公开(公告)号：US06830638B2

公开(公告)日：2004-12-14

申请号：US10155910

申请日：2002-05-24

申请人： John F. Boylan ,  William J. Boyle ,  Kevin M. Magrini ,  Scott J. Huter

发明人： John F. Boylan ,  William J. Boyle ,  Kevin M. Magrini ,  Scott J. Huter

IPC分类号： C22F110

CPC分类号： C22F1/10 ,  A61B17/221 ,  A61B2017/00867 ,  A61B2017/2212 ,  A61F2/013 ,  A61F2/91 ,  A61F2002/821 ,  C22F1/006

摘要： Nickel-titanium alloys that have been deep drawn in a cold working process have linear pseudoelastic behavior without a phase transformation or onset of stress-induced martensite. A medical device made from a structural element which has been deep drawn and subsequently formed into a desired medical device geometry will experience such linear pseudoelastic behavior.

摘要翻译： 在冷加工过程中深拉制的镍 - 钛合金具有无相变或应力诱发马氏体开始的线性假弹性行为。 由已经深拉并随后形成所需医疗装置几何形状的结构元件制成的医疗装置将经历这种线性假弹性行为。

公开(公告)号：US06702834B1

公开(公告)日：2004-03-09

申请号：US09727102

申请日：2000-11-28

申请人： John F. Boylan ,  William J. Boyle ,  Andy E. Denison ,  Debashis Dutta ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  Samir Patel ,  Christopher J. Tarapata ,  Chicheng Wang ,  Francisco Sanchez ,  Kent C. B. Stalker

发明人： John F. Boylan ,  William J. Boyle ,  Andy E. Denison ,  Debashis Dutta ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  Samir Patel ,  Christopher J. Tarapata ,  Chicheng Wang ,  Francisco Sanchez ,  Kent C. B. Stalker

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.

摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

公开(公告)号：US06706053B1

公开(公告)日：2004-03-16

申请号：US09561747

申请日：2000-04-28

申请人： John F. Boylan ,  Scott J. Huter

发明人： John F. Boylan ,  Scott J. Huter

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067

摘要： An embolic protection device that employs a superelastic alloy self-expanding strut assembly with a small profile delivery system for use with interventional procedures is disclosed. The expandable strut assembly is covered with a filter element and both are compressed into a restraining sheath for delivery to a deployment site downstream and distal to the interventional procedure. Once at the desired site, the restraining sheath is retracted to deploy the embolic protection device, which captures flowing emboli generated during the interventional procedure. The expandable strut assembly is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element in order to minimize the stress hysteresis of the superelastic material. The stress hysteresis is defined by the difference between the loading plateau stress and the unloading plateau stress of the superelastic material. The resulting delivery system including the restraining sheath has a small profile and has a thin wall.

摘要翻译： 公开了一种栓塞保护装置，其采用具有小型轮廓输送系统的超弹性合金自扩张支架组件用于介入程序。 可膨胀支柱组件被过滤元件覆盖，并且两者被压缩成约束护套，用于递送到介入过程下游和远端的部署部位。 一旦在期望的位置，约束护套被缩回以部署栓塞保护装置，其捕获在介入手术期间产生的流动栓塞。 可膨胀支柱组件由镍 - 钛或镍钛镍超弹性合金制成，并且包括三元元件以使超弹性材料的应力滞后最小化。 应力滞后由载荷平台应力与超弹性材料的卸载平台应力之间的差异定义。 所产生的包括约束鞘的输送系统具有小的轮廓并且具有薄壁。

公开(公告)号：US06551341B2

公开(公告)日：2003-04-22

申请号：US09882930

申请日：2001-06-14

申请人： John F. Boylan ,  William J. Boyle ,  John E. Papp ,  Anuja H. Patel

发明人： John F. Boylan ,  William J. Boyle ,  John E. Papp ,  Anuja H. Patel

IPC分类号： A61M2900

CPC分类号： A61L31/022 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0067

摘要： Cold worked nickel-titanium alloys that have linear pseudoelastic behavior without a phase transformation or onset of stress-induced martensite as applied to a medical device having a strut formed body deployed from a sheath is disclosed. In one application, an embolic protection device that employs a linear pseudoelastic nitinol self-expanding strut assembly with a small profile delivery system for use with interventional procedures is disclosed. Linear pseudoelastic nitinol is used in the medical device as distinct from non-linear pseudoelastic (i.e., superelastic) nitinol. The expandable strut assembly is made from a small diameter tubing of cold worked nickel-titanium alloys. The self-expanding struts that deploy the filter element is laser cut from a large diameter cold worked nickel-titanium alloy, then joined to the small diameter tubing.

