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公开(公告)号：US07235375B2
公开(公告)日：2007-06-26
申请号：US10736936
申请日：2003-12-16
申请人： Todd G. Kirchgessner , Bonnie Hsiang , Yingjie Zhu , Yuli Wu , Zhaoging Wang , Jean S. Lynch , Xin Huang , Wen-Pin Yang
发明人： Todd G. Kirchgessner , Bonnie Hsiang , Yingjie Zhu , Yuli Wu , Zhaoging Wang , Jean S. Lynch , Xin Huang , Wen-Pin Yang
CPC分类号： G01N33/6872 , C07K14/47 , C07K14/705 , G01N2500/04
摘要： The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.
摘要翻译： 本发明公开了新型有机阴离子转移蛋白（“OATPs”）的核酸和氨基酸序列。 本发明包括本文所述的OATP以及含有cDNA序列的载体，含有载体的宿主细胞和具有全部或部分OATP的多肽。 还包括OATPs用于将药物靶向特定器官和调节内源底物浓度的用途。
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公开(公告)号：US06692934B1
公开(公告)日：2004-02-17
申请号：US09575081
申请日：2000-05-19
申请人： Todd G. Kirchgessner , Bonnie Hsiang , Yingjie Zhu , Yuli Wu , Zhaoqing Wang , Jean S. Lynch , Xin Huang , Wen-Pin Yang
发明人： Todd G. Kirchgessner , Bonnie Hsiang , Yingjie Zhu , Yuli Wu , Zhaoqing Wang , Jean S. Lynch , Xin Huang , Wen-Pin Yang
IPC分类号： C12P2106
CPC分类号： G01N33/6872 , C07K14/47 , C07K14/705 , G01N2500/04
摘要： The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.
摘要翻译： 本发明公开了新型有机阴离子转移蛋白（“OATPs”）的核酸和氨基酸序列。 本发明包括本文所述的OATP以及含有cDNA序列的载体，含有载体的宿主细胞和具有全部或部分OATP的多肽。 还包括OATPs用于将药物靶向特定器官和调节内源底物浓度的用途。
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公开(公告)号：US07795392B2
公开(公告)日：2010-09-14
申请号：US11804103
申请日：2007-05-17
申请人： Todd G. Kirchgessner , Bonnie Hsiang , Yingjie Zhu , Yuli Wu , Zhaoqing Wang , Jean S. Lynch , Xin Huang , Wen-Pin Yang
发明人： Todd G. Kirchgessner , Bonnie Hsiang , Yingjie Zhu , Yuli Wu , Zhaoqing Wang , Jean S. Lynch , Xin Huang , Wen-Pin Yang
CPC分类号： G01N33/6872 , C07K14/47 , C07K14/705 , G01N2500/04
摘要： The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.
摘要翻译： 本发明公开了新型有机阴离子转移蛋白（“OATPs”）的核酸和氨基酸序列。 本发明包括本文所述的OATP以及含有cDNA序列的载体，含有载体的宿主细胞和具有全部或部分OATP的多肽。 还包括OATPs用于将药物靶向特定器官和调节内源底物浓度的用途。
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公开(公告)号：US20070243586A1
公开(公告)日：2007-10-18
申请号：US11804103
申请日：2007-05-17
申请人： Todd Kirchgessner , Bonnie Hsiang , Yingjie Zhu , Yuli Wu , Zhaoqing Wang , Jean Lynch , Xin Huang , Wen-Pin Yang
发明人： Todd Kirchgessner , Bonnie Hsiang , Yingjie Zhu , Yuli Wu , Zhaoqing Wang , Jean Lynch , Xin Huang , Wen-Pin Yang
CPC分类号： G01N33/6872 , C07K14/47 , C07K14/705 , G01N2500/04
摘要： The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for OATPs for targeting drugs to specific organs and for modulating the concentration of endogenous substrates.
摘要翻译： 本发明公开了新型有机阴离子转移蛋白（“OATPs”）的核酸和氨基酸序列。 本发明包括本文所述的OATP以及含有cDNA序列的载体，含有载体的宿主细胞和具有全部或部分OATP的多肽。 还包括OATPs用于将药物靶向特定器官和调节内源底物浓度的用途。
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