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1.发明授权公开(公告)号：US09597395B2
公开(公告)日：2017-03-21
申请号：US11138083
申请日：2005-05-25
申请人： John K. Fraser , Marc H. Hedrick , Min Zhu , Brian M. Strem , Eric Daniels , Isabella Wulur
发明人： John K. Fraser , Marc H. Hedrick , Min Zhu , Brian M. Strem , Eric Daniels , Isabella Wulur
CPC分类号： A61K45/06 , A61K35/28 , C12N5/0653 , A61K2300/00
摘要： Adipose derived regenerative cells are used to treat patients, including patients with cardiovascular conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells, e.g., stem and/or progenitor cells, obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, adipose derived regenerative cells are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic cardiovascular benefit.
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2.发明申请METHODS OF USING ADIPOSE TISSUE-DERIVED CELLS IN THE TREATMENT OF CARDIOVASCULAR CONDITIONS 审中-公开将ADIPOSE TISSUE衍生细胞用于治疗心血管事件的方法公开(公告)号：US20090269315A1
公开(公告)日：2009-10-29
申请号：US12414582
申请日：2009-03-30
申请人： John K. Fraser , Marc H. Hedrick , Min Zhu , Brian M. Strem , Eric Daniels , Isabella Wulur
发明人： John K. Fraser , Marc H. Hedrick , Min Zhu , Brian M. Strem , Eric Daniels , Isabella Wulur
IPC分类号： A61K35/12
CPC分类号： A61K35/28 , A61K35/34 , A61K35/44 , A61L27/3834 , A61L27/3886 , A61L27/54 , A61L2300/414 , A61L2430/36 , C12N5/0667 , C12N5/069 , C12N2506/1384
摘要： Cells present in processed lipoaspirate tissue are used to treat patients, including patients with cardiovascular conditions, diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in processed lipoaspirate are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic cardiovascular benefit.
摘要翻译： 存在于加工的脂肪抽吸组织中的细胞用于治疗患者，包括患有心血管病症，疾病或病症的患者。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的干细胞输送给患者。 所述方法可以在封闭系统中实施，使得干细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于加工的lipoaspirate中的细胞与用于促进，产生或支持治疗性心血管益处所必需的这种添加剂一起直接放置在受体中。
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3.发明申请SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS 有权用于分离和使用临床安全性ADIPOSE衍生的再生细胞的系统和方法公开(公告)号：US20100136668A1
公开(公告)日：2010-06-03
申请号：US12554755
申请日：2009-09-04
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12M1/00
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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4.发明授权Automated methods for isolating and using clinically safe adipose derived regenerative cells 有权用于分离和使用临床安全的脂肪来源的再生细胞的自动化方法公开(公告)号：US07585670B2
公开(公告)日：2009-09-08
申请号：US10884638
申请日：2004-07-02
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12N5/00
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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5.发明申请SYSTEMS AND METHODS FOR ISOLATING AND USING CLINICALLY SAFE ADIPOSE DERIVED REGENERATIVE CELLS 有权用于分离和使用临床安全性ADIPOSE衍生的再生细胞的系统和方法公开(公告)号：US20120264200A1
公开(公告)日：2012-10-18
申请号：US13452349
申请日：2012-04-20
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Rhonda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Rhonda Elizabeth Schreiber , Isabella Wulur
IPC分类号： C12M1/12
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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6.发明授权Systems and methods for isolating and using clinically safe adipose derived regenerative cells 有权用于分离和使用临床安全的脂肪来源的再生细胞的系统和方法公开(公告)号：US08163276B2
公开(公告)日：2012-04-24
申请号：US12554755
申请日：2009-09-04
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Schreiber , Isabella Wulur
IPC分类号： C12N5/00
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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7.发明授权Systems and methods for isolating and using clinically safe adipose derived regenerative cells 有权用于分离和使用临床安全的脂肪来源的再生细胞的系统和方法公开(公告)号：US08883499B2
公开(公告)日：2014-11-11
申请号：US13452349
申请日：2012-04-20
申请人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
发明人： Marc H. Hedrick , John K. Fraser , Michael J. Schulzki , Bobby Byrnes , Grace Carlson , Ronda Elizabeth Schreiber , Isabella Wulur
摘要： Systems and methods are described that are used to separate cells from a wide variety of tissues. In particular, automated systems and methods are described that separate regenerative cells, e.g., stem and/or progenitor cells, from adipose tissue. The systems and methods described herein provide rapid and reliable methods of separating and concentrating regenerative cells suitable for re-infusion into a subject.
