公开(公告)号：US08100875B2

公开(公告)日：2012-01-24

申请号：US11548553

申请日：2006-10-11

申请人： John Cline ,  John L. Blum ,  Gary Stacey ,  Phillip Davies ,  Trevor Beckett

发明人： John Cline ,  John L. Blum ,  Gary Stacey ,  Phillip Davies ,  Trevor Beckett

IPC分类号： A61F5/44

CPC分类号： A61F5/448 ,  A61F5/445 ,  A61F2005/4402 ,  A61F2005/4486

摘要： A single-use ostomy appliance is described including an ostomy coupling for releasable coupling first and second portions at a stomal orifice. The two portions may be separable body-side and non-body-side parts, or the two portions may be portions of a unitary ostomy device such as a controlled evacuation device. The coupling includes a mechanical fastener configured such that the coupling is rendered substantially not resecurable after the fastener is released.

摘要翻译： 描述了一种一次性造口术装置，其包括用于在口咽口处可释放地联接第一和第二部分的造口术联接器。 两个部分可以是可分离的身体侧部分和非体侧部分，或者两个部分可以是诸如受控排泄装置的整体造口术装置的部分。 联接器包括机械紧固件，其被配置为使得在紧固件被释放之后，联接器基本上不可再生。

公开(公告)号：US20070088300A1

公开(公告)日：2007-04-19

申请号：US11548553

申请日：2006-10-11

申请人： John Cline ,  John Blum ,  Gary Stacey ,  Phillip Davies ,  Trevor Beckett

发明人： John Cline ,  John Blum ,  Gary Stacey ,  Phillip Davies ,  Trevor Beckett

IPC分类号： A61F5/44

CPC分类号： A61F5/448 ,  A61F5/445 ,  A61F2005/4402 ,  A61F2005/4486

摘要： A single-use ostomy appliance is described including an ostomy coupling for releasable coupling first and second portions at a stomal orifice. The two portions may be separable body-side and non-body-side parts, or the two portions may be portions of a unitary ostomy device such as a controlled evacuation device. The coupling includes a mechanical fastener configured such that the coupling is rendered substantially not resecurable after the fastener is released.

摘要翻译： 描述了一种一次性造口术装置，其包括用于在口咽口处可释放地联接第一和第二部分的造口术联接器。 两个部分可以是可分离的身体侧部分和非体侧部分，或者两个部分可以是诸如受控排泄装置的整体造口术装置的部分。 联接器包括机械紧固件，其被配置为使得在紧固件被释放之后，联接器基本上不可再生。

公开(公告)号：US20120179124A1

公开(公告)日：2012-07-12

申请号：US13395047

申请日：2010-09-09

申请人： Tinh Nguyen-Demary ,  John Cline ,  John Blum ,  Gary Stacey ,  Philip Davies ,  Trevor Beckett

发明人： Tinh Nguyen-Demary ,  John Cline ,  John Blum ,  Gary Stacey ,  Philip Davies ,  Trevor Beckett

IPC分类号： A61F5/441 ,  A61F5/445

CPC分类号： A61F5/445 ,  A61F5/441 ,  A61F5/448 ,  A61F2005/4486

摘要： A controlled discharge ostomy appliance assembly comprises (i) a stoma seal that is self-urging with a dynamic damping characteristic that resists changes of seal volume, (ii) a press-fit coupling member displaceable from an unlocked position to a locked position as part of a press-fit process, and (iii) a single-use frangible portion. The assembly further includes a protector shield removably fastened to the appliance forming a combined assembly therewith. The protector shield comprises (i) a seal displacer manipulable for displacing the stoma seal to a non-operative position ready for fitting, (ii) a substantially rigid coupling member guard portion for protecting the state of the coupling member, and (iii) a bracing portion for bracing the single-use frangible portion.

摘要翻译： 受控放电造口术器具组件包括（i）具有阻止密封体积变化的动态阻尼特性的自推动的造口密封，（ii）可从解锁位置移位到锁定位置的压配合联构件作为部分 的压配合过程，以及（iii）单次使用的易碎部分。 组件还包括可拆卸地紧固到器具的保护器屏蔽件，其形成与之组合的组件。 保护罩包括（i）可操纵的密封置换器，用于将造口密封件移位到准备好装配的非操作位置，（ii）用于保护联接构件的状态的基本上刚性的联接构件保护部分，以及（iii） 用于支撑单次使用的易碎部分的支撑部分。

