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16 条记录 (耗时 0.022 秒)

    Aminomethylene amide analogs of pyrazinamide with intracellular antimycobacterial activity against pyrazinamide-resistant mycobacteria combined with a rifamycin
    1.
    发明授权
    Aminomethylene amide analogs of pyrazinamide with intracellular antimycobacterial activity against pyrazinamide-resistant mycobacteria combined with a rifamycin 失效
    吡嗪酰胺的氨基亚甲酰胺类似物与抗吡嗪酰胺抗性分枝杆菌与利福霉素联合的胞内抗分枝杆菌活性

    公开(公告)号：US06399607B1

    公开(公告)日：2002-06-04

    申请号：US09607893

    申请日：2000-06-30

    申请人： John T. Welch ,  Leonid B. Heifets ,  Michael H. Cynamon

    发明人： John T. Welch ,  Leonid B. Heifets ,  Michael H. Cynamon

    IPC分类号： A61K3150

    CPC分类号： A61K31/495 ,  A61K31/395 ,  A61K2300/00

    摘要： Methods for treating diseases involving pyrazinamide-resistant mycobacteria comprise administering to a mammal in need of treatment a therapeutically effective amount of a combination of rifamycin and a compound of formula I: wherein R1 is hydrogen haloalkyl, or lower alkyl; R2 and R3 are independently chosen from alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl, alkylaryl and substituted alkylaryl, or R2 and R3 taken together form a five- or six-membered heterocyclic or substituted heterocyclic ring; and X is hydrogen, halogen, or lower alkyl; or a pharmaceutically acceptable salt thereof.

    摘要翻译： 用于治疗涉及吡嗪酰胺抗性分枝杆菌的疾病的方法包括向需要治疗的哺乳动物施用治疗有效量的利福霉素和式I化合物的组合：其中R 1是氢卤代烷基或低级烷基; R 2和R 3独立地选自 烷基，取代的烷基，环烷基，芳基，取代的芳基，烷基芳基和取代的烷基芳基，或者R 2和R 3一起形成五元或六元杂环或取代的杂环; 和X是氢，卤素或低级烷基;或其药学上可接受的盐。

    Pyrazinoic acid esters as antituberculosis agents
    2.
    发明授权
    Pyrazinoic acid esters as antituberculosis agents 失效
    吡嗪酸酯类作为抗结核药

    公开(公告)号：US4962111A

    公开(公告)日：1990-10-09

    申请号：US364067

    申请日：1989-06-08

    申请人： John T. Welch ,  Michael H. Cynamon

    发明人： John T. Welch ,  Michael H. Cynamon

    IPC分类号： C07D241/24

    CPC分类号： C07D241/24 ,  Y10S514/924

    摘要： Pyrazinoic esters have been prepared. Compounds of this group are effective against mycobacteria including Mycobacteria tuberculosis, pyrazinamide-resistant Mycobacteria tuberculosis, Mycobacteria bovis and Mycobacteria kansasii.

    摘要翻译： 已经制备了吡嗪类酯。 该组的化合物对结核分枝杆菌，吡嗪酰胺抗性结核分枝杆菌，牛分枝杆菌和堪萨斯分支杆菌分枝杆菌有效。

    Cone mapping physical optics for design of indoor communication system
    5.
    发明授权
    Cone mapping physical optics for design of indoor communication system 有权
    锥形映射物理光学设计室内通信系统

    公开(公告)号：US06446031B1

    公开(公告)日：2002-09-03

    申请号：US09235865

    申请日：1999-01-22

    申请人： John T. Welch

    发明人： John T. Welch

    IPC分类号： G06F1710

    CPC分类号： H04W16/20 ,  H04B17/23 ,  H04B17/309 ,  H04B17/3912

    摘要： A system of physical optics is provided which is employed in the design of indoor wireless communication systems, where transmitters are placed and oriented within a model of a building complex. The system provides for forward tracing of rays, which makes practical signal coverage displays that respond interactively to communication system design changes. The physical optics system consists of a method of generating semi-rectangular cone elements covering space, and a method of enumerating receiver test points within each cone for accumulation and display of electromagnetic signal coverage.

