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1.发明授权Applicators, dispensers and methods for dispensing and applying adhesive material 有权涂抹器，分配器以及分配和施加粘合剂材料的方法公开(公告)号：US08376642B2
公开(公告)日：2013-02-19
申请号：US11928658
申请日：2007-10-30
IPC分类号： B43K5/14
CPC分类号： A61B17/0057 , A61B17/00491 , B05C17/002 , B05C17/00583 , B05C17/00586 , B05C17/0116
摘要： An applicator/dispenser assembly for dispensing and/or applying an adhesive material comprises: a first body portion and a second body portion, at least one of the first and second body portions being movable relative to the other of the first and second body portions; a cavity in at least one of the first and second body portions; and a piercing or breaking member arranged on one of the first and second body portions. Movement of one of the first and second body portions relative to the other of the first and second body portions moves the piercing or breaking member into the cavity. When a container of adhesive material is at least partially disposed within the cavity, movement of one of the first and second body portions relative to the other moves the piercing or breaking member to rupture the container for dispensing and/or applying the adhesive material.
摘要翻译： 一种用于分配和/或施加粘合剂材料的施加器/分配器组件包括：第一主体部分和第二主体部分，第一和第二主体部分中的至少一个可相对于第一和第二主体部分中的另一个运动; 在所述第一和第二主体部分中的至少一个中的空腔; 以及布置在所述第一和第二主体部分中的一个上的刺穿或断裂构件。 第一和第二主体部分中的一个相对于第一和第二主体部分中的另一个的移动将穿孔或断裂部件移动到空腔中。 当粘合剂材料的容器至少部分地设置在空腔内时，第一和第二主体部分之一相对于另一主体部分的运动移动穿孔或断裂部件以使容器破裂以分配和/或施加粘合剂材料。
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2.发明授权Applicators, dispensers and methods for dispensing and applying adhesive material 有权涂抹器，分配器以及分配和施加粘合剂材料的方法公开(公告)号：US07306390B2
公开(公告)日：2007-12-11
申请号：US10663909
申请日：2003-09-17
IPC分类号： B43K5/14
CPC分类号： B05C17/00583 , A61B17/00491 , B05C17/002 , B05C17/00586 , B05C17/0116
摘要： An applicator/dispenser assembly for dispensing and/or applying an adhesive material comprises: a first body portion and a second body portion, at least one of the first and second body portions being movable relative to the other of the first and second body portions; a cavity in at least one of the first and second body portions; and a piercing or breaking member arranged on one of the first and second body portions. Movement of one of the first and second body portions relative to the other of the first and second body portions moves the piercing or breaking member into the cavity. When a container of adhesive material is at least partially disposed within the cavity, movement of one of the first and second body portions relative to the other moves the piercing or breaking member to rupture the container for dispensing and/or applying the adhesive material.
摘要翻译： 一种用于分配和/或施加粘合剂材料的施加器/分配器组件包括：第一主体部分和第二主体部分，第一和第二主体部分中的至少一个可相对于第一和第二主体部分中的另一个运动; 在所述第一和第二主体部分中的至少一个中的空腔; 以及布置在所述第一和第二主体部分中的一个上的刺穿或断裂构件。 第一和第二主体部分中的一个相对于第一和第二主体部分中的另一个的移动将穿孔或断裂部件移动到空腔中。 当粘合剂材料的容器至少部分地设置在空腔内时，第一和第二主体部分之一相对于另一主体部分的运动移动穿孔或断裂部件以使容器破裂以分配和/或施加粘合剂材料。
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公开(公告)号：US20080241249A1
公开(公告)日：2008-10-02
申请号：US11731839
申请日：2007-03-30
申请人： Julian A. Quintero , Jerry Y. Jonn
发明人： Julian A. Quintero , Jerry Y. Jonn
CPC分类号： A61K31/78 , A61L24/0089 , A61L24/06 , C08L35/04
摘要： An adhesive composite composition is provided including one or more polymerizable monomers and one or more metal stearates. The one or more polymerizable monomers may be a cyanoacrylate monomer. The adhesive composite composition may further comprise a plasticizer, an initiator, a rate modifier, a stabilizer, a colorant, a heat dissipating agent, or other additives. Methods for the application of the adhesive composite compositions to living tissue are also provided. The adhesive composite composition provides an adhesive composite material upon polymerization which is a polymer matrix entrapping the metal stearate. Polymerization of the adhesive composite composition at a site on living tissue provides an adhesive composite material which promotes microcirculation and tissue growth at the site of application of the adhesive composite composition.
