公开(公告)号：US20050049146A1

公开(公告)日：2005-03-03

申请号：US10494770

申请日：2002-11-02

申请人： John Chiarello ,  William Wood ,  Deborah Culbertson ,  Daniel Smith ,  Robin Sperry ,  Thomas Schmidt ,  Gerd Steiner ,  Markus Kordes ,  Wolfgang Deyn ,  Norbert Gotz ,  Michael Hofmann ,  Keith Barnes ,  James Takasugi ,  Michael Treacy ,  Hassan Oloumi-sadeghi ,  Robert Diehl

发明人： John Chiarello ,  William Wood ,  Deborah Culbertson ,  Daniel Smith ,  Robin Sperry ,  Thomas Schmidt ,  Gerd Steiner ,  Markus Kordes ,  Wolfgang Deyn ,  Norbert Gotz ,  Michael Hofmann ,  Keith Barnes ,  James Takasugi ,  Michael Treacy ,  Hassan Oloumi-sadeghi ,  Robert Diehl

IPC分类号： A01N43/22 ,  A01N43/42 ,  A01N43/46 ,  A01N43/60 ,  A01N43/62 ,  A01N43/84 ,  A01N45/02 ,  A01N47/36 ,  C07D295/02 ,  C07D295/033 ,  C07D295/073 ,  C07D313/14 ,  C07D337/14 ,  A01N43/02 ,  C07D223/18

CPC分类号： C07D337/14 ,  A01N43/22 ,  A01N43/42 ,  A01N43/46 ,  A01N43/60 ,  A01N43/62 ,  A01N43/84 ,  A01N45/02 ,  A01N47/36 ,  C07D295/033 ,  C07D295/073 ,  C07D313/14

摘要： A composition comprising a) compounds of formula (I) wherein A-B denotes C—C or C═C; X is S, O, SO, SO2, NRa, or CRbRc; R1, R2 are H, halogen, OH, SH, NH2, CN, NO2, alkyl, alkoxy, alkylamino, dialkylamino, alkylthio, alkenyl, alkenyloxy, alkenylamino, alkenylthio, alkynyl, alkynyloxy, alkynylamino, alkynylthio, alkylsulfonyl, alkylsulfoxyl, alkenylsulfonyl, alkynylsulfoxyl, formyl, alkylcarbonyl, hydroxycarbonyl, alkoxycarbonyl, carbonyloxy, alkylcarbonyloxy, phenyloxy, C(O)NRdRe, (SO2)nNRdRe, or C(═NORf)-Γp-Rf′, a mono- or bicyclic 5- to 10-membered aromatic ringsystem, a 5- to 10-membered heteroaromatic ring system, or cycloalkyl, each optionally substituted, which is unfused or fused to the aromatic group to which it is bonded and which, when unfused, is bonded directly or through an O, S, alkyl, or alkoxy linkage; R3, R4 are each independently H, alkyl, haloalkyl, alkylamine, alkoxy, cycloalkyl, wherein the carbon atoms in these aliphatic groups may be substituted, or R3 and R4 together with the nitrogen atom to which they are attached form a saturated or partially saturated mono-or bi-cyclic 5- to 10-membered ringsystem or a 5-membered hetaryl, wherein the rings are optionally substituted and are bonded directly or via an O, S, or alkyl linkage, and cycloalkenyl, wherein the carbon atoms in these aliphatic groups can be substituted, and wherein the group NR3R4 can be present as [N+—O−]R3R4 (aminoxide) if R3 and R4 are bonded through a single bond to the nitrogen atom; and Ra, Rb, Rc, Rd, Re, Rf′, Rf, Γ and p are as defined in the description; m is 0, 1, 2, 3, or 4; n is 0, 1, 2, 3, or 4; or the enantiomers or diastereomers, salts or esters thereof, and b) an agronomically acceptable carrier, methods for protecting crops from attack by insects, arachnids and nematodes by contacting the crop or the target species with a pesticidally effective amount of the compound of formula (I), compounds of formula I, and a process for their preparation.

公开(公告)号：US07629145B2

公开(公告)日：2009-12-08

申请号：US11427463

申请日：2006-06-29

申请人： James Lee ,  William Wood

发明人： James Lee ,  William Wood

IPC分类号： C12P21/02 ,  C12N15/03 ,  C12N15/09 ,  C07H21/04

CPC分类号： C07K16/22 ,  A61K38/00 ,  C07K14/52 ,  C07K14/71 ,  C07K2319/00 ,  C07K2319/30

摘要： A human VEGF-related protein (VRP) has been identified and isolated that binds to, and stimulates the phosphorylation of, the receptor tyrosine kinase Flt4. The VRP is postulated to be a third member of the VEGF protein family. Also provided are antibodies that bind to VRP and neutralize a biological activity of VRP, compositions containing the VRP or antibody, methods of use, chimeric polypeptides, and a signal polypeptide for VRP.

