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    PRODUCTION METHOD OF CYST EXPRESSED TRANSGENIC ANIMAL USING PKD2 GENE
    1.
    发明申请
    PRODUCTION METHOD OF CYST EXPRESSED TRANSGENIC ANIMAL USING PKD2 GENE 审中-公开
    使用PKD2基因的CYST表达转基因动物的生产方法

    公开(公告)号：US20100281553A1

    公开(公告)日：2010-11-04

    申请号：US11814723

    申请日：2006-11-03

    申请人： Jong-Hoon Park ,  Han-Woong Lee ,  Ji-Yeon Noh ,  Moon-Hee Yang ,  Yong-Hoon Sung ,  Tae-Young Lee

    发明人： Jong-Hoon Park ,  Han-Woong Lee ,  Ji-Yeon Noh ,  Moon-Hee Yang ,  Yong-Hoon Sung ,  Tae-Young Lee

    IPC分类号： A01K67/027 ,  C12N15/63

    CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/035 ,  C07K14/47 ,  C12N15/8509

    摘要： Disclosed herein is a method for producing a cyst-expressed transgenic animal using a PDK2 gene. The production method comprises preparing a PKD2 protein expression vector, inserting the expression vector into the nucleus of a fertilized egg to produce a PKD2 expression vector-containing fertilized egg, and transplanting the produced fertilized egg into the uterus of a surrogate mother. According to the invention disclosed herein, there is provided a method for producing transgenic animals, in which cysts are expressed only by the overexpression of the PKD2 gene. Also, transgenic mice are provided which can be effectively used in the investigation of cyst expression mechanisms and cyst control systems.

    摘要翻译： 本文公开了使用PDK2基因产生囊肿表达的转基因动物的方法。 制备方法包括制备PKD2蛋白表达载体，将表达载体插入受精卵的细胞核中以产生含有PKD2表达载体的受精卵，并将产生的受精卵移植到代孕母亲的子宫中。 根据本文公开的发明，提供了一种生产转基因动物的方法，其中囊肿仅通过PKD2基因的过表达来表达。 此外，提供可以有效地用于调查囊肿表达机制和囊肿控制系统的转基因小鼠。

    Role of p62 in aging-related disease
    2.
    发明授权
    Role of p62 in aging-related disease 失效
    p62在老龄化相关疾病中的作用

    公开(公告)号：US07435872B2

    公开(公告)日：2008-10-14

    申请号：US10438516

    申请日：2003-05-14

    申请人： Jaekyoon Shin ,  Han-Woong Lee ,  Goo Taeg Oh

    发明人： Jaekyoon Shin ,  Han-Woong Lee ,  Goo Taeg Oh

    IPC分类号： A01K67/00 ,  A01K67/027 ,  A01N63/00 ,  C12N15/00 ,  C12N15/63

    CPC分类号： C12Q1/6883 ,  A01K2217/075 ,  C07K14/4702 ,  C07K2319/60 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality, intracellular inclusion named sequestosome, and redox regulation. In particular the application discloses a method of detecting the formation of inclusion bodies in neurodegenerative diseases. The invention further relates to a method of screening for therapeutic agents that disperse the inclusions. Further, transgenic mice containing a mutation in the p62 gene and having a functionally disrupted p62 gene locus are also disclosed.

    摘要翻译： 该应用揭示了p62在老龄化相关疾病中的作用，如肥胖发展，2型糖尿病，非酒精性脂肪肝，各种肿瘤，男性死亡率增高，细胞内包涵体命名为后遗症和氧化还原调节。 特别地，该申请公开了一种检测神经变性疾病中包涵体形成的方法。 本发明还涉及筛选分散夹杂物的治疗剂的方法。 此外，还公开了含有p62基因突变且具有功能性破坏的p62基因座的转基因小鼠。

    ROLE OF p62 IN AGING-RELATED DISEASE
    3.
    发明申请
    ROLE OF p62 IN AGING-RELATED DISEASE 审中-公开
    p62在老年相关疾病中的作用

    公开(公告)号：US20080132460A1

    公开(公告)日：2008-06-05

    申请号：US11871146

    申请日：2007-10-11

    申请人： Jaekyoon SHIN ,  Han-Woong Lee ,  Goo Taeg Oh

    发明人： Jaekyoon SHIN ,  Han-Woong Lee ,  Goo Taeg Oh

    IPC分类号： A61K31/70 ,  G01N33/53 ,  G01N33/574 ,  A01K67/00 ,  C12N5/06 ,  C12Q1/68 ,  C40B40/08 ,  A61P43/00

    CPC分类号： C12Q1/6883 ,  A01K2217/075 ,  C07K14/4702 ,  C07K2319/60 ,  C12Q2600/136 ,  C12Q2600/158

    摘要： The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality, intracellular inclusion named sequestosome, and redox regulation. In particular the application discloses a method of detecting the formation of inclusion bodies in neurodegenerative diseases. The invention further relates to a method of screening for therapeutic agents that disperse the inclusions. Further, transgenic mice containing a mutation in the p62 gene and having a functionally disrupted p62 gene locus are also disclosed.

    摘要翻译： 该应用揭示了p62在老龄化相关疾病中的作用，如肥胖发展，2型糖尿病，非酒精性脂肪肝，各种肿瘤，男性死亡率增高，细胞内包涵体命名为后遗症和氧化还原调节。 特别地，该申请公开了一种检测神经变性疾病中包涵体形成的方法。 本发明还涉及筛选分散夹杂物的治疗剂的方法。 此外，还公开了含有p62基因突变且具有功能性破坏的p62基因座的转基因小鼠。