公开(公告)号：US07938843B2

公开(公告)日：2011-05-10

申请号：US10457218

申请日：2003-06-09

申请人： John F. Boylan ,  Keif Fitzgerald ,  Zhi Cheng Lin

发明人： John F. Boylan ,  Keif Fitzgerald ,  Zhi Cheng Lin

IPC分类号： A61M29/00 ,  A61F11/00

CPC分类号： A61F2/013 ,  A61F2002/018 ,  A61F2210/0023 ,  A61F2230/0006 ,  A61F2230/0067 ,  A61M2025/09141 ,  C22F1/006

摘要： Cold worked nickel-titanium alloys that have linear pseudoelastic behavior without a phase transformation or onset of stress-induced martensite as applied to a medical device having a strut formed body deployed from a sheath is disclosed. In one application, an embolic protection device that employs a linear pseudoelastic nitinol self-expanding strut assembly with a small profile delivery system for use with interventional procedures is disclosed. The expandable strut assembly is covered with a filter element and both are compressed into a restraining sheath for delivery to a deployment site downstream and distal to an interventional procedure. Once at the desired site, the restraining sheath is retracted to deploy the embolic protection device, which captures flowing emboli generated during the interventional procedure. Linear pseudoelastic nitinol is used in the medical device as distinct from non-linear pseudoelastic (i.e., superelastic) nitinol.

摘要翻译： 公开了一种冷加工的镍 - 钛合金，其具有线性假弹性特性，而不会发生应变诱发马氏体的相变或起始应用于具有从护套展开的支柱成形体的医疗装置。 在一个应用中，公开了一种栓塞保护装置，其采用线性假弹性镍钛诺自扩张支架组件，其具有用于介入程序的小型轮廓输送系统。 可膨胀支柱组件被过滤元件覆盖，并且两者被压缩成约束护套，用于递送到介入过程下游和远端的部署部位。 一旦在期望的位置，约束护套被缩回以部署栓塞保护装置，其捕获在介入手术期间产生的流动栓塞。 在医疗装置中使用线性假弹性镍钛诺不同于非线性假弹性（即超弹性）镍钛诺。

公开(公告)号：US07918011B2

公开(公告)日：2011-04-05

申请号：US11870262

申请日：2007-10-10

申请人： John F. Boylan ,  Daniel L. Cox

发明人： John F. Boylan ,  Daniel L. Cox

IPC分类号： B23P13/04 ,  A61F2/06

CPC分类号： A61F2/915 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/18 ,  A61L2400/16 ,  C22C19/00 ,  Y10S623/901 ,  Y10T29/49995

摘要： A radiopaque nitinol medical device such as a stent for use with or implantation in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element selected from the group of chemical elements consisting of iridium, platinum, gold, rhenium, tungsten, palladium, rhodium, tantalum, silver, ruthenium, or hafnium. The added ternary element improves the radiopacity of the nitinol stent comparable to that of a stainless steel stent of the same and strut pattern coated with a thin layer of gold. The nitinol stent has improved radioplacity yet retains its superelastic and shape memory behavior and further maintains a thin strut/wall thickness for high flexibility.

摘要翻译： 公开了一种不透射线的镍钛诺医疗装置，例如用于或植入体腔内的支架。 支架由镍 - 钛或镍钛诺等超弹性合金制成，并且包括选自由铱，铂，金，铼，钨，钯，铑，钽，银，钌等组成的化学元素组的三元元素， 或铪。 添加的三元元素提高了镍钛诺支架的不透射线能力，与不锈钢支架相同，并且镀有薄层金的支柱图案。 镍钛诺支架具有改善的放射性，但仍然保持其超弹性和形状记忆行为，并进一步保持薄的支柱/壁厚以获得高灵活性。

