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    2,4-DIAMINOPYRIMIDINE COMPOUND
    2.
    发明申请
    2,4-DIAMINOPYRIMIDINE COMPOUND 审中-公开
    2,4-二氨基吡啶化合物

    公开(公告)号：US20110159019A1

    公开(公告)日：2011-06-30

    申请号：US13061311

    申请日：2009-08-31

    申请人： Akira Tanaka ,  Koichiro Mukoyoshi ,  Shigeki Kunikawa ,  Yuji Takasuna ,  Jun Maeda ,  Noboru Chida ,  Shinya Nagashima

    发明人： Akira Tanaka ,  Koichiro Mukoyoshi ,  Shigeki Kunikawa ,  Yuji Takasuna ,  Jun Maeda ,  Noboru Chida ,  Shinya Nagashima

    IPC分类号： A61K31/551 ,  C07D403/12 ,  C07D401/12 ,  C07D239/48 ,  C07D413/12 ,  C07D405/12 ,  C07D409/12 ,  C07D405/14 ,  C07D413/14 ,  A61K31/506 ,  A61K31/505 ,  A61K31/5377 ,  A61P37/06

    CPC分类号： C07D239/48

    摘要： Provided is a compound which is useful as an active ingredient for a pharmaceutical having a PKCθ inhibition activity, particularly a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. The present inventors have conducted extensive studies on a compound having a PKCθ inhibition activity, and as a result, they have found that a compound having a structure such as aralkyl and the like on an amino group at the 2-position and also having a structure such as an adamantylalkyl group and the like on an amino group at the 4-position of 2,4-diaminopyrimidine, or a salt thereof has an excellent PKCθ inhibition activity, thereby completing the present invention. The 2,4-diaminopyrimidine compound of the present invention can be used as a PKCθ inhibitor or an inhibitor of acute rejection occurring in transplantation.

    摘要翻译： 提供可用作具有PKC和药物的药物的活性成分的化合物; 特别是用于抑制移植中发生急性排斥反应的药物组合物。 本发明人对具有PKC的化合物进行了广泛的研究; 抑制活性，结果发现，在2-位的氨基上具有芳烷基等结构的化合物，还具有金刚烷基烷基等的结构，氨基上的氨基上 2,4-二氨基嘧啶的4位或其盐具有优异的PKC和重量; 从而完成了本发明。 本发明的2,4-二氨基嘧啶化合物可以用作PKC＆amp; 抑制剂或移植中发生的急性排斥抑制剂。

    METHOD AND APPARATUS FOR COLLECTING AND DELIVERING STATISTICAL DATA
    4.
    发明申请
    METHOD AND APPARATUS FOR COLLECTING AND DELIVERING STATISTICAL DATA 审中-公开
    用于收集和传递统计数据的方法和装置

    公开(公告)号：US20100106830A1

    公开(公告)日：2010-04-29

    申请号：US12648730

    申请日：2009-12-29

    申请人： Masaaki Takase ,  Mitsuyasu Ogawa ,  Makoto Kanazawa ,  Kenichi Fukuda ,  Masafumi Katoh ,  Jun Maeda

    发明人： Masaaki Takase ,  Mitsuyasu Ogawa ,  Makoto Kanazawa ,  Kenichi Fukuda ,  Masafumi Katoh ,  Jun Maeda

    IPC分类号： G06F15/16

    CPC分类号： H04M3/24 ,  H04L41/5054 ,  H04M3/36 ,  H04M7/006 ,  H04M7/0084 ,  H04M2201/12

    摘要： A statistical-data collecting-and-providing apparatus receives, through a statistical-data-acquisition-criterion setting interface, setting of a statistical-data acquisition criterion and setting of a notification destination, which is a destination of statistical data delivery. Subsequently, the statistical-data collecting-and-providing apparatus collects statistical data based on the thus-received statistical-data acquisition criterion. Thereafter, the statistical-data collecting-and-providing apparatus delivers the thus-collected statistical data to a service-providing application server, which is the notification destination received through the statistical-data-acquisition-criterion setting interface.

