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公开(公告)号：US20110274646A1
公开(公告)日：2011-11-10
申请号：US13102451
申请日：2011-05-06
申请人： Johanna Nystedt , Heidi Anderson , Tero Satomaa , Jari Natunen , Jari Helin , Juhani Saarinen
发明人： Johanna Nystedt , Heidi Anderson , Tero Satomaa , Jari Natunen , Jari Helin , Juhani Saarinen
IPC分类号： A61K31/737 , C08B37/08 , A61P7/00 , A61K38/19
CPC分类号： A61K31/728 , A61K31/737 , A61K38/193 , C08B37/0072 , A61K2300/00
摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention also relates to a method for altering the relative amounts of blood cells and/or the types of blood cells in a subject by administering the combination to the subject. Further, the present invention relates to a method for mobilizing stem cells to the bloodstream of a subject by administering the combination to the subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.
摘要翻译： 本发明涉及透明质酸低聚物和/或聚合物的组合以及能够动员干细胞的因子。 本发明还涉及通过对受试者施用组合来改变受试者的血细胞相对量和/或血细胞类型的方法。 此外，本发明涉及一种通过向受试者施用组合来将干细胞移动到受试者的血液中的方法。 另外，本发明涉及透明质酸低聚物和/或聚合物。
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公开(公告)号：US08546353B2
公开(公告)日：2013-10-01
申请号：US13102451
申请日：2011-05-06
申请人： Johanna Nystedt , Heidi Anderson , Tero Satomaa , Jari Natunen , Jari Helin , Juhani Saarinen
发明人： Johanna Nystedt , Heidi Anderson , Tero Satomaa , Jari Natunen , Jari Helin , Juhani Saarinen
IPC分类号： A61K31/728 , C08B37/00 , C08L5/00 , C08B37/08
CPC分类号： A61K31/728 , A61K31/737 , A61K38/193 , C08B37/0072 , A61K2300/00
摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention also relates to a method for altering the relative amounts of blood cells and/or the types of blood cells in a subject by administering the combination to the subject. Further, the present invention relates to a method for mobilizing stem cells to the bloodstream of a subject by administering the combination to the subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.
摘要翻译： 本发明涉及透明质酸低聚物和/或聚合物的组合以及能够动员干细胞的因子。 本发明还涉及通过对受试者施用组合来改变受试者的血细胞相对量和/或血细胞类型的方法。 此外，本发明涉及一种通过向受试者施用组合来将干细胞移动到受试者的血液中的方法。 另外，本发明涉及透明质酸低聚物和/或聚合物。
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公开(公告)号：US20090148839A1
公开(公告)日：2009-06-11
申请号：US11988418
申请日：2006-07-07
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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4.发明授权Enzymatical modification of cell glycosylation using serum albumin and divalent cations 有权使用血清白蛋白和二价阳离子对细胞糖基化进行酶学修饰公开(公告)号：US09234169B2
公开(公告)日：2016-01-12
申请号：US13054541
申请日：2009-07-16
申请人： Johanna Nystedt , Heidi Anderson , Leena Valmu , Jari Natunen , Tero Satomaa
发明人： Johanna Nystedt , Heidi Anderson , Leena Valmu , Jari Natunen , Tero Satomaa
IPC分类号： C12P21/04 , C12N9/10 , C12N5/071 , C07H21/04 , C12N5/00 , C12P21/00 , C12N5/0775 , A61K35/12
CPC分类号： C12N5/0006 , A61K2035/124 , C12N5/0663 , C12N5/0665 , C12N9/1051 , C12N2501/70 , C12N2501/724 , C12P21/005
摘要： The invention is directed to a method and kit to control and modify the status of cells, such as human stem cells, by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where culture medium reagents, such as divalent cations, are present and cells are kept non-adherent. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明涉及一种方法和试剂盒，用于通过在反应条件下改变其糖基化，特别是唾液酸化和岩藻糖基化水平来控制和修饰细胞状态，例如人类干细胞，其中培养基试剂如二价阳离子， 存在并且细胞保持不粘附。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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5.发明申请ENZYMATICAL MODIF ICATION OF CELL GLYCOSYLATION USING SERUM ALBUMIN AND DIVALENT CATIONS 有权使用血清白蛋白和多种方式进行细胞糖化的酶学修饰公开(公告)号：US20110136203A1
公开(公告)日：2011-06-09
申请号：US13054541
申请日：2009-07-16
申请人： Johanna Nystedt , Heidi Anderson , Leena Valmu , Jari Natunen , Tero Satomaa
发明人： Johanna Nystedt , Heidi Anderson , Leena Valmu , Jari Natunen , Tero Satomaa
IPC分类号： C12N5/0775 , C12N5/071 , C12N9/10 , C12N9/24
