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公开(公告)号：US20110311496A1
公开(公告)日：2011-12-22
申请号：US13222701
申请日：2011-08-31
CPC分类号： A61K35/28 , A61K38/2026 , A61K38/2066 , A61K45/06 , A61K2035/124 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , Y02A50/409
摘要： The present technology provides compositions of mesenchymal stem cells for promoting wound healing or fracture healing and methods of promoting wound healing or fracture healing comprising the steps of administering mesenchymal stem cells in an effective amount.
摘要翻译： 本技术提供了用于促进伤口愈合或骨折愈合的间充质干细胞的组合物和促进伤口愈合或骨折愈合的方法，包括以有效量施用间充质干细胞的步骤。
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公开(公告)号：US20110142807A1
公开(公告)日：2011-06-16
申请号：US12974125
申请日：2010-12-21
CPC分类号： A61K35/28 , A61K38/2026 , A61K38/2066 , A61K45/06 , A61K2035/124 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , Y02A50/409
摘要： Methods of treating autoimmune diseases, allergic responses, cancer, or inflammatory diseases in an animal, promoting would healing, and promoting angiogenesis in an organ or tissue of an animal by administering to the animal mesenchymal stem cells in an effective amount.
摘要翻译： 治疗动物的自身免疫性疾病，过敏反应，癌症或炎性疾病的方法，通过以有效量施用于动物间充质干细胞来促进动物的愈合和促进动物的器官或组织中的血管发生。
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3.发明授权Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders 有权白细胞介素-22多肽，编码它们的核酸和治疗胰腺疾病的方法公开(公告)号：US07445905B2
公开(公告)日：2008-11-04
申请号：US11627492
申请日：2007-01-26
申请人： Austin L. Gurney , Sudeepta Aggarwal , Ming-Hong Xie , Ellen M. Maruoka , Jessica S. Foster , Audrey Goddard , William I. Wood
发明人： Austin L. Gurney , Sudeepta Aggarwal , Ming-Hong Xie , Ellen M. Maruoka , Jessica S. Foster , Audrey Goddard , William I. Wood
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： C07K14/54 , G01N33/6869 , G01N2333/54
摘要： The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及白细胞介素-22多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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4.发明申请INTERLEUKIN-22 POLYPEPTIDES, NUCLEIC ACIDS ENCODING THE SAME AND METHODS FOR THE TREATMENT OF PANCREATIC DISORDERS 有权INTERLEUKIN-22多肽，编码其的核酸和治疗胰腺疾病的方法公开(公告)号：US20070160612A1
公开(公告)日：2007-07-12
申请号：US11627492
申请日：2007-01-26
申请人： Austin Gurney , Sudeepta Aggarwal , Ming-Hong Xie , Ellen Maruoka , Jessica Foster , Audrey Goddard , William Wood
发明人： Austin Gurney , Sudeepta Aggarwal , Ming-Hong Xie , Ellen Maruoka , Jessica Foster , Audrey Goddard , William Wood
IPC分类号： A61K48/00 , G01N33/53 , A61K39/395
CPC分类号： C07K14/54 , G01N33/6869 , G01N2333/54
摘要： The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及白细胞介素-22多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20110245096A1
公开(公告)日：2011-10-06
申请号：US13033177
申请日：2011-02-23
申请人： Sudeepta Aggarwal , Hilary Clark , Austin L. Gurney , Jill R. Schoenfeld , P. Mickey Williams , William I. Wood , Thomas D. Wu
发明人： Sudeepta Aggarwal , Hilary Clark , Austin L. Gurney , Jill R. Schoenfeld , P. Mickey Williams , William I. Wood , Thomas D. Wu
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/463
摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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公开(公告)号：US20080213227A1
公开(公告)日：2008-09-04
申请号：US11541853
申请日：2006-10-02
CPC分类号： A61K35/28 , A61K38/2026 , A61K38/2066 , A61K45/06 , A61K2035/124 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , Y02A50/409
摘要： Methods of treating autoimmune diseases, allergic responses, cancer, or inflammatory diseases in an animal, promoting would healing, repairing epithelial damage and promoting angiogenesis in an organ or tissue of an animal by administering to the animal mesenchymal stem cells in an effective amount.
