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    RECOMBINANT SELF-ASSEMBLING PROTEIN COMPRISING TARGET-ORIENTED PEPTIDE AND USE THEREOF
    1.
    发明申请
    RECOMBINANT SELF-ASSEMBLING PROTEIN COMPRISING TARGET-ORIENTED PEPTIDE AND USE THEREOF 有权
    包含靶向靶蛋白的重组蛋白自组装蛋白及其用途

    公开(公告)号：US20160074511A1

    公开(公告)日：2016-03-17

    申请号：US14849379

    申请日：2015-09-09

    Applicant: Korea University Research and Business Foundation

    Inventor： Jeewon Lee ,  Koo-Chul Kwon

    IPC: A61K41/00 ,  A61N5/06 ,  A61K49/08 ,  C07K14/005 ,  A61K49/14

    CPC classification number: A61N5/062 ,  A61K41/0052 ,  A61K47/62 ,  A61K49/0428 ,  C07K14/005 ,  C07K14/47 ,  C07K14/71 ,  C07K14/78 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/21 ,  C07K2319/32 ,  C07K2319/33 ,  C07K2319/735 ,  C12N2730/10122 ,  C12N2730/10123 ,  C12N2730/10133 ,  C12N2730/10142 ,  C12N2810/855

    Abstract: The present invention relates to a recombinant self-assembled protein comprising a target-oriented peptide and a use thereof. The recombinant self-assembled protein according to the present invention, comprising a target-oriented peptide, does not require an additional process for providing target-orientedness, and is thus capable of delivering a desired drug to a target tissue or target cell without using additives, such as chemical binders or stabilizers; therefore, the protein can be used for photothermal therapy, drug delivery, imaging, or the like. In particular, according to the present invention, it is to possible to prepare gold-protein nanoparticle fusions in which uniform high-density gold nanoparticles having target-orientedness are bound to protein surfaces, without an additional process of surface stabilization or process for providing target-orientedness. Compared with conventional gold nanoparticles, the gold-protein nanoparticle fusions according to the present invention show structural stability against pH variation and concentration variation, and also have excellent target-orientedness; therefore, the fusions can bring a dramatic enhancement to the utilization of gold nanoparticles in photothermal therapy.

    Abstract translation: 本发明涉及包含靶向取向肽的重组自组装蛋白及其用途。 包含目标取向肽的根据本发明的重组自组装蛋白质不需要另外的提供靶向的方法，因此能够在不使用添加剂的情况下将期望的药物递送至靶组织或靶细胞 ，如化学粘合剂或稳定剂; 因此，蛋白质可以用于光热治疗，药物递送，成像等。 特别地，根据本发明，可以制备金蛋白纳米颗粒融合物，其中均匀的具有靶向取向性的高密度金纳米颗粒与蛋白质表面结合，而没有额外的表面稳定化过程或用于提供靶标的方法 方向性 与传统的金纳米颗粒相比，本发明的金蛋白纳米颗粒融合体显示出对pH变化和浓度变化的结构稳定性，并具有优异的靶向性; 因此，融合可以显着提高金纳米粒子在光热疗中的应用。

    Protein nanoparticle linked with cancer specific epitope and composition for cancer immunotherapy comprising the same
    4.
    发明授权
    Protein nanoparticle linked with cancer specific epitope and composition for cancer immunotherapy comprising the same 有权

    公开(公告)号：US10206987B2

    公开(公告)日：2019-02-19

    申请号：US15299993

    申请日：2016-10-21

    Applicant: Korea University Research And Business Foundation ,  Korea Institute of Science and Technology

    Inventor： Jeewon Lee ,  Bo Ram Lee ,  Kwangmeyung Kim ,  Ju Hee Ryu ,  Ho Kyung Ko

