公开(公告)号：US20090192045A1

公开(公告)日：2009-07-30

申请号：US12355906

申请日：2009-01-19

申请人： Yuqiu Jiang ,  Yi Zhang ,  Yixin Wang

发明人： Yuqiu Jiang ,  Yi Zhang ,  Yixin Wang

IPC分类号： C40B30/00 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16

摘要： Kits and articles include reagents for conducting a seven gene assay to stage colon cancer as Stage II or Stage III colon cancer.

摘要翻译： 试剂盒和制品包括用于进行七个基因测定以分期结肠癌作为II期或III期结肠癌的试剂。

公开(公告)号：US20140011685A1

公开(公告)日：2014-01-09

申请号：US13540756

申请日：2012-07-03

申请人： Yixin WANG ,  Baoying Huang ,  Jack Hu ,  Yuqiu Jiang ,  Tim Jatkoe ,  Yashoda Rajpurohit

发明人： Yixin WANG ,  Baoying Huang ,  Jack Hu ,  Yuqiu Jiang ,  Tim Jatkoe ,  Yashoda Rajpurohit

IPC分类号： C40B30/04 ,  C40B40/06 ,  C40B20/00

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G01N33/56966

摘要： Circulating Endothelial Cells are isolated from patient blood and gene expression of the cells is analyzed to assess a medical condition or the tissue of origin of the cell. Kits for conducting the method are also provided.

摘要翻译： 从患者血液中分离循环内皮细胞，分析细胞的基因表达以评估细胞的医学状况或原始组织。 还提供了用于进行该方法的套件。

公开(公告)号：US20110166030A1

公开(公告)日：2011-07-07

申请号：US12924506

申请日：2010-09-28

申请人： Yixin Wang ,  Yuqiu Jiang ,  John F. Palma

发明人： Yixin Wang ,  Yuqiu Jiang ,  John F. Palma

IPC分类号： C40B30/00

CPC分类号： G01N33/57434 ,  G01N2800/52

摘要： A method for predicting with high specificity from RTPCR detected markers if a patent is likely to respond to docetaxel treatment is disclosed. RTPCR detects the presence of absence of certain mutations due to fusion events. Together, with other protein markers, additional stratification is possible to identify patents suited for docetaxel therapy as opposed to for alternative treatments.

摘要翻译： 公开了一种如果专利可能对多西紫杉醇治疗作出反应，则从RTPCR检测的标记物以高特异性预测的方法。 RTPCR检测由于融合事件而不存在某些突变。 与其他蛋白质标记一起，额外的分层可以鉴定适合多西他赛治疗的专利，而不是替代治疗。

公开(公告)号：US20070037186A1

公开(公告)日：2007-02-15

申请号：US11435266

申请日：2006-05-16

申请人： Yuqiu Jiang ,  John Backus ,  Abhijit Mazumder ,  Dondapati Chowdary ,  Fei Yang ,  Yixin Wang ,  Timothy Jatkoe

发明人： Yuqiu Jiang ,  John Backus ,  Abhijit Mazumder ,  Dondapati Chowdary ,  Fei Yang ,  Yixin Wang ,  Timothy Jatkoe

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57407 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/154

摘要： The present invention relates to methods, compositions and articles directed to diagnosing thyroid carcinoma, differentiating between thyroid carcinoma and benign thyroid diseases, testing indeterminate thyroid fine needle aspirate samples of thyroid nodules, and determining patient protocols and outcomes.

摘要翻译： 本发明涉及用于诊断甲状腺癌，区分甲状腺癌和良性甲状腺疾病的方法，组合物和制品，测定甲状腺结节的不确定甲状腺细针抽吸样品，并确定患者的方案和结果。

公开(公告)号：US20080058432A1

公开(公告)日：2008-03-06

申请号：US11714755

申请日：2007-03-05

申请人： Yixin Wang ,  Abhijit Mazumder ,  Yuqiu Jiang ,  Thomas Briggs

发明人： Yixin Wang ,  Abhijit Mazumder ,  Yuqiu Jiang ,  Thomas Briggs

IPC分类号： C12Q1/68 ,  A61K45/00 ,  C40B30/00 ,  C40B40/08 ,  C40B30/04 ,  A61P35/00

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

摘要： A method of providing a prognosis of colorectal cancer is conducted by analyzing the expression of a group of genes. Gene expression profiles in a variety of medium such as microarrays are included as are kits that contain them.

摘要翻译： 通过分析一组基因的表达来进行提供结肠直肠癌预后的方法。 包括微阵列在内的各种培养基中的基因表达谱也包含在其中。

公开(公告)号：US20060269532A1

公开(公告)日：2006-11-30

申请号：US11344932

申请日：2006-02-01

申请人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Robert Henderson ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky ,  William Hepler ,  John Hural ,  Patricia McNeill ,  Raymond Houghton ,  Carlota Vinals y de Bassols ,  Teresa Foy ,  Yoshihiro Watanabe ,  Madeleine Meagher ,  Ta Deng

发明人： Jiangchun Xu ,  Davin Dillon ,  Jennifer Mitcham ,  Susan Harlocker ,  Yuqiu Jiang ,  Robert Henderson ,  Michael Kalos ,  Gary Fanger ,  Marc Retter ,  John Stolk ,  Craig Day ,  Thomas Vedvick ,  Darrick Carter ,  Samuel Li ,  Aijun Wang ,  Yasir Skeiky ,  William Hepler ,  John Hural ,  Patricia McNeill ,  Raymond Houghton ,  Carlota Vinals y de Bassols ,  Teresa Foy ,  Yoshihiro Watanabe ,  Madeleine Meagher ,  Ta Deng

IPC分类号： A61K48/00 ,  C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K2039/505 ,  C07K16/3069 ,  C07K2317/34 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US07074898B2

公开(公告)日：2006-07-11

申请号：US10010940

申请日：2001-12-05

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Steven G. Reed ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Steven G. Reed ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day

IPC分类号： C07K1/00 ,  C07K14/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022 ,  C12N2760/16222

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06620922B1

公开(公告)日：2003-09-16

申请号：US09636215

申请日：2000-08-09

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C07H2104

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US20080219988A1

公开(公告)日：2008-09-11

申请号：US11928383

申请日：2007-10-30

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick

IPC分类号： A61K39/395 ,  C07K7/06 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00 ,  C07K16/00 ,  A61K35/12 ,  A61P35/00 ,  A61K38/16 ,  G01N33/574 ,  C07K14/00 ,  C12N5/00 ,  A61K38/08 ,  A61K31/7052

CPC分类号： C07K14/005 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US06680197B2

公开(公告)日：2004-01-20

申请号：US09834759

申请日：2001-04-13

申请人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler ,  Robert A. Henderson

发明人： Yuqiu Jiang ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Jiangchun Xu ,  Susan L. Harlocker ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： C12N508

CPC分类号： C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K14/4748 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。