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    Flow control of electrochemical-based assay devices
    1.
    发明申请
    Flow control of electrochemical-based assay devices 审中-公开
    基于电化学的测定装置的流量控制

    公开(公告)号：US20050136550A1

    公开(公告)日：2005-06-23

    申请号：US10742589

    申请日：2003-12-19

    申请人： Kaiyuan Yang ,  Charles Hughes ,  Xuedong Song ,  Rosann Marie Kaylor

    发明人： Kaiyuan Yang ,  Charles Hughes ,  Xuedong Song ,  Rosann Marie Kaylor

    IPC分类号： C12Q1/54 ,  G01N33/543 ,  G01N33/558

    CPC分类号： G01N33/54373

    摘要： Various techniques for controlling the flow of a test sample through an electrochemical-based assay device are provided. The assay device contains a porous membrane provided with certain properties to selectively control the flow of a test sample to a detection working electrode. The detection working electrode communicates with affinity reagents, such as redox mediators and capture ligands. For instance, capture ligands that are specific binding members for the analyte of interest are applied to the detection electrode to serve as the primary location for detection of the analyte.

    摘要翻译： 提供了用于通过基于电化学的测定装置来控制测试样品的流动的各种技术。 测定装置包含具有某些性质的多孔膜，以选择性地将测试样品的流动控制到检测工作电极。 检测工作电极与亲和试剂如氧化还原介体和捕获配体连通。 例如，将作为感兴趣的分析物的特异性结合成员的捕获配体施加到检测电极，以用作检测分析物的主要位置。

    Flow-through assay devices
    2.
    发明申请
    Flow-through assay devices 审中-公开
    流通测定装置

    公开(公告)号：US20050136500A1

    公开(公告)日：2005-06-23

    申请号：US10742590

    申请日：2003-12-19

    申请人： Kaiyuan Yang ,  RameshBabu Boga ,  Shawn Feaster ,  Rosann Marie Kaylor ,  David Cohen

    发明人： Kaiyuan Yang ,  RameshBabu Boga ,  Shawn Feaster ,  Rosann Marie Kaylor ,  David Cohen

    IPC分类号： G01N33/52 ,  G01N33/543 ,  G01N33/558 ,  C12Q1/54

    CPC分类号： G01N33/558 ,  G01N33/52 ,  G01N33/5438

    摘要： A flow-through assay device capable of detecting the presence or quantity of an analyte of interest is provided that is accurate, reliable, and easy-to-use. The device contains a substrate printed with a channel to facilitate the flow of a test sample to a detection working electrode. The detection working electrode communicates with affinity reagents, such as redox mediators and capture ligands. For instance, capture ligands that are specific binding members for the analyte of interest are applied to the detection electrode to serve as the primary location for detection of the analyte.

    摘要翻译： 提供了能够检测感兴趣的分析物的存在或数量的流通测定装置，其是准确，可靠和易于使用的。 该装置包含印刷有通道以便于将测试样品流动到检测工作电极的基底。 检测工作电极与亲和试剂如氧化还原介体和捕获配体连通。 例如，将作为感兴趣的分析物的特异性结合成员的捕获配体施加到检测电极，以用作检测分析物的主要位置。

    Luminescent metallic cluster particles and uses thereof
    6.
    发明申请
    Luminescent metallic cluster particles and uses thereof 审中-公开
    发光金属簇粒子及其用途

    公开(公告)号：US20070141727A1

    公开(公告)日：2007-06-21

    申请号：US11304864

    申请日：2005-12-15

    申请人： Lei Huang ,  Kaiyuan Yang ,  Xuedong Song

    发明人： Lei Huang ,  Kaiyuan Yang ,  Xuedong Song

    IPC分类号： G01N33/553

    CPC分类号： G01N33/551 ,  A61K49/0065 ,  A61K49/0093 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/188 ,  G01N33/5438 ,  G01N33/553 ,  G01N33/66

    摘要： A luminescent particle having a luminescent core structure formed from at least one type of luminescent metallic cluster complex and a shell that covers said core structure is described. The luminescent core structure includes one or more aggregates of metal cluster complexes. The shell has one or more layers of thin films formed predominately of organic or inorganic polymers, hydrid polymers, or combinations thereof. The luminescent particles can be adapted for optical detection or imaging applications. Methods of fabricating the various iterations of the luminescent particles are also provided.