摘要翻译： 提供了包含一种或多种可聚合单体和一种或多种金属硬脂酸酯的粘合剂复合组合物。 一种或多种可聚合单体可以是氰基丙烯酸酯单体。 粘合剂复合组合物还可以包含增塑剂，引发剂，速率调节剂，稳定剂，着色剂，散热剂或其它添加剂。 还提供了将粘合剂复合组合物应用于生物体组织的方法。 粘合剂复合组合物在聚合时提供粘合剂复合材料，其是捕获金属硬脂酸酯的聚合物基质。 粘合剂复合组合物在活组织部位的聚合提供粘合剂复合材料，其在粘合剂复合组合物的应用位置促进微循环和组织生长。
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公开(公告)号：US20080003196A1
公开(公告)日：2008-01-03
申请号：US11479424
申请日：2006-06-30
申请人： Jerry Y. Jonn , Ibraheem T. Badejo , Julian A. Quintero , Teresa Warren , Melanie A. Vander Klok
发明人： Jerry Y. Jonn , Ibraheem T. Badejo , Julian A. Quintero , Teresa Warren , Melanie A. Vander Klok
IPC分类号： A61K31/74
摘要： An adhesive composition is provided including one or more polymerizable cyanoacrylate monomers and boron trifluoride as a stabilizer or complexing agent. The adhesive composition may also include or be used with a decomplexing agent, particularly one or more quaternary ammonium fluoride salts or one or more quaternary ammonium ether salts. A polymerization initiator or accelerator may also be used. The viscosity of the adhesive composition may be controlled by addition of a thickening agent which may be a polymer or copolymer catalyzed by a boron trifluoride complex or compound. Methods for the application of the adhesive compositions to living tissue are also provided.
摘要翻译： 提供了包含一种或多种可聚合的氰基丙烯酸酯单体和三氟化硼作为稳定剂或络合剂的粘合剂组合物。 粘合剂组合物还可以包括或与解络剂一起使用，特别是一种或多种季铵氟化物盐或一种或多种季铵醚盐。 也可以使用聚合引发剂或促进剂。 粘合剂组合物的粘度可以通过加入增稠剂来控制，增稠剂可以是由三氟化硼配合物或化合物催化的聚合物或共聚物。 还提供了将粘合剂组合物施用于生物组织的方法。
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5.发明授权Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto 失效生物相容性聚合物和粘合剂：与其相关的组合物，制备和使用方法公开(公告)号：US07255874B1
公开(公告)日：2007-08-14
申请号：US10024143
申请日：2001-12-21
申请人： John S. Bobo , Julian A. Quintero , Jerry Y. Jonn , Joe B. Barefoot , Jeffrey G. Clark , Upvan Narang , Scott Marc Cannizaro , J. Christopher Marmo
发明人： John S. Bobo , Julian A. Quintero , Jerry Y. Jonn , Joe B. Barefoot , Jeffrey G. Clark , Upvan Narang , Scott Marc Cannizaro , J. Christopher Marmo
IPC分类号： A61K9/127
CPC分类号： A61K9/5026 , A61L24/06 , A61L27/34 , C08L35/04
摘要： Biocompatible polymers and adhesives have a cyanoacrylic core and other substituents such as therapeutic agents, targeting moieties, imaging agents, amino acid residues or other organic moieties. Exemplary uses of inventive compositions include use as sealants and adhesives for medical uses, and as polymeric formulations for biocompatible implants and matrices and drug delivery.
摘要翻译： 生物相容的聚合物和粘合剂具有氰基丙烯酸核心和其它取代基，例如治疗剂，靶向部分，成像剂，氨基酸残基或其它有机部分。 本发明组合物的示例性用途包括用作医疗用途的密封剂和粘合剂，以及用作生物相容性植入物和基质和药物递送的聚合物制剂。
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公开(公告)号：US06235869B1
公开(公告)日：2001-05-22
申请号：US09416367
申请日：1999-10-09
IPC分类号： C08G6308
摘要： Synthetic absorbable medical devices made totally or in part from a random polymer comprising glycolide, lactide, trimethylene carbonate, and caprolactone are provided. The polymer can be fabricated into a monofilament which exhibits physical characteristics equivalent to or superior than gut sutures.
