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    Controlled delivery of electrical pacing therapy for treating mitral regurgitation
    1.
    发明申请
    Controlled delivery of electrical pacing therapy for treating mitral regurgitation 审中-公开
    用于治疗二尖瓣反流的电起搏治疗的控制递送

    公开(公告)号：US20060173505A1

    公开(公告)日：2006-08-03

    申请号：US11116955

    申请日：2005-04-28

    申请人： Rodney Salo ,  Allan Shuros ,  Joseph Pastore ,  Qingsheng Zhu

    发明人： Rodney Salo ,  Allan Shuros ,  Joseph Pastore ,  Qingsheng Zhu

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus or papillary muscles in a manner that pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

    摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过在左心室的选定区域（例如在二尖瓣装置或乳头肌附近的区域）以在早期心室收缩期间预激活该区域的方式提供起搏刺激，可以获得有益效果，其可以预防或减少 二尖瓣反流的程度。

    Electrical pacing therapy for treating mitral regurgitation
    4.
    发明申请
    Electrical pacing therapy for treating mitral regurgitation 审中-公开
    用于治疗二尖瓣反流的电起搏治疗

    公开(公告)号：US20060173504A1

    公开(公告)日：2006-08-03

    申请号：US11046215

    申请日：2005-01-28

    申请人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

    发明人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus in a manner which pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

    摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过以在早期心室收缩期间预激活该区域的方式向左心室的选定区域（例如二尖瓣装置附近的一个）提供起搏刺激，可获得有益效果，其可以防止或减少 二尖瓣反流。

    Apparatus and method for temporary treatment of acute heart failure decompensation
    6.
    发明申请
    Apparatus and method for temporary treatment of acute heart failure decompensation 有权

    公开(公告)号：US20060167511A1

    公开(公告)日：2006-07-27

    申请号：US11044971

    申请日：2005-01-27

    申请人： Joseph Pastore ,  Qingsheng Zhu

    发明人： Joseph Pastore ,  Qingsheng Zhu

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3627 ,  A61N1/368

    摘要： A system for providing temporary therapy, such as cardiac resynchronization therapy, to a patient suffering a decompensation event. The system can include a device having an external module for generating electrical stimuli, a first lead coupled to the module and implanted into an atrial region of a patient's heart, and a second lead coupled to the module and implanted into a ventricular region of the patient's heart. The device can also include a storage module coupled to the external module to store data associated with physiological data measured by the device. The external module is configured to temporarily generate electrical stimuli that are delivered by at least one of the first and second leads to provide therapy cardiac resynchronization therapy to the heart. A network can be coupled to the device to allow data stored in the device to be downloaded through the network to a central repository.

    Linear stimulation of the heart for improved hemodynamic benefit
    7.
    发明申请
    Linear stimulation of the heart for improved hemodynamic benefit 审中-公开
    心脏的线性刺激改善血液动力学效益

    公开(公告)号：US20050102000A1

    公开(公告)日：2005-05-12

    申请号：US10981019

    申请日：2004-11-03

    申请人： Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

    发明人： Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

    IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/36

    CPC分类号： A61N1/3627 ,  A61N1/3684

    摘要： A method and apparatus for linear stimulation of the heart to resynchronize contraction for improved hemodynamic benefit. Linear stimulation may be accomplished using a linear source, which may comprise an elongated electrode or plurality of electrodes arranged so as to linearly stimulate the heart. A linear source may be coupled to the left ventricle, and one or more additional electrodes may be positioned so as to stimulate a separate region of the left ventricle or one or more additional chambers of the heart as well. Application of an electrical stimulus by the linear source may function to stimulate a larger region of the heart, thereby enhancing the resynchronization effect as well as providing other hemodynamic benefits.

    摘要翻译： 用于线性刺激心脏以重新同步收缩以改善血液动力学益处的方法和装置。 线性刺激可以使用线性源实现，线性源可以包括细长电极或多个电极，其布置成线性刺激心脏。 线性源可以耦合到左心室，并且可以定位一个或多个附加电极，以便也刺激心脏的左心室或一个或多个另外的腔室的单独区域。 通过线性源的电刺激的应用可以起到刺激心脏的较大区域的作用，从而增强再同步效应以及提供其它血液动力学优点。

    SDF-1 DELIVERY FOR TREATING ISCHEMIC TISSUE
    8.
    发明申请
    SDF-1 DELIVERY FOR TREATING ISCHEMIC TISSUE 审中-公开
    SDF-1交付用于治疗组织组织

    公开(公告)号：US20120283315A1

    公开(公告)日：2012-11-08

    申请号：US13393141

    申请日：2010-08-30

    申请人： Marc S. Penn ,  Rahul Aras ,  Joseph Pastore ,  Timothy R. Miller

    发明人： Marc S. Penn ,  Rahul Aras ,  Joseph Pastore ,  Timothy R. Miller

    IPC分类号： A61K31/711 ,  A61P9/10

    CPC分类号： A61K38/19 ,  A61K9/0019 ,  A61K31/711 ,  A61K38/00 ,  A61K48/005 ,  C07K14/521 ,  C07K2319/02 ,  C07K2319/09

    摘要： A method of treating a cardiomyopathy in a subject includes administering directly to or expressing locally in a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification.

    摘要翻译： 治疗受试者心肌病的方法包括在受试者的心肌组织的弱化，缺血和/或梗死周围区域内直接施用或表达一定量的有效引起至少一种功能改善的SDF-1 的以下参数：左心室容积，左心室面积，左心室尺寸，心脏功能，6分钟步行测试或纽约心脏协会（NYHA）功能分类。

    Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
    9.
    发明申请
    Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure 有权
    在缺血后或心力衰竭期间调节细胞代谢的方法和装置

    公开(公告)号：US20080091138A1

    公开(公告)日：2008-04-17

    申请号：US11998969

    申请日：2007-12-03

    申请人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

    发明人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

    IPC分类号： A61M31/00

    CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

    摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

    摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。