公开(公告)号：US20050269127A1

公开(公告)日：2005-12-08

申请号：US11099187

申请日：2005-04-04

申请人： Joseph Mitchell ,  Spring Haby ,  Dennis Rushforth ,  Mark Van Dyke ,  Henry Oviatt ,  Andrew Philips ,  Ralph Hill ,  Mary Marshall

发明人： Joseph Mitchell ,  Spring Haby ,  Dennis Rushforth ,  Mark Van Dyke ,  Henry Oviatt ,  Andrew Philips ,  Ralph Hill ,  Mary Marshall

IPC分类号： H01B17/32 ,  H01B17/50 ,  H01B17/06

CPC分类号： H01B17/50 ,  H01B17/325 ,  Y10T428/31515

摘要： A composite insulator containing means for providing early warning of impending failure due to stress corrosion cracking, flashunder, or destruction of the rod by discharge activity conditions is described. A composite insulator comprising a fiberglass rod surrounded by a polymer housing and connected with metal end fittings on either end of the rod is doped with a dye-based chemical dopant. The dopant is located around the vicinity of the outer surface of the fiberglass rod. The dopant is formulated to possess migration and diffusion characteristics, and to be inert in dry conditions and compatible with the insulator components. The dopant is positioned within the insulator such that upon the penetration of moisture through the housing to the rod through a permeation pathway in the outer surface of the insulator, the dopant will become activated and will leach out of the same permeation pathway or diffuse through the housing. The activated dopant then creates a deposit or stain on the outer surface of the insulator housing. The dopant comprises an oil-soluble dye, an indicator, or a stain compound that can either be visually identified, or is sensitive to radiation at one or more specific wavelengths. The dopant could also be formulated by a nanoparticle enabled material. Deposits of activated dopant on the outer surface of the insulator can be detected upon imaging of the outer surface of the insulator by appropriate imaging instruments or the naked eye.

摘要翻译： 描述了一种用于通过放电活动条件提供由于应力腐蚀开裂，闪光或棒的破坏而引起的即将发生的故障的复合绝缘体。 复合绝缘体包括由聚合物壳体包围并与杆的任一端上的金属端配件连接的玻璃纤维棒，掺杂有基于染料的化学掺杂剂。 掺杂剂位于玻璃纤维棒的外表面附近。 掺杂剂配制成具有迁移和扩散特性，并且在干燥条件下是惰性的并且与绝缘体组分相容。 掺杂剂定位在绝缘体内，使得当绝缘体的外表面通过渗透通道将水分穿过壳体穿过壳体时，掺杂剂将被激活并将从相同的渗透通道中浸出或扩散通过 住房。 活化的掺杂剂然后在绝缘体外壳的外表面上产生沉积物或污渍。 该掺杂剂包括油溶性染料，指示剂或染色剂，其可以在视觉上被鉴定，或对一个或多个特定波长的辐射敏感。 掺杂剂也可以由具有纳米粒子的材料制成。 可以通过适当的成像仪器或肉眼对绝缘体的外表面进行成像后，检测绝缘体外表面上活化的掺杂剂的沉积。

公开(公告)号：US20070298070A1

公开(公告)日：2007-12-27

申请号：US11673212

申请日：2007-02-09

申请人： Mark Van Dyke

发明人： Mark Van Dyke

IPC分类号： A61K8/65 ,  A61F2/72 ,  A61P25/00

CPC分类号： A61L27/26 ,  A61K38/185 ,  A61L27/227 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2430/32 ,  A61N1/0551 ,  Y10S524/916

摘要： A keratin hydrogel matrix serves as an effective acellular scaffold for axonal regeneration and facilitates functional nerve recovery.

