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公开(公告)号：US06844344B2
公开(公告)日：2005-01-18
申请号：US10148658
申请日：2000-12-06
申请人： John Xiaoqiang He , Nicholas Allan Honigschmidt , Todd Jonathan Kohn , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , Kumiko Takeuchi
发明人： John Xiaoqiang He , Nicholas Allan Honigschmidt , Todd Jonathan Kohn , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , Kumiko Takeuchi
IPC分类号： A61P25/24 , A61P25/34 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/14 , C07D413/14 , A61K31/4545 , C07D401/14
CPC分类号： C07D405/12 , C07D409/12 , C07D409/14 , C07D417/14
摘要： The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine
摘要翻译： 本发明提供式（I）化合物，其可用于治疗抑郁症，焦虑症和减轻由于使用烟草或尼古丁而引起的部分戒断或症状
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公开(公告)号：US07144898B2
公开(公告)日：2006-12-05
申请号：US10149476
申请日：2000-12-06
申请人： Marvin Martin Hansen , John Xiaoqiang He , Nicholas Allan Honigschmidt , Daniel James Koch , Todd Jonathan Kohn , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , Kumiko Takeuchi
发明人： Marvin Martin Hansen , John Xiaoqiang He , Nicholas Allan Honigschmidt , Daniel James Koch , Todd Jonathan Kohn , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , Kumiko Takeuchi
IPC分类号： A11K31/445
CPC分类号： C07D401/12 , C07D409/14 , C07D417/14
摘要： The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
摘要翻译： 本发明提供了式（I）化合物：其可用于治疗抑郁，焦虑和减轻由于使用烟草或尼古丁引起的部分戒断引起的症状。
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公开(公告)号：US06835733B2
公开(公告)日：2004-12-28
申请号：US10148768
申请日：2002-09-09
申请人： John Xiaoqiang He , Nicholas Allan Honigschmidt , Todd Jonathan Kohn , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , Kumiko Takeuchi
发明人： John Xiaoqiang He , Nicholas Allan Honigschmidt , Todd Jonathan Kohn , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , Kumiko Takeuchi
IPC分类号： C07D40514
CPC分类号： C07D451/02
摘要： The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
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4.发明授权公开(公告)号：US06784180B2
公开(公告)日：2004-08-31
申请号：US10148655
申请日：2002-09-09
申请人： John Xiaoqiang He , Nicholas Allan Honigschmidt , Todd Jonathan Kohn , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , Kumiko Takeuchi
发明人： John Xiaoqiang He , Nicholas Allan Honigschmidt , Todd Jonathan Kohn , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , Kumiko Takeuchi
IPC分类号： C07D40904
CPC分类号： C07D409/12 , C07D409/14 , C07D417/04
摘要： The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of tobacco or of nicotine.
摘要翻译： 本发明提供了式（I）化合物：其可用于治疗抑郁，焦虑和减轻由于使用烟草或尼古丁引起的部分戒断引起的症状。
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公开(公告)号：US06251921B1
公开(公告)日：2001-06-26
申请号：US09312593
申请日：1999-05-14
申请人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号： A61K314436
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要： This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
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公开(公告)号：US6025382A
公开(公告)日：2000-02-15
申请号：US846647
申请日：1997-04-30
申请人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号： C07D295/08 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4436 , A61K31/4439 , A61K31/4453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P7/02 , C07D333/56 , C07D333/58 , C07D333/62 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/12 , C07D413/06 , C07D521/00 , A61K31/40 , A61K31/38 , C07D409/14
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要： This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
摘要翻译： 本申请涉及作为本文定义的式I二胺的凝血酶抑制剂，凝血抑制剂和血栓栓塞障碍剂的用途。 它还提供式I的新型化合物，其制备方法和中间体，以及包含式I化合物的药物制剂。
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7.发明授权公开(公告)号：US08101638B2
公开(公告)日：2012-01-24
申请号：US12169057
申请日：2008-07-08
IPC分类号： C07D211/72 , A61K31/44
CPC分类号： C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12
摘要： A compound of the formula (I) or a pharmaceutically acceptable salt, enantiomer, racemate, diasteromers or mixtures thereof, or a solvate thereof, formulations and methods of use thereof, as opioid receptor antagonists are disclosed wherein the variables are as described herein.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，对映异构体，外消旋体，非对映体或其混合物，或其溶剂化物，其制剂及其使用方法作为阿片受体拮抗剂，其中变量如本文所述。
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8.发明申请6-SUBSTITUTED NICOTINAMIDE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS 有权6-取代的NICOTINAMIDE衍生物作为阿片受体拮抗剂公开(公告)号：US20090023785A1
公开(公告)日：2009-01-22
申请号：US12169057
申请日：2008-07-08
IPC分类号： A61K31/44 , A61K31/166
CPC分类号： C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12
摘要： A compound of the formula (I) or a pharmaceutically acceptable salt, enantiomer, racemate, diasteromers or mixtures thereof, or a solvate thereof, formulations and methods of use thereof, as opioid receptor antagonists are disclosed wherein the variables are as described herein.
