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公开(公告)号:US5413906A
公开(公告)日:1995-05-09
申请号:US974595
申请日:1993-03-19
申请人: Josef Eberle , Rudolf Seibl , Christoph Kessler , Bernhard Konig
发明人: Josef Eberle , Rudolf Seibl , Christoph Kessler , Bernhard Konig
IPC分类号: C12Q1/48 , C12Q1/68 , C12Q1/70 , G01N33/573 , C12P19/34
CPC分类号: G01N33/573 , C12Q1/48 , C12Q1/703 , Y10S435/81
摘要: Method of determining polymerase activity by incubating the polymerase with a template nucleic acid, one detectable mononucleoside triphosphate and one immobilizable nucleoside triphosphate, binding the immobilizable nucleotides to a solid phase and detecting the bound detectable nucleotides and tests based thereon.
摘要翻译: PCT No.PCT / EP91 / 01016 Sec。 371日期1993年3月19日 102(e)1993年3月19日PCT PCT 1991年5月31日PCT。 出版物WO92 / 04467 1992年3月19日。通过用模板核酸,一个可检测的单核苷三磷酸和一个可固定的核苷三磷酸孵育聚合酶来测定聚合酶活性的方法,将可固定的核苷酸与固相结合并检测结合的可检测的核苷酸并基于其测试 。
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公开(公告)号:US5635350A
公开(公告)日:1997-06-03
申请号:US382891
申请日:1995-02-03
申请人: Josef Eberle , Rudolf Seibl , Christoph Kessler , Bernhard Konig
发明人: Josef Eberle , Rudolf Seibl , Christoph Kessler , Bernhard Konig
IPC分类号: C12Q1/48 , C12Q1/68 , C12Q1/70 , G01N33/573
CPC分类号: G01N33/573 , C12Q1/48 , C12Q1/703 , Y10S435/81
摘要: Method of determining polymerase activity by incubating the polymerase with a template nucleic acid, one detectable mononucleoside triphosphate and one immobilizable nucleoside triphosphate, binding the immobilizable nucleotides to a solid phase and detecting the bound delectable nucleotides and tests based thereon.
摘要翻译: 通过用模板核酸,一种可检测的单核苷三磷酸和一种可固定核苷三磷酸孵育聚合酶来测定聚合酶活性的方法,将可固定的核苷酸与固相结合,并基于此检测结合的可选择的核苷酸和测试。
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公开(公告)号:US20060291983A1
公开(公告)日:2006-12-28
申请号:US11475402
申请日:2006-06-26
IPC分类号: B65G13/00
CPC分类号: B65G13/065 , B64D9/00 , B64D2009/006 , Y02T50/46
摘要: In an apparatus for transporting freight, in particular freight containers in freight compartments of airplanes, in particular a power drive unit (PDU) having a transporting roller (2), which is inserted into a frame, is driven by a drive and can be moved out of the frame by a lifting drive (10), the drive (9) for driving the transporting roller (2) and the lifting drive (10) for moving the transporting roller (2) out of the frame should be arranged within a common motor housing (6).
摘要翻译: 在用于运输货物的装置中,特别是飞机货舱中的货物集装箱,特别是具有插入框架的输送辊(2)的动力驱动单元(PDU)由驱动器驱动并且可以移动 通过升降驱动器(10)离开框架,用于驱动传送辊(2)的驱动器(9)和用于将传送辊(2)移出框架的提升驱动装置(10)应设置在共同的 电机外壳(6)。
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公开(公告)号:US4729517A
公开(公告)日:1988-03-08
申请号:US879644
申请日:1986-06-27
申请人: Werner Krokor , Wolfgang Finken , Bernhard Konig
发明人: Werner Krokor , Wolfgang Finken , Bernhard Konig
CPC分类号: B02C13/095
摘要: The invention concerns a rebound crusher having at least one rotor provided with hammers which is mounted rotatably in a crusher housing and cooperates with at least one rebound mechanism which is arranged swingable against spring force within the crusher housing and the distance of which from the hammers of the rotor is adjustable. In order, in a space-saving development, to permit remote adjustment of the nip between hammers and rebound mechanism, the rebound mechanism is pivotally connected to the piston rod of a damping piston which rests against the crusher housing and the front end position of which is infinitely variable via an adjustment piston of a setting cylinder.
