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    Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer
    2.
    发明申请
    Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer 审中-公开
    修复串联重复DNA序列和延长细胞寿命核转移的方法

    公开(公告)号：US20050255596A1

    公开(公告)日：2005-11-17

    申请号：US11079930

    申请日：2005-03-09

    申请人： Michael West ,  Robert Lanza ,  Jose Cibelli

    发明人： Michael West ,  Robert Lanza ,  Jose Cibelli

    IPC分类号： C12N5/08 ,  C12N15/63 ,  C12N15/85 ,  C12Q1/68

    CPC分类号： C12N15/85 ,  C12N2517/04

    摘要： This invention relates to methods for rejuvenating normal somatic cells and for making normal somatic cells of a different type having the same genotype as a normal somatic cell of interest. These cells have particular application in cell and tissue transplantation. Also encompassed are methods of re-cloning cloned animals, particularly methods where the offspring of cloned mammals are designed to be genetically altered in comparison to their cloned parent, e.g., that are “hyper-young.” These animals should be healthier and possess desirable properties relative to their cloned parent. Also included are methods for activating endogenous telomerase, EPC-1 activity, and or the ALT pathway and/or extending the life-span of a normal somatic cell, and other genes associated with cell aging and proliferation capacity.

    摘要翻译： 本发明涉及用于恢复正常体细胞和用于制备具有与感兴趣的正常体细胞相同基因型的不同类型的正常体细胞的方法。 这些细胞在细胞和组织移植中具有特殊应用。 还包括重新克隆克隆动物的方法，特别是其克隆的哺乳动物的后代被设计为与其克隆的亲本（例如“超年龄”）相比被遗传改变的方法。 这些动物应该更健康，并且相对于其克隆的亲本具有所需的性质。 还包括用于激活内源性端粒酶，EPC-1活性和/或ALT途径和/或延长正常体细胞的寿命和与细胞衰老和增殖能力相关的其它基因的方法。

    Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells
    3.
    发明授权
    Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells 有权
    桑ula或内细胞群细胞的分化方法及其谱系缺陷胚胎干细胞的制备方法

    公开(公告)号：US08753884B2

    公开(公告)日：2014-06-17

    申请号：US12152779

    申请日：2008-05-16

    申请人： Jose Cibelli ,  Michael D. West ,  Robert Lanza

    发明人： Jose Cibelli ,  Michael D. West ,  Robert Lanza

    IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N15/00

    CPC分类号： C12N5/16 ,  A61K35/12 ,  C12N5/0606 ,  C12N2510/00

    摘要： An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired gene. The differentiated progenitor cells are useful in cell therapy and as a I source of cells for the production of tissues and organs for transplantation. Also provided is a method of producing a lineage-defective human embryonic stem cell.

    摘要翻译： 一种改进的产生分化祖细胞的方法，包括从囊胚获得内细胞质量细胞并诱导内细胞大量细胞的分化以产生分化祖细胞。 可以转染分化的祖细胞，使得存在所需基因的添加，缺失或改变。 分化的祖细胞可用于细胞治疗和作为用于产生移植组织和器官的细胞的I来源。 还提供了产生谱系缺陷型人胚胎干细胞的方法。

    Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells
    5.
    发明申请
    Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells 有权
    桑ula或内细胞群细胞的分化方法及其谱系缺陷胚胎干细胞的制备方法

    公开(公告)号：US20090104697A1

    公开(公告)日：2009-04-23

    申请号：US12152779

    申请日：2008-05-16

    申请人： Jose Cibelli ,  Michael D. West ,  Robert Lanza

    发明人： Jose Cibelli ,  Michael D. West ,  Robert Lanza

    IPC分类号： C12N5/02

    CPC分类号： C12N5/16 ,  A61K35/12 ,  C12N5/0606 ,  C12N2510/00

    摘要： An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired gene. The differentiated progenitor cells are useful in cell therapy and as a I source of cells for the production of tissues and organs for transplantation. Also provided is a method of producing a lineage-defective human embryonic stem cell.

    摘要翻译： 一种改进的产生分化祖细胞的方法，包括从囊胚获得内细胞质量细胞并诱导内细胞大量细胞的分化以产生分化祖细胞。 可以转染分化的祖细胞，使得存在所需基因的添加，缺失或改变。 分化的祖细胞可用于细胞治疗和作为用于产生移植组织和器官的细胞的I来源。 还提供了产生谱系缺陷型人胚胎干细胞的方法。

    Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells
    10.
    发明申请
    Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells 审中-公开
    用于促进从胚胎和成体多能细胞和多能细胞分化细胞类型和组织的产生的方法

    公开(公告)号：US20050153443A1

    公开(公告)日：2005-07-14

    申请号：US10948841

    申请日：2004-09-23

    申请人： Robert Lanza ,  Michael West

    发明人： Robert Lanza ,  Michael West

    IPC分类号： A61K35/12 ,  C12N5/0735 ,  C12N5/08

    CPC分类号： C12N5/0606 ,  A61K35/12 ,  C12N2502/1394 ,  C12N2502/28

    摘要： The invention is concerned with producing differentiated cells, tissues and organs from pluripotent and mutlipotent cells. The methods of the invention are particularly useful for producing differentiated cells from pluripotent cells wherein communication between the cells of more than one embryonic germ layer or more than one organ system are required for development along a specific cell lineage. The invention methods are effected by in vivo or in vitro culturing of embryonic and developing or developed allogeneic or xenogeneic cells.

    摘要翻译： 本发明涉及从多能细胞和多能细胞产生分化的细胞，组织和器官。 本发明的方法特别可用于从多能细胞产生分化的细胞，其中需要多于一个胚胎胚层或更多个器官系统的细胞之间的连通以沿特定细胞谱系发育。 本发明方法通过体内或体外培养胚胎和发育或发育的同种异体或异种细胞来实现。