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    Devices and methods for transluminal or transthoracic interstitial electrode placement
    5.
    发明授权
    Devices and methods for transluminal or transthoracic interstitial electrode placement 有权
    用于经腔或经胸腔间隙电极放置的装置和方法

    公开(公告)号：US08295947B2

    公开(公告)日：2012-10-23

    申请号：US11591295

    申请日：2006-10-31

    申请人： Theodore C. Lamson ,  Joshua Makower ,  J. Christopher Flaherty

    发明人： Theodore C. Lamson ,  Joshua Makower ,  J. Christopher Flaherty

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0573 ,  A61B2017/22095 ,  A61N1/056 ,  A61N1/0587 ,  A61N2001/0578 ,  A61N2001/0585

    摘要： Methods and devices for implanting pacing electrodes or other apparatus, or for delivering substances, to the heart of other tissues within the body. A guided tissue penetrating catheter is inserted into a body lumen (e.g., blood vessel) or into a body cavity or space (e.g., the pericardial space) and a penetrator is advanced from the catheter to a target location. In some embodiments, a substance or an apparatus (such as an electrode) may be delivered through a lumen in the penetrator. In other embodiments, a guidewire may be advanced through the penetrator, the penetrating catheter may then be removed and an apparatus (e.g., electrode) may then be advanced over that guidewire. Also disclosed are various implantable electrodes and electrode anchoring apparatus.

    摘要翻译： 用于将起搏电极或其他装置植入或用于输送物质的方法和装置到体内其他组织的心脏。 将引导组织穿透导管插入体腔（例如血管）或插入体腔或空间（例如心包空间）中，并且穿透器从导管前进到目标位置。 在一些实施例中，物质或装置（例如电极）可以通过穿透器中的内腔递送。 在其他实施例中，导丝可以穿过穿透器前进，然后可以移除穿透导管，然后可以在该导丝上前进装置（例如电极）。 还公开了各种可植入电极和电极锚定装置。

    Devices and methods for transluminal or transthoracic interstitial electrode placement
    6.
    发明授权
    Devices and methods for transluminal or transthoracic interstitial electrode placement 有权
    用于经腔或经胸腔间隙电极放置的装置和方法

    公开(公告)号：US07191015B2

    公开(公告)日：2007-03-13

    申请号：US10411891

    申请日：2003-04-11

    申请人： Theodore C. Lamson ,  Joshua Makower ,  J. Christopher Flaherty

    发明人： Theodore C. Lamson ,  Joshua Makower ,  J. Christopher Flaherty

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0573 ,  A61B2017/22095 ,  A61N1/056 ,  A61N1/0587 ,  A61N2001/0578 ,  A61N2001/0585

    摘要： Methods and devices for implanting pacing electrodes or other apparatus, or for delivering substances, to the heart of other tissues within the body. A guided tissue penetrating catheter is inserted into a body lumen (e.g., blood vessel) or into a body cavity or space (e.g., the pericardial space) and a penetrator is advanced from the catheter to a target location. In some embodiments, a substance or an apparatus (such as an electrode) may be delivered through a lumen in the penetrator. In other embodiments, a guidewire may be advanced through the penetrator, the penetrating catheter may then be removed and an apparatus (e.g., electrode) may then be advanced over that guidewire. Also disclosed are various implantable electrodes and electrode anchoring apparatus.

    摘要翻译： 用于将起搏电极或其他装置植入或用于输送物质的方法和装置到体内其他组织的心脏。 将引导组织穿透导管插入体腔（例如血管）或插入体腔或空间（例如心包空间）中，并且穿透器从导管前进到目标位置。 在一些实施例中，物质或装置（例如电极）可以通过穿透器中的内腔递送。 在其他实施例中，导丝可以穿过穿透器前进，然后可以移除穿透导管，然后可以在该导丝上前进装置（例如电极）。 还公开了各种可植入电极和电极锚定装置。

    Methods and Apparatus for Acute or Chronic Delivery or Substances or Apparatus to Extravascular Treatment Sites
    7.
    发明申请
    Methods and Apparatus for Acute or Chronic Delivery or Substances or Apparatus to Extravascular Treatment Sites 有权
    用于急性或慢性输送的方法和装置，或用于血管外治疗部位的物质或装置

    公开(公告)号：US20100016836A1

    公开(公告)日：2010-01-21

    申请号：US12567915

    申请日：2009-09-28

    申请人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    发明人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    IPC分类号： A61M25/06 ,  A61K35/12

    CPC分类号： A61M25/065 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12186 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00575 ,  A61B2018/00392 ,  A61M25/0069 ,  A61M25/0084 ,  A61M25/0102 ,  A61M2025/018

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

    Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites
    8.
    发明授权
    Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
    将物质或器械急性或慢性传播至血管外治疗部位的方法和装置

    公开(公告)号：US07606615B2

    公开(公告)日：2009-10-20

    申请号：US10458153

    申请日：2003-06-10

    申请人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    发明人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    IPC分类号： A61M25/00

    CPC分类号： A61M25/065 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12186 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00575 ,  A61B2018/00392 ,  A61M25/0069 ,  A61M25/0084 ,  A61M25/0102 ,  A61M2025/018

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

    Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
    9.
    发明授权
    Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
    用于急性或慢性传播物质或器械至血管外治疗部位的装置，系统和方法

    公开(公告)号：US07357794B2

    公开(公告)日：2008-04-15

    申请号：US10466622

    申请日：2002-01-17

    申请人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    发明人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    IPC分类号： A61M31/00

    CPC分类号： A61M25/0108 ,  A61B6/12 ,  A61M5/007 ,  A61M25/0084 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2210/12

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。