公开(公告)号：US09833528B2

公开(公告)日：2017-12-05

申请号：US14851178

申请日：2015-09-11

Applicant: KCI Licensing, Inc.

Inventor： Rodolfo M. Alarcon ,  Amy K. McNulty

IPC: A61L2/16 ,  C07K16/12 ,  A61K39/395 ,  C07K14/00 ,  A61K38/48 ,  A61M1/00 ,  A61L29/16 ,  A61K39/40 ,  A61K45/06

CPC classification number: A61L2/16 ,  A61K38/48 ,  A61K39/395 ,  A61K39/40 ,  A61K45/06 ,  A61L29/16 ,  A61L2300/404 ,  A61M1/00 ,  C07K14/001 ,  C07K16/12 ,  Y02A50/475

Abstract: Methods and compositions for the treatment of biofilms and/or the inhibition of biofilm formation. In one embodiment, a biofilm is treated and/or biofilm formation is inhibited by a method comprising contacting a biofilm or a surface with a bifunctional ligand comprising a quorum-sensing-peptide-binding region and a protease-binding region, whereby the biofilm is treated and/or biofilm formation on the surface is inhibited.

公开(公告)号：US20150257686A1

公开(公告)日：2015-09-17

申请号：US14625402

申请日：2015-02-18

Applicant: KCI Licensing. Inc.

Inventor： Amy K. McNulty ,  Deepak V. Kilpadi ,  George Hutchinson ,  Nancy Price

IPC: A61B5/1455 ,  A61F13/00 ,  A61M1/00 ,  C12Q1/66 ,  A61M35/00

CPC classification number: A61B5/1455 ,  A61B5/0082 ,  A61B5/145 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/445 ,  A61B46/00 ,  A61B2562/0233 ,  A61F13/00063 ,  A61F13/00068 ,  A61L15/38 ,  A61L15/425 ,  A61M1/0025 ,  A61M1/0088 ,  A61M35/00 ,  A61M2202/20 ,  A61M2205/3306 ,  A61M2205/583 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/66 ,  C12Q1/689 ,  G01N33/56911 ,  G01N33/6893 ,  G01N2800/26

Abstract: Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site. Additionally, a porous pad comprising luciferase is provided.

公开(公告)号：US10369240B2

公开(公告)日：2019-08-06

申请号：US15802817

申请日：2017-11-03

Applicant: KCI Licensing, Inc.

Inventor： Rodolfo M. Alarcon ,  Amy K. McNulty

IPC: A61L2/16 ,  C07K16/12 ,  A61K39/395 ,  C07K14/00 ,  A61K38/48 ,  A61M1/00 ,  A61L29/16 ,  A61K39/40 ,  A61K45/06

Abstract: Methods and compositions for the treatment of biofilms and/or the inhibition of biofilm formation. In one embodiment, a biofilm is treated and/or biofilm formation is inhibited by a method comprising contacting a biofilm or a surface with a bifunctional ligand comprising a quorum-sensing-peptide-binding region and a protease-binding region, whereby the biofilm is treated and/or biofilm formation on the surface is inhibited.

公开(公告)号：US08986940B2

公开(公告)日：2015-03-24

申请号：US13890096

申请日：2013-05-08

Applicant: KCI Licensing, Inc.

Inventor： Amy K. McNulty ,  Deepak V. Kilpadi ,  George Hutchinson ,  Nancy Price

IPC: C12Q1/66 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  A61L15/38 ,  A61L15/42 ,  A61M1/00 ,  G01N33/569 ,  G01N33/68 ,  A61B19/08 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/68

CPC classification number: A61B5/1455 ,  A61B5/0082 ,  A61B5/145 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/445 ,  A61B46/00 ,  A61B2562/0233 ,  A61F13/00063 ,  A61F13/00068 ,  A61L15/38 ,  A61L15/425 ,  A61M1/0025 ,  A61M1/0088 ,  A61M35/00 ,  A61M2202/20 ,  A61M2205/3306 ,  A61M2205/583 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/66 ,  C12Q1/689 ,  G01N33/56911 ,  G01N33/6893 ,  G01N2800/26

Abstract: Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site. Additionally, a porous pad comprising luciferase is provided.

Abstract translation: 提供一种检测伤口部位感染生物体引起的伤口感染的方法。 还提供了一种用于检测伤口部位的伤口感染的系统。 另外，提供了包含荧光素酶的多孔垫。

公开(公告)号：US09169319B2

公开(公告)日：2015-10-27

申请号：US13841200

申请日：2013-03-15

Applicant: KCI Licensing, Inc.

Inventor： Rodolfo Alarcon ,  Amy K. McNulty

IPC: A61K38/48 ,  C07K16/12 ,  A61K39/395 ,  C07K14/00 ,  A61M1/00 ,  A61L29/16

CPC classification number: A61L2/16 ,  A61K38/48 ,  A61K39/395 ,  A61K39/40 ,  A61K45/06 ,  A61L29/16 ,  A61L2300/404 ,  A61M1/00 ,  C07K14/001 ,  C07K16/12 ,  Y02A50/475

Abstract: Methods and compositions for the treatment of biofilms and/or the inhibition of biofilm formation. In one embodiment, a biofilm is treated and/or biofilm formation is inhibited by a method comprising contacting a biofilm or a surface with a bifunctional ligand comprising a quorum-sensing-peptide-binding region and a protease-binding region, whereby the biofilm is treated and/or biofilm formation on the surface is inhibited.

