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公开(公告)号：US5670342A
公开(公告)日：1997-09-23
申请号：US417640
申请日：1995-04-06
申请人： Josette Francoise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
发明人： Josette Francoise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P11/00 , A61P25/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12R1/91 , C07K19/00 , A61K38/18 , C12N15/62
CPC分类号： C07K14/4756 , C07K14/4705 , A61K38/00
摘要： Novel peptides are described which are biologically active derivatives of the EGF-like domain of NDF/heregulins and which stimulate the proliferation and differentiation of colon epithelial cells and support the survival and growth of Schwann cells.
摘要翻译： 描述了新的肽，其是NDF /本土的EGF样结构域的生物活性衍生物，其刺激结肠上皮细胞的增殖和分化并支持施万细胞的存活和生长。
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公开(公告)号：US5929032A
公开(公告)日：1999-07-27
申请号：US761038
申请日：1996-12-05
申请人： Josette Fran.cedilla.oise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
发明人： Josette Fran.cedilla.oise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P11/00 , A61P25/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12R1/91 , A61K38/18
CPC分类号： C07K14/4756 , C07K14/4705 , A61K38/00
摘要： The survival and proliferation of Schwann cells can be promoted by culturing such cells in the presence of peptides derived from the EGF-like domain of proteins from the NDF/heregulin family. Colon epithelial cells can be stimulated to multiply and differentiate by culturing such cells in the presence of the same peptides.
摘要翻译： 通过在衍生自NDF / asgulin家族的蛋白质的EGF样结构域的肽存在下培养这样的细胞可以促进雪旺氏细胞的存活和增殖。 可以通过在相同的肽存在下培养这样的细胞来刺激结肠上皮细胞繁殖和分化。
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公开(公告)号：US5686415A
公开(公告)日：1997-11-11
申请号：US760815
申请日：1996-12-05
申请人： Josette Fran.cedilla.oise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
发明人： Josette Fran.cedilla.oise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P11/00 , A61P25/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12R1/91 , C07K13/00 , C12N15/12 , A61K37/02
CPC分类号： C07K14/4756 , C07K14/4705 , A61K38/00
摘要： Colon epithelial cells are stimulated to multiply, grow and mature by contacting them in vivo with peptides derived from the EGF-like domain of proteins of the NDF/heregulin family.
摘要翻译： 通过将其体内接触来源于NDF / asgulin家族的蛋白质的EGF样结构域的肽，刺激结肠上皮细胞繁殖，生长和成熟。
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公开(公告)号：US07435796B1
公开(公告)日：2008-10-14
申请号：US09890729
申请日：2000-01-27
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2827 , C07K2317/73 , C07K2317/76 , C07K2319/30
摘要： Novel polypeptides which comprise a receptor-ligand pair involved in T-cell activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
摘要翻译： 公开了包含参与T细胞活化的受体 - 配体对的新型多肽。 还公开了编码所述多肽的核酸分子，以及用于表达其的载体和宿主细胞。 多肽或其激动剂和拮抗剂用于治疗T细胞介导的病症。
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公开(公告)号：US20090004237A1
公开(公告)日：2009-01-01
申请号：US12163258
申请日：2008-06-27
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N1/16 , C12N5/10 , C12N5/06 , C12N5/12 , A61K38/16 , C12Q1/68 , C40B40/08 , A01K67/027 , A61K9/00 , A61K31/711 , G01N33/53 , C12P21/00 , C07K2/00 , C12Q1/02 , C07K14/47 , C07K16/00
CPC分类号： C07K14/70532 , A01K2217/05 , A61K2039/505 , C07K2319/00
摘要： The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with B7-L polypeptides.
摘要翻译： 本发明提供B7样（B7-L）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生B7-L多肽的方法。 本发明进一步提供用于诊断，治疗，改善和/或预防与B7-L多肽相关的疾病，病症和病症的药物组合物和方法。
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公开(公告)号：US20110104757A1
公开(公告)日：2011-05-05
申请号：US12976802
申请日：2010-12-22
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RP1 antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RP1 antibodies are also provided.
