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公开(公告)号：US08748466B2
公开(公告)日：2014-06-10
申请号：US14110157
申请日：2012-03-23
申请人： Joseph Alan Abramite , Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
发明人： Joseph Alan Abramite , Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
IPC分类号： C07D261/08 , C07D413/04
CPC分类号： C07D261/14 , C07D261/08 , C07D413/04
摘要： The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.
摘要翻译： 本发明涉及一类新的异羟肟酸衍生物，它们用作LpxC抑制剂，更具体地，其用于治疗细菌感染。
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公开(公告)号：US20140024690A1
公开(公告)日：2014-01-23
申请号：US14110157
申请日：2012-03-23
申请人： Joseph Alan Abramite , Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
发明人： Joseph Alan Abramite , Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
IPC分类号： C07D261/14
CPC分类号： C07D261/14 , C07D261/08 , C07D413/04
摘要： The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.
摘要翻译： 本发明涉及一类新的异羟肟酸衍生物，它们用作LpxC抑制剂，更具体地，其用于治疗细菌感染。
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3.发明授权公开(公告)号：US08809333B2
公开(公告)日：2014-08-19
申请号：US14110165
申请日：2012-03-27
申请人： Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
发明人： Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
IPC分类号： C07D231/12 , C07D233/61 , C07D249/06 , C07D403/04 , C07D413/04 , C07D413/10 , C07D417/04 , C07D405/04 , A61K31/4192
CPC分类号： C07D413/10 , A61K31/4192 , C07D231/12 , C07D233/61 , C07D249/06 , C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , Y02A50/473
摘要： The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.
摘要翻译： 本发明涉及一类新的异羟肟酸衍生物，它们用作LpxC抑制剂，更具体地，其用于治疗细菌感染。
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4.发明申请公开(公告)号：US20140038975A1
公开(公告)日：2014-02-06
申请号：US14110165
申请日：2012-03-27
申请人： Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
发明人： Matthew Frank Brown , Jinshan Michael Chen , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
IPC分类号： C07D413/10 , C07D249/06 , C07D413/04 , C07D233/61 , C07D231/12 , C07D403/04
CPC分类号： C07D413/10 , A61K31/4192 , C07D231/12 , C07D233/61 , C07D249/06 , C07D403/04 , C07D405/04 , C07D413/04 , C07D417/04 , Y02A50/473
摘要： The present invention is directed to a new class of hydroxamic acid derivatives, their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.
摘要翻译： 本发明涉及一类新的异羟肟酸衍生物，它们用作LpxC抑制剂，更具体地，其用于治疗细菌感染。
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公开(公告)号：US08664401B2
公开(公告)日：2014-03-04
申请号：US13515607
申请日：2010-12-06
申请人： Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
发明人： Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
IPC分类号： C07D401/00 , A61K31/444
CPC分类号： A61K31/4412 , A61K31/4439 , C07D211/86 , C07D213/64 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , Y02A50/473
摘要： The present invention is directed to a new class of hydroxamic acid derivatives of formula I, wherein the variables G, T, D, L, R1, R2, R3 are as described herein, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections in a patient in need thereof.
摘要翻译： 本发明涉及一类新的式I的异羟肟酸衍生物，其中变量G，T，D，L，R 1，R 2，R 3如本文所述，它们作为LpxC抑制剂的用途，更具体地说， 在有需要的患者中治疗细菌感染。
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公开(公告)号：US20120258948A1
公开(公告)日：2012-10-11
申请号：US13515607
申请日：2010-12-06
申请人： Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
发明人： Matthew Frank Brown , Ye Che , Anthony Marfat , Michael Joseph Melnick , Justin Ian Montgomery , Usa Reilly
IPC分类号： A61K31/4412 , A61K31/4439 , C07D213/64 , C07D401/12 , A61K31/4545 , A61K31/4418 , C07D405/10 , A61K31/4433 , A61K31/506 , C07D413/10 , C07D213/643 , A61K31/444 , A61K31/4709 , A61K31/4427 , C07D401/14 , C07D417/12 , A61K31/541 , C07D413/12 , A61K31/5377 , A61P31/04 , C07D401/10
CPC分类号： A61K31/4412 , A61K31/4439 , C07D211/86 , C07D213/64 , C07D401/04 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/10 , C07D409/04 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/10 , C07D417/12 , Y02A50/473
摘要： The present invention is directed to a new class of hydroxamic acid derivatives of formula I, wherein the variables G, T, D, L, R1, R2, R3 are as described herein, their use as LpxC inhibitors, and more specifically their use to treat bacterial infections in a patient in need thereof.
