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17 条记录 (耗时 0.025 秒)

    Degradation fragments
    1.
    发明申请
    Degradation fragments 失效

    公开(公告)号：US20070015816A1

    公开(公告)日：2007-01-18

    申请号：US11479024

    申请日：2006-06-30

    申请人： Joseph Clark ,  Thomas Cadoux-Hudson ,  Christopher Schofield

    发明人： Joseph Clark ,  Thomas Cadoux-Hudson ,  Christopher Schofield

    IPC分类号： A61K31/4025 ,  A61K31/4015 ,  C07D403/14 ,  C07D403/02 ,  G01N33/53

    CPC分类号： C07D207/44 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/4025 ,  A61K41/0019 ,  C07D207/448 ,  C07D413/06 ,  G01N33/728 ,  Y10S436/822

    摘要： A pharmaceutical composition comprising a compound of formula (I) wherein X is an electron withdrawing group, Y1 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R4, —CO2R4, —CONHR4 or —COR4, and each of R1, R2 and R4, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, or a compound of formula (II) wherein each of Y2 and Y3, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R9, —CO2R9, —CONHR9 or —COR9, Z is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, —CH═C(NHR10)CH((CH2)mCO2R11)(C═O)CH3 or —CH2(C═O)CH((CH2)mCO2R11)(C═O)CH3, R8 is —(CH2)nCO2R12, each of R5 to R7 and R9 to R12, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and each of m and n, which may be the same or different, is 1 to 6 or a compound of formula (III) wherein each of Y4 to Y6, which may be the same or different, is hydrogen, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, —SO2R19, —CO2R19, —CONHR19 or —COR19, each of R16 and R17, which may be the same or different, is —(CH2)pCO2R20, each of R13 to R15 and R18 to R20, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocyclyl, and p is 1 to 6, or other photolabile degradation product of bilirubin or biliverdin or derivative of a photolabile degradation fragment of bilirubin or biliverdin, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier or diluent.

    Method and system for creating VoIP routing registry
    2.
    发明申请
    Method and system for creating VoIP routing registry 审中-公开
    创建VoIP路由注册表的方法和系统

    公开(公告)号：US20070121603A1

    公开(公告)日：2007-05-31

    申请号：US11541855

    申请日：2007-01-23

    申请人： Joseph Clark ,  Stephen Walters ,  Kaj Tesink ,  Joseph Clark

    发明人： Joseph Clark ,  Stephen Walters ,  Kaj Tesink ,  Joseph Clark

    IPC分类号： H04L12/66

    CPC分类号： H04L12/6418

    摘要： VoIP Routing Registry (VRR) has been created to allow VoIP Service Providers to direct calls properly over their IP networks. In operation, the VRR translates a 10-digit or 6-digit telephone number into a URI that can be used for routing. The VRR must also take into consideration Local Number Portability (LNP).

    摘要翻译： 已创建VoIP路由注册表（VRR），以允许VoIP服务提供商通过其IP网络正确呼叫呼叫。 在操作中，VRR将10位或6位电话号码转换为可用于路由的URI。 VRR还必须考虑本地号码携带（LNP）。

    Electronics module assembly
    4.
    发明申请
    Electronics module assembly 有权
    电子模块组装

    公开(公告)号：US20060256541A1

    公开(公告)日：2006-11-16

    申请号：US11125993

    申请日：2005-05-10

    申请人： Daniel Sandgren ,  Joseph Clark

    发明人： Daniel Sandgren ,  Joseph Clark

    IPC分类号： H05K7/14

    CPC分类号： H05K7/1461 ,  G02B6/4453

    摘要： An electronics module assembly for detachably retaining a pair of electronic sub-modules in a single slot of a chassis. A host module of the electronics module assembly is configured to be detachably received and retained in a slot of the chassis. The host module has a height corresponding with a height of the slot of the chassis. A pair of sub-modules are configured to be detachably received and retained in the host module. The combined height of the sub-modules is no greater than the height dimension of the slot of the chassis. Therefore, where there was once only room for one electronics module in a single slot of the chassis, a pair of sub-modules with the host module may now be utilized in the single slot of the chassis.

    摘要翻译： 一种用于将一对电子子模块可拆卸地保持在底盘的单个槽中的电子模块组件。 电子模块组件的主机模块被配置为可拆卸地接收并保持在底盘的槽中。 主机模块具有与机箱的槽的高度相对应的高度。 一对子模块被配置为可拆卸地接收并保持在主机模块中。 子模块的组合高度不大于底盘槽的高度尺寸。 因此，在机箱的单个插槽中一次只有一个电子模块的空间的情况下，具有主机模块的一对子模块现在可以用在机箱的单个槽中。

    Spinal fusion implant and related methods
    6.
    发明授权
    Spinal fusion implant and related methods 有权
    脊柱融合植入物及相关方法

