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    Parametric control in pulsed light sterilization
    8.
    发明授权
    Parametric control in pulsed light sterilization 失效
    脉冲光灭菌中的参数控制

    公开(公告)号：US06566659B1

    公开(公告)日：2003-05-20

    申请号：US09326168

    申请日：1999-06-04

    申请人： Reginald Wayne Clark ,  James C. Lierman ,  Donald Lander ,  Joseph E. Dunn

    发明人： Reginald Wayne Clark ,  James C. Lierman ,  Donald Lander ,  Joseph E. Dunn

    IPC分类号： B65B5508

    CPC分类号： A61L12/063 ,  A23L3/26 ,  A23L3/28 ,  A61L2/08 ,  A61L2/24 ,  A61L12/06 ,  A61L12/086 ,  B65B9/20 ,  B65B25/008 ,  B65B55/02 ,  B65B55/08 ,  B65B55/16

    摘要： An approach for sterilizing microorganisms at a target object employs a flashlamp system including means for generating pulses of light, and for deactivating microorganisms within the target object by illuminating the target object with the pulses of light having been generated; a photo-sensitive detector positioned so as to receive a portion of each of the pulses of light as a measure of an amount of light illuminating the target object, for generating an output signal in response thereto; and a control system, coupled to the flashlamp system and the photo-sensitive detector, for determining, in response to the output signal, whether the pulses of light are sufficient to effect a prescribed level of deactivation of microorganisms at the target object. In accordance with this approach sterilizing microorganisms involves steps of generating a pulse of light; deactivating microorganisms at the target object by directing the pulse of light having been generated at the target object; receiving a portion of the pulse of light as a measure of an amount of the pulse of light illuminating the target object; generating an output signal in response to the receiving of the portion of the pulse of light; and determining, in response to the generating of the output signal, whether the pulse of light is sufficient to effect a prescribed level of deactivation of microorganisms at the target object.

    摘要翻译： 用于在目标物体上灭菌微生物的方法采用闪光灯系统，其包括用于产生光脉冲的装置，以及通过用已产生的光脉冲照射目标物体来使目标物体内的微生物失活; 光敏检测器，其被定位成接收每个所述脉冲的一部分作为照射所述目标物体的光量的量度，以响应于此产生输出信号; 以及耦合到所述闪光灯系统和所述光敏检测器的控制系统，用于响应于所述输出信号确定所述光脉冲是否足以影响所述目标对象处微生物的规定水平的失活。 根据这种方法，消毒微生物包括产生光脉冲的步骤; 通过引导已经在目标物体处产生的光的脉冲来使目标物体上的微生物失活; 接收光脉冲的一部分作为照射目标物体的光的脉冲量的量度; 响应于所述部分所述光脉冲的接收而产生输出信号; 以及响应于所述输出信号的产生，确定所述光脉冲是否足以影响所述目标对象处的微生物的规定的失活水平。

    Sterilization of packages and their contents using high-intensity, short-duration pulses of incoherent, polychromatic light in a broad spectrum
    10.
    发明授权
    Sterilization of packages and their contents using high-intensity, short-duration pulses of incoherent, polychromatic light in a broad spectrum 失效
    使用高强度，短持续时间脉冲的非相干，多色光在广谱中灭菌包装及其内容物

    公开(公告)号：US5786598A

    公开(公告)日：1998-07-28

    申请号：US651275

    申请日：1996-05-22

    申请人： Reginald Wayne Clark ,  James C. Lierman ,  Donald Lander ,  Joseph E. Dunn

    发明人： Reginald Wayne Clark ,  James C. Lierman ,  Donald Lander ,  Joseph E. Dunn

    IPC分类号： A23L3/26 ,  A23L3/28 ,  A61L2/08 ,  A61L2/24 ,  A61L12/06 ,  A61L12/08 ,  B65B25/00 ,  B65B55/02 ,  B65B55/16 ,  B65B55/08 ,  A61L2/10

    CPC分类号： A61L2/24 ,  A23L3/26 ,  A23L3/28 ,  A61L12/06 ,  A61L12/063 ,  A61L12/086 ,  A61L2/08 ,  B65B25/008 ,  B65B55/02 ,  B65B55/16

    摘要： An approach for sterilizing product containers and deactivating microorganisms in such containers employs the container, which, in one embodiment, includes a polyolefin, and which transmits light in a spectrum of from between 180 nm and 300 nm. The container may be coupled to a port through which a product within the container can be withdrawn, or, alternatively, may include a blister that together with a backing material forms a cavity in which a contact lens is contained. A flashlamp system generates high-intensity, short-duration pulses of polychromatic light in a broad spectrum. The pulses of light generated by the flashlamp illuminate the container and thereby deactivate microorganisms within the container. In some embodiments, the container contains a transmissive product that transmits more than about one percent of light at a wavelength of 260 nm. In further embodiments, the high-intensity, short-duration pulses of polychromatic light in a broad spectrum deactivate microorganisms both within the container and within the port. In additional embodiments, the flashlamp advantageously deactivates sufficient microorganisms to achieve a sterility assurance level of at least 10.sup.-6.

    摘要翻译： 在这种容器中灭菌产品容器和灭活微生物的方法使用容器，在一个实施方案中，该容器包括聚烯烃，并且透射从180nm到300nm的光谱的光。 容器可以联接到容器中的产品可以被抽出的端口，或者替代地，可以包括与背衬材料一起形成其中包含隐形眼镜的空腔的泡罩。 闪光灯系统在广谱中产生高强度，短时间的多色光脉冲。 由闪光灯产生的光脉冲照亮容器，从而使容器内的微生物失活。 在一些实施例中，容器包含透射产物，其透射波长为260nm的大于约1％的光。 在另外的实施方案中，广谱中的多色光的高强度，短持续时间的脉冲在容器内和端口内都使微生物失活。 在另外的实施方案中，闪光灯有利地使足够的微生物失活以达到至少10-6的无菌保证水平。