Abstract translation: 用于治疗生物膜和/或抑制生物膜形成的方法和组合物。 在一个实施方案中，通过包括使生物膜或表面与包含群体感应肽结合区域和蛋白酶结合区域的双功能配体接触的方法来处理生物膜和/或生物膜形成，由此生物膜为 表面上的处理和/或生物膜形成被抑制。

公开(公告)号：US20130244899A1

公开(公告)日：2013-09-19

申请号：US13890096

申请日：2013-05-08

Applicant: KCI LICENSING, INC.

Inventor： Amy K. McNulty ,  Deepak V. Kilpadi ,  George Hutchinson ,  Nancy Price

IPC: A61B5/00 ,  C12Q1/66 ,  A61B19/08 ,  G01N33/569 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/68

CPC classification number: A61B5/1455 ,  A61B5/0082 ,  A61B5/145 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/445 ,  A61B46/00 ,  A61B2562/0233 ,  A61F13/00063 ,  A61F13/00068 ,  A61L15/38 ,  A61L15/425 ,  A61M1/0025 ,  A61M1/0088 ,  A61M35/00 ,  A61M2202/20 ,  A61M2205/3306 ,  A61M2205/583 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/66 ,  C12Q1/689 ,  G01N33/56911 ,  G01N33/6893 ,  G01N2800/26

Abstract: Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site. Additionally, a porous pad comprising luciferase is provided.

公开(公告)号：US11318218B2

公开(公告)日：2022-05-03

申请号：US16447173

申请日：2019-06-20

Applicant: KCI Licensing, Inc.

Inventor： Rodolfo M. Alarcon ,  Amy K. McNulty

IPC: A61L2/16 ,  C07K16/12 ,  A61K39/395 ,  C07K14/00 ,  A61K38/48 ,  A61L29/16 ,  A61K39/40 ,  A61K45/06

Abstract: Methods and compositions for the treatment of biofilms and/or the inhibition of biofilm formation. In one embodiment, a biofilm is treated and/or biofilm formation is inhibited by a method comprising contacting a biofilm or a surface with a bifunctional ligand comprising a quorum-sensing-peptide-binding region and a protease-binding region, whereby the biofilm is treated and/or biofilm formation on the surface is inhibited.

公开(公告)号：US11529453B2

公开(公告)日：2022-12-20

申请号：US16206560

申请日：2018-11-30

Applicant: KCI Licensing, Inc.

Inventor： Christopher Brian Locke ,  Timothy Mark Robinson ,  Amy K. McNulty

IPC: A61M1/00 ,  A61M1/36 ,  A61M27/00

Abstract: A reduced-pressure treatment system for debriding a treatment area of a tissue site and applying reduced pressure is disclosed. The reduced-pressure treatment system includes a hydrogel having a blocked acid debriding agent. The hydrogel is adapted to cover the treatment area and enhance autolytic debridement at the treatment area. The reduced-pressure treatment system includes a manifold that is adapted to cover the hydrogel and distribute reduced pressure to the tissue site. The reduce-pressure treatment system also includes a sealing drape for forming a fluid seal over the tissue site and manifold. Other systems, methods, and dressings are presented.

公开(公告)号：US09215994B2

公开(公告)日：2015-12-22

申请号：US14625402

申请日：2015-02-18

Applicant: KCI Licensing, Inc.

Inventor： Amy K. McNulty ,  Deepak V. Kilpadi ,  George Hutchinson ,  Nancy Price

IPC: A61M1/00 ,  A61B5/1455 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/00 ,  A61L15/38 ,  A61L15/42 ,  C12Q1/66 ,  G01N33/569 ,  G01N33/68 ,  A61B19/08 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/68 ,  A61F13/00 ,  A61M35/00

CPC classification number: A61B5/1455 ,  A61B5/0082 ,  A61B5/145 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/445 ,  A61B46/00 ,  A61B2562/0233 ,  A61F13/00063 ,  A61F13/00068 ,  A61L15/38 ,  A61L15/425 ,  A61M1/0025 ,  A61M1/0088 ,  A61M35/00 ,  A61M2202/20 ,  A61M2205/3306 ,  A61M2205/583 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q1/66 ,  C12Q1/689 ,  G01N33/56911 ,  G01N33/6893 ,  G01N2800/26

Abstract: Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site. Additionally, a porous pad comprising luciferase is provided.

公开(公告)号：US08900821B2

公开(公告)日：2014-12-02

申请号：US13869433

申请日：2013-04-24

Applicant: KCI Licensing, Inc.

Inventor： Amy K. McNulty ,  Kristine Kieswetter ,  Todd Matthew Fruchterman

IPC: G01N33/53 ,  A61K49/00 ,  G01N33/52 ,  G01N33/569

CPC classification number: A61K49/0006 ,  G01N33/52 ,  G01N33/56966 ,  G01N2510/00

Abstract: Provided are methods of determining whether a cell in a tissue site is viable or nonviable. Also provided are methods of debriding tissue from a tissue site. Further provided are kits comprising a compound that distinguishes between viable and nonviable cells and instructions for using the compound on a tissue site. Additionally, the use of a compound that distinguishes between viable and nonviable cells is provided, where the use is to determine whether a cell in a tissue site is viable or nonviable. Also provided is a use of a compound that distinguishes between viable and nonviable cells, where the use is for the manufacture of the above-described kit.

Abstract translation: 提供了确定组织部位中的细胞是否存活或不可行的方法。 还提供了从组织部位去除组织的方法。 还提供了包含鉴别存活细胞和不可维持细胞的化合物的试剂盒和在组织部位上使用化合物的说明书。 另外，提供区分可行细胞和不可行细胞的化合物的用途，其中用途是确定组织部位中的细胞是否存活或不可行。 还提供了区分可行细胞和不可维持细胞的化合物的用途，其中用于制造上述试剂盒。