    摘要翻译： 提供了一种用于设计室内无线通信系统的物理光学系统，其中发射机被放置并定向在建筑群的模型内。 该系统提供射线的前向跟踪，这使得实际的信号覆盖显示器能够交互地响应通信系统设计变化。 物理光学系统包括产生覆盖空间的半矩形圆锥元件的方法，以及枚举每个锥体内的接收器测试点的方法，用于积累和显示电磁信号覆盖。

    Clause counter map inference engine
    7.
    发明授权
    Clause counter map inference engine 失效
    条款计数器地图信息引擎

    公开(公告)号：US5230061A

    公开(公告)日：1993-07-20

    申请号：US815968

    申请日：1992-01-02

    申请人： John T. Welch

    发明人： John T. Welch

    IPC分类号： G05B19/05 ,  G06N5/04

    CPC分类号： G05B19/052 ,  G06N5/046 ,  Y10S706/903 ,  Y10S706/904 ,  Y10S706/906

    摘要： The invention describes a clause counter map inference engine which is an interpreter method based upon the Boolean form, in which Boolean inference is directly assisted by a programmable data structure. The system provides a translation of a series of Boolean logic functions into a compact map representation, which may then be used for Boolean inference by means of an interpreter algorithm or inference engine adapted to update function values based upon any changed input value. The invention provides a rule-based model for logical control systems having an imbeddable, event-chaining inference engine which is independent of the rule-based model. The time to complete a scan cycle of the system depends directly upon the number of inferences in an up-date interval between input and output variable changes, and the lengths of inference chains of events in the logic. The clause counter map inference engine generally provides a method of implementing logical functions where inferencing is at an optimum, thereby reducing inference processing time and providing a system which may take the place of other on-line control methods for implementation of a PLC, and also may be applied to expert and knowledge-based decision systems which utilize logic programming and rule search methods.

    摘要翻译： 本发明描述了一种基于布尔形式的解释器方法，其中布尔推理由可编程数据结构直接辅助。 该系统将一系列布尔逻辑函数的翻译提供给紧凑的映射表示，然后可以通过解释器算法或适用于基于任何改变的输入值来更新函数值的推理引擎来用于布尔推理。 本发明为具有独立于基于规则的模型的可嵌入的事件链接推理机的逻辑控制系统提供了基于规则的模型。 完成系统扫描周期的时间直接取决于输入和输出变量变化之间的最新间隔以及逻辑中事件推理链长度的推断次数。 子句计数器映射推理机通常提供一种实现逻辑功能的方法，其中推理处于最佳状态，从而减少推理处理时间，并提供可代替用于实现PLC的其他在线控制方法的系统，以及 可以应用于利用逻辑编程和规则搜索方法的专家和基于知识的决策系统。

    Relay ladder control system for simulation and monitoring
    10.
    发明授权
    Relay ladder control system for simulation and monitoring 失效

    公开(公告)号：US5777869A

    公开(公告)日：1998-07-07

    申请号：US353181

    申请日：1994-12-09

    申请人： John T. Welch

    发明人： John T. Welch

    IPC分类号： G05B19/05 ,  G06F19/00 ,  G06F9/305

    CPC分类号： G05B19/056

    摘要： An improved method of implementing and solving relay ladder logic, such as in programmable logic controllers, more efficiently to allow greater flexibility is provided. Solving relay ladder logic is performed with scan times dependent only upon the number of input and state changes on a scan, and the resulting number of flow changes at ladder connectors. The scan time will therefore be independent of the size of the ladder. The method comprises the steps of recording the structure of a relay ladder and the current flow on the ladder via a ladder coding convention which specifies adjacent relay ladder connections for a particular diagram. Based upon input or state variable changes or events, the process of the invention will act to toggle all of the ladder contacts associated with these events between open and closed positions. This procedure is accomplished by following precomputed lists of such contacts which will be affected by a particular event or change in system model variables. Once the scan events have been posted in the ladder, the scan continues with a processing sweep which computes flow change across one column of the ladder at a time. In each column during a scan, each posted event which has been updated in the control model may be retrieved and expanded across the ladder to vertical paths of the next column to the right in the ladder. When the column sweep reaches a coil element, the changed state variable will be output and retained for the next scan calculation. The relay logic event sweep performs a left to right computation of events or changes in the input or state variables of the control model ladder flow, such that the computation will always move downstream with respect to the power flow on the ladder. This insures that flow change is not doubly calculated on the same scan, returning to an original value. The process maintains a complete record of ladder flow on every scan, and is adaptable to any relay ladder logic system, having no formatting restrictions.