公开(公告)号：US06881542B1

公开(公告)日：2005-04-19

申请号：US09909474

申请日：2001-07-19

申请人： John F. Boylan ,  Alex J. Bowers

发明人： John F. Boylan ,  Alex J. Bowers

IPC分类号： C12N9/64 ,  C12Q1/68 ,  C07H21/04 ,  C12N5/00 ,  C12N9/20 ,  C12N15/00

CPC分类号： C12N9/6424 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156

摘要： The present invention relates to a serine threonine kinase. The invention also relates to nucleic acids encoding the kinase, vectors, host cells, antibodies and recombinant methods for producing the h2520-59 polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for h2520-59 and related products.

摘要翻译： 本发明涉及丝氨酸苏氨酸激酶。 本发明还涉及编码激酶，载体，宿主细胞，抗体的核酸和用于产生h2520-59多肽的重组方法。 此外，本发明公开了用于h2520-59及相关产品的治疗，诊断和研究用途。

公开(公告)号：US20090248130A1

公开(公告)日：2009-10-01

申请号：US12369360

申请日：2009-02-11

申请人： John F. Boylan

发明人： John F. Boylan

IPC分类号： A61F2/06

CPC分类号： A61F2/915 ,  A61F2/91 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2230/0013 ,  Y10T29/18

摘要： A stent and a delivery system for implanting the stent in a body lumen is disclosed. The stent is made from a superelastic alloy such as nickel-titanium or nitinol, and includes a ternary element in order to minimize the stress hysteresis of the superelastic material. The stress hysteresis is defined by the difference between the loading plateau stress and the unloading plateau stress of the superelastic material. The resulting delivery system has a small profile and includes a sheath covering the stent that has a thin wall.

摘要翻译： 公开了用于将支架植入体腔的支架和输送系统。 支架由超弹性合金如镍钛或镍钛诺制成，并且包括三元元件以使超弹性材料的应力滞后最小化。 应力滞后由载荷平台应力与超弹性材料的卸载平台应力之间的差异定义。 所得到的输送系统具有小的轮廓并且包括覆盖具有薄壁的支架的护套。

公开(公告)号：US20090099645A1

公开(公告)日：2009-04-16

申请号：US12153254

申请日：2008-05-15

申请人： John A. Simpson ,  John F. Boylan ,  Wayne Cornish

发明人： John A. Simpson ,  John F. Boylan ,  Wayne Cornish

IPC分类号： A61F2/06

CPC分类号： A61F2/91 ,  A61F2250/0098

摘要： There is disclosed medical devices, such as stents, guidewires and embolic filters, comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold. There is also disclosed a radiopaque marker comprising the disclosed binary alloy, as well as medical devices having the radiopaque marker attached thereto. Methods of attaching the radiopaque marker to the medical devices, such as by welding, are also disclosure also disclosed.

摘要翻译： 公开了包括钛的二元合金和选自铂，钯，铑和金的一种二元元素的医疗装置，例如支架，导丝和栓塞过滤器。 还公开了一种包括所公开的二元合金的不透射线标记，以及具有附着于其上的不透射线标记的医疗装置。 另外还公开了将不透射线标记物附接到医疗装置的方法，例如通过焊接。

公开(公告)号：US20080288056A1

公开(公告)日：2008-11-20

申请号：US11748797

申请日：2007-05-15

申请人： John A. Simpson ,  John F. Boylan

发明人： John A. Simpson ,  John F. Boylan

IPC分类号： A61F2/06

CPC分类号： A61F2/91 ,  A61F2250/0098

摘要： There is disclosed a radiopaque marker comprising a binary alloy of titanium and one binary element selected from platinum, palladium, rhodium, and gold. There is also disclosed various medical devices, such as stents, guidewires and embolic filters, that have the radiopaque marker attached thereto. Methods of attaching the radiopaque marker to the medical devices, such as by welding, are also disclosed.

摘要翻译： 公开了一种不透射线的标记，其包括钛的二元合金和选自铂，钯，铑和金的一种二元元素。 还公开了具有附着于其上的不透射线标记的各种医疗装置，例如支架，导丝和栓塞过滤器。 还公开了将不透射线标记物附接到医疗装置的方法，例如通过焊接。