分段流离开保留拉伸的第二端时分离材料的晶体。 还公开了一种用于执行该方法的装置。

    Process and apparatus for producing inhalable medicaments
    6.
    发明申请
    Process and apparatus for producing inhalable medicaments 有权
    生产可吸入药物的方法和设备

    公开(公告)号：US20050244314A1

    公开(公告)日：2005-11-03

    申请号：US11173772

    申请日：2005-06-30

    申请人： Joerg Schiewe ,  Bernd Zierenberg

    发明人： Joerg Schiewe ,  Bernd Zierenberg

    IPC分类号： A61J3/02 ,  A61K9/00 ,  A61K9/08 ,  A61K9/12 ,  A61K9/14 ,  A61K9/16 ,  A61K9/72 ,  A61M15/00 ,  B01D9/00 ,  B01F5/04 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00

    CPC分类号： B01F13/0071 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0036 ,  B01D9/0063 ,  B01F5/0453 ,  B01F5/046 ,  B01F13/0066 ,  B01F2005/0031 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00984 ,  B01J2219/0245

    摘要： A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exists from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch. Also disclosed is an apparatus for carrying out the method.

    摘要翻译： 一种使物质特别是可吸入药物结晶的方法，包括以下步骤：（a）将所述物质溶解在溶剂中，以产生所述物质的溶液，（b）产生由所述溶液的交替段组成的分段流 的物质和运输介质，（c）将所述分段流引入保持拉伸的第一端，所述保持拉伸具有第一端和第二端，使得所述分段流从所述第一端到所述第二端 所述保留拉伸的端部，并且从保持拉伸的第二端存在，（d）冷却保留拉伸，从而在分段流中在分段流中导致溶液段中物质的结晶，因为所述分段流通过 保留拉伸，和（e）当从分段流离开保留拉伸的第二端时分离材料的晶体。 还公开了一种用于执行该方法的装置。

    Process and apparatus for producing inhalable medicaments
    7.
    发明授权
    Process and apparatus for producing inhalable medicaments 有权
    生产可吸入药物的方法和设备

    公开(公告)号：US07066171B2

    公开(公告)日：2006-06-27

    申请号：US10340314

    申请日：2003-05-19

    申请人： Joerg Schiewe ,  Bernd Zierenberg

    发明人： Joerg Schiewe ,  Bernd Zierenberg

    IPC分类号： A61M11/00 ,  A61M15/00 ,  A61M9/00

    CPC分类号： B01F13/0071 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0036 ,  B01D9/0063 ,  B01F5/0453 ,  B01F5/046 ,  B01F13/0066 ,  B01F2005/0031 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00984 ,  B01J2219/0245

    摘要： A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exits from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch. Also disclosed is an apparatus for carrying out the method.

    摘要翻译： 一种使物质特别是可吸入药物结晶的方法，包括以下步骤：（a）将所述物质溶解在溶剂中，以产生所述物质的溶液，（b）产生由所述溶液的交替段组成的分段流 的物质和运输介质，（c）将所述分段流引入保持拉伸的第一端，所述保持拉伸具有第一端和第二端，使得所述分段流从所述第一端到所述第二端 所述保留拉伸的端部并且从保持拉伸的第二端离开，（d）冷却保留拉伸，从而在分段流中导致溶液段中物质的结晶，因为所述分段流通过 保留拉伸，和（e）当从分段流离开保留拉伸的第二端时分离材料的晶体。 还公开了一种用于执行该方法的装置。

    Process and apparatus for producing inhalable medicaments
    8.
    发明授权
    Process and apparatus for producing inhalable medicaments 有权
    生产可吸入药物的方法和设备

    公开(公告)号：US06663848B2

    公开(公告)日：2003-12-16

    申请号：US10125044

    申请日：2002-04-18

    申请人： Joerg Schiewe ,  Bernd Zierenberg

    发明人： Joerg Schiewe ,  Bernd Zierenberg

    IPC分类号： A61K912

    CPC分类号： B01F13/0071 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/14 ,  A61K9/1688 ,  B01D9/0013 ,  B01D9/0036 ,  B01D9/0063 ,  B01F5/0453 ,  B01F5/046 ,  B01F13/0066 ,  B01F2005/0031 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00984 ,  B01J2219/0245

    摘要： A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exits from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch. Also disclosed is an apparatus for carrying out the method.

    摘要翻译： 一种使物质特别是可吸入药物结晶的方法，包括以下步骤：（a）将所述物质溶解在溶剂中，以产生所述物质的溶液，（b）产生由所述溶液的交替段组成的分段流 的物质和运输介质，（c）将所述分段流引入保持拉伸的第一端，所述保持拉伸具有第一端和第二端，使得所述分段流从所述第一端到所述第二端 所述保留拉伸的端部并且从保持拉伸的第二端离开，（d）冷却保留拉伸，从而在分段流中导致溶液段中物质的结晶，因为所述分段流通过 保留拉伸，以及（e）从分段流中的晶体从保留拉伸的第二端离开时也分离。还公开了一种用于承载ou 方法。

    Container for a medicinal liquid
    9.
    发明授权
    Container for a medicinal liquid 有权
    药用液体容器

    公开(公告)号：US07963955B2

    公开(公告)日：2011-06-21

    申请号：US10754499

    申请日：2004-01-12

    申请人： Bernhard Freund ,  Dieter Hochrainer ,  Heinrich Kladders ,  Bernd Zierenberg ,  Joachim Eicher ,  Johannes Geser ,  Martin Essing ,  Holger Reinecke

    发明人： Bernhard Freund ,  Dieter Hochrainer ,  Heinrich Kladders ,  Bernd Zierenberg ,  Joachim Eicher ,  Johannes Geser ,  Martin Essing ,  Holger Reinecke

    IPC分类号： A61B19/00

    CPC分类号： B65D83/0061 ,  E05F3/10 ,  E05F3/102 ,  E05Y2900/602

    摘要： Foil bags are used as a primary packaging for liquids, the bags permitting the liquid to be taken therefrom without the application of a considerable amount of force. A container is provided for a medicinal liquid, the container being gas-tight and liquid-tight so that it is storable over many months. The container includes a collapsible foil bag on which a flange, which is stable in respect of shape, is disposed. The flange is designed for fitting onto a discharge connection member. The container can be disposed in a casing which is stable in respect of shape. The medicinal liquid does not come into contact with air and is protected from the effect of light. The medicinal liquid may be dispensed from the foil bag in many partial quantities over a prolonged period of time, with a respective partial amount thereof being converted into an aerosol by means of an atomizer.

    摘要翻译： 箔袋用作液体的主要包装，允许从其中取出液体的袋不施加相当大的力。 为药液提供容器，该容器是气密和液密的，以便可以在几个月内储存。 容器包括可折叠的箔袋，其上设置有关于形状稳定的凸缘。 凸缘设计用于安装在排放连接构件上。 容器可以设置在相对于形状稳定的壳体中。 药用液体不会与空气接触并被保护免受光线的影响。 医药液体可以在较长的时间段内以多个部分量从箔袋中分配，其相应的部分量通过雾化器转化成气溶胶。