摘要翻译： 角蛋白水凝胶基质用作轴突再生的有效无细胞支架，并促进功能性神经恢复。

公开(公告)号：US4457172A

公开(公告)日：1984-07-03

申请号：US406872

申请日：1982-08-10

申请人： Ray Mathes ,  Mark Van Dyke

发明人： Ray Mathes ,  Mark Van Dyke

IPC分类号： G01M1/22

CPC分类号： G01M1/225

摘要： A dynamic electric wheel balancer for measuring the imbalance condition in a vehicle wheel and indicating the position and correction weights required for balancing the wheel in one or two planes. The wheel balancer contains a rotating shaft in order to make the dynamic measurements. The shaft is freewheeling during measurement and is brought up to a predetermined minimum r.p.m. value through a motor and clutch arrangement. In order to take the measurements, piezoelectric sensors are used to measure the vertical force components exhibited by the imbalance condition of the vehicle wheel secured to the rotating main shaft. The measured force components are converted into digital form through the use of a voltage controlled oscillator and a counter in conjunction with a timing wheel.

摘要翻译： 一种动态电动车轮平衡器，用于测量车辆车轮的不平衡状况，并指示在一个或两个平面中平衡车轮所需的位置和校正重量。 车轮平衡器包含旋转轴以进行动态测量。 轴在测量期间自由运转，并达到预定的最小r.p.m。 通过电机和离合器装置的值。 为了进行测量，使用压电传感器来测量由固定到旋转主轴的车轮的不平衡状态所显示的垂直力分量。 测量的力分量通过使用压控振荡器和计数器与定时轮一起转换成数字形式。

公开(公告)号：US20110097379A1

公开(公告)日：2011-04-28

申请号：US12991811

申请日：2009-05-11

申请人： James Yoo ,  Sang Jin Lee ,  Mark Van Dyke ,  Anthony Atala

发明人： James Yoo ,  Sang Jin Lee ,  Mark Van Dyke ,  Anthony Atala

IPC分类号： A61K9/00 ,  A61K38/39 ,  A61K38/43 ,  A61K38/18 ,  A61K38/48 ,  A61P13/12 ,  A61K47/30 ,  A61K31/573

CPC分类号： A61K38/39 ,  A61K9/0024 ,  A61K38/4886 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/434 ,  A61L2400/06 ,  A61L2430/26 ,  A61K2300/00

摘要： The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.

摘要翻译： 本发明涉及在受试者的靶位点诱导细胞募集和组织再生的方法。 它也部分地基于发现一个受试者自己的生物资源和环境条件可用于原位组织再生，从而减少或消除对供体细胞采购和离体操作这种供体细胞的需要。 公开了通过在目标部位（例如肾）处诱导持续的正压来将受试者自己的干细胞募集到靶区域的方法，从而增加能够分化以再生靶组织的多能细胞的数量。

公开(公告)号：US20060051732A1

公开(公告)日：2006-03-09

申请号：US11205800

申请日：2005-08-17

申请人： Mark Van Dyke

发明人： Mark Van Dyke

IPC分类号： A01N1/02 ,  A61K31/715

CPC分类号： A61K9/0026 ,  A01N1/0205 ,  A01N1/021 ,  A01N1/0226 ,  A61K31/715

摘要： A liquid plasma expander or resuscitation fluid composition for use in a subject in need thereof, comprising, consisting of, or consisting essentially of: (a) a keratin derivative (preferably alpha keratose, gamma keratose, or combinations thereof, and with basic alpha keratose preferred over acidic alpha keratose); and (b) an electrolyte solution, with the keratin derivative solubilized in the electrolyte solution to form a homogeneous liquid composition. Blood substitutes formed therefrom and methods of making and using the same are also described.