公开(公告)号：US08845606B2

公开(公告)日：2014-09-30

申请号：US13395047

申请日：2010-09-09

申请人： Tinh Nguyen-Demary ,  John Cline ,  John Blum ,  Gary Stacey ,  Philip Davies ,  Trevor Beckett

发明人： Tinh Nguyen-Demary ,  John Cline ,  John Blum ,  Gary Stacey ,  Philip Davies ,  Trevor Beckett

IPC分类号： A61F5/44 ,  A61F5/445 ,  A61F5/441 ,  A61F5/448

CPC分类号： A61F5/445 ,  A61F5/441 ,  A61F5/448 ,  A61F2005/4486

摘要： A controlled discharge ostomy appliance assembly comprises (i) a stoma seal that is self-urging with a dynamic damping characteristic that resists changes of seal volume, (ii) a press-fit coupling member displaceable from an unlocked position to a locked position as part of a press-fit process, and (iii) a single-use frangible portion. The assembly further includes a protector shield removably fastened to the appliance forming a combined assembly therewith. The protector shield comprises (i) a seal displacer manipulable for displacing the stoma seal to a non-operative position ready for fitting, (ii) a substantially rigid coupling member guard portion for protecting the state of the coupling member, and (iii) a bracing portion for bracing the single-use frangible portion.

摘要翻译： 受控放电造口术器具组件包括（i）具有阻止密封体积变化的动态阻尼特性的自推动的造口密封，（ii）可从解锁位置移位到锁定位置的压配合联构件作为部分 的压配合过程，以及（iii）单次使用的易碎部分。 组件还包括可拆卸地紧固到器具的保护器屏蔽件，其形成与之组合的组件。 保护罩包括（i）可操纵的密封置换器，用于将造口密封件移位到准备好装配的非操作位置，（ii）用于保护联接构件的状态的基本上刚性的联接构件保护部分，以及（iii） 用于支撑单次使用的易碎部分的支撑部分。

公开(公告)号：US20080119804A1

公开(公告)日：2008-05-22

申请号：US12022335

申请日：2008-01-30

申请人： John Cline ,  Tinh DeMary ,  Andrew Lovatt ,  Philip Davies ,  Paul Johnson ,  Gary Stacey ,  Iain Ansell

发明人： John Cline ,  Tinh DeMary ,  Andrew Lovatt ,  Philip Davies ,  Paul Johnson ,  Gary Stacey ,  Iain Ansell

IPC分类号： A61F5/445

CPC分类号： A61F5/445 ,  A61F5/448

摘要： An ostomy appliance is described in the form of a controlled discharge device for controlling discharge from the stoma and/or an ostomy pouch for collecting discharged waste. The appliance may include one or more of: an elastomeric stoma seal for providing a seal around or directly against the stoma; a stoma occluder for occluding the stoma without passing internally into the stoma; a peristomal foam wall; a confinement seal for confining at least solid excreta to a confinement region adjacent to the stoma; a stowable collector bag; and interchangeable controlled discharge devices and ostomy pouches. The foam wall may provide a barrier to stool, but allow escape of flatus. The foam wall and/or the stoma occluder and/or the confinement seal may apply a force in a direction to increase the sealing force on the stoma seal.

摘要翻译： 造口术器具以控制排出装置的形式进行描述，用于控制从造口排出的排泄物和/或用于收集排出的废物的造口袋。 器具可以包括以下中的一个或多个：用于在围绕或直接抵靠造口提供密封的弹性体造口密封件; 用于封闭造口而不通过内部进入造口的造口闭塞器; 围壁泡沫壁; 用于将至少固体排泄物限制在与造口相邻的限制区域的限制密封件; 一个可收起的收集袋; 和可互换的控制排放装置和造口术袋。 泡沫壁可以为粪便提供屏障，但允许排泄口。 泡沫壁和/或造口闭塞器和/或限制密封件可以沿着增加密封力的方向施加力。

公开(公告)号：US20130060214A1

公开(公告)日：2013-03-07

申请号：US13697014

申请日：2011-05-10

申请人： Alastair Willoughby ,  Mark Rogers ,  Gary Stacey ,  Wai Chan

发明人： Alastair Willoughby ,  Mark Rogers ,  Gary Stacey ,  Wai Chan

IPC分类号： A61F5/445

CPC分类号： A61F5/445 ,  A61F5/448

摘要： An ostomy body side member with a sealing member is provided. The sealing member has a fixed base member defining an opening having a first diameter and a resilient sealing element comprising a stoma receiving orifice defining an inner boundary. The inner boundary of the stoma receiving orifice has a second diameter that is smaller than the first diameter of the frame. The sealing member is also provided with at least one adjustment member coupled between the fixed base member and the resilient sealing element. Furthermore, an alignment member for adjusting the tension of the at least one adjustment member is provided thereby allowing the diametrical dimension of the stoma sealing orifice to be adjusted from a first diameter to a second diameter.