    摘要翻译： 统计数据收集和提供装置通过统计数据采集标准设置界面接收统计数据获取标准的设置和作为统计数据传送的目的地的通知目的地的设置。 随后，统计数据收集和提供装置基于由此接收到的统计数据获取标准来收集统计数据。 此后，统计数据收集和提供装置将如此收集的统计数据传送到作为通过统计数据采集准则设置接口接收的通知目的地的服务提供应用服务器。

    Liquid dispensing apparatus, automatic analyzer using same, and liquid surface detecting apparatus
    5.
    发明授权
    Liquid dispensing apparatus, automatic analyzer using same, and liquid surface detecting apparatus 有权
    液体分配装置，使用其的自动分析装置和液面检测装置

    公开(公告)号：US07670564B2

    公开(公告)日：2010-03-02

    申请号：US11044593

    申请日：2005-01-28

    申请人： Goro Yoshida ,  Jun Maeda

    发明人： Goro Yoshida ,  Jun Maeda

    IPC分类号： G05D9/00

    CPC分类号： G01N35/1016 ,  G01F23/292 ,  G01N2035/1025

    摘要： In a liquid dispensing apparatus comprising a dispensing probe for sipping and injecting a liquid sample and a dispensing controller for operating the dispensing probe to ascend, descend and rotate, the liquid dispensing apparatus includes a sample moving device for moving a rack holding the liquid sample, a light beam generator, a photosensor for receiving a light beam reflected from a surface of the liquid sample, a computing unit for computing a liquid surface level based on an output signal from the photosensor, and a controller for controlling operations of those components in a supervising way and processing information necessary for the operations. With the liquid dispensing apparatus, precise information of the liquid surface level can be obtained before the start of the dispensing operation.

    摘要翻译： 在包括用于汲取和注射液体样品的分配探针和用于操作分配探针上升，下降和旋转的分配控制器的液体分配装置中，液体分配装置包括用于移动保持液体样品的架子的样品移动装置， 光束发生器，用于接收从液体样品的表面反射的光束的光传感器，用于基于来自光电传感器的输出信号计算液面水平的计算单元，以及控制器，用于控制 监督操作所需的方式和处理信息。 利用液体分配装置，可以在分配操作开始之前获得液面水平的精确信息。

    Foreign matter detecting system
    6.
    发明申请
    Foreign matter detecting system 审中-公开
    异物检测系统

    公开(公告)号：US20050219523A1

    公开(公告)日：2005-10-06

    申请号：US11060499

    申请日：2005-02-18

    申请人： Chieko Onuma ,  Mitsuji Ikeda ,  Noriko Ilzumi ,  Jun Maeda ,  Takashi Matsuyama

    发明人： Chieko Onuma ,  Mitsuji Ikeda ,  Noriko Ilzumi ,  Jun Maeda ,  Takashi Matsuyama

    IPC分类号： G01B11/00 ,  G01N21/88 ,  G01N21/90

    CPC分类号： G01N21/9027 ,  G01N21/8806

    摘要： A foreign matter detecting system which can acquire a clear image and detect a foreign matter with high accuracy based on the acquired image regardless of whether a subject is located far or near from an image capturing device in spite of a depth variation or a level difference. An image capturing unit having an externally controllable focus position is disposed above or below a liquid surface, and a ray of light from an LED is illuminated toward the liquid surface from above or the side at least at a focus position of the image capturing unit so that a foreign matter on the liquid surface causes mirror reflection. The focus position of the image capturing unit is changed over the range from the top of a container containing a liquid to the bottom thereof. At each focus position, an input image from the image capturing unit is taken into an image input unit of an image processing section. An image selecting unit of the image processing section selects an image focused on the liquid surface or a clearest image of the liquid surface from among the input images. An image detecting unit of the image processing section checks the presence and position of the mirror reflection, thereby detecting the foreign matter.

    摘要翻译： 不管深度变化还是水平差，即使拍摄对象远离摄影装置，无论拍摄对象是远距离还是远离拍摄装置，均可以基于获取的图像，以高精度获取清晰图像并检测异物的异物检测系统。 具有外部可控焦点位置的图像捕获单元设置在液面的上方或下方，并且来自LED的光线至少在图像捕获单元的焦点位置从上方或侧面向液体表面照射， 液面上的异物引起镜面反射。 图像拍摄单元的聚焦位置在从包含液体的容器的顶部到其底部的范围内改变。 在每个焦点位置，将来自图像捕获单元的输入图像带入图像处理部分的图像输入单元。 图像处理部分的图像选择单元从输入图像中选择聚焦在液面上的图像或液面的最清晰图像。 图像处理部的图像检测单元检查镜面反射的存在和位置，从而检测异物。

