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    SYSTEMS, METHODS AND GUI FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) ANALYSIS
    1.
    发明申请
    SYSTEMS, METHODS AND GUI FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) ANALYSIS 有权
    化学交换饱和转移（CEST）分析的系统，方法和图形

    公开(公告)号：US20160084928A1

    公开(公告)日：2016-03-24

    申请号：US14490793

    申请日：2014-09-19

    申请人： Kabushiki Kaisha Toshiba ,  Toshiba Medical Systems Corporation

    发明人： Cheng OUYANG ,  Xiangzhi Zhou ,  Mitsue Miyazaki

    IPC分类号： G01R33/56 ,  G01R33/48

    CPC分类号： G01R33/5605 ,  G01R33/4828 ,  G01R33/546

    摘要： Chemical exchange saturation transfer (CEST) effects are enhanced by forming, for each of a plurality of magnetization transfer (MT) offset frequencies within a specified first range, a respective image representing CEST effects. A subset of the formed CEST images is displayed and a preferred or optimum one is selected from a display screen. The thus identified target frequency is then used to generate a composite enhanced CEST image based upon a combination of formed CEST images having MT frequencies within a specified second, smaller range, around the identified target frequency.

    摘要翻译： 化学交换饱和转移（CEST）效应通过为指定的第一范围内的多个磁化转移（MT）偏移频率中的每一个形成表示CEST效果的相应图像来增强。 显示所形成的CEST图像的子集，并且从显示屏幕中选择优选的或最佳的。 这样确定的目标频率然后被用于基于在所识别的目标频率周围的具有指定的第二较小范围内的MT频率的形成的CEST图像的组合来生成复合增强的CEST图像。

    NON-CONTRAST MRI WITH DIFFERENTIATION OF ISCHEMIC, INFARCT AND NORMAL TISSUE
    2.
    发明申请
    NON-CONTRAST MRI WITH DIFFERENTIATION OF ISCHEMIC, INFARCT AND NORMAL TISSUE 有权
    非对照MRI与异位，无创和正常组织差异

    公开(公告)号：US20150216429A1

    公开(公告)日：2015-08-06

    申请号：US14689261

    申请日：2015-04-17

    申请人： KABUSHIKI KAISHA TOSHIBA ,  TOSHIBA MEDICAL SYSTEMS CORPORATION

    发明人： MITSUE MIYAZAKI ,  Xiangzhi Zhou ,  Tsutomu Hoshino

    IPC分类号： A61B5/026 ,  A61B5/055

    CPC分类号： A61B5/0263 ,  A61B5/055 ,  A61B5/7289 ,  A61B2576/023 ,  G01R33/56366 ,  G06T7/0016 ,  G06T2207/30048 ,  G06T2207/30104

    摘要： Elicited MRI signals are processed into MR image data in conjunction (a) with use of an initial spatially-selective RF tag pulse (tag-on) and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (TI) intervals without using an injected contrast agent. Acquired image data sets are subtracted for each TI interval to produce difference values as a function of time representing blood perfusion for the ROI that differentiates between normal, ischemic and infarct tissues.

    摘要翻译： 使用初始空间选择性RF标签脉冲（标签打开）和（b）不使用初始空间选择性NMR RF标签脉冲（标签关闭）将引发的MRI信号结合（a）处理成MR图像数据 ）分别对应的数据采集子序列。 在不使用注入的造影剂的情况下，对多个时间 - 反转（TI）间隔中的每一个使用多维标记和标记数据采集子序列。 对每个TI间隔减去获取的图像数据集，以产生差异值作为时间的函数，代表对正常，缺血和梗死组织进行区分的ROI的血液灌注。

    Background suppression by time dependent flip angle of saturation pulses
    5.
    发明授权
    Background suppression by time dependent flip angle of saturation pulses 有权
    背景抑制时间依赖的饱和脉冲的翻转角

    公开(公告)号：US09498139B2

    公开(公告)日：2016-11-22

    申请号：US14171225

    申请日：2014-02-03

    申请人： TOSHIBA MEDICAL SYSTEMS CORPORATION

    发明人： Xiangzhi Zhou ,  Mitsue Miyazaki

    IPC分类号： A61B5/026 ,  A61B5/00 ,  G01R33/48 ,  G01R33/483 ,  G01R33/56 ,  G01R33/561 ,  G01R33/563

    CPC分类号： A61B5/0263 ,  A61B5/0037 ,  A61B5/7292 ,  G01R33/48 ,  G01R33/4818 ,  G01R33/4838 ,  G01R33/5602 ,  G01R33/5607 ,  G01R33/5614 ,  G01R33/5635

    摘要： A magnetic resonance imaging (MRI) system, method and/or computer readable storage medium is configured to effect QISS (quiescent interval single shot) MR imaging (e.g., MR angiography or MRA) where an optimized flip angle for one or more initial saturation pulses minimizes background signal from tissue and/or venous blood. Upon expiration of first configurable time interval from a start of a scan interval, at least one saturation pulse having a flip angle greater than ninety degrees is applied so that longitudinal magnetization of background tissue and venous blood in the selected area is approximately at a null value at the beginning of a readout time (occurring upon expiry of a second time interval) and/or when a lowest frequency of k-space data is acquired for the selected area.

    摘要翻译： 磁共振成像（MRI）系统，方法和/或计算机可读存储介质被配置为实现用于一个或多个初始饱和脉冲的优化翻转角度的QISS（静态间隔单次）MR成像（例如，MR血管造影或MRA） 使来自组织和/或静脉血的背景信号最小化。 在从扫描间隔的开始到达第一可配置时间间隔之后，施加具有大于九十度的翻转角的至少一个饱和脉冲，使得所选区域中的背景组织和静脉血的纵向磁化强度近似为零值 在读出时间的开始（在第二时间间隔期满时发生）和/或当为所选择的区域获取k空间数据的最低频率时。

    Magnetic resonance imaging apparatus
    6.
    发明授权
    Magnetic resonance imaging apparatus 有权

    公开(公告)号：US10215828B2

    公开(公告)日：2019-02-26

    申请号：US14470137

    申请日：2014-08-27

    申请人： TOSHIBA MEDICAL SYSTEMS CORPORATION

    发明人： Mitsue Miyazaki ,  Cheng Ouyang ,  Xiangzhi Zhou

    IPC分类号： G01R33/56 ,  G01R33/50 ,  G01R33/48 ,  G01R33/54

    摘要： A magnetic resonance imaging apparatus includes a sequence controller. The sequence controller is configured to apply MT (Magnetization Transfer) pulses having a frequency different from a resonance frequency of free water protons and then acquires magnetic resonance signals of an object to be imaged. The sequence controller acquires the magnetic resonance signals for each of multiple frequencies while changing the frequency of MT pulses within a frequency band based on a T2 relaxation time of restricted protons contained in the object to be imaged.