摘要翻译： 在动物中治疗自身免疫性疾病，过敏反应，癌症或炎症性疾病的方法，通过以有效量施用于动物间充质干细胞，促进将愈合，修复上皮损伤并促进动物的器官或组织中的血管生成。
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公开(公告)号：US20070185017A1
公开(公告)日：2007-08-09
申请号：US10533069
申请日：2003-10-28
申请人： Sudeepta Aggarwal , Hilary Clark , Austin Gurney , Jill Schoenfeld , P. Williams , William Wood , Thomas Wu
发明人： Sudeepta Aggarwal , Hilary Clark , Austin Gurney , Jill Schoenfeld , P. Williams , William Wood , Thomas Wu
CPC分类号： C07K14/47 , A61K38/00 , Y02A50/463
摘要： The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
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公开(公告)号：US20050239897A1
公开(公告)日：2005-10-27
申请号：US11080298
申请日：2005-03-15
申请人： Mark Pittenger , Sudeepta Aggarwal
发明人： Mark Pittenger , Sudeepta Aggarwal
IPC分类号： A61K35/14 , A61K35/28 , C12N5/00 , C12N5/0775 , H04Q7/20
CPC分类号： A61K35/28 , A61K38/2026 , A61K38/2066 , A61K45/06 , A61K2035/124 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , Y02A50/409
摘要： Methods of treating autoimmune diseases, allergic responses, cancer, or inflammatory diseases in an animal, promoting would healing, and promoting angiogenesis in an organ or tissue of an animal by administering to the animal mesenchymal stem cells in an effective amount.
摘要翻译： 治疗动物的自身免疫性疾病，过敏反应，癌症或炎性疾病的方法，通过以有效量施用于动物间充质干细胞来促进动物的愈合和促进动物的器官或组织中的血管发生。
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公开(公告)号：US08524238B2
公开(公告)日：2013-09-03
申请号：US13436411
申请日：2012-03-30
申请人： Dong Fang , Paul Moore , Steve Ruben , Sudeepta Aggarwal
发明人： Dong Fang , Paul Moore , Steve Ruben , Sudeepta Aggarwal
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/249 , A61K39/39533 , A61K2039/505 , C07K14/47 , C07K14/57 , C07K16/18 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/5011 , G01N33/574 , G01N33/57484 , G01N2500/10
摘要： Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
摘要翻译： 提供了使用癌症相关靶标（“CAT”）评估，治疗和预防疾病，特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT（例如拮抗剂或激动剂）如抗体，蛋白质，小分子化合物和核酸试剂（例如RNAi和反义试剂）的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法，以及通过这些筛选方法鉴定的试剂。
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10.发明申请Multipotent Adult Stem Cells And Uses of Multipotent Adult Stem Cells To Treat Inflammation 审中-公开多能成人干细胞和多能成人干细胞治疗炎症的用途公开(公告)号：US20100172885A1
公开(公告)日：2010-07-08
申请号：US12727971
申请日：2010-03-19
CPC分类号： A61K35/28 , A61K38/2026 , A61K38/2066 , A61K45/06 , A61K2035/124 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , Y02A50/409
摘要： Disclosed are cell preparations comprising multipotent adult stem cells and methods for using multipotent adult stem cells to treat autoimmune diseases, treat allergic responses, treat cancer, treat inflammatory diseases, treat fibrotic disorders, reduce inflammation and/or fibrosis, promote would healing, repair epithelial damage, and/or promote angiogenesis.
摘要翻译： 公开了包含多潜能成体干细胞的细胞制剂和使用多潜能成体干细胞治疗自身免疫疾病，治疗过敏反应，治疗癌症，治疗炎性疾病，治疗纤维化疾病，减轻炎症和/或纤维化，促进愈合，修复上皮的方法 和/或促进血管生成。
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