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公开(公告)号：US20100316670A1
公开(公告)日：2010-12-16
申请号：US12664293
申请日：2008-06-10
CPC分类号： C12N15/86 , A61K2039/5254 , C12N7/00 , C12N2770/24143 , C12N2770/24161 , Y02A50/386
摘要： Embodiments described herein concern attenuated, St. Louis Encephalitis Virus/dengue virus type 4 antigenic chimeric viruses, which can be used to prepare immunogenic compositions, vaccines, and diagnostic reagents. Methods of making and using the foregoing are provided.
摘要翻译： 本文描述的实施方案涉及减毒的圣路易脑炎病毒/登革热病毒4型抗原嵌合病毒，其可用于制备免疫原性组合物，疫苗和诊断试剂。 提供制造和使用前述的方法。
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2.发明申请DEVELOPMENT OF MUTATIONS USEFUL FOR ATTENUATING DENGUE VIRUSES AND CHIMERIC DENGUE VIRUSES 有权开发有用于减少登革热病毒和濒危病毒的突变公开(公告)号：US20120114694A1
公开(公告)日：2012-05-10
申请号：US13240849
申请日：2011-09-22
IPC分类号： A61K39/12 , C12N7/04 , A61K39/295 , C07H21/02 , A61P37/04 , A61P31/14 , C12N7/00 , C07H21/04
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24171 , C12Q1/701 , C12Q2600/156 , G01N2333/18 , G01N2500/10 , Y02A50/386
摘要： A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
摘要翻译： 开发了一个突变菜单，可用于微调登革病毒疫苗的衰减和生长特性。
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公开(公告)号：US07560118B2
公开(公告)日：2009-07-14
申请号：US11446050
申请日：2006-06-02
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24171 , C12Q1/701 , C12Q2600/156 , G01N2333/18 , G01N2500/10 , Y02A50/386
摘要： A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
摘要翻译： 开发了一个突变菜单，可用于微调登革病毒疫苗的衰减和生长特性。
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4.发明申请DEVELOPMENT OF MUTATIONS USEFUL FOR ATTENUATING DENGUE VIRUSES AND CHIMERIC DENGUE VIRUSES 有权开发有用于减少登革热病毒和濒危病毒的突变公开(公告)号：US20090263424A1
公开(公告)日：2009-10-22
申请号：US12396376
申请日：2009-03-02
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24171 , C12Q1/701 , C12Q2600/156 , G01N2333/18 , G01N2500/10 , Y02A50/386
摘要： A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
摘要翻译： 开发了一个突变菜单，可用于微调登革病毒疫苗的衰减和生长特性。
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公开(公告)号：US08337860B2
公开(公告)日：2012-12-25
申请号：US12376756
申请日：2007-08-15
CPC分类号： C12N7/045 , A61K2039/5254 , C07K14/005 , C07K14/1825 , C12N7/00 , C12N2770/24122 , C12N2770/24162 , Y02A50/386
摘要： The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.
摘要翻译： 本发明涉及在3'非翻译区（3'-UTR）中含有突变的登革热病毒或嵌合登革热病毒，其包含在每个登革热病毒血清型1中除去TL-2同源结构的＆Dgr 30突变 ，2,3和4，以及从3'-UTR缺失的＆Dgr 30突变体附加的核苷酸，其去除在5'方向上的序列，直到每个的TL-3同源结构的5'边界 登革热病毒血清型1,2,3和4，或用第二血清型登革病毒的3'-UTR替换第一血清型登革病毒的3'-UTR，任选含有'Dgr 30 来自3'-UTR缺失的＆Dgr 30突变的突变和核苷酸; 和免疫原性组合物，诱导免疫应答的方法，以及产生登革热病毒或嵌合登革病毒的方法。
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6.发明授权公开(公告)号：US07226602B2
公开(公告)日：2007-06-05
申请号：US10719547
申请日：2003-11-21
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24171 , C12Q1/701 , C12Q2600/156 , G01N2333/18 , G01N2500/10 , Y02A50/386
摘要： A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
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7.发明授权Recombinant attenuated dengue viruses comprising mutations in NS5 and the 3′ untranslated region 有权包含NS5和3'非翻译区突变的重组减毒登革热病毒公开(公告)号：US08632782B2
公开(公告)日：2014-01-21
申请号：US13240849
申请日：2011-09-22
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24171 , C12Q1/701 , C12Q2600/156 , G01N2333/18 , G01N2500/10 , Y02A50/386
摘要： The invention features novel attenuated dengue virus mutants and compositions thereof.
