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公开(公告)号：US08906831B2
公开(公告)日：2014-12-09
申请号：US12384097
申请日：2009-03-30
申请人： John Eid , Stephen Turner , Ravi Dalal , Benjamin Flusberg , Jonas Korlach , Steven Lin , Adrian Fehr , Fred Christians , Robin Emig , Jeremy Gray , Robert Sebra , Lei Sun , Stephen Dudek
发明人： John Eid , Stephen Turner , Ravi Dalal , Benjamin Flusberg , Jonas Korlach , Steven Lin , Adrian Fehr , Fred Christians , Robin Emig , Jeremy Gray , Robert Sebra , Lei Sun , Stephen Dudek
CPC分类号： B01J19/0046 , B01J2219/00596 , C12N2310/50 , C12N2310/51 , C12Q1/6869 , C12Q2535/122 , C40B40/06 , G01N33/54313 , G01N33/54366
摘要： Methods for non-random loading of single analyte molecules into array structures are provided. The methods allow for distribution of a population of target molecules into a plurality of size confined regions such as wells. Sizing moieties are linked to individual target molecules. The sizing moieties are of sufficient size, relative to the size-confined reaction or observation regions, such that only a selected number of sizing moieties will fit into the size confined regions. The confined regions and the sizing moieties or target molecules comprise a selected charge that allow for controlling the loading of the sizing moities.
摘要翻译： 提供了将单一分析物分子非随机加载到阵列结构中的方法。 所述方法允许将目标分子群体分配到多个尺寸的限制区域例如孔中。 上限部分与单独的靶分子连接。 尺寸部分相对于尺寸限制的反应或观察区域具有足够的尺寸，使得只有选定数量的施胶部分将适合尺寸限制区域。 限制区域和施胶部分或靶分子包括允许控制施胶剂的载荷的选定的电荷。
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公开(公告)号：US08501406B1
公开(公告)日：2013-08-06
申请号：US12797260
申请日：2010-06-09
申请人： Jeremy Gray , Ronald Cicero , Gregory Kearns , Stephen Dudek , Natasha Popovich , Robert Sebra
发明人： Jeremy Gray , Ronald Cicero , Gregory Kearns , Stephen Dudek , Natasha Popovich , Robert Sebra
CPC分类号： C12Q1/6869 , B01J19/0046 , B01J2219/00317 , B01J2219/00443 , B01J2219/00596 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00722
摘要： Methods, substrates, and devices related to arrays of optical confinements having surfaces with high levels of bias. Substrates having transparent or silica based portions and opaque or reflective portions are treated with 1) a selective passivating agent, that selectively coats the opaque or reflective regions, 2) a functionalizing agent such as a coupling agent, and 3) a selective removal agent, which selectively removes functionalizing agent from the passivated opaque or reflective surfaces.
摘要翻译： 与具有高偏差水平的光学限制阵列相关的方法，衬底和器件。 具有透明或二氧化硅基部分和不透明或反射部分的基板用1）选择性钝化剂处理，其选择性地涂覆不透明或反射区域，2）官能化试剂例如偶联剂，和3）选择性除去剂， 其从钝化的不透明或反射表面选择性地除去官能化剂。
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公开(公告)号：US08715930B2
公开(公告)日：2014-05-06
申请号：US13429019
申请日：2012-03-23
申请人： Thang Pham , Jeremy Gray , Adrian Fehr , Albert James Chmura , Yu-Chih Tsai , Arunashree Bhamidipati
发明人： Thang Pham , Jeremy Gray , Adrian Fehr , Albert James Chmura , Yu-Chih Tsai , Arunashree Bhamidipati
CPC分类号： C12Q1/6874 , B01L9/523 , C12Q1/6869 , C40B60/14 , G01N33/54313 , G01N33/54353 , G01N2333/922 , C12Q2521/543 , C12Q2523/303 , C12Q2525/301
摘要： Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.
