-
1.发明申请公开(公告)号：US20180037914A1
公开(公告)日：2018-02-08
申请号：US15552647
申请日：2016-02-23
CPC分类号： C12P7/16 , C12M45/07 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N9/90 , C12N15/52 , C12Y101/01001 , C12Y101/01027 , C12Y101/01157 , C12Y102/0101 , C12Y102/01046 , C12Y102/01057 , C12Y102/04001 , C12Y103/01006 , C12Y103/01038 , C12Y203/01008 , C12Y203/01009 , C12Y203/01054 , C12Y401/02043 , C12Y503/01027 , C25B3/04 , C25B9/08 , C25B15/02 , C25B15/08 , Y02E50/10
摘要： A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency.
-
公开(公告)号：US09963684B2
公开(公告)日：2018-05-08
申请号：US15125785
申请日：2014-05-29
发明人： Jung-Kul Lee , Ranjitha Ramakrishnan , Ji-Hyun Park , Tae-Su Kim , Sun-Chang Kim
CPC分类号： C12N9/0008 , C12N15/52 , C12P7/24 , C12Y102/01046
摘要： This invention relates to a novel formaldehyde dehydrogenase expressed by a formaldehyde dehydrogenase gene and having independent reduction activity for formic acid, a method of preparing the formaldehyde dehydrogenase from a strain transformed with a recombinant expression vector including the gene, and a method of producing formaldehyde from formic acid through a reduction reaction of the formaldehyde dehydrogenase.
-
3.发明申请公开(公告)号：US20130196342A1
公开(公告)日：2013-08-01
申请号：US13094091
申请日：2011-04-26
申请人： Jonathan S. Stamler , Limin Liu
发明人： Jonathan S. Stamler , Limin Liu
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035 , A61K31/155 , A61K31/41 , A61K38/44 , C12N9/0008 , C12N15/8509 , C12Q1/26 , C12Y102/01046 , G01N2333/90212 , G01N2800/00 , A61K2300/00
摘要： Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions.
摘要翻译： 本文公开了用于在体内或体外调节S-亚硝基谷胱甘肽还原酶（GSNOR）的水平和/或活性的方法和组合物。 具体公开的是GSNOR缺失构建体，宿主细胞和包含GSNOR缺失的非人哺乳动物，以及使用GSNOR缺失突变体进行筛选的方法。 还具体公开了用于测量，监测或改变与各种医学状况有关的GSNOR水平或活性（以及一氧化氮和S-亚硝基硫醇水平）的试剂和程序。
-
公开(公告)号：US20230332191A1
公开(公告)日：2023-10-19
申请号：US18042589
申请日：2021-08-26
发明人： Ramon GONZALEZ , Alexander CHOU , James CLOMBURG , Fayin ZHU , Seung Hwan LEE
CPC分类号： C12P7/56 , C12P7/42 , C12N15/52 , C12N9/0006 , C12Y101/01244 , C12N9/0008 , C12Y102/01 , C12Y102/05 , C12Y102/01046 , C12N9/0071 , C12Y114/18003 , C12N9/0093 , C12Y117/01 , C12N9/1029 , C12Y203/01 , C12N9/1217 , C12Y207/02006
摘要： Many biotechnologically relevant organisms cannot utilize cheap and abundant one carbon feedstocks, e.g. CO2, CO, formaldehyde, methanol, and methane, for growth and instead prefer complex feedstocks such as sugars. Disclosed herein is a system that enables organisms to consume one carbon molecules for growth and maintenance via a formyl-CoA elongation pathway. Utilization of one carbon feedstocks can replace the use of sugar as the primary means of cultivating organisms in biotechnological applications. This has the potential to be more cost effective and avoid the controversial use of food as feedstocks. Intermediates of the formyl-CoA elongation pathway may be also be converted to desired chemical products.
