公开(公告)号：US06939956B2

公开(公告)日：2005-09-06

申请号：US10146305

申请日：2002-05-15

申请人： Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Moo Young Song ,  Tae Hun Song ,  Chang Seok Kim

发明人： Jong Wook Lee ,  In Young Ko ,  Heui Keun Kang ,  Moo Young Song ,  Tae Hun Song ,  Chang Seok Kim

IPC分类号： C12N15/09 ,  C07K16/08 ,  C12N1/21 ,  C12N15/33 ,  C12N15/36 ,  C12N15/51 ,  C12P21/08 ,  C12R1/19 ,  C07H21/04 ,  C12N15/00

CPC分类号： C07K16/082 ,  C07K2317/56 ,  C07K2317/92 ,  C12N2730/10122

摘要： The present invention relates to a variable region of the monoclonal antibody against the S-surface antigen of hepatitis B virus and a gene encoding the same, a recombinant vector containing the gene, and a transformant obtained from the recombinant vector.

摘要翻译： 本发明涉及针对乙型肝炎病毒的S表面抗原的单克隆抗体的可变区和编码该抗体的基因，含有该基因的重组载体和从重组载体获得的转化体。

公开(公告)号：US07109320B2

公开(公告)日：2006-09-19

申请号：US10988617

申请日：2004-11-16

申请人： Heui Il Kang ,  In Young Ko ,  Moo Young Song ,  Chang Seok Kim ,  Sang Koo Park ,  Jae Sun Lee ,  Tae Hyoung Yoo ,  Kang In Na

发明人： Heui Il Kang ,  In Young Ko ,  Moo Young Song ,  Chang Seok Kim ,  Sang Koo Park ,  Jae Sun Lee ,  Tae Hyoung Yoo ,  Kang In Na

IPC分类号： C07H21/04 ,  C12N5/06 ,  C12N1/20 ,  C07K16/00

CPC分类号： C07K16/241 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： An antibody variable region of a monoclonal antibody specifically binding to human tumor necrosis factor-α contains at least one of a heavy chain variable region and a light chain variable region having specific complementarity determining regions therein. A nucleic acid molecule encoding the same, a recombinant vector containing the nucleic acid molecule, and a cell transformed with the recombinant vector are also provided.

摘要翻译： 与人肿瘤坏死因子-α特异性结合的单克隆抗体的抗体可变区含有其中具有特异性互补决定区的重链可变区和轻链可变区中的至少一个。 还提供了编码该核酸分子的核酸分子，含有核酸分子的重组载体和用重组载体转化的细胞。

公开(公告)号：US07196177B2

公开(公告)日：2007-03-27

申请号：US11376338

申请日：2006-03-16

申请人： Heui II Kang ,  In Young Ko ,  Moo Young Song ,  Chang Seok Kim ,  Sang Koo Park ,  Jae Sun Lee ,  Tae Hyoung Yoo ,  Kang In Na

发明人： Heui II Kang ,  In Young Ko ,  Moo Young Song ,  Chang Seok Kim ,  Sang Koo Park ,  Jae Sun Lee ,  Tae Hyoung Yoo ,  Kang In Na

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： C07K16/241 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： An antibody variable region of a monoclonal antibody specifically binding to human tumor necrosis factor-α contains at least one of a heavy chain variable region and a light chain variable region having specific complementarity determining regions therein. A nucleic acid molecule encoding the same, a recombinant vector containing the nucleic acid molecule, and a cell transformed with the recombinant vector are also provided.