    IPC: A61K39/00 ,  A61K9/14 ,  B82Y5/00

    Abstract: The present invention relates to a protein nanoparticle having a surface on which a cancer-specific epitope is fused and expressed, a method for producing the same, and a composition for cancer immunotherapy containing the protein nanoparticle as an active ingredient, and more specifically, to a recombinant microorganism into which a vector in which a promoter, a gene of a human ferritin heavy chain protein, and a gene encoding the cancer-specific epitope are operably linked is introduced, a protein nanoparticle in which a cancer-specific epitope is fused and expressed on a surface of the human ferritin heavy chain protein, a method of producing the protein nanoparticle, and a composition for cancer immunotherapy including the protein nanoparticle as the active ingredient, wherein the cancer-specific epitope on the surface of the protein nanoparticle according to the present invention is able to be expressed with correct orientation and high density, and the composition for cancer immunotherapy including the protein nanoparticle as the active ingredient has significantly excellent cancer immunotherapeutic effect as compared to the existing nanoparticle-based composition.

    Recombinant self-assembling protein comprising target-oriented peptide and use thereof
    6.
    发明授权
    Recombinant self-assembling protein comprising target-oriented peptide and use thereof 有权

    公开(公告)号：US10478638B2

    公开(公告)日：2019-11-19

    申请号：US15782234

    申请日：2017-10-12

    Applicant: Korea University Research and Business Foundation

    Inventor： Jeewon Lee ,  Koo-Chul Kwon

    IPC: A61K47/62 ,  A61N5/06 ,  A61K41/00 ,  C07K14/71 ,  C07K14/78 ,  C07K14/47 ,  A61K49/04 ,  C07K14/005

    Abstract: The present invention relates to a recombinant self-assembled protein comprising a target-oriented peptide and a use thereof The recombinant self-assembled protein according to the present invention, comprising a target-oriented peptide, does not require an additional process for providing target-orientedness, and is thus capable of delivering a desired drug to a target tissue or target cell without using additives, such as chemical binders or stabilizers; therefore, the protein can be used for photothermal therapy, drug delivery, imaging, or the like. In particular, according to the present invention, it is possible to prepare gold-protein nanoparticle fusions in which uniform high-density gold nanoparticles having target-orientedness are bound to protein surfaces, without an additional process of surface stabilization or process for providing target-orientedness. Compared with conventional gold nanoparticles, the gold-protein nanoparticle fusions according to the present invention show structural stability against pH variation and concentration variation, and also have excellent target-orientedness; therefore, the fusions can bring a dramatic enhancement to the utilization of gold nanoparticles in photothermal therapy.

    RECOMBINANT SELF-ASSEMBLING PROTEIN COMPRISING TARGET-ORIENTED PEPTIDE AND USE THEREOF
    7.
    发明申请
    RECOMBINANT SELF-ASSEMBLING PROTEIN COMPRISING TARGET-ORIENTED PEPTIDE AND USE THEREOF 审中-公开

    公开(公告)号：US20180028833A1

    公开(公告)日：2018-02-01

    申请号：US15782234

    申请日：2017-10-12

    Applicant: Korea University Research and Business Foundation

    Inventor： Jeewon Lee ,  Koo-Chui Kwon

    IPC: A61N5/06 ,  C07K14/71 ,  A61K49/04 ,  C07K14/005

    Abstract: The present invention relates to a recombinant self-assembled protein comprising a target-oriented peptide and a use thereof The recombinant self-assembled protein according to the present invention, comprising a target-oriented peptide, does not require an additional process for providing target-orientedness, and is thus capable of delivering a desired drug to a target tissue or target cell without using additives, such as chemical binders or stabilizers; therefore, the protein can be used for photothermal therapy, drug delivery, imaging, or the like. In particular, according to the present invention, it is possible to prepare gold-protein nanoparticle fusions in which uniform high-density gold nanoparticles having target-orientedness are bound to protein surfaces, without an additional process of surface stabilization or process for providing target-orientedness. Compared with conventional gold nanoparticles, the gold-protein nanoparticle fusions according to the present invention show structural stability against pH variation and concentration variation, and also have excellent target-orientedness; therefore, the fusions can bring a dramatic enhancement to the utilization of gold nanoparticles in photothermal therapy.

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