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    Electrical pacing therapy for treating mitral regurgitation
    1.
    发明申请
    Electrical pacing therapy for treating mitral regurgitation 审中-公开
    用于治疗二尖瓣反流的电起搏治疗

    公开(公告)号：US20060173504A1

    公开(公告)日：2006-08-03

    申请号：US11046215

    申请日：2005-01-28

    申请人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

    发明人： Qingsheng Zhu ,  Joseph Pastore ,  Allan Shuros ,  Rodney Salo

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus in a manner which pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

    摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过以在早期心室收缩期间预激活该区域的方式向左心室的选定区域（例如二尖瓣装置附近的一个）提供起搏刺激，可获得有益效果，其可以防止或减少 二尖瓣反流。

    Controlled delivery of electrical pacing therapy for treating mitral regurgitation
    2.
    发明申请
    Controlled delivery of electrical pacing therapy for treating mitral regurgitation 审中-公开
    用于治疗二尖瓣反流的电起搏治疗的控制递送

    公开(公告)号：US20060173505A1

    公开(公告)日：2006-08-03

    申请号：US11116955

    申请日：2005-04-28

    申请人： Rodney Salo ,  Allan Shuros ,  Joseph Pastore ,  Qingsheng Zhu

    发明人： Rodney Salo ,  Allan Shuros ,  Joseph Pastore ,  Qingsheng Zhu

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method and apparatus are disclosed for treating mitral or tricuspid regurgitation with electrical stimulation. By providing pacing stimulation to a selected region of the left ventricle, such as one in proximity to the mitral valve apparatus or papillary muscles in a manner that pre-excites the region during early ventricular systole, a beneficial effect is obtained which can prevent or reduce the extent of mitral regurgitation.

    摘要翻译： 公开了一种用于用电刺激治疗二尖瓣或三尖瓣反流的方法和装置。 通过在左心室的选定区域（例如在二尖瓣装置或乳头肌附近的区域）以在早期心室收缩期间预激活该区域的方式提供起搏刺激，可以获得有益效果，其可以预防或减少 二尖瓣反流的程度。

    Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
    4.
    发明申请
    Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure 有权
    在缺血后或心力衰竭期间调节细胞代谢的方法和装置

    公开(公告)号：US20080091138A1

    公开(公告)日：2008-04-17

    申请号：US11998969

    申请日：2007-12-03

    申请人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

    发明人： Joseph Pastore ,  Julio Spinelli ,  Helen Reeve ,  Jeffrey Ross ,  Rodney Salo ,  Allan Shuros

    IPC分类号： A61M31/00

    CPC分类号： A61M5/1723 ,  A61B5/0031 ,  A61B5/1107 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/4839 ,  A61M5/14244 ,  A61M5/14276 ,  A61M2205/3523 ,  A61N1/3627

    摘要： A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid to glucose. One example of such a system includes an implantable device detecting an ischemia and a transdermal drug delivery device delivering a drug when an ischemic condition is detected. Another example of such a system includes one or more implantable devices detecting a predefined change in cardiac metabolic level and delivering a drug when the change is detected. Such systems are applied to treat, for example, patients suffering ischemia and/or heart failure and patients having suffered myocardial infarction.

    摘要翻译： 药物递送系统检测指示需要增加心脏代谢水平的心脏状况，并且作为响应将药物释放到组织或血液中以将促进心脏收缩的代谢合成能量的来源从脂肪酸转移到葡萄糖。 这种系统的一个实例包括检测缺血的可植入装置和当检测到缺血状况时递送药物的透皮药物递送装置。 这种系统的另一个例子包括一个或多个可植入装置，用于检测心脏代谢水平的预定变化并在检测到变化时递送药物。 这种系统被应用于治疗例如患有缺血和/或心力衰竭的患者和患有心肌梗塞的患者。

    Linear stimulation of the heart for improved hemodynamic benefit
    7.
    发明申请
    Linear stimulation of the heart for improved hemodynamic benefit 审中-公开
    心脏的线性刺激改善血液动力学效益

    公开(公告)号：US20050102000A1

    公开(公告)日：2005-05-12

    申请号：US10981019

    申请日：2004-11-03

    申请人： Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

    发明人： Joseph Pastore ,  Qingsheng Zhu ,  Rodney Salo

    IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/36

    CPC分类号： A61N1/3627 ,  A61N1/3684

    摘要： A method and apparatus for linear stimulation of the heart to resynchronize contraction for improved hemodynamic benefit. Linear stimulation may be accomplished using a linear source, which may comprise an elongated electrode or plurality of electrodes arranged so as to linearly stimulate the heart. A linear source may be coupled to the left ventricle, and one or more additional electrodes may be positioned so as to stimulate a separate region of the left ventricle or one or more additional chambers of the heart as well. Application of an electrical stimulus by the linear source may function to stimulate a larger region of the heart, thereby enhancing the resynchronization effect as well as providing other hemodynamic benefits.

