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    Caffeine coated chewing gum product and process of making
    4.
    发明授权
    Caffeine coated chewing gum product and process of making 有权
    咖啡因包衣口香糖产品及其制作工艺

    公开(公告)号：US06444241B1

    公开(公告)日：2002-09-03

    申请号：US09651514

    申请日：2000-08-30

    申请人： Henry T. Tyrpin ,  Michael P. Russell ,  David L. Witkewitz ,  Sonya S. Johnson ,  Ronald L. Ream ,  Christine L. Corriveau

    发明人： Henry T. Tyrpin ,  Michael P. Russell ,  David L. Witkewitz ,  Sonya S. Johnson ,  Ronald L. Ream ,  Christine L. Corriveau

    IPC分类号： A23G330

    CPC分类号： A23G4/06 ,  A23G4/068 ,  A23G4/20

    摘要： A method for producing a chewing gum with a controlled release of caffeine, as well as the chewing gum so produced, is obtained by physically modifying caffeine's properties by coating and drying. Caffeine is coated by encapsulation, partially coated by agglomeration, entrapped by absorption, or treated by multiple steps of encapsulation, agglomeration, and absorption. The coated caffeine is then preferably co-dried and particle sized to produce a release-modified caffeine for use in chewing gum. When incorporated into the chewing gum, these particles are adapted to produce a fast release or a delayed release when the gum is chewed. Also disclosed is a chewing gum pellet having a coating including caffeine or a caffeine salt compound.

    摘要翻译： 通过涂覆和干燥物理地改变咖啡因的性质，可获得生产具有可控释放的咖啡因的口香糖的方法以及所生产的口香糖。 咖啡因通过包封进行包衣，通过附聚部分包被，通过吸收包埋，或者通过包封，聚集和吸收的多个步骤进行处理。 然后优选将涂覆的咖啡因共干燥并调整颗粒大小以产生用于口香糖的释放改性的咖啡因。 当掺入口香糖中时，当咀嚼口香糖时，这些颗粒适于产生快速释放或延迟释放。 还公开了具有包括咖啡因或咖啡因盐化合物的涂层的口香糖颗粒。

    Over-coated chewing gum formulations
    5.
    发明授权
    Over-coated chewing gum formulations 失效
    涂覆过的口香糖配方

    公开(公告)号：US06355265B1

    公开(公告)日：2002-03-12

    申请号：US09510878

    申请日：2000-02-23

    申请人： Ronald L. Ream ,  Michael J. Greenberg ,  William J. Wokas ,  Christine L. Corriveau

    发明人： Ronald L. Ream ,  Michael J. Greenberg ,  William J. Wokas ,  Christine L. Corriveau

    IPC分类号： A61K968

    CPC分类号： A61K9/209 ,  A23G3/343 ,  A23G4/08 ,  A23G4/20 ,  A23G2200/04 ,  A61K9/0058

    摘要： Methods and products for delivering a medicament or agent to an individual are provided. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.

    摘要翻译： 提供了将药物或药剂递送至个体的方法和产品。 该产品包括具有药物或试剂的涂层。 药物或药剂存在于围绕牙龈中心（水溶性部分和水不溶性基底部分）的涂层内。 通过咀嚼牙龈，药物或药剂从产品中释放出来。 继续咀嚼口香糖在口腔内产生压力，通过口腔中包含的口腔粘膜将药剂或药物直接压入个体的系统系统。 这大大增强了药物在系统系统中的吸收以及药物在系统内的生物利用度。

    Over-coated chewing gum formulations including tableted center
    7.
    发明授权
    Over-coated chewing gum formulations including tableted center 有权

    公开(公告)号：US06290985B1

    公开(公告)日：2001-09-18

    申请号：US09759838

    申请日：2001-01-11

    申请人： Ronald L. Ream ,  Christine L. Corriveau ,  Gwendolyn Graff ,  Leonard Matulewicz

    发明人： Ronald L. Ream ,  Christine L. Corriveau ,  Gwendolyn Graff ,  Leonard Matulewicz

    IPC分类号： A61K928

    摘要： Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.

    Over-coated chewing gum formulations
    9.
    发明授权
    Over-coated chewing gum formulations 有权
    涂覆过的口香糖配方

    公开(公告)号：US06773716B2

    公开(公告)日：2004-08-10

    申请号：US09992122

    申请日：2001-11-13

    申请人： Ronald L. Ream ,  Michael J. Greenberg ,  William J. Wokas ,  Christine L. Corriveau

    发明人： Ronald L. Ream ,  Michael J. Greenberg ,  William J. Wokas ,  Christine L. Corriveau

    IPC分类号： A61K968

    CPC分类号： A61K9/0058 ,  A23G3/343 ,  A23G4/08 ,  A23G4/20 ,  A23G2200/04 ,  A61K9/209

    摘要： Methods and products for delivering a medicament or agent to an individual are provided. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a center comprising a gum base. By chewing the product, the medicament or agent is released from the product. Continuing to chew the product creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.

    摘要翻译： 提供了将药物或药剂递送至个体的方法和产品。 该产品包括具有药物或试剂的涂层。 药物或药剂存在于围绕包含胶基的中心的涂层内。 通过咀嚼产品，药物或药剂从产品中释放出来。 继续咀嚼产品会在口腔内产生压力，通过口腔内的口腔粘膜将药剂或药物直接压入个体的系统系统。 这大大增强了药物在系统系统中的吸收以及药物在系统内的生物利用度。