摘要翻译: 本发明涉及一种回弹式破碎机,其具有至少一个设有锤的转子,该转子可旋转地安装在破碎机壳体中并与至少一个回弹机构配合,所述回弹机构可摆动地抵抗破碎机壳体内的弹簧力,并且其与锤的距离 转子可调。 为了在节省空间的开发中,为了允许远程调节锤之间的辊隙和回弹机构,回弹机构枢转地连接到抵靠破碎机壳体并且其前端位置的阻尼活塞的活塞杆 通过调节柱塞的调节活塞无级变化。
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公开(公告)号:US20090179224A1
公开(公告)日:2009-07-16
申请号:US12317334
申请日:2008-12-22
申请人: Bernhard Konig
发明人: Bernhard Konig
CPC分类号: H01L29/8611 , H01L29/417 , H01L29/66128
摘要: A power semiconductor component and a method for producing such a component. The component comprises a semiconductor base body having a first doping. A pn junction is formed in the base body by a contact region having a second doping with a first doping profile. A field ring structure has a second doping with a second doping profile. The contact region and the field ring structure are arranged at respectively assigned first and second partial areas of a first surface of the base body. Both extend into the base body, wherein the base body has, for the field ring structure, a trench-type cutout assigned to each respective field ring, the surface of said cutout following the contour of the assigned doping profile.
摘要翻译: 功率半导体元件及其制造方法。 该组件包括具有第一掺杂的半导体基体。 通过具有第一掺杂分布的第二掺杂的接触区域在基体中形成pn结。 场环结构具有第二掺杂,具有第二掺杂分布。 接触区域和场环结构被布置在基体的第一表面的分别分配的第一和第二部分区域。 两者都延伸到基体中,其中,对于场环结构,基体具有分配给每个相应的场环的沟槽型切口,所述切口的表面遵循所分配的掺杂轮廓的轮廓。
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公开(公告)号:US6025142A
公开(公告)日:2000-02-15
申请号:US458585
申请日:1995-06-02
申请人: Ulrich Pessara , Ulrich Weidle , Bernhard Konig , Ulrich Kohnert , Ilse Bartke , Keld Dan.o slashed. , Michael Ploug , Vincent Ellis
发明人: Ulrich Pessara , Ulrich Weidle , Bernhard Konig , Ulrich Kohnert , Ilse Bartke , Keld Dan.o slashed. , Michael Ploug , Vincent Ellis
IPC分类号: G01N33/53 , A61K38/00 , A61K39/395 , A61P7/02 , A61P9/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/00 , C07K16/18 , C07K16/28 , C12N15/02 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577
CPC分类号: C07K16/2896 , A61K38/00
摘要: The invention relates to an antibody which inhibits the binding between u-PA and u-PAR to an extent of at least 90% in an assay as defined in the specification, or an active fragment or immunological equivalent of said antibody. Examples of such antibodies are deposited Jul. 7, 1994 at Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSM) with accession numbers DSM ACC2178 and DSM ACC2179 under the terms and conditions of the Budapest Treaty. The invention furthermore relates to a method for detecting or quantifying u-PAR or a glycosylation variant of u-PAR in a sample by use of an antibody according to the invention.Furthermore, the invention relates to a method for the manufacture of a therapeutic agent for preventing or counteracting localized proteolytic activity using of an antibody of the invention as well as to use of an antibody according to the invention for the preparation of a diagnostic agent which is capable of targeting a diagnostic to a cell that contains a u-PAR on the surface.
摘要翻译: 本发明涉及在本说明书中定义的测定中抑制u-PA和u-PAR之间的结合至少90%的抗体或所述抗体的活性片段或免疫相当的抗体。 这种抗体的实例在1994年7月7日在德国知识产权组织(DSM)保藏号为DSM ACC2178和DSM ACC2179的情况下,根据布达佩斯条约的条款和条件。 本发明还涉及通过使用本发明的抗体来检测或定量样品中u-PAR或u-PAR的糖基化变体的方法。 此外,本发明涉及一种制备用于使用本发明的抗体预防或抵消局部蛋白水解活性的治疗剂的方法,以及使用根据本发明的抗体制备诊断剂,其为 能够将诊断定位到表面上含有u-PAR的细胞。
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7.