摘要翻译： 用于有需要的受试者的液体血浆扩张剂或复苏液组合物，其包含，或由其基本上由以下物质组成：（a）角蛋白衍生物（优选α角蛋白，γ角化糖或其组合）和碱性α角化糖 优于酸性α角质消融）; 和（b）电解质溶液，其中角蛋白衍生物溶解在电解质溶液中以形成均匀的液体组合物。 还描述了由其形成的血液代用品及其制备和使用方法。

公开(公告)号：US20050169963A1

公开(公告)日：2005-08-04

申请号：US11047474

申请日：2005-01-31

申请人： Mark Van Dyke ,  Cheryl Blanchard ,  Scott Timmons ,  Arlene Siller-Jackson ,  Robert Smith

发明人： Mark Van Dyke ,  Cheryl Blanchard ,  Scott Timmons ,  Arlene Siller-Jackson ,  Robert Smith

IPC分类号： A61L27/00 ,  A61F2/12 ,  A61F2/30 ,  A61F2/44 ,  A61L27/22 ,  A61L27/30 ,  A61L27/34 ,  A61L27/52 ,  A61F2/28 ,  A61K9/70

CPC分类号： A61L27/52 ,  A61F2/0059 ,  A61F2/12 ,  A61F2/441 ,  A61F2002/30971 ,  A61L27/227 ,  A61L27/306 ,  A61L27/34 ,  A61L2430/04 ,  A61L2430/38 ,  A61L27/38 ,  C08L83/04

摘要： A keratin hydrogel-filled implantable prosthetic device. One device is a breast implant for augmenting or reconstructing a human breast including an envelope containing a keratin hydrogel. One keratin hydrogel is formed from a solid precursor which forms a keratin hydrogel upon addition of water. One source of keratin is human hair. In one method, an envelope suitable for implantation and a solid keratin hydrogel precursor are provided. The solid can be in fibrous or powder form. The solid precursor can be inserted into the envelope interior. A small incision near the breast can be made and the envelope inserted into the incision. After insertion, water can be injected into the envelope interior, preferably through the incision and through a self-sealing port in the envelope. In one method, the implant is provided as a kit, with the envelope and keratin hydrogel provided. The hydrogel can be injected into the envelope either before or after insertion into the breast area. One kit has a powdered, keratin hydrogel precursor disposed within the envelope interior, awaiting the addition of water, preferably after insertion of the implant into the body.

摘要翻译： 角蛋白水凝胶填充的可植入假体装置。 一种装置是用于增强或重建人乳房的乳房植入物，其包括含有角蛋白水凝胶的包膜。 一种角蛋白水凝胶由固体前体形成，其在加入水时形成角蛋白水凝胶。 角蛋白的一个来源是人的头发。 在一种方法中，提供适于植入的包膜和固体角蛋白水凝胶前体。 固体可以是纤维或粉末形式。 固体前体可以插入信封内部。 乳房附近有一个小切口，信封插入切口。 插入后，水可以注入信封内部，优选通过切口并通过信封中的自密封端口注入。 在一种方法中，植入物作为试剂盒提供，其中提供了包膜和角蛋白水凝胶。 在插入乳房区域之前或之后，可以将水凝胶注入到信封中。 一个试剂盒具有设置在信封内部的粉末状角蛋白水凝胶前体，等待加入水，优选在将植入物插入体内之后。

公开(公告)号：US20110220125A1

公开(公告)日：2011-09-15

申请号：US13048091

申请日：2011-03-15

申请人： Mark Van Dyke ,  John H. Tucker

发明人： Mark Van Dyke ,  John H. Tucker

IPC分类号： A61F5/56

CPC分类号： A61F5/566

摘要： A mandibular advancement splint provides for adjustable lateral movement of upper and lower appliances. An upper appliance is inserted onto a user's upper jaw and a lower appliance is inserted onto a user's lower jaw. A first protrusion is formed on the upper appliance. A second protrusion is formed on the lower appliance. One of the first protrusion and the second protrusion can be adjusted to offset the lower jaw with respect to the upper jaw.The splint can have an upper appliance having a body mounted to an upper jaw of a user; and a lower appliance having a body mounted to a lower jaw of a user. The upper appliance has a pair of adjustable wings attached to the upper appliance body; and the lower appliance has a pair of fixed wings attached to the lower appliance body. The pair of wings attached to said upper appliance are slidably adjustable with respect to the upper appliance body to determine the offset between the upper and lower jaws of the user.