摘要翻译： 与人肿瘤坏死因子-α特异性结合的单克隆抗体的抗体可变区含有其中具有特异性互补决定区的重链可变区和轻链可变区中的至少一个。 还提供了编码该核酸分子的核酸分子，含有核酸分子的重组载体和用重组载体转化的细胞。

公开(公告)号：US07435414B2

公开(公告)日：2008-10-14

申请号：US11100553

申请日：2005-04-07

申请人： Heui Il Kang ,  Byung Kyu Lee ,  Se Cheol Park ,  Moo Young Song ,  Tae Hyoung Yoo ,  Jae Sun Lee ,  Chang Seok Kim ,  Sang Koo Park ,  Kang In Na

发明人： Heui Il Kang ,  Byung Kyu Lee ,  Se Cheol Park ,  Moo Young Song ,  Tae Hyoung Yoo ,  Jae Sun Lee ,  Chang Seok Kim ,  Sang Koo Park ,  Kang In Na

IPC分类号： A61K39/395

CPC分类号： C07K16/082 ,  C07K2317/24

摘要： A humanized antibody of the present invention shows similar antigen-binding affinity to a mouse monoclonal antibody and significantly low immunogenecity. Therefore, the humanized antibody of the present invention can be effectively used for treating chronic hepatitis B and preventing HBV infection of a patient received liver transplantation and vertical transmission from a mother infected with HBV to a fetus.

摘要翻译： 本发明的人源化抗体对小鼠单克隆抗体显示出类似的抗原结合亲和力，并且显着低的免疫原性。 因此，本发明的人源化抗体可以有效地用于治疗慢性乙型肝炎并预防接受肝移植的患者和从感染HBV的母亲到胎儿的垂直传播的HBV感染。

公开(公告)号：US20080008703A1

公开(公告)日：2008-01-10

申请号：US11722094

申请日：2005-12-29

申请人： Tae Hyoung Yoo ,  Moo Young Song ,  Chang Seok Kim ,  Sang Koo Park ,  Kang In Na ,  Byung Kyu Lee ,  Heui Il Kang

发明人： Tae Hyoung Yoo ,  Moo Young Song ,  Chang Seok Kim ,  Sang Koo Park ,  Kang In Na ,  Byung Kyu Lee ,  Heui Il Kang

IPC分类号： A61K39/00 ,  A61P19/02 ,  C07K16/00 ,  C12N1/00 ,  C12N15/00

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Humanized antibodies specifically binding to hTNF-α are prepared from a mouse monoclonal antibody by the CDR (complementarity determining region) grafting method, and they show an antigen binding affinity similar to the original mouse monoclonal antibody and significantly low immunogenicity. Therefore, the humanized antibodies can be effectively used for treating a hTNF-α-related disease such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis, psoriasis, septicemia, asthma, Wegener's granulomatosis, inflammation, and ankylosing spondylitis.

摘要翻译： 通过CDR（互补决定区）接枝方法由小鼠单克隆抗体制备与hTNF-α特异性结合的人源化抗体，它们显示与原始小鼠单克隆抗体相似的抗原结合亲和力，并且显着低的免疫原性。 因此，人源化抗体可以有效地用于治疗hTNF-α相关疾病如类风湿性关节炎，克罗恩病，牛皮癣关节炎，银屑病，败血病，哮喘，韦格纳肉芽肿病，炎症和强直性脊柱炎。

公开(公告)号：US07645450B2

公开(公告)日：2010-01-12

申请号：US11722094

申请日：2005-12-29

申请人： Tae Hyoung Yoo ,  Moo Young Song ,  Chang Seok Kim ,  Sang Koo Park ,  Kang In Na ,  Byung Kyu Lee ,  Heui Il Kang

发明人： Tae Hyoung Yoo ,  Moo Young Song ,  Chang Seok Kim ,  Sang Koo Park ,  Kang In Na ,  Byung Kyu Lee ,  Heui Il Kang

IPC分类号： A61K39/395

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Humanized antibodies specifically binding to hTNF-α are prepared from a mouse monoclonal antibody by the CDR (complementarity determining region) grafting method, and they show an antigen binding affinity similar to the original mouse monoclonal antibody and significantly low immunogenicity. Therefore, the humanized antibodies can be effectively used for treating a hTNF-α-related disease such as rheumatoid arthritis, Crohn's disease, psoriatic arthritis, psoriasis, septicemia, asthma, Wegener's granulomatosis, inflammation, and ankylosing spondylitis.