公开(公告)号:US5397794A
公开(公告)日:1995-03-14
申请号:US50067
申请日:1993-07-20
申请人: Harald Zilch , Alfred Mertens , Herbert Leinert , Ulrike Leser , Bernhard Konig , Hans Seidel
发明人: Harald Zilch , Alfred Mertens , Herbert Leinert , Ulrike Leser , Bernhard Konig , Hans Seidel
IPC分类号: A61K31/425 , A61P31/12 , C07D513/04
CPC分类号: A61K31/425 , Y10S514/934
摘要: The present invention concerns the use of compounds of the general formula I ##STR1## for the preparation of medicaments for the treatment of viral or retroviral infections, whereby R signifies a hydrogen atom or a straight-chained or branched, saturated or unsaturated alkyl radical with 1-7 carbon atoms, which can possibly be substituted by phenyl, or a phenyl ring which can possibly be substituted one or more times by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, hydroxyl, trifluoromethyl, methylsulphonyl or halogen, such as fluorine, chlorine or bromine, n stands for the numbers 0, 1 or 2, as well as of their pharmacologically compatible salts or tautomers.
摘要翻译: PCT No.PCT / EP91 / 02101 Sec。 371日期:1993年7月20日 102(e)日期1993年7月20日PCT 1991年11月6日PCT PCT。 公开号WO92 / 08457 日期:1992年5月29日。本发明涉及通式I的化合物(I)用于制备用于治疗病毒或逆转录病毒感染的药物,其中R表示氢原子或直链 或具有1-7个碳原子的支链,饱和或不饱和的烷基,其可以被苯基取代,或可以被C1-C4-烷基,C1-C4-烷氧基,羟基取代一次或多次的苯环 ,三氟甲基,甲基磺酰基或卤素如氟,氯或溴,n代表数字0,1或2,以及它们的药理学上相容的盐或互变异构体。
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公开(公告)号:US20090146018A1
公开(公告)日:2009-06-11
申请号:US11999365
申请日:2007-12-05
申请人: Bernhard Konig
发明人: Bernhard Konig
IPC分类号: B64C13/04
CPC分类号: G05G9/047 , G05G2009/04718 , Y10T74/20201
摘要: The invention relates to a control device, in particular for an aircraft, having a multiaxially tiltable joystick for the actuation of signal transducers, in particular for the pitch control and roll control of an aircraft, as well as having a cardan-like joint by means of which the joystick is tiltable about different pivot axes, said joint furthermore having at least one freewheel for a tilt movement of the joystick about one of the pivot axes. In accordance with the invention, the freewheel is formed by a lever mechanism or by an elastic component.
摘要翻译: 本发明涉及一种特别是用于飞行器的控制装置,其具有用于致动信号传感器的多轴可倾斜操纵杆,特别是用于飞行器的桨距控制和侧倾控制,以及通过装置具有万丝节形接头 其中操纵杆可围绕不同的枢转轴线倾斜,所述接头还具有用于操纵杆围绕其中一个枢转轴线的倾斜运动的至少一个空转轮。 根据本发明,自由轮由杠杆机构或弹性部件形成。
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公开(公告)号:US5446139A
公开(公告)日:1995-08-29
申请号:US809506
申请日:1992-02-21
申请人: Frank Seela , Werner Bourgeouis , Rainer Gumbiowski , Angelika Roling , Helmut Rosemeyer , Alfred Mertens , Harald Zilch , Bernhard Konig , Edith Koch
发明人: Frank Seela , Werner Bourgeouis , Rainer Gumbiowski , Angelika Roling , Helmut Rosemeyer , Alfred Mertens , Harald Zilch , Bernhard Konig , Edith Koch