摘要翻译： 公开的是通过使具有附着于其上的感兴趣分子的珠与基底相接触来将感兴趣的分子加载到基底上的组合物，装置和方法，例如通过提供使珠子接近或接触基底的场， 相对于基底的珠。 感兴趣的分子可以沉积在底物上用于单分子分析。
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公开(公告)号：US20120322692A1
公开(公告)日：2012-12-20
申请号：US13429019
申请日：2012-03-23
申请人： Thang Pham , Jeremy Gray , Adrian Fehr , AJ Chmura , Yu-Chih Tsai , Arunashree Bhamidipati
发明人： Thang Pham , Jeremy Gray , Adrian Fehr , AJ Chmura , Yu-Chih Tsai , Arunashree Bhamidipati
CPC分类号： C12Q1/6874 , B01L9/523 , C12Q1/6869 , C40B60/14 , G01N33/54313 , G01N33/54353 , G01N2333/922 , C12Q2521/543 , C12Q2523/303 , C12Q2525/301
摘要： Disclosed are compositions, devices, and methods for loading molecules of interest onto a substrate by contacting beads having molecules of interest attached to them with the substrate, for example by providing a field that brings the beads into proximity or contact with the substrate and moves the beads with respect to the substrate. Such molecules of interest can be deposited onto substrates for single-molecule analysis.
摘要翻译： 公开的是通过使具有附着于其上的感兴趣分子的珠与基底相接触来将感兴趣的分子加载到基底上的组合物，装置和方法，例如通过提供使珠子接近或接触基底的场， 相对于基底的珠。 感兴趣的分子可以沉积在底物上用于单分子分析。
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公开(公告)号：US20110210094A1
公开(公告)日：2011-09-01
申请号：US12962249
申请日：2010-12-07
申请人： Jeremy Gray , Ronald L. Cicero , Annette Grot , Natasha Popovich , Stephen Dudek
发明人： Jeremy Gray , Ronald L. Cicero , Annette Grot , Natasha Popovich , Stephen Dudek
CPC分类号： G02B6/122 , G01N21/6428
摘要： The application relates to methods for producing islands of functionality within nanoscale apertures. Islands of functionality can be produced by growing an aperture constriction layer from the walls, functionalizing the exposed base of the aperture, then removing the aperture constriction layer. The aperture constriction layer can be produced, for example, by anodically growing an oxide layer onto a cladding through which the aperture extends. The islands of functionality can be used to bind a single molecule of interest, such as an enzyme within the nanoscale aperture.
摘要翻译： 该应用涉及在纳米尺度孔内产生功能岛的方法。 功能岛可以通过从壁上生长孔径收缩层来实现，使孔的暴露的基底功能化，然后去除孔径收缩层。 孔径收缩层可以例如通过将氧化物层阳极生长到孔径延伸穿过的包层上来产生。 功能岛可以用来结合单一的目标分子，例如在纳米尺度孔内的酶。
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公开(公告)号：US08906670B2
公开(公告)日：2014-12-09
申请号：US12877764
申请日：2010-09-08
申请人： Jeremy Gray , Ronald L. Cicero , Annette Grot , Natasha Popovich , Stephen Dudek
发明人： Jeremy Gray , Ronald L. Cicero , Annette Grot , Natasha Popovich , Stephen Dudek
CPC分类号： G02B6/107 , C23F1/00 , C23F17/00 , C25D11/022 , C25D11/04 , G01N21/6452 , G01N21/7743 , G02B6/10 , G02B6/136
摘要： The application relates to improved optical containment structures, methods of manufacture and use, and systems for employing same. The optical containment structures generally comprise zero-mode waveguide structures having non-reflective walls. The non-reflective walls allow the preparation of optical containment regions in which the optical containment dimensions can be decoupled from the solution containment dimensions. The application also relates to methods for producing islands of functionality within nanoscale apertures.
摘要翻译： 本申请涉及改进的光学容纳结构，制造和使用方法以及使用它们的系统。 光学容纳结构通常包括具有非反射壁的零模式波导结构。 非反射壁允许制备光学容纳区域，其中光学容纳尺寸可以与溶液容纳尺寸分离。 该应用还涉及在纳米尺度孔内产生功能岛的方法。
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公开(公告)号：US08367159B2
公开(公告)日：2013-02-05
申请号：US12962249
申请日：2010-12-07
申请人： Jeremy Gray , Ronald L. Cicero , Annette Grot , Natasha Popovich , Stephen Dudek
发明人： Jeremy Gray , Ronald L. Cicero , Annette Grot , Natasha Popovich , Stephen Dudek
CPC分类号： G02B6/122 , G01N21/6428
摘要： The application relates to methods for producing islands of functionality within nanoscale apertures. Islands of functionality can be produced by growing an aperture constriction layer from the walls, functionalizing the exposed base of the aperture, then removing the aperture constriction layer. The aperture constriction layer can be produced, for example, by anodically growing an oxide layer onto a cladding through which the aperture extends. The islands of functionality can be used to bind a single molecule of interest, such as an enzyme within the nanoscale aperture.
