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    METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS
    2.
    发明申请
    METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS 有权
    有效建立诱导型脑干细胞的方法

    公开(公告)号：US20130183759