    Thread joint for tube
    7.
    发明授权
    Thread joint for tube 失效
    管接头

    公开(公告)号：US5649725A

    公开(公告)日：1997-07-22

    申请号：US544137

    申请日：1995-10-17

    申请人： Shigeo Nagasaku ,  Kenichi Ohyabu ,  Jun Maeda ,  Akira Narita

    发明人： Shigeo Nagasaku ,  Kenichi Ohyabu ,  Jun Maeda ,  Akira Narita

    IPC分类号： E21B17/042 ,  F16L15/00 ,  F16L15/04 ,  F16L25/00

    CPC分类号： E21B17/042 ,  F16L15/004

    摘要： A thread joint for a tube which suppresses galling without deteriorating its sealing performance since a sliding distance L.sub.S which expresses a quantity of spiral sliding of sealing portions relative to each other during a tightening period from the start of a contact between the sealing portions until shoulder portions abut each other satisfies the following relationship:Sliding Distance L.sub.S .ltoreq.-0.0093.times. (Tube Outer Diameter).sup.2 +4.73.times. (Tube Outer Diameter).To shorten the sliding distance L.sub.S, the sealing portion of a box portion is formed shorter than the sealing portion of a pin portion. In this case, a circumferential groove may be formed to discharge a dope. Conversely, the sealing portion of the pin portion is formed shorter than the sealing portion of the box portion. In this case, a precedent-stage unthread portion whose inclination is smaller than that of the sealing portion of the pin portion is formed between a male thread and the sealing portion of the pin portion. In addition, tapers of the sealing portions of the pin portion and the box portion are set at 1/6 or larger, and/or, a distance where the sealing portion of the box portion (pin portion) is formed so as to contact a curve which is tangent to the sealing portion of the pin portion (box portion) is 1.45 mm or larger.

    摘要翻译： 一种用于管的螺纹接头，其在从密封部分之间的接触开始直到肩部部分的紧固期间的紧固期间，表现出密封部分相对于彼此的螺旋滑动量的滑动距离LS，从而抑制磨损，而不会降低其密封性能 彼此相邻满足以下关系：滑动距离LS <= - 0.0093x（管外直径）2 + 4.73x（管外直径）。 为了缩短滑动距离LS，盒部的密封部形成为比销部的密封部短。 在这种情况下，可以形成周向槽以排出涂料。 相反，销部分的密封部分形成得比盒部分的密封部分短。 在这种情况下，在外螺纹和销部的密封部之间形成有倾斜小于销部的密封部的倾斜度的前级无螺纹部。 此外，销部分和箱部分的密封部分的锥度设定为+ E，fra 1/6 + EE或更大，和/或设置在盒部分（销部分）的密封部分 形成为与销部（盒部）的密封部相切的曲线接触的距离为1.45mm以上。

    PET VISUALIZATION OF AMYLOID-ASSOCIATED NEUROINFLAMMATION IN THE BRAIN
    9.
    发明申请
    PET VISUALIZATION OF AMYLOID-ASSOCIATED NEUROINFLAMMATION IN THE BRAIN 审中-公开
    在脑中的AMYLOID相关神经炎症的PET可视化

    公开(公告)号：US20100055036A1

    公开(公告)日：2010-03-04

    申请号：US12531051

    申请日：2008-03-12

    申请人： Tetsuya Suhara ,  Kazutoshi Suzuki ,  Makoto Higuchi ,  Ming-Rong Zhang ,  Jun Maeda ,  Bin Ji

    发明人： Tetsuya Suhara ,  Kazutoshi Suzuki ,  Makoto Higuchi ,  Ming-Rong Zhang ,  Jun Maeda ,  Bin Ji

    IPC分类号： A61K51/00 ,  C07C233/00

    CPC分类号： A61K51/04 ,  A61B6/037 ,  A61B6/508

    摘要： The present invention relate to a method for monitoring a response to a therapy on a mammal having a neurodegenerative or neuroinflammatory disorder. According to a preferred embodiment, the method comprising the steps of:a) imaging the mammal using a radio-labeled peripheral benzodiazepine receptor ligand;b) administrating in the mammal at least one anti-amyloid or anti-neuroinflammatory agent;c) imaging the mammal of step b) using a radio-labeled peripheral benzodiazepine receptor ligand; andd) detecting the level of CNS neuroinflammation by the signals from the radio-labeled peripheral benzodiazepine receptor ligand.

    摘要翻译： 本发明涉及用于监测对具有神经变性或神经炎症性疾病的哺乳动物的治疗反应的方法。 根据优选实施方案，所述方法包括以下步骤：a）使用放射性标记的外周苯并二氮杂受体配体对哺乳动物进行成像; b）在哺乳动物中施用至少一种抗淀粉样蛋白或抗神经炎症药物; c）使用放射性标记的外周苯并二氮杂受体配体对步骤b）的哺乳动物进行成像; 和d）通过来自放射性标记的外周苯并二氮杂受体配体的信号检测CNS神经炎症的水平。