IPC分类号: A61K31/40 , A61K31/435 , A61K31/505 , A61K31/53 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61P31/12 , C07D405/04 , C07D471/04 , C07D487/04 , C07F9/09 , C07F9/6561 , C07H19/04 , C12Q1/68 , C07H19/16
CPC分类号: C07H19/04
摘要: The invention concerns nucleoside derivatives of the formula I ##STR1## in which Ba signifies an indolyl (A), benzimidazolyl (B), pyrrolopyridinyl (C), imidazopyridinyl (D), triazolopyrimidinyl (E), imidazotriazinyl (F) or imidazopyrimidinyl (G) group substituted by R.sup.1, R.sup.2 and R.sup.3, in which R.sup.1, R.sup.2 and R.sup.3, which can be the same or different, signify hydrogen, halogen, a C.sub.1 -C.sub.7 -alkyl, C.sub.2 -C.sub.7 -alkenyl, hydroxy, mercapto, C.sub.1 -C.sub.7 -alkylthio, C.sub.1 -C.sub.7 -alkoxy, C.sub.2 -C.sub.7 -alkenyloxy, ar-C.sub.1 -C.sub.5 -alkyl, ar-C.sub.2 -C.sub.5 -alkenyl, ar-C.sub.1 -C.sub.5 -alkoxy, ar-C.sub.2 -C.sub.5 -alkenyloxy, aryloxy, nitro, amino-C.sub.1 -C.sub.7 -alkyl, C.sub.1 -C.sub.7 -alkylamino-C.sub.1 -C.sub.7 -alkyl, di-C.sub.1 -C.sub.7 -alkylamino-C.sub.1 -C.sub.7 -alkyl, amino, a substituted amino group --NMR.sup.4 or --N(R.sup.4).sub.2 or an imino group --N.dbd.CH--R.sup.4, and R.sup.4 has the meaning given in the description, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 each signify hydrogen or one or two of the radicals R.sup.5, R.sup.6, R.sup.7 and R.sup.8 a hydroxyl, halogen, cyano, azido or a substituted amino group --NHR.sup.4 or --N(R.sup.4).sub.2 or R.sup.5 and R.sup.7 can together represent a further bond between C-2' and C-3' and Y represents hydrogen or a C.sub.1 -C.sub.7 -alkylcarbonyl, monophosphate, diphosphate or triphosphate group, whereby "aryl" signifies a phenyl or naphthyl group and "hetaryl" a furanyl, thienyl or pyridyl group, as well as their possible anomers, N.sup.7 - or N.sup.9 -regioisomers (purine nomenclature), tautomers and salts.
摘要翻译: PCT No.PCT / EP90 / 00650 Sec。 一九九二年二月二十一日 102(e)日期1992年2月21日PCT提交1990年4月23日PCT公布。 第WO91 / 01325号公报 1991年2月7日,本发明涉及式Ⅰ(I)的核苷衍生物,其中Ba表示吲哚基(A),苯并咪唑基(B),吡咯并吡啶基(C),咪唑并吡啶基(D),三唑并嘧啶基(E ),被R1,R2和R3取代的咪唑并吡嗪基(F)或咪唑并嘧啶基(G)基团,其中可以相同或不同的R 1,R 2和R 3表示氢,卤素,C 1 -C 7 - 烷基, C7-烯基,羟基,巯基,C1-C7-烷硫基,C1-C7-烷氧基,C2-C7-烯氧基,芳基-C1-C5-烷基,ar-C2-C5-烯基,ar-C1-C5-烷氧基, 芳基氧基,硝基,氨基-C 1 -C 7 - 烷基,C 1 -C 7 - 烷基氨基-C 1 -C 7 - 烷基,二-C 1 -C 7 - 烷基氨基-C 1 -C 7 - 烷基,氨基,取代的 氨基-NMR4或-N(R4)2或亚氨基-N = CH-R4,R4具有说明书中给出的含义,R5,R6,R7和R8各自表示氢或一个或两个基团R 5 ,R6,R7和R8是羟基,卤素,氰基,叠氮基或取代的氨基-NHR4或-N(R4)2或R5和R7可以一起代表另一个b C-2'和C-3'之间,Y表示氢或C1-C7-烷基羰基,一磷酸,二磷酸或三磷酸基,其中“芳基”表示苯基或萘基,“杂芳基”是呋喃基,噻吩基或吡啶基 组,以及它们可能的端基异构体,N7-或N9-区域异构体(嘌呤命名法),互变异构体和盐。
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