摘要翻译： 通过CDR（互补决定区）接枝方法由小鼠单克隆抗体制备与hTNF-α特异性结合的人源化抗体，它们显示与原始小鼠单克隆抗体相似的抗原结合亲和力，并且显着低的免疫原性。 因此，人源化抗体可以有效地用于治疗hTNF-α相关疾病如类风湿性关节炎，克罗恩病，牛皮癣关节炎，银屑病，败血病，哮喘，韦格纳肉芽肿病，炎症和强直性脊柱炎。

公开(公告)号：US09207063B2

公开(公告)日：2015-12-08

申请号：US13814061

申请日：2011-07-28

申请人： Chang Seok Kim ,  Myung Yung Jeong ,  Hwi Don Lee

发明人： Chang Seok Kim ,  Myung Yung Jeong ,  Hwi Don Lee

IPC分类号： G01B9/02 ,  G01N21/47 ,  H01S3/067 ,  H01S3/11 ,  G01N21/31 ,  H01S3/23

CPC分类号： G01B9/02091 ,  G01B9/02004 ,  G01N21/31 ,  G01N21/4795 ,  H01S3/067 ,  H01S3/06791 ,  H01S3/1112 ,  H01S3/2383

摘要： Discloses is an optical coherence tomography (OCT) which uses an active mode-locking fiber laser in order to obtain image information of a sample. An imaging device in accordance with an embodiment comprises: a light source unit; a light separation unit; a reference unit; a diagnostic unit; a light coupling unit; and a signal processing unit. The imaging device removes a high-priced variable filter which has mechanical restrictions by directly delivering a modulation signal to a light source unit, so it can overcome mechanical restrictions and reduce costs.

摘要翻译： 公开了一种光学相干断层扫描（OCT），其使用主动模式锁定光纤激光器来获得样本的图像信息。 根据实施例的成像装置包括：光源单元; 光分离单元; 参考单位 诊断单位 光耦合单元; 和信号处理单元。 该成像装置通过将调制信号直接传送到光源单元来去除具有机械限制的高价可变滤波器，因此可以克服机械限制并降低成本。

公开(公告)号：US20130169972A1

公开(公告)日：2013-07-04

申请号：US13814061

申请日：2011-07-28

申请人： Chang Seok Kim ,  Myung Yung Jeong ,  Hwi Don Lee

发明人： Chang Seok Kim ,  Myung Yung Jeong ,  Hwi Don Lee

IPC分类号： G01B9/02

CPC分类号： G01B9/02091 ,  G01B9/02004 ,  G01N21/31 ,  G01N21/4795 ,  H01S3/067 ,  H01S3/06791 ,  H01S3/1112 ,  H01S3/2383

摘要： Discloses is an optical coherence tomography (OCT) which uses an active mode-locking fiber laser in order to obtain image information of a sample. An imaging device in accordance with an embodiment comprises: a light source unit; a light separation unit; a reference unit; a diagnostic unit; a light coupling unit; and a signal processing unit. The imaging device removes a high-priced variable filter which has mechanical restrictions by directly delivering a modulation signal to a light source unit, so it can overcome mechanical restrictions and reduce costs.

摘要翻译： 公开了一种光学相干断层扫描（OCT），其使用主动模式锁定光纤激光器来获得样本的图像信息。 根据实施例的成像装置包括：光源单元; 光分离单元; 参考单位 诊断单位 光耦合单元; 和信号处理单元。 该成像装置通过将调制信号直接传送到光源单元来去除具有机械限制的高价可变滤波器，因此可以克服机械限制并降低成本。