    摘要翻译： 用于线性刺激心脏以重新同步收缩以改善血液动力学益处的方法和装置。 线性刺激可以使用线性源实现，线性源可以包括细长电极或多个电极，其布置成线性刺激心脏。 线性源可以耦合到左心室，并且可以定位一个或多个附加电极，以便也刺激心脏的左心室或一个或多个另外的腔室的单独区域。 通过线性源的电刺激的应用可以起到刺激心脏的较大区域的作用，从而增强再同步效应以及提供其它血液动力学优点。

    Drug eluting implants to prevent cardiac apoptosis
    8.
    发明申请
    Drug eluting implants to prevent cardiac apoptosis 审中-公开
    药物洗脱植入物以预防心脏细胞凋亡

    公开(公告)号：US20050267556A1

    公开(公告)日：2005-12-01

    申请号：US10856201

    申请日：2004-05-28

    申请人： Allan Shuros ,  Avram Scheiner ,  Rodney Salo

    发明人： Allan Shuros ,  Avram Scheiner ,  Rodney Salo

    IPC分类号： A61L31/16 ,  A61N1/05 ,  A61K9/22 ,  A61N1/362

    CPC分类号： A61L31/16 ,  A61L2300/40 ,  D04C1/06 ,  D10B2509/00

    摘要： Implantable devices are configured to be positioned in or near the heart and to carry and deliver an anti-apoptotic drug to a treatment site in or near the heart. The implantable devices include, but are not limited to, leads, stents, heart valves, atrial septal defect devices, cardiac patches and ventricular restraint devices. Depending on the composition of the device, the drug may be carried by the device through a coating applied to the device, or may be included in the device during the device manufacturing process. The drug may also be included in microparticles, such a microspheres, that are delivered locally through a conduit, such as a catheter.

    摘要翻译： 可植入装置被配置为定位在心脏中或附近，并将抗细胞凋亡药物携带并递送至心脏内或附近的治疗部位。 可植入装置包括但不限于引线，支架，心脏瓣膜，心房间隔缺损装置，心脏贴片和心室约束装置。 根据装置的组成，药物可以由装置通过施加到装置的涂层携带，或者可以在装置制造过程中包括在装置中。 药物也可以包括在通过导管（例如导管）局部递送的微粒（例如微球体）中。

    Implantable physiologic monitoring system
    9.
    发明申请
    Implantable physiologic monitoring system 审中-公开
    植入式生理监测系统

    公开(公告)号：US20070088214A1

    公开(公告)日：2007-04-19

    申请号：US11250928

    申请日：2005-10-14

    申请人： Allan Shuros ,  Rodney Salo ,  Michael Kane

    发明人： Allan Shuros ,  Rodney Salo ,  Michael Kane

    IPC分类号： A61B8/00

    CPC分类号： A61B8/065 ,  A61B5/076 ,  A61B5/1076 ,  A61B5/6876 ,  A61B5/6884 ,  A61B8/02 ,  A61B8/06 ,  A61B8/12 ,  A61B8/4483

    摘要： An ultrasonic implantable device includes an ultrasonic sensor having a plurality of transducers. The sensor is configured for mounting to a vessel wall. A first of the transducers directs sound waves in a direction at least partially upstream or downstream in the vessel. A second of the transducers directs sound waves in a radial direction through an interior of the vessel against a sidewall of the vessel. The sensor monitors a change in frequency of the sound waves from the first transducer to determine a fluid velocity in the vessel. The sensor also monitors a reflection time of the sound waves from the second transducer that return from the sidewall to determine an internal diameter of the vessel. The determined fluid velocity and vessel diameter can be used to determine a volumetric flow rate of the fluid in the vessel.

    摘要翻译： 超声波可植入装置包括具有多个换能器的超声波传感器。 传感器被配置为安装到血管壁。 换能器中的第一个将声波沿至少部分在容器的上游或下游的方向引导。 传感器中的第二个将声波沿径向引导通过容器的内部抵靠容器的侧壁。 传感器监测来自第一换能器的声波的频率变化以确定容器中的流体速度。 传感器还监测来自第二换能器的声波的反射时间，其从侧壁返回以确定容器的内径。 确定的流体速度和容器直径可用于确定容器中流体的体积流量。

    Lead and delivery system to detect and treat a myocardial infarction region
    10.
    发明申请
    Lead and delivery system to detect and treat a myocardial infarction region 审中-公开
    用于检测和治疗心肌梗死区域的牵引和传递系统

    公开(公告)号：US20070100383A1

    公开(公告)日：2007-05-03

    申请号：US11261202

    申请日：2005-10-28

    申请人： Joseph Pastore ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

    发明人： Joseph Pastore ,  Rodney Salo ,  Ronald Heil ,  Randy Westlund

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0587 ,  A61N1/059 ,  A61N1/3627

    摘要： A method includes mounting an anchor member to a surface of a heart, the anchor member having a tension member coupled to the anchor member, advancing a lead body along the tension member, the lead body including a plurality of electrodes disposed along the lead body, identifying an MI region of the heart, positioning the plurality of electrodes at or near the MI region, affixing the tension member to the lead body to hold the electrodes in position, and delivering pulses through the plurality of electrodes to the heart.

    摘要翻译： 一种方法包括将锚定构件安装到心脏的表面，所述锚定构件具有联接到所述锚定构件的张紧构件，使所述引线体沿着所述张紧构件前进，所述引线主体包括沿着所述引线主体设置的多个电极， 识别心脏的MI区域，将多个电极定位在MI区域处或附近，将张紧构件固定到引线体以将电极保持在适当位置，并且将脉冲通过多个电极传递到心脏。