    摘要翻译： 描述了由至少一种类型的发光金属簇络合物形成的具有发光核心结构的发光颗粒和覆盖所述芯结构的外壳。 发光核心结构包括一个或多个金属簇复合物的聚集体。 壳体具有主要由有机或无机聚合物，杂质聚合物或其组合形成的一层或多层薄膜。 发光颗粒可以适用于光学检测或成像应用。 还提供了制造发光颗粒的各种迭代的方法。

    Dynamic Article for Toilet Training
    7.
    发明申请
    Dynamic Article for Toilet Training 审中-公开
    厕所培训动态条款

    公开(公告)号：US20130157236A1

    公开(公告)日：2013-06-20

    申请号：US13328490

    申请日：2011-12-16

    申请人： Kaiyuan Yang ,  Xuedong Song ,  Juan Pablo Aragon

    发明人： Kaiyuan Yang ,  Xuedong Song ,  Juan Pablo Aragon

    IPC分类号： G09B19/00

    CPC分类号： G09B19/0076

    摘要： A dynamic inflatable pillow for toilet training children has a compartment wherein a gas-generating composition disposed. Once water enters the pillow compartment through water permeable sides, gas is generated and bubbles are released from at least one gas-release outlet. Dyes may be added to the gas-generating composition to create colored effluent. Functional dyes may be printed on the pillow surface(s), which may appear or, disappear when wetted.

    摘要翻译： 用于厕所训练儿童的动态充气枕头具有排出气体组合物的隔室。 一旦水通过透水侧进入枕头隔间，就产生气体并从至少一个气体释放出口释放气泡。 可以将染料加入到气体发生组合物中以产生有色流出物。 功能性染料可以印在枕头表面上，这可能会出现或在润湿时消失。

    Laminated assay devices
    9.
    发明授权
    Laminated assay devices 有权
    层压测定装置

    公开(公告)号：US07943089B2

    公开(公告)日：2011-05-17

    申请号：US10741434

    申请日：2003-12-19

    申请人： Kaiyuan Yang ,  Xuedong Song ,  Rosann Kaylor

    发明人： Kaiyuan Yang ,  Xuedong Song ,  Rosann Kaylor

    IPC分类号： G01N27/00

    CPC分类号： G01N33/5438

    摘要： An electrochemical-based assay device capable of detecting the presence or quantity of an analyte of interest that is provided. The device contains two or more substrates, one containing a detection working electrode and another containing an auxiliary electrode, such as a counter/reference electrode(s). The substrates are positioned in a face-to-face relationship so that the electrodes are adjacent to each other during performance of the assay. Besides the electrodes, any of a variety of other components may also be employed in the assay device.

    摘要翻译： 能够检测所提供的感兴趣分析物的存在或数量的基于电化学的测定装置。 该装置包含两个或更多个基板，一个包含检测工作电极，另一个基板包含辅助电极，例如计数器/参考电极。 基板以面对面的关系定位，使得在测定过程中电极彼此相邻。 除了电极之外，还可以在测定装置中使用各种其它组分中的任何一种。

    Metering Technique for Lateral Flow Assay Devices
    10.
    发明申请
    Metering Technique for Lateral Flow Assay Devices 有权
    侧流测试装置的计量技术

    公开(公告)号：US20080026484A1

    公开(公告)日：2008-01-31

    申请号：US11867788

    申请日：2007-10-05

    申请人： James Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn Feaster

    发明人： James Takeuchi ,  Xuedong Song ,  Kaiyuan Yang ,  Ning Wei ,  Shawn Feaster

    IPC分类号： G01N1/28 ,  G01N1/38

    CPC分类号： G01N33/558 ,  Y10S436/825 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25375 ,  Y10T436/25625

    摘要： A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the collection region and the detection region. The collection region is saturated with the test sample having a volume of less than about 100 microliters so that a known volume of the test sample is contained in the collection region. The barrier is removed from between the collection region and detection region of the membrane and a diluent is supplied to the collection region of the membrane to facilitate flow of the test sample from the collection region to the detection region of the membrane.

    摘要翻译： 提供了用于检测驻留在测试样品中的分析物的诊断方法和相关测试试剂盒。 使用具有收集区域和检测区域的样品膜，所述收集区域具有用于预期测试样品的已知饱和体积。 在收集区域和检测区域之间限定屏障。 收集区域用体积小于约100微升的测试样品饱和，使得已知体积的测试样品被包含在收集区域中。 从收集区域和膜的检测区域之间移除屏障，并且将稀释剂供应到膜的收集区域，以促进测试样品从收集区域流到膜的检测区域。