摘要翻译： 提供了由包含乙交酯，丙交酯，三亚甲基碳酸酯和己内酯的无规聚合物全部或部分制备的合成可吸收医疗装置。 聚合物可以制成单丝，其显示出等同于或优于肠缝线的物理特征。
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公开(公告)号：US09623142B2
公开(公告)日：2017-04-18
申请号：US12163021
申请日：2008-06-27
申请人： Jerry Y. Jonn , Julian Quintero , Glenn Hoskin
发明人： Jerry Y. Jonn , Julian Quintero , Glenn Hoskin
IPC分类号： A61L15/58
CPC分类号： A61L15/58 , A61L15/24 , A61L15/425 , A61L15/44 , Y10T442/10 , Y10T442/172 , Y10T442/183 , Y10T442/20
摘要： An article, such as a tissue bonding article, includes a flexible material, a polymerization initiator or rate modifier disposed in or on the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material, where the polymerization initiator or rate modifier is a polymerization initiator or rate modifier for the polymerizable adhesive composition.
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公开(公告)号：US06620846B1
公开(公告)日：2003-09-16
申请号：US09630437
申请日：2000-08-02
申请人： Jerry Y. Jonn , John Bobo , Julian Quintero , Jon P. Moseley
发明人： Jerry Y. Jonn , John Bobo , Julian Quintero , Jon P. Moseley
IPC分类号： A61K31275
CPC分类号： A61L24/06 , C09J4/00 , C08L35/04 , C08F222/32
摘要： A method of treating living tissue includes applying to living tissue a biocompatible adhesive composition containing at least one alkyl ester cyanoacrylate monomer and a polymerization initiator or accelerator, wherein the polymerization initiator or accelerator is a quaternary amine.
摘要翻译： 一种治疗活组织的方法包括向生物组织施用含有至少一种氰基丙烯酸烷基酯单体和聚合引发剂或促进剂的生物相容性粘合剂组合物，其中聚合引发剂或促进剂是季胺。
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公开(公告)号：US07318937B2
公开(公告)日：2008-01-15
申请号：US11084326
申请日：2005-03-18
申请人： Jerry Y. Jonn , Brian McCrum , Wendy Su , Teresa Warren , Ibraheem T. Badejo
发明人： Jerry Y. Jonn , Brian McCrum , Wendy Su , Teresa Warren , Ibraheem T. Badejo
IPC分类号： A61K47/32
CPC分类号： C08K5/5419 , C08K5/01 , C08L43/04 , C08L83/04 , C08L83/00
摘要： Liquid coating compositions are provided that comprise siloxane containing polymer, volatile polydimethylsiloxane, and aliphatic hydrocarbon. The liquid coating compositions preferably comprise from 18-55 weight % of volatile polydimethylsiloxane, from 5-55 weight % of aliphatic hydrocarbon, from 1-40 weight % of siloxane containing polymer, and from 0-15 weight % of adjuvant.
摘要翻译： 提供了包含含硅氧烷的聚合物，挥发性聚二甲基硅氧烷和脂族烃的液体涂料组合物。 液体涂料组合物优选包含18-55重量％的挥发性聚二甲基硅氧烷，5-55重量％的脂族烃，1-40重量％的含硅氧烷的聚合物和0-15重量％的佐剂。
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公开(公告)号：US6165202A
公开(公告)日：2000-12-26
申请号：US326926
申请日：1999-06-05
IPC分类号： A61B17/00 , A61B17/06 , A61B17/064 , A61B19/00 , A61L15/26 , A61L17/12 , A61L27/18 , A61L31/04 , A61L31/06 , D01F6/84 , A61B17/04
CPC分类号： D01F6/84 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61B2017/00526 , A61B2090/3937 , A61L15/26 , A61L17/12 , A61L27/18 , A61L31/041 , A61L31/06 , C08L67/04
摘要： Synthetic absorbable medical devices made totally or in part from a random polymer comprising glycolide, lactde and caprolactone are provided. The polymer can be fabricated into a monofilament which exhibits physical characteristics equivalent to or superior than gut sutures.
摘要翻译： 提供由包含乙交酯，乳糖和己内酯的无规聚合物全部或部分制备的合成可吸收医疗装置。 聚合物可以制成单丝，其显示出等同于或优于肠缝线的物理特征。
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