-
5.发明申请COMPOSITIONS AND METHODS FOR MODULATING S-NITROSOGLUTHIONE REDUCTASE 审中-公开用于调节S-NITROSOGLUTHIONE还原的组合物和方法公开(公告)号：US20100266581A1
公开(公告)日：2010-10-21
申请号：US12723282
申请日：2010-03-12
申请人： JONATHAN S. STAMLER , LIMIN LIU
发明人： JONATHAN S. STAMLER , LIMIN LIU
IPC分类号： A61K39/395 , A61K31/155 , A61P25/16 , A61P25/28 , A61P9/10 , A61P35/00 , A61P9/12 , A61K31/7088 , A61K31/713 , A61K31/416 , A61K31/198
CPC分类号： G01N33/573 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035 , A61K31/155 , A61K31/41 , A61K38/44 , C12N9/0008 , C12N15/8509 , C12Q1/26 , C12Y102/01046 , G01N2333/90212 , G01N2800/00 , A61K2300/00
摘要： Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions.
摘要翻译： 本文公开了用于在体内或体外调节S-亚硝基谷胱甘肽还原酶（GSNOR）的水平和/或活性的方法和组合物。 具体公开的是GSNOR缺失构建体，宿主细胞和包含GSNOR缺失的非人哺乳动物，以及使用GSNOR缺失突变体进行筛选的方法。 还具体公开了用于测量，监测或改变与各种医学状况有关的GSNOR水平或活性（以及一氧化氮和S-亚硝基硫醇水平）的试剂和程序。
-
公开(公告)号：US20170145389A1
公开(公告)日：2017-05-25
申请号：US15125785
申请日：2014-05-29
发明人： Jung-Kul Lee , Ranjitha Ramakrishnan , Ji-Hyun Park , Tae-Su Kim , Sun-Chang Kim
CPC分类号： C12N9/0008 , C12N15/52 , C12P7/24 , C12Y102/01046
摘要： This invention relates to a novel formaldehyde dehydrogenase expressed by a formaldehyde dehydrogenase gene and having independent reduction activity for formic acid, a method of preparing the formaldehyde dehydrogenase from a strain transformed with a recombinant expression vector including the gene, and a method of producing formaldehyde from formic acid through a reduction reaction of the formaldehyde dehydrogenase.
-
7.发明申请公开(公告)号：US20080206738A1
公开(公告)日：2008-08-28
申请号：US11974367
申请日：2007-10-12
申请人： Jonathan S. Stamler , Limin Liu
发明人： Jonathan S. Stamler , Limin Liu
IPC分类号： C12Q1/25
CPC分类号： G01N33/573 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035 , A61K31/155 , A61K31/41 , A61K38/44 , C12N9/0008 , C12N15/8509 , C12Q1/26 , C12Y102/01046 , G01N2333/90212 , G01N2800/00 , A61K2300/00
摘要： Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions.
摘要翻译： 本文公开了用于在体内或体外调节S-亚硝基谷胱甘肽还原酶（GSNOR）的水平和/或活性的方法和组合物。 具体公开的是GSNOR缺失构建体，宿主细胞和包含GSNOR缺失的非人哺乳动物，以及使用GSNOR缺失突变体进行筛选的方法。 还具体公开了用于测量，监测或改变与各种医学状况有关的GSNOR水平或活性（以及一氧化氮和S-亚硝基硫醇水平）的试剂和程序。
-
8.发明申请公开(公告)号：US20050014697A1
公开(公告)日：2005-01-20
申请号：US10861304
申请日：2004-06-04
申请人： Jonathan Stamler , Limin Liu
发明人： Jonathan Stamler , Limin Liu
IPC分类号： A61K20060101 , A61K31/198 , A61K38/18
CPC分类号： G01N33/573 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/035 , A61K31/155 , A61K31/41 , A61K38/44 , C12N9/0008 , C12N15/8509 , C12Q1/26 , C12Y102/01046 , G01N2333/90212 , G01N2800/00 , A61K2300/00
摘要： Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures for measuring, monitoring, or altering GSNOR levels or activity (as well as nitric oxide and S-nitrosothiol levels) in connection with various medical conditions.
摘要翻译： 本文公开了用于在体内或体外调节S-亚硝基谷胱甘肽还原酶（GSNOR）的水平和/或活性的方法和组合物。 具体公开的是GSNOR缺失构建体，宿主细胞和包含GSNOR缺失的非人哺乳动物，以及使用GSNOR缺失突变体进行筛选的方法。 还具体公开了用于测量，监测或改变与各种医学状况有关的GSNOR水平或活性（以及一氧化氮和S-亚硝基硫醇水平）的试剂和程序。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.039 秒)