公开(公告)号：US20070160091A1

公开(公告)日：2007-07-12

申请号：US11583152

申请日：2006-10-19

申请人： Jun Han Lee ,  Young Geun Han ,  Sang Bae Lee ,  Chang Seok Kim

发明人： Jun Han Lee ,  Young Geun Han ,  Sang Bae Lee ,  Chang Seok Kim

IPC分类号： H01S3/30

CPC分类号： H01S3/067 ,  H01S3/06791 ,  H01S3/108 ,  H01S3/1608

摘要： Disclosed are a continuous wave supercontinuum laser source resonator using low-priced multimode semiconductor lasers as pumping light and applying a rare-earth doped optical fiber and a Highly Nonlinear Dispersion Shifted Fiber (HNL-DSF) to a ring resonator structure to embody a continuous wave supercontinuum light source, and a medical diagnostic apparatus using the same. The resonator consists of a pump combiner for inputting pumping light into the resonator; a rare-earth doped optical fiber for receiving and converting the pumping light into seed light of a predetermined wavelength band; a Highly Nonlinear Dispersion Shifted Fiber (HNL-DSF) for converting the light converted by the rare-earth doped optical fiber and oscillating in the resonator into a continuous wave supercontinuum laser source; and a coupler for outputting the supercontinuum laser source generated from the Highly Nonlinear Dispersion Shifted Fiber (HNL-DSF). Accordingly, it is possible to embody a simple and inexpensive continuous wave supercontinuum laser source.

摘要翻译： 公开了一种使用低价多模半导体激光器作为泵浦光并将稀土掺杂光纤和高非线性色散移位光纤（HNL-DSF）应用于环形谐振器结构的连续波超连续光谱激光源谐振器，以体现连续波 超连续光源，以及使用其的医疗诊断装置。 谐振器由用于将泵浦光输入谐振器的泵组合器组成; 用于接收并将泵送光转换成预定波长带的种子光的稀土掺杂光纤; 用于将由稀土掺杂光纤转换并在谐振器中振荡的光转换成连续波超连续光源的高非线性色散位移光纤（HNL-DSF）; 以及用于输出由高非线性色散移位光纤（HNL-DSF）产生的超连续光谱激光源的耦合器。 因此，可以体现简单廉价的连续波超连续谱激光源。

公开(公告)号：US09278490B2

公开(公告)日：2016-03-08

申请号：US13699363

申请日：2010-12-31

申请人： Myung Yung Jeong ,  Chang Seok Kim ,  Jin Hwa Ryu ,  Seung Hun Oh ,  Tae Ho Lee ,  Sang Uk Cho

发明人： Myung Yung Jeong ,  Chang Seok Kim ,  Jin Hwa Ryu ,  Seung Hun Oh ,  Tae Ho Lee ,  Sang Uk Cho

IPC分类号： B29D11/00 ,  G02B6/122 ,  G02B6/138 ,  G03F7/00 ,  B82Y10/00 ,  B82Y40/00

CPC分类号： B29D11/00663 ,  B82Y10/00 ,  B82Y40/00 ,  G02B6/1221 ,  G02B6/138 ,  G03F7/0002

摘要： The present invention relates to a method for manufacturing a two-dimensional polymer optical waveguide, which is used for manufacturing a two-dimensional optical waveguide through simplified processes using a single imprint original master. The method includes: replicating a pattern through a first hot-embossing process on a thermoplastic polymer sheet using a single original master; forming a buffer layer on the surface of the replicated pattern; manufacturing a polymer mold having a cladding pattern on the other side without a buffer layer through a second hot-embossing process using the original master; replicating a pattern by molding the polymer mold out of an elastic material and forming an upper elastic mold and a lower elastic mold by vertically separating the elastic material; and forming middle cladding using the upper and lower elastic molds, filling regions on and below the middle cladding with core resin patterns, and performing a curing process after stacking upper and lower cladding to form a two-dimensional optical waveguide.

摘要翻译： 本发明涉及一种用于制造二维聚合物光波导的方法，其通过使用单个压印原始母版的简化处理用于制造二维光波导。 该方法包括：使用单个原始母版在热塑性聚合物片材上通过第一热压花加工复制图案; 在复制图案的表面上形成缓冲层; 通过使用原始主机的第二热压花加工制造在另一侧上没有缓冲层的具有包层图案的聚合物模具; 通过将聚合物模具从弹性材料成型而复制图案，并通过垂直分离弹性材料形成上弹性模具和下弹性模具; 并使用上下弹性模具形成中间包层，用中心树脂图案填充中间包层上方和下方，并且在堆叠上下包层之后进行固化过程以形成二维光波导。