摘要翻译： 下颌前移夹板提供上下装置的可调横向运动。 上部器具被插入到用户的上颚上，并且将下部器具插入到用户的下颚上。 第一突起形成在上部器具上。 在下部器具上形成第二突起。 可以调整第一突起和第二突起中的一个以相对于上颌来抵消下颌。 夹板可以具有上部器具，其具有安装到使用者的上颚的主体; 以及具有安装到使用者的下颚的主体的下部器具。 上部电器具有连接到上部电器主体的一对可调节翼; 并且下部器具具有连接到下部器具主体的一对固定翼。 附接到所述上部器具的一对翼片相对于上部器具主体可滑动地调节，以确定使用者的上颚和下颌之间的偏移。

公开(公告)号：US20050058686A1

公开(公告)日：2005-03-17

申请号：US10626907

申请日：2003-07-25

申请人： Mark Van Dyke ,  Arlene Siller-Jackson

发明人： Mark Van Dyke ,  Arlene Siller-Jackson

IPC分类号： A61L27/00 ,  A61L27/34 ,  A61L31/00 ,  B60Q1/26 ,  C09D189/04 ,  C09D189/06 ,  F21W107/10 ,  A61K38/18

CPC分类号： A61L27/34 ,  B60Q1/2661 ,  B60R2019/505 ,  C09D189/04 ,  C09D189/06 ,  C08L89/04 ,  C08L2666/28

摘要： A medical device (and method for making same) comprising a passivating coating comprising keratin.

摘要翻译： 包括包含角蛋白的钝化涂层的医疗装置（及其制造方法）。

公开(公告)号：US09694055B2

公开(公告)日：2017-07-04

申请号：US12991811

申请日：2009-05-11

申请人： James Yoo ,  Sang Jin Lee ,  Mark Van Dyke ,  Anthony Atala

发明人： James Yoo ,  Sang Jin Lee ,  Mark Van Dyke ,  Anthony Atala

IPC分类号： A61K47/30 ,  A61K38/39 ,  A61K9/00 ,  A61K38/48 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54

CPC分类号： A61K38/39 ,  A61K9/0024 ,  A61K38/4886 ,  A61L27/24 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/41 ,  A61L2300/434 ,  A61L2400/06 ,  A61L2430/26 ,  A61K2300/00

摘要： The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. Methods are disclosed for recruitment of a subject's own stem cells to a target region by inducing a sustained positive pressure at a target site, such as the kidney, thereby increasing the number of pluripotent cells capable of differentiating to regenerate the target tissue.

公开(公告)号：US20170051027A1

公开(公告)日：2017-02-23

申请号：US15308285

申请日：2015-05-01

申请人： Mark Van Dyke ,  Maria Rahmany

发明人： Mark Van Dyke ,  Maria Rahmany

IPC分类号： C07K14/47 ,  C07K1/34

CPC分类号： C07K14/4741 ,  A61L15/32 ,  A61L24/108 ,  A61L26/0047 ,  A61L27/227 ,  A61L2400/12 ,  B82Y5/00 ,  C07K1/34

摘要： The present disclosure relates to keratin nanomaterials, methods for obtaining keratin nanomaterials, and biomaterials made from keratin nanomaterials. In particular, keratin nanomaterials comprising Type I and Type II monomer pairs are disclosed as well as a method for obtaining keratin nanomaterials comprising obtaining a solution of keratin and processing the solution by ultrafiltration with buffer solution containing phosphate.

摘要翻译： 本公开涉及角蛋白纳米材料，获得角蛋白纳米材料的方法和由角蛋白纳米材料制成的生物材料。 特别地，公开了包含I型和II型单体对的角蛋白纳米材料以及获得角蛋白纳米材料的方法，包括获得角蛋白溶液并用含磷酸盐的缓冲溶液通过超滤处理溶液。