摘要翻译： 描述了用于从多种组织分离细胞的系统和方法。 特别地，描述了从脂肪组织分离再生细胞例如干细胞和/或祖细胞的自动化系统和方法。 本文所述的系统和方法提供了快速且可靠的分离和浓缩适于再次输注到受试者中的再生细胞的方法。
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8.发明授权Methods of using regenerative cells in the treatment of stroke and related diseases and disorders 有权使用再生细胞治疗中风及相关疾病和病症的方法公开(公告)号：US09511094B2
公开(公告)日：2016-12-06
申请号：US13586735
申请日：2012-08-15
申请人： John K. Fraser , Marc H. Hedrick , Brian M. Strem
发明人： John K. Fraser , Marc H. Hedrick , Brian M. Strem
IPC分类号： A61K35/12 , A61K35/28 , C12N5/0775 , C12N5/071 , A61K35/36 , A61K35/44 , A61K38/18 , A61K45/06
CPC分类号： A61K35/28 , A61K9/0014 , A61K35/12 , A61K35/35 , A61K35/36 , A61K35/44 , A61K38/1866 , A61K45/06 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2300/64 , C12N5/0667 , C12N5/069 , C12N2506/1384 , A61K2300/00
摘要： Cells present in adipose tissue are used to stroke and stroke related diseases and disorders in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
摘要翻译： 存在于脂肪组织中的细胞用于卒中和中风患者的疾病和病症。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得再生细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的细胞与促进，产生或支持治疗益处所必需的这种添加剂一起直接放置在受体中。
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9.发明申请METHODS OF USING REGENERATIVE CELLS IN THE TREATMENT OF STROKE AND RELATED DISEASES AND DISORDERS 有权再生细胞在治疗和相关疾病和病症中的应用方法公开(公告)号：US20120308518A1
公开(公告)日：2012-12-06
申请号：US13586735
申请日：2012-08-15
申请人： John K. Fraser , Marc H. Hedrick , Brian M. Strem
发明人： John K. Fraser , Marc H. Hedrick , Brian M. Strem
CPC分类号： A61K35/28 , A61K9/0014 , A61K35/12 , A61K35/35 , A61K35/36 , A61K35/44 , A61K38/1866 , A61K45/06 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2300/64 , C12N5/0667 , C12N5/069 , C12N2506/1384 , A61K2300/00
摘要： Cells present in adipose tissue are used to stroke and stroke related diseases and disorders in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
摘要翻译： 存在于脂肪组织中的细胞用于卒中和中风患者的疾病和病症。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得再生细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的细胞与促进，产生或支持治疗益处所必需的这种添加剂一起直接放置在受体中。
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公开(公告)号：US08691216B2
公开(公告)日：2014-04-08
申请号：US13360022
申请日：2012-01-27
申请人： John K. Fraser , Marc H. Hedrick , Eric Daniels
发明人： John K. Fraser , Marc H. Hedrick , Eric Daniels
IPC分类号： C12N5/00
CPC分类号： A61K35/28 , A61K9/0014 , A61K35/12 , A61K35/35 , A61K35/36 , A61K35/44 , A61K38/1866 , A61K45/06 , A61L15/40 , A61L15/44 , A61L27/3604 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2300/412 , A61L2300/64 , C12N5/0667 , C12N5/069 , C12N2506/1384 , A61K2300/00
摘要： Cells present in adipose tissue are used to promote wound healing in a patient. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of regenerative cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the regenerative cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
摘要翻译： 存在于脂肪组织中的细胞用于促进患者的伤口愈合。 治疗患者的方法包括加工脂肪组织以将从脂肪组织获得的浓缩量的再生细胞输送给患者。 所述方法可以在封闭系统中实施，使得再生细胞在施用于患者之前不暴露于外部环境。 因此，在优选的方法中，存在于脂肪组织中的细胞与促进，产生或支持治疗益处所必需的这种添加剂一起直接放置在受体中。
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