摘要翻译： 本发明涉及一类新的式I的异羟肟酸衍生物，其中变量G，T，D，L，R 1，R 2，R 3如本文所述，它们作为LpxC抑制剂的用途，更具体地说， 在有需要的患者中治疗细菌感染。
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公开(公告)号：US08853258B2
公开(公告)日：2014-10-07
申请号：US13501776
申请日：2010-10-04
IPC分类号： A61K31/382 , A61K31/47 , A61K31/661 , C07D215/06 , C07C317/44 , C07D231/56 , C07F9/12 , C07C323/65 , C07C317/46 , C07D213/56 , C07C317/48 , C07D263/08 , C07D295/03 , C07D263/20 , C07D335/02 , C07D213/30
CPC分类号： C07C317/50 , C07C317/44 , C07C317/46 , C07C317/48 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/16 , C07C2601/18 , C07D213/30 , C07D213/56 , C07D215/06 , C07D231/12 , C07D231/56 , C07D233/36 , C07D239/26 , C07D261/08 , C07D263/08 , C07D263/20 , C07D295/03 , C07D335/02 , C07F9/09 , C07F9/12
摘要： The present invention is directed to a new class of hydroxamic acid derivatives of Formula I, wherein the variables G, T, D, L, A, X, R1 and R2 are as described hereinabove, and their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.
摘要翻译： 本发明涉及新一类式I的异羟肟酸衍生物，其中变量G，T，D，L，A，X，R 1和R 2如上所述，并且它们作为LpxC抑制剂的用途，更具体地 它们用于治疗细菌感染。
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公开(公告)号：US20120202777A1
公开(公告)日：2012-08-09
申请号：US13501776
申请日：2010-10-04
IPC分类号： A61K31/165 , C07D213/56 , A61K31/4418 , C07F9/12 , A61K31/661 , C07D261/08 , A61K31/42 , C07D231/12 , A61K31/415 , C07C323/63 , C07D263/24 , A61K31/421 , C07D231/56 , A61K31/416 , C07D413/04 , A61K31/5377 , A61P31/04 , C07C317/50
CPC分类号： C07C317/50 , C07C317/44 , C07C317/46 , C07C317/48 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/16 , C07C2601/18 , C07D213/30 , C07D213/56 , C07D215/06 , C07D231/12 , C07D231/56 , C07D233/36 , C07D239/26 , C07D261/08 , C07D263/08 , C07D263/20 , C07D295/03 , C07D335/02 , C07F9/09 , C07F9/12
摘要： The present invention is directed to a new class of hydroxamic acid derivatives of Formula I, wherein the variables G, T, D, L, A, X, R1 and R2 are as described hereinabove, and their use as LpxC inhibitors, and more specifically their use to treat bacterial infections.
摘要翻译： 本发明涉及新一类式I的异羟肟酸衍生物，其中变量G，T，D，L，A，X，R 1和R 2如上所述，并且它们作为LpxC抑制剂的用途，更具体地 它们用于治疗细菌感染。
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9.发明授权Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of MIP-1-&agr; binding to its CCR 1 receptor 失效杂芳基 - 己酸酰胺衍生物，它们的制备及其作为MIP-1-α与其CCR1受体结合的选择性抑制剂的用途公开(公告)号：US06403587B1
公开(公告)日：2002-06-11
申请号：US09380269
申请日：2000-05-18
IPC分类号： A61K3150
CPC分类号： C07D213/82 , C07C237/22 , C07D209/42 , C07D213/81 , C07D215/48 , C07D215/54 , C07D217/26 , C07D221/16 , C07D235/24 , C07D237/28 , C07D241/24 , C07D241/44 , C07D277/68 , C07D307/84 , C07D307/85 , C07D333/68 , C07D333/70 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： Compounds of the formula wherein R1, R2, R3, R4, R5 and R6 are as described in the specification are useful to treat inflammation and other immune disorders.
摘要翻译： 化学式R 1，R 2，R 3，R 4，R 5和R 6的化合物如本说明书所述用于治疗炎症和其它免疫疾病。
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公开(公告)号：US20100120794A1
公开(公告)日：2010-05-13
申请号：US12651885
申请日：2010-01-04
IPC分类号： A61K31/497 , C07D413/04 , A61K31/4439 , C07D417/04 , A61P37/00 , A61P19/02 , A61P3/10 , A61P1/00 , A61P29/00 , A61P11/06 , A61P9/10 , A61K31/506 , C07D271/06 , A61K31/4245 , A61K31/4436
CPC分类号： C07D213/38 , C07D271/06 , C07D271/10 , C07D271/107 , C07D401/04 , C07D413/04 , C07D417/04
摘要： The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R1, R2, R3, R4, R5, R8, m, n, p, q, r, s, t and u are as defined herein. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，前体药物，溶剂合物或水合物; 其中B，D，E，R 1，R 2，R 3，R 4，R 5，R 8，m，n，p，q，r，s，t和u如本文所定义。 本发明还涉及使用这些化合物治疗哺乳动物，特别是人类的过度增殖性疾病和自身免疫性疾病的方法，以及含有这些化合物的药物组合物。
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