公开(公告)号：US20070207147A1

公开(公告)日：2007-09-06

申请号：US11552437

申请日：2006-10-24

申请人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

发明人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

IPC分类号： A61K39/395 ,  C07K14/00 ,  C07K16/30 ,  G01N33/574

CPC分类号： C07K14/705 ,  C07K14/47 ,  G01N33/574

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20070185017A1

公开(公告)日：2007-08-09

申请号：US10533069

申请日：2003-10-28

申请人： Sudeepta Aggarwal ,  Hilary Clark ,  Austin Gurney ,  Jill Schoenfeld ,  P. Williams ,  William Wood ,  Thomas Wu

发明人： Sudeepta Aggarwal ,  Hilary Clark ,  Austin Gurney ,  Jill Schoenfeld ,  P. Williams ,  William Wood ,  Thomas Wu

IPC分类号： A61K38/17 ,  C07K14/47 ,  C07K16/18 ,  C12P21/06 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  Y02A50/463

摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

公开(公告)号：US20070178486A1

公开(公告)日：2007-08-02

申请号：US11535718

申请日：2006-09-27

申请人： Avi Ashkenazi ,  Dan Eaton ,  Audrey Goddard ,  Austin Gurney ,  William Wood ,  Thomas Wu

发明人： Avi Ashkenazi ,  Dan Eaton ,  Audrey Goddard ,  Austin Gurney ,  William Wood ,  Thomas Wu

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： C07K16/30 ,  C12Q1/6886 ,  C12Q2600/158

摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。

公开(公告)号：US20070154475A1

公开(公告)日：2007-07-05

申请号：US11709185

申请日：2007-02-20

申请人： J. Grimaldi ,  Somasekar Seshagiri ,  Jeremy Stinson ,  William Wood ,  Zemin Zhang

发明人： J. Grimaldi ,  Somasekar Seshagiri ,  Jeremy Stinson ,  William Wood ,  Zemin Zhang

IPC分类号： A61K39/395 ,  C07K16/38 ,  C07K16/28

CPC分类号： A61K39/395

摘要： The present invention is directed to novel polypeptides having sequence similarity to GDNFR and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及与GDNFR具有序列相似性的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US07189566B2

公开(公告)日：2007-03-13

申请号：US09944896

申请日：2001-08-31

申请人： David Botstein ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  Margaret Ann Roy ,  William Wood

发明人： David Botstein ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  Margaret Ann Roy ,  William Wood

IPC分类号： C12N5/10 ,  C07H21/04

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4703 ,  C07K14/70578 ,  C07K16/18 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/02

摘要： The present invention is directed to novel polypeptides having homology to cysteine-rich secretory protein-3 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cell comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及与富含半胱氨酸的分泌蛋白-3和编码这些多肽的核酸分子具有同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20070037148A1

公开(公告)日：2007-02-15

申请号：US10533416

申请日：2003-11-06

申请人： Sherman Fong ,  Kathryn Dennis ,  Hilary Clark ,  Henry Chiu ,  Jill Schoenfeld ,  P. Williams ,  William Wood ,  Thomas Wu

发明人： Sherman Fong ,  Kathryn Dennis ,  Hilary Clark ,  Henry Chiu ,  Jill Schoenfeld ,  P. Williams ,  William Wood ,  Thomas Wu

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： G01N33/54353 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00385 ,  B01J2219/00427 ,  B01J2219/00529 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00677 ,  B01J2219/00722 ,  B82Y30/00 ,  C03C17/3405 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14 ,  G01N33/6893 ,  G01N2800/24

摘要： Compositions and methods for improving detection sensitivity in nucleic acid microarray analysis are disclosed, including methods of purifying nucleic acids, methods of synthesizing fluorescent DNA probes, methods of hybridization, and methods of activating a substrate for target molecule attachment are disclosed.

摘要翻译： 公开了用于提高核酸微阵列分析中检测灵敏度的组合物和方法，包括纯化核酸的方法，合成荧光DNA探针的方法，杂交方法和激活靶分子连接底物的方法。

公开(公告)号：US20070031901A1

公开(公告)日：2007-02-08

申请号：US11457750

申请日：2006-07-14

申请人： Avi Ashkenazi ,  Audrey Goddard ,  Paul Godowski ,  Austin Gurney ,  Paul Polakis ,  P. Williams ,  William Wood ,  Thomas Wu ,  Zemin Zhang

发明人： Avi Ashkenazi ,  Audrey Goddard ,  Paul Godowski ,  Austin Gurney ,  Paul Polakis ,  P. Williams ,  William Wood ,  Thomas Wu ,  Zemin Zhang

IPC分类号： G01N33/574 ,  C07K16/30

CPC分类号： C07K16/30 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  G01N33/574

摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20070003935A1

公开(公告)日：2007-01-04

申请号：US11102284

申请日：2005-04-07

申请人： Dan Eaton ,  Ellen Filvaroff ,  Mary Gerrilsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Colin Watanabe ,  William Wood

发明人： Dan Eaton ,  Ellen Filvaroff ,  Mary Gerrilsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Colin Watanabe ,  William Wood

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6874

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。