公开(公告)号：US20100152708A1

公开(公告)日：2010-06-17

申请号：US12632686

申请日：2009-12-07

申请人： Jun Li ,  Trevor Squier ,  Zheng Zhang ,  Chad Huval ,  William Shannan O'Shaughnessy ,  Michael Hencke ,  Michael Bouchard ,  Christopher R. Loose

发明人： Jun Li ,  Trevor Squier ,  Zheng Zhang ,  Chad Huval ,  William Shannan O'Shaughnessy ,  Michael Hencke ,  Michael Bouchard ,  Christopher R. Loose

IPC分类号： A61L29/14 ,  C08F290/14 ,  B32B5/02 ,  B32B15/08 ,  B32B27/04 ,  B32B27/36 ,  B32B9/04 ,  B32B27/38 ,  C08F112/08 ,  C08F283/04 ,  C08F283/06 ,  C08F283/12 ,  C08F220/56 ,  C08F210/00 ,  C07H1/00 ,  C07H23/00 ,  C08J3/28 ,  B05D3/06

CPC分类号： A61L33/06 ,  A61L27/14 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C08F4/40 ,  C08F265/04 ,  C08F283/00 ,  C08F283/006 ,  C08F291/18 ,  C08L25/08 ,  C08L75/04 ,  C09D5/1637 ,  C09D5/1693 ,  C09D151/003 ,  C09D151/06 ,  C09D151/08 ,  C09D151/085 ,  C08F220/38 ,  C08F220/56 ,  C08L2666/02

摘要： Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.

摘要翻译： 本文描述了任选地涂覆有底涂层的底物，其从一种或多种非结垢材料接枝到其上。 不污染的聚合物材料可以从各种基材，特别是聚合物基材和/或聚合物底涂层移植。 本文所述的接枝技术可以导致非污染材料相对于接枝与制剂的更高的表面密度。 可以使用接枝方法制备共价连接的聚合物。 本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。 本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。 非污染材料可以从衬底或任选地从衬底上的底涂层移植，优选不显着影响衬底材料的机械和/或物理性能。

公开(公告)号：US09895470B2

公开(公告)日：2018-02-20

申请号：US12632686

申请日：2009-12-07

申请人： Jun Li ,  Trevor Squier ,  Zheng Zhang ,  Chad Huval ,  William Shannan O'Shaughnessy ,  Michael Hencke ,  Michael Bouchard ,  Christopher R. Loose

发明人： Jun Li ,  Trevor Squier ,  Zheng Zhang ,  Chad Huval ,  William Shannan O'Shaughnessy ,  Michael Hencke ,  Michael Bouchard ,  Christopher R. Loose

IPC分类号： A61L33/06 ,  A61L27/34 ,  A61L27/50 ,  A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C07H23/00 ,  C09D5/16 ,  C09D151/00 ,  C09D151/06 ,  C09D151/08 ,  C08L75/04 ,  C08L25/08

CPC分类号： A61L33/06 ,  A61L27/14 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C08F4/40 ,  C08F265/04 ,  C08F283/00 ,  C08F283/006 ,  C08F291/18 ,  C08L25/08 ,  C08L75/04 ,  C09D5/1637 ,  C09D5/1693 ,  C09D151/003 ,  C09D151/06 ,  C09D151/08 ,  C09D151/085 ,  C08F220/38 ,  C08F220/56 ,  C08L2666/02

摘要： Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.