摘要翻译： 提供具有密封构件的造口体侧构件。 密封构件具有限定具有第一直径的开口的固定基部构件和包括限定内部边界的造口接收孔的弹性密封元件。 造口接收孔的内边界具有小于框架的第一直径的第二直径。 密封构件还设置有联接在固定基部构件和弹性密封元件之间的至少一个调节构件。 此外，提供了用于调节至少一个调节构件的张力的对准构件，从而允许气孔密封孔的直径尺寸从第一直径调节到第二直径。

公开(公告)号：US20120110696A1

公开(公告)日：2012-05-03

申请号：US13347199

申请日：2012-01-10

申请人： Jinrong Wan ,  Gary Stacey ,  Minviluz Stacey ,  Xuecheng Zhang

发明人： Jinrong Wan ,  Gary Stacey ,  Minviluz Stacey ,  Xuecheng Zhang

IPC分类号： A01H5/00 ,  A01H1/06

CPC分类号： C12N15/8282 ,  C12N9/12

摘要： Perception of chitin fragments (chitooligosaccharides) is an important first step in plant defense response against fungal pathogen. LysM receptor-like kinases (LysM RLKs) are instrumental in this perception process. LysM RLKs also play a role in activating transcription of chitin-responsive genes (CRGs) in plants. Mutations in the LysM kinase receptor genes or the downstream CRGs may affect the fungal susceptibility of a plant. Mutations in LysM RLKs or transgenes carrying the same may be beneficial in imparting resistance against fungal pathogens.

摘要翻译： 几丁质片段（壳寡糖）的感知是植物对真菌病原体防御反应的重要第一步。 LysM受体样激酶（LysM RLKs）在此感知过程中起了重要作用。 LysM RLKs也在植物中激活壳多糖应答基因（CRG）的转录中发挥作用。 LysM激酶受体基因或下游CRG中的突变可能影响植物的真菌易感性。 LysM RLK中的突变或携带其的转基因可能有益于赋予对真菌病原体的抗性。

公开(公告)号：US20110026009A1

公开(公告)日：2011-02-03

申请号：US12440949

申请日：2007-09-14

申请人： Christopher Knutson ,  Crystal Duke ,  Gary Stacey ,  Dan Mueth ,  Evan Tanner ,  Osman Akcakir ,  Haojun Fu ,  Robert Lancelot ,  Tania Chakrabarty ,  Kenneth Bradley

发明人： Christopher Knutson ,  Crystal Duke ,  Gary Stacey ,  Dan Mueth ,  Evan Tanner ,  Osman Akcakir ,  Haojun Fu ,  Robert Lancelot ,  Tania Chakrabarty ,  Kenneth Bradley

IPC分类号： G01N33/48 ,  G01B11/30

CPC分类号： G01N33/48 ,  G01N33/54373 ,  G01N33/80

摘要： Methods and apparatus for analyzing surface properties of particles are provided. A method for analyzing the surface properties of the particle includes a associating a first particle with a first capture zone having a specific binding affinity for a first chemical species, applying an optical force to the first particle, sensing a response of the first particle to the optical force, and using the sensed response to determine the presence, absence or quantity of the first chemical species on the first particle surface. This process may be repeated in parallel to test multiple particles. In addition to directly testing the surface properties of the particles, the method can be used in direct, indirect and competitive assays to determine the presence, absence or quantity of free or immobilized analytes. A fluidic cartridge with capture zones having avidities that are tuned for the use of optical forces is provided. A software routine for performing the method is also provided.

摘要翻译： 提供了分析颗粒表面性质的方法和装置。 用于分析颗粒的表面性质的方法包括将第一颗粒与对第一化学物质具有特异性结合亲和力的第一捕获区缔合，向第一颗粒施加光学力，感测第一颗粒对第一颗粒的响应 并且使用感测到的响应来确定第一颗粒表面上的第一化学物质的存在，不存在或数量。 该过程可以并行重复以测试多个颗粒。 除了直接测试颗粒的表面性质之外，该方法可用于直接，间接和竞争性测定，以确定游离或固定化分析物的存在，不存在或数量。 提供了一种具有捕获区域的流体盒，其具有被调整以用于光学力的空间。 还提供了用于执行该方法的软件程序。