    公开(公告)号：US08623088B1

    公开(公告)日：2014-01-07

    申请号：US12329195

    申请日：2008-12-05

    申请人： Antoine G. Tohmeh ,  Joseph Clark

    发明人： Antoine G. Tohmeh ,  Joseph Clark

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4455 ,  A61F2/28 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/3008 ,  A61F2002/30616 ,  A61F2002/30785 ,  A61F2002/30841 ,  A61F2002/30892 ,  A61F2002/30904 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2310/00179

    摘要： A spinal fusion implant of non-bone construction to be introduced into any variety of spinal target sites. The spinal fusion implant of the present invention includes a top surface, a bottom surface, first and second lateral sides, a proximal (posterior) end and a distal (anterior) end. The spinal fusion implant of the present invention may be used to provide temporary or permanent fixation within an orthopedic target site. To do so, the spinal fusion implant may be introduced into a disc space while locked to a surgical insertion instrument and thereafter employed in the proper orientation and released. Once deposited in the disc space, the spinal fusion implant of the present invention effects spinal fusion over time as the natural healing process integrates and binds the implant.

    摘要翻译： 非骨骼结构的脊柱融合植入物可引入各种脊柱靶点。 本发明的脊椎融合植入物包括顶表面，底表面，第一和第二侧面，近端（后端）和远端（前端）。 本发明的脊柱融合植入物可用于在整形外科目标部位内提供临时或永久固定。 为了做到这一点，脊柱融合植入物可被引入椎间盘空间中，同时被锁定到手术插入器械上，然后以正确的取向并被释放。 一旦沉积在椎间盘空间中，随着自然愈合过程整合和结合植入物，本发明的脊柱融合植入物随着时间的推移实现脊柱融合。

    Methods and apparatus of managing a power amplifier
    8.
    发明申请
    Methods and apparatus of managing a power amplifier 有权
    管理功率放大器的方法和装置

    公开(公告)号：US20070024356A1

    公开(公告)日：2007-02-01

    申请号：US11191571

    申请日：2005-07-28

    申请人： Leroy Plymale ,  Joseph Clark ,  Henry Nguyen ,  John Ruppel ,  Thomas Sears ,  Ronald Porco ,  Armando Jimenez

    发明人： Leroy Plymale ,  Joseph Clark ,  Henry Nguyen ,  John Ruppel ,  Thomas Sears ,  Ronald Porco ,  Armando Jimenez

    IPC分类号： H03F1/14

    CPC分类号： H03F1/0277 ,  H03F1/0288

    摘要： In the present technique for power management of a power amplifier, an amplifier bank from a plurality of amplifier banks in a power amplifier that has been switched off for a longest period of time is assessed (826) to provide a lowest amplifier bank. With this lowest amplifier bank, an up-threshold that is associated to the lowest amplifier bank is assessed (828), followed by another assessment (820) of a current power output of the power amplifier. It is next determined (830) whether the current power output corresponds at least in a predetermined way to the up-threshold, and if so, the lowest amplifier bank is accordingly switched on (832).

    摘要翻译： 在用于功率放大器的功率管理的现有技术中，评估了已经被关闭最长时间段的功率放大器中的多个放大器组的放大器组（826）以提供最低放大器组。 利用这个最低的放大器组，评估与最低放大器组相关联的上限阈值（828），接着是功率放大器当前功率输出的另一个评估（820）。 接下来确定（830）当前功率输出是否至少以预定方式对应于上限阈值，如果是，则最小放大器组相应地被接通（832）。

    Methods for assessing a condition by analyzing blood in cerebrospinal fluid
    9.
    发明申请
    Methods for assessing a condition by analyzing blood in cerebrospinal fluid 有权
    通过分析脑脊液中的血液来评估病情的方法

    公开(公告)号：US20060034730A1

    公开(公告)日：2006-02-16

    申请号：US11194878

    申请日：2005-08-01

    申请人： Fred Beyette ,  Joseph Clark

    发明人： Fred Beyette ,  Joseph Clark

    IPC分类号： G01N21/41 ,  G01J3/00

    CPC分类号： G01N21/31

    摘要： The present invention provides methods for assessing a condition in an individual by analyzing a cerebrospinal fluid sample from the individual, for example, by spectroscopy. Further, the invention provides methods for determining an amount of blood in the cerebrospinal fluid sample; methods for determining concentrations of analytes in the cerebrospinal fluid sample; methods for determining a length of time the blood has been in the cerebrospinal fluid sample; and methods for rapidly obtaining a differential diagnosis between conditions indicated by blood in the cerebral spinal fluid. Moreover, the present invention provides instruments capable of rapidly assessing a condition in and individual by point-of-care analysis of a cerebral fluid sample from an individual.

    摘要翻译： 本发明提供了通过例如通过光谱法分析来自个体的脑脊液样品来评估个体状况的方法。 此外，本发明提供了确定脑脊液样品中血液量的方法; 确定脑脊液样品中分析物浓度的方法; 用于确定血液已经在脑脊液样品中的时间长度的方法; 以及用于在脑脊髓液中由血液指示的条件之间快速获得鉴别诊断的方法。 此外，本发明提供了能够通过来自个体的脑液样品的护理点分析快速评估病症和个体的仪器。