摘要翻译： 该应用涉及在纳米尺度孔内产生功能岛的方法。 功能岛可以通过从壁上生长孔径收缩层来实现，使孔的暴露的基底功能化，然后去除孔径收缩层。 孔径收缩层可以例如通过将氧化物层阳极生长到孔径延伸穿过的包层上来产生。 功能岛可以用来结合单一的目标分子，例如在纳米尺度孔内的酶。
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公开(公告)号：US20110117637A1
公开(公告)日：2011-05-19
申请号：US12877764
申请日：2010-09-08
申请人： Jeremy Gray , Ronald L. Cicero , Annette Grot , Natasha Popovich , Stephen Dudek
发明人： Jeremy Gray , Ronald L. Cicero , Annette Grot , Natasha Popovich , Stephen Dudek
CPC分类号： G02B6/107 , C23F1/00 , C23F17/00 , C25D11/022 , C25D11/04 , G01N21/6452 , G01N21/7743 , G02B6/10 , G02B6/136
摘要： The application relates to improved optical containment structures, methods of manufacture and use, and systems for employing same. The optical containment structures generally comprise zero-mode waveguide structures having non-reflective walls. The non-reflective walls allow the preparation of optical containment regions in which the optical containment dimensions can be decoupled from the solution containment dimensions. The application also relates to methods for producing islands of functionality within nanoscale apertures.
摘要翻译： 本申请涉及改进的光学容纳结构，制造和使用方法以及使用它们的系统。 光学容纳结构通常包括具有非反射壁的零模式波导结构。 非反射壁允许制备光学容纳区域，其中光学容纳尺寸可以与溶液容纳尺寸分离。 该应用还涉及在纳米尺度孔内产生功能岛的方法。
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9.发明申请CONNECTOR SOCKET, A CONNECTOR PLUG, AND AN APPLIANCE FITTED WITH A CONNECTOR 审中-公开连接器插座，连接器插头和连接器附件公开(公告)号：US20100130042A1
公开(公告)日：2010-05-27
申请号：US12524859
申请日：2008-01-11
申请人： Jeremy Gray
发明人： Jeremy Gray
CPC分类号： H01R13/748 , H01R4/4818 , H01R13/113 , H01R13/582 , H01R13/5833 , H01R13/6275
摘要： A socket (102) and plug (152) for an electrical connector arrangement are designed so that the contact blades (158) of the plug are elongate and oriented transverse to the body (154) of the plug and the direction of connexion is parallel to the plane of the blades and transverse to the major axis of the contact blades.
摘要翻译： 用于电连接器装置的插座（102）和插头（152）被设计成使得插头的接触片（158）是细长的并且横向于插头的本体（154）定向，并且连接方向平行于 叶片的平面并且横向于接触片的长轴。
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公开(公告)号：US20220361683A1
公开(公告)日：2022-11-17
申请号：US17318607
申请日：2021-05-12
申请人： Jeremy Gray , Renee Gray
发明人： Jeremy Gray , Renee Gray
IPC分类号： A47C20/02
摘要： A body pillow with attachable tail apparatus for wrinkle prevention and comfortable side sleeping includes a pillow body having a body front side, a body back side, a body top side, and a body bottom side. The body bottom side is planar and the body top side is arcuate to rest against the user's back. A cover is coupled to the pillow body. The cover is selectively engageable with the pillow body to cover the body front side, the body back side, the body top side, and the body bottom side. A first attachment member is coupled to the cover adjacent the body back side. A tail has a tail proximal end and a tail distal end and is configured to rest between the user's knees. A second attachment member is coupled to the tail proximal end and is selectively engageable with the first attachment member.
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