公开(公告)号：US10457705B2

公开(公告)日：2019-10-29

申请号：US16227688

申请日：2018-12-20

Applicant: KANEKA CORPORATION

Inventor： Takahiro Okubo ,  Yoshikazu Kawai ,  Masaru Hirano ,  Fuminori Konoike ,  Keiichi Karasugi ,  Tatsuya Honda

IPC: B01J20/24 ,  C07K1/22 ,  B01J20/30 ,  C08B1/08 ,  C08B15/08 ,  C08B15/10 ,  C08B3/06 ,  C07K16/00 ,  B01J20/26 ,  B01J20/285 ,  C08J3/16 ,  B01J20/28 ,  B01J20/32 ,  B01J20/286 ,  B01D15/38 ,  C08L1/12 ,  C08L1/04 ,  C08L1/02 ,  C08B16/00 ,  C08B15/00 ,  C08J9/00

Abstract: A carrier for ligand immobilization obtained by shrinking polysaccharide porous beads not less than 10% by a shrinkage rate defined by the following formula, and crosslinking the polysaccharide porous beads: Shrinkage rate (%)=(1−V2/V1)×100 (wherein, V1 indicates the gel volume of polysaccharide porous beads before shrinkage, and V2 indicates the gel volume of polysaccharide porous beads after shrinkage).

公开(公告)号：US08993800B2

公开(公告)日：2015-03-31

申请号：US13897079

申请日：2013-05-17

Applicant: Kaneka Corporation

Inventor： Takahiro Ohishi ,  Hirokazu Nanba ,  Masanobu Sugawara ,  Masashi Izumida ,  Tatsuya Honda ,  Kohei Mori ,  Satohiro Yanagisawa ,  Nobuo Nagashima ,  Kenji Inoue

IPC: C07C315/00 ,  C12P13/12 ,  C07C319/06 ,  C07D233/76 ,  C12P17/04 ,  C12P17/10 ,  C12P41/00

CPC classification number: C12P13/12 ,  C07C319/06 ,  C07D233/76 ,  C12P17/04 ,  C12P17/10 ,  C12P41/009 ,  C07C323/58

Abstract: The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.

Abstract translation: 本发明提供了一种简单的工业方法，用于从容易获得的便宜的原料制备作为有用的药物中间体的L-或D-光学活性的α-甲基半胱氨酸衍生物或其盐。 在制备L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的方法中，外消旋的N-氨基甲酰基-α-甲基半胱氨酸衍生物或其盐与乙内酰脲酶D选择性环化以产生D-5-甲基 - 5-硫代甲基乙内酰脲衍生物或其盐和N-氨基甲酰基-α-甲基-L-半胱氨酸衍生物或其盐，然后进行氨基和硫原子的脱保护和水解。

公开(公告)号：US10221211B2

公开(公告)日：2019-03-05

申请号：US15025152

申请日：2014-09-26

Applicant: KANEKA CORPORATION

Inventor： Takahiro Okubo ,  Yoshikazu Kawai ,  Masaru Hirano ,  Fuminori Konoike ,  Keiichi Karasugi ,  Tatsuya Honda

IPC: B01D15/38 ,  C07K1/22 ,  B01J20/24 ,  C08B1/08 ,  C08B15/08 ,  C08B15/10 ,  C08B3/06 ,  C08B15/00 ,  C08B16/00 ,  C08L1/02 ,  C08L1/04 ,  C08L1/12 ,  B01J20/286 ,  B01J20/32 ,  B01J20/28 ,  C08J3/16 ,  B01J20/26 ,  B01J20/285 ,  B01J20/30 ,  C07K16/00 ,  C08J9/00

Abstract: A process for producing porous cellulose beads of the present invention is characterized by comprising the steps of: a) mixing an alkali aqueous solution and cellulose to prepare cellulose micro dispersion at low temperature, b) adding water to the cellulose micro dispersion to prepare cellulose slurry, and d) bringing the cellulose slurry into contact with coagulation solvent. A carrier for ligand immobilization of the present invention is characterized by being by shrinking polysaccharide porous beads not less than 10% by a shrinkage rate defined by the following formula, and crosslinking the polysaccharide porous beads: Shrinkage rate (%)=(1−V2/V1)×100 (wherein, V1 indicates the gel volume of polysaccharide porous beads before shrinkage, and V2 indicates the gel volume of polysaccharide porous beads after shrinkage).

公开(公告)号：US20180179250A1

公开(公告)日：2018-06-28

申请号：US15905635

申请日：2018-02-26

Applicant: Kaneka Corporation

Inventor： Fuminori Konoike ,  Tatsuya Honda ,  Keiichi Karasugi

IPC: C07K1/22 ,  C07K17/12 ,  C07K17/10 ,  C07K17/08 ,  C07K17/14 ,  B01J20/24 ,  B01J20/26 ,  B01J20/32 ,  B01D15/38

CPC classification number: C07K1/22 ,  B01D15/38 ,  B01D15/3809 ,  B01J20/24 ,  B01J20/265 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3208 ,  B01J20/321 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3229 ,  B01J20/3274 ,  B01J20/3278 ,  C07K16/00 ,  C07K16/06 ,  C07K17/08 ,  C07K17/10 ,  C07K17/12 ,  C07K17/14

Abstract: A method for immobilizing a ligand on a formyl group-containing insoluble base material includes producing an imine by mixing the ligand and the formyl group-containing insoluble base material, and reducing the imine by using a borane complex, wherein the ligand comprises an amino group and has a specific affinity for a target compound, and wherein the borane complex has a Lewis base ligand having pKa of 6.5 or less.

公开(公告)号：US20130261331A1

公开(公告)日：2013-10-03

申请号：US13897079

申请日：2013-05-17

Applicant: Kaneka Corporation

Inventor： Takahiro Ohishi ,  Hirokazu Nanba ,  Masanobu Sugawara ,  Masashi Izumida ,  Tatsuya Honda ,  Kohei Mori ,  Satohiro Yanagisawa ,  Nabuo Nagashima ,  Kenji Inoue

IPC: C12P13/12

CPC classification number: C12P13/12 ,  C07C319/06 ,  C07D233/76 ,  C12P17/04 ,  C12P17/10 ,  C12P41/009 ,  C07C323/58

Abstract: The present invention provides a simple industrial process for producing an L- or D-optically active α-methylcysteine derivative or its salt, which is a useful pharmaceutical intermediate, from readily available, inexpensive raw materials. In a process for producing an L- or D-optically active α-methylcysteine derivative or its salt, a racemic N-carbamoyl-α-methylcysteine derivative or its salt is D-selectively cyclized with hydantoinase to produce a D-5-methyl-5-thiomethylhydantoin derivative or its salt and an N-carbamoyl-α-methyl-L-cysteine derivative or its salt, which are then subjected to deprotection of the amino group and the sulfur atom, and hydrolysis.

Abstract translation: 本发明提供了一种用于从容易得到的廉价原料生产L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的简单工业方法，其是有用的药物中间体。 在制备L-或D-光学活性α-甲基半胱氨酸衍生物或其盐的方法中，外消旋的N-氨基甲酰基-α-甲基半胱氨酸衍生物或其盐与乙内酰脲酶D选择性环化以产生D-5-甲基 - 5-硫代甲基乙内酰脲衍生物或其盐和N-氨基甲酰基-α-甲基-L-半胱氨酸衍生物或其盐，然后对氨基和硫原子进行脱保护和水解。