CPC分类号： C12N5/0006 , A61K2035/124 , C12N5/0663 , C12N5/0665 , C12N9/1051 , C12N2501/70 , C12N2501/724 , C12P21/005
摘要： The invention is directed to a method and kit to control and modify the status of cells, such as human stem cells, by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where culture medium reagents, such as divalent cations, are present and cells are kept non-adherent. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明涉及一种方法和试剂盒，用于通过在反应条件下改变其糖基化，特别是唾液酸化和岩藻糖基化水平来控制和修饰细胞状态，例如人类干细胞，其中培养基试剂如二价阳离子， 存在并且细胞保持不粘附。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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公开(公告)号：US09382512B2
公开(公告)日：2016-07-05
申请号：US13352269
申请日：2012-01-17
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
IPC分类号： C12N5/00 , G01N33/50 , G01N33/569 , C12N5/0775
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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公开(公告)号：US20120190058A1
公开(公告)日：2012-07-26
申请号：US13352269
申请日：2012-01-17
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sari Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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公开(公告)号：US08110366B2
公开(公告)日：2012-02-07
申请号：US11988418
申请日：2006-07-07
申请人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sarl Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
发明人： Jarmo Laine , Taina Jaatinen , Heidi Anderson , Johanna Nystedt , Sarl Tiitinen , Anita Laitinen , Ulla Impola , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen
CPC分类号： C12N5/0006 , C12N5/0663 , G01N33/5073 , G01N33/5091 , G01N33/56966 , G01N2333/91102 , G01N2400/38 , Y10S436/809
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过观察细胞唾液酸化的变化来控制干细胞状态的方法。 并控制生物材料的潜在污染; 以及与细胞结合使用的试剂和方法，以避免通过污染材料改变细胞糖基化。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。
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公开(公告)号：US20100047892A1
公开(公告)日：2010-02-25
申请号：US12522853
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Taina Jaatinen , Annamari Heiskanen , Johanna Nystedt
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Taina Jaatinen , Annamari Heiskanen , Johanna Nystedt
CPC分类号： C12N5/0663 , C08B37/00 , C12N5/0006 , C12N5/0665 , C12N9/1051 , C12N9/1081 , C12N2500/25 , C12N2500/38 , C12N2501/11 , C12N2501/115 , C12N2501/135 , C12N2501/39 , C12N2501/70 , C12N2501/90 , C12N2502/13 , C12Q1/48 , G01N33/6842
摘要： The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by changing sialylation and/or fucosylation levels of the cells. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered. The control methods are preferably mass spectrometric methods.
摘要翻译： 本发明描述存在于人干细胞上的特定的唾液酸化结构及其衍生的细胞群。 本发明特别涉及通过改变细胞的唾液酸化和/或岩藻糖基化水平来控制干细胞状态的方法。 本发明进一步涉及其糖基化被特异性改变的新型干细胞。 控制方法优选是质谱方法。
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10.发明申请AN ANTIBODY-GLYCAN COMPLEX TARGETING THE DISIALYL CORE II AND SIALYL LEWIS X STRUCTURES, AND USES THEREOF INVOLVING ANALYSIS OF STEM CELLS OR CANCER CELLS 审中-公开一种针对分子核心II和SIALYL LEWIS X的抗体 - GLYCAN复合物及其涉及干细胞或癌细胞分析的应用公开(公告)号：US20120202701A1
公开(公告)日：2012-08-09
申请号：US13265953
申请日：2010-04-23
申请人： Suvi Natunen , Johanna Nystedt , Heidi Anderson , Jari Natunen
发明人： Suvi Natunen , Johanna Nystedt , Heidi Anderson , Jari Natunen
CPC分类号： G01N33/574 , C07K16/18 , C07K16/2896 , C08B37/006 , G01N33/5005 , G01N2400/38
摘要： Antibody-saccharide-complexes and methods and uses related to analysis of cells. Also disclosed is a method of selection of new antibody with CHO-specificity and to a use of antibodies produced for the analysis of stem cells or cancer cells or other cells or tissues known to bind to CHO-antibodies.
摘要翻译： 抗体 - 糖复合物以及与细胞分析相关的方法和用途。 还公开了选择具有CHO-特异性的新抗体的方法以及用于分析已知与CHO-抗体结合的干细胞或癌细胞或其他细胞或组织产生的抗体的用途。
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