公开(公告)号：US07348203B2

公开(公告)日：2008-03-25

申请号：US10523528

申请日：2003-09-01

申请人： Tej Paul Kaushal ,  Paul Antony Manning ,  John Peter Gillham ,  Gary Stacey ,  David Martin Pooley ,  Peter Georg Laitenberger

发明人： Tej Paul Kaushal ,  Paul Antony Manning ,  John Peter Gillham ,  Gary Stacey ,  David Martin Pooley ,  Peter Georg Laitenberger

IPC分类号： H01L21/00 ,  H01L31/0203 ,  H01J5/02 ,  G02B6/36

CPC分类号： B81B7/0041 ,  G01J5/02 ,  G01J5/0285 ,  G01J5/04 ,  G01J5/045 ,  G01J5/08 ,  G01J5/0806 ,  G02B6/4201 ,  G02B6/4204 ,  G02B6/4251 ,  H01L21/50 ,  H01L23/10 ,  H01L2224/48091 ,  H01L2924/01322 ,  H01L2924/00014 ,  H01L2924/00

摘要： A method of hermetically packaging an electronic device (8), in an enclosure (2) comprising mutually inter-engageable first and second housing members (4, 6), comprising the steps of securing the electronic device (8) to the first housing member (4), engaging the first (4) and second (6) housing members such that an hermetic seal is provided there between, wherein the engagement step is performed in a controlled atmosphere. The hermetic seal may be provided by an interference fit between the first (4) and second (6) housing members or via sealing means (16) interposed between the housing members (4, 6). The second housing member (6) may comprise an optical element (20), for example a window or lens. The packaging method is particularly applicable to packaging thermal detectors, for example microbolometer arrays.

摘要翻译： 一种在包括相互可互相接合的第一和第二壳体构件（4,6）的外壳（2）中气密地包装电子设备（8）的方法，包括以下步骤：将所述电子设备（8）固定到所述第一壳体构件 （4），接合所述第一（4）和第二（6）壳体构件，使得在其间设置气密密封，其中所述接合步骤在受控的气氛中进行。 气密密封可以通过第一（4）和第二（6）壳体构件之间的过盈配合或者插入在壳体构件（4,6）之间的密封装置（16）来提供。 第二壳体构件（6）可以包括光学元件（20），例如窗口或透镜。 包装方法特别适用于包装热检测器，例如微电热计阵列。

公开(公告)号：US5769811A

公开(公告)日：1998-06-23

申请号：US551150

申请日：1995-10-31

申请人： Gary Stacey ,  Frederick York ,  David Lamborghini ,  Steven Liberatore

发明人： Gary Stacey ,  Frederick York ,  David Lamborghini ,  Steven Liberatore

IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/34 ,  A61M1/36 ,  A61M35/00

CPC分类号： A61M1/3693 ,  A61M1/303 ,  A61M1/306 ,  A61M1/308 ,  A61M1/3696 ,  A61M1/30 ,  A61M1/3496 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2205/50 ,  A61M2205/6018 ,  A61M2205/6072

摘要： A multiprotocol blood-processing machine and disposable units for use therewith. The disposable units generally comprise a centrifuge bowl for separating whole blood into blood constituents, an inlet tube for conveying blood into the bowl, an outlet tube for conveying the blood constituents away from the bowl, and a manifold for placing the inlet tube and the outlet tube in fluid communication with a tube from a donor. The manifold has a machine-readable bar-code label for identifying to the blood processing machine which type of disposable unit is being coupled to it. The machine itself comprises a central processing unit that controls overall operation, a first computer memory containing safety-monitoring instructions that cause the central processing unit to monitor various state parameters in order to ensure donor safety, and a second computer memory containing instructions that define at least one apheresis or blood-processing protocol. In some implementations, the second computer memory is removable from and insertable into the blood processing machine by an operator.

摘要翻译： 一种多协议血液处理机及其一次性使用单元。 一次性单元通常包括用于将全血分离成血液成分的离心机碗，用于将血液输送到碗中的入口管，用于将血液成分输送到碗中的出口管，以及用于将入口管和出口 管与来自供体的管流体连通。 歧管具有用于识别血液处理机的机器可读条形码标签，该类型的一次性单元正在耦合到该处理机。 机器本身包括控制整体操作的中央处理单元，包含安全监视指令的第一计算机存储器，其使中央处理单元监视各种状态参数以确保供体安全;以及第二计算机存储器，其包含在 至少一个单采或血液处理协议。 在一些实施方式中，第二计算机存储器可由操作者从血液处理机器中移除并插入到血液处理机器中。