摘要:
The present invention provides novel compositions, methods and apparatus for DNA sequencing that can be performed, e.g., in a two-electrode chamber. The present invention also provides a method for sequencing a nucleic acid comprising immobilizing a plurality of complexes comprising a target nucleic acid, a primer nucleic acid, and a polymerase onto a surface, contacting the surface with a plurality of charged particles comprising a nucleotide phosphate by applying an electric field, reversing the electric field to transport unbound charged particles away from the surface, and detecting the incorporation of a nucleotide phosphate into a single molecule of the primer nucleic acid.
摘要:
The invention relates to the discovery of novel mutant DNA polymerases that possess altered kinetics for incorporating phosphate-labeled nucleotides during polymerization. The invention further relates to the use of these mutant DNA polymerases in sequencing and genotyping methods.
摘要:
Methods are disclosed utilizing single-molecule proteomics with dynamic probes to accomplish a variety of protein analytic applications. A panel of probes, when used in combination, can resolve and quantify a proteome in a simple assay detecting transient binding to single protein targets.
摘要:
A manually manipulable actuator mechanism includes a body and a manually manipulable element. The body has at least one wall element having a length extending along a first axis and a height extending along a second axis orthogonal to the first axis. The manually manipulable element has a button portion adapted for human digital manipulation and at least one wing portion extending outwardly from the button portion. The manually manipulable element is movable along the first axis between a first position in which an operative element is in a non-actuated condition and a second position in which the operative element is in an actuated condition. The wall element, which has a first height at the first position and a different second height at the second position, cooperates with the wing portion to constrain movement of the manually manipulable element at least along a third axis orthogonal to the first and second axes while the manually manipulable element is moved between the first and second positions.
摘要:
A data interface for transferring digital data between a host and a client over a communication path using packet structures linked together to form a communication protocol for communicating a pre-selected set of digital control and presentation data. The signal protocol is used by link controllers configured to generate, transmit, and receive packets forming the communications protocol, and to form digital data into one or more types of data packets, with at least one residing in the host device and being coupled to the client through the communications path. The interface provides a cost-effective, low power, bi-directional, high-speed data transfer mechanism over a short-range “serial” type data link, which lends itself to implementation with miniature connectors and thin flexible cables which are especially useful in connecting display elements such as wearable micro-displays to portable computers and wireless communication devices.
摘要:
A data Interface for transferring digital data between a host and a client over a communication path using packet structures linked together to form a communication protocol for communicating a pre-selected set of digital control and presentation data. The signal protocol is used by link controllers configured to generate, transmit, and receive packets forming the communications protocol, and to form digital data into one or more types of data packets, with at least one residing in the host device and being coupled to the client through the communications path. The interface provides a cost-effective, low power, bi-directional, high-speed data transfer mechanism over a short-range “serial” type data link, which lends itself to implementation with miniature connectors and thin flexible cables which are especially useful in connecting display elements such as wearable micro-displays to portable computers and wireless communication devices.
摘要:
The invention relates to topical cosmetic and pharmaceutical composition for enhancing collagen levels in skin cells, the compositions comprising an effective amount of a biologically active phenolic compound-containing extract, or active fraction thereof, obtainable from Mimosa pudica.
摘要:
A system and method for determining timing offset errors in a low earth orbit satellite system based upon Doppler and Doppler rate of change is provided. A user terminal determines first and second timing offsets respectively associated with first and second satellite beams from respective first and second satellites. Next, the user terminal determines the Doppler and Doppler rate of change associated with the first and second satellite beams. A timing offset is estimated from the measured Doppler and Doppler rate of change and is then compared with the user terminal's own determined timing offset. If the comparison does not produce a value within a predetermined threshold, a beam identification error is declared.
摘要:
A device which in an optical interface adapts XFP to a 300 pin MSA transponder socket, permitting replacement of 300 pin MSA transponders with an XFP module on an existing host circuit pack. The device performs dispersion compensation in a removable module, addressing issues of jitter, path length equalization, cross talk and electromagnetic compatibility. As deployed, the device presents at the optical interface the attributes of XFP, hence connected optical devices are “fooled” into reading a connection to XFP instead of the 300 pin MSA.
摘要:
A data interface for transferring digital data between a host and a client over a communication path using packet structures linked together to form a communication protocol for communicating a pre-selected set of digital control and presentation data. The signal protocol is used by link controllers configured to generate, transmit, and receive packets forming the communications protocol, and to form digital data into one or more types of data packets, with at least one residing in the host device and being coupled to the client through the communications path. The interface provides a cost-effective, low power, bi-directional, high-speed data transfer mechanism over a short-range “serial” type data link, which lends itself to implementation with miniature connectors and thin flexible cables which are especially useful in connecting display elements such as wearable micro-displays to portable computers and wireless communication devices.