摘要翻译： 公开了式（I）化合物或其药学上可接受的盐，对映异构体，外消旋体，非对映体或其混合物，或其溶剂化物，其制剂及其使用方法作为阿片受体拮抗剂，其中变量如本文所述。
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公开(公告)号：US6075147A
公开(公告)日：2000-06-13
申请号：US148288
申请日：1998-09-04
IPC分类号： C07D413/10
CPC分类号： C07D413/10
摘要： This invention relates to carbamoyl substituted heterocycles which are .omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring and which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as pharmaceutical formulations containing them, methods for their use, and processes and intermediates for their preparation.
摘要翻译： 本发明涉及在苯环上带有氨基甲酰基取代的恶唑基或恶唑啉基的ω-苯基-ω-（3-吡啶基） - ω-亚烯基酸衍生物的氨基甲酰基取代的杂环，其表现出用于血栓烷受体拮抗作用和/或血栓烷 合成酶抑制，以及含有它们的药物制剂，其使用方法，以及其制备方法和中间体。
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公开(公告)号：US20080269296A1
公开(公告)日：2008-10-30
申请号：US12052972
申请日：2008-03-21
申请人： Maria-Jesus Blanco-Pillado , Mark Donald Chappell , Marta Garcia De La Torre , Nuria Diaz Buezo , James Erwin Fritz , William Glen Holloway , James Edward Matt , Charles Howard Mitch , Concepcion Pedregal-Tercero , Steven James Quimby , Miles Goodman Siegel , Dana Rae Smith , Russell Dean Stucky , Kumiko Takeuchi , Elizabeth Marie Thomas , Chad Nolan Wolfe
发明人： Maria-Jesus Blanco-Pillado , Mark Donald Chappell , Marta Garcia De La Torre , Nuria Diaz Buezo , James Erwin Fritz , William Glen Holloway , James Edward Matt , Charles Howard Mitch , Concepcion Pedregal-Tercero , Steven James Quimby , Miles Goodman Siegel , Dana Rae Smith , Russell Dean Stucky , Kumiko Takeuchi , Elizabeth Marie Thomas , Chad Nolan Wolfe
IPC分类号： A61K31/4433 , A61P25/32
CPC分类号： C07D213/643 , C07C235/46 , C07D213/38 , C07D213/64 , C07D213/78 , C07D213/81 , C07D213/82 , C07D217/02 , C07D217/04 , C07D237/24 , C07D239/34 , C07D241/24 , C07D307/14 , C07D307/52 , C07D333/20 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： A compound of the formula (I) wherein the variables X1 to X10, R1 to R7 including R3′, E, v, y, z. A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.
摘要翻译： 式（I）的化合物，其中变量X 1至X 10，R 1至R 7， 包括R 3'，E，v，y，z。 A和B如所述，或其药学上可接受的盐，溶剂化物，对映体，外消旋物，非对映异构体或其混合物，其可用于治疗，预防或改善肥胖症和相关疾病。
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