摘要翻译： 本发明的特征在于新型减毒登革热病毒突变体及其组合物。
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8.发明授权公开(公告)号：US08039003B2
公开(公告)日：2011-10-18
申请号：US12396376
申请日：2009-03-02
CPC分类号： A61K39/12 , A61K39/295 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24134 , C12N2770/24161 , C12N2770/24162 , C12N2770/24171 , C12Q1/701 , C12Q2600/156 , G01N2333/18 , G01N2500/10 , Y02A50/386
摘要： The invention provides compositions featuring an attenuated dengue virus mutant or an attenuated chimeric dengue virus mutant.
摘要翻译： 本发明提供具有减毒登革热病毒突变体或减毒嵌合登革热病毒突变体的组合物。
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公开(公告)号：US20100104598A1
公开(公告)日：2010-04-29
申请号：US12376756
申请日：2007-08-15
CPC分类号： C12N7/045 , A61K2039/5254 , C07K14/005 , C07K14/1825 , C12N7/00 , C12N2770/24122 , C12N2770/24162 , Y02A50/386
摘要： The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3′ untranslated region (3′-UTR) comprising a Δ30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR that removes sequence in the 5′ direction as far as the 5′ boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3′-UTR of a dengue virus of a first serotype with the 3′-UTR of a dengue virus of a second serotype, optionally containing the Δ30 mutation and nucleotides additional to the Δ30 mutation deleted from the 3′-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.
摘要翻译： 本发明涉及在3'非翻译区（3'-UTR）中含有突变的登革热病毒或嵌合登革热病毒，其包含在每个登革热病毒血清型1中除去TL-2同源结构的＆Dgr 30突变 ，2,3和4，以及从3'-UTR缺失的＆Dgr 30突变体附加的核苷酸，其去除在5'方向上的序列，直到每个的TL-3同源结构的5'边界 登革热病毒血清型1,2,3和4，或用第二血清型登革病毒的3'-UTR替换第一血清型登革病毒的3'-UTR，任选含有'Dgr 30 来自3'-UTR缺失的＆Dgr 30突变的突变和核苷酸; 和免疫原性组合物，诱导免疫应答的方法，以及产生登革热病毒或嵌合登革病毒的方法。
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公开(公告)号：US20140212434A1
公开(公告)日：2014-07-31
申请号：US13983545
申请日：2012-02-02
IPC分类号： C12N15/86 , A61K39/12 , A61K45/06 , A61K39/205
CPC分类号： A61K45/06 , A61K39/08 , A61K39/12 , A61K39/205 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2760/14134 , C12N2760/14234 , C12N2760/20043 , C12N2760/20134 , C12N2760/20143
摘要： The present invention provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a filovirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a filovirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present invention provides a recombinant rabies virus vector omprising a nucleotide sequence encoding at least one filovirus glycoprotein or an immunogenic fragment thereof, as well as pharmaceutical compostions comprising the vaccine vectors.
摘要翻译： 本发明提供用于诱导免疫应答的方法和组合物，所述免疫应答赋予双重保护以抵抗狂犬病病毒和弗洛伊病毒中的任一种或两者的感染，和/或可用于治疗性地用于狂犬病病毒和/或病毒性病毒的现有感染 以治疗其至少一种症状和/或中和或清除感染剂。 特别地，本发明提供重组狂犬病病毒载体，其包含编码至少一种病毒糖蛋白或其免疫原性片段的核苷酸序列，以及包含疫苗载体的药物组合物。
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