摘要翻译： 本发明提供与人B7相关蛋白-1（B7RP1）相互作用或与之结合的抗体以及结合并中和B7RP1功能的抗体。 本发明还提供所述抗体的药物组合物和中和B7RP1功能的方法，特别是通过施用药学上有效量的抗B7RP1抗体来治疗免疫疾病（例如，不适当的免疫应答）。 还提供了使用抗B7RP1抗体检测样品中B7RP1的量的方法。
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公开(公告)号：US07868140B2
公开(公告)日：2011-01-11
申请号：US11458260
申请日：2006-07-18
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RP1 antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RP1 antibodies are also provided.
摘要翻译： 本发明提供与人B7相关蛋白-1（B7RP1）相互作用或与之结合的抗体以及结合并中和B7RP1功能的抗体。 本发明还提供所述抗体的药物组合物和中和B7RP1功能的方法，特别是通过施用药学上有效量的抗B7RP1抗体来治疗免疫疾病（例如，不适当的免疫应答）。 还提供了使用抗B7RP1抗体检测样品中B7RP1的量的方法。
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8.发明授权公开(公告)号：US07482325B2
公开(公告)日：2009-01-27
申请号：US11229307
申请日：2005-09-16
IPC分类号： A61K38/16 , A61K39/395 , C07K14/705 , C07K16/46
CPC分类号： C07K14/70532
摘要： The present invention provides B7 Related Protein-2 (B7RP-2) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7RP-2 polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with B7RP-2 polypeptides.
摘要翻译： 本发明提供B7相关蛋白-2（B7RP-2）多肽和编码该多肽的核酸分子。 本发明还提供选择性结合剂，载体，宿主细胞和用于产生B7RP-2多肽的方法。 本发明进一步提供用于诊断，治疗，改善和/或预防与B7RP-2多肽相关的疾病，病症和病症的药物组合物和方法。
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公开(公告)号：US20080166352A1
公开(公告)日：2008-07-10
申请号：US11458260
申请日：2006-07-18
IPC分类号： A61K39/395 , C07K16/00 , G01N33/53 , C07H21/00 , C12N1/00 , C07K7/06 , C07K7/08 , A61K38/08 , A61K38/10 , A61P37/00 , A61P29/00
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/18 , C07K16/2827 , C07K2317/20 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RP1 antibodies Methods of detecting the amount of B7RP1 in a sample using anti-B7RP1 antibodies are also provided.
摘要翻译： 本发明提供了与人B7相关蛋白-1（B7RP1）相互作用或与之结合的抗体以及结合并中和B7RP1功能的抗体。本发明还提供所述抗体的药物组合物和中和B7RP1功能的方法，特别是用于 通过施用药物有效量的抗B7RP1抗体来治疗免疫疾病（例如，不适当的免疫应答）也提供使用抗B7RP1抗体检测样品中B7RP1的量的方法。
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公开(公告)号：US08470317B2
公开(公告)日：2013-06-25
申请号：US12286099
申请日：2008-09-25
IPC分类号： A61K39/395
CPC分类号： C07K14/70532 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K14/70521 , C07K2319/00
摘要： Novel polypeptides which comprise a receptor-ligand pair involved in T-cell, activation are disclosed. Nucleic acid molecules encoding said polypeptides, and vectors and host cells for expressing same are also disclosed. The polypeptides, or agonists and antagonists thereof, are used to treat T-cell mediated disorders.
摘要翻译： 公开了包含参与T细胞活化的受体 - 配体对的新型多肽。 还公开了编码所述多肽的核酸分子，以及用于表达其的载体和宿主细胞。 多肽或其激动剂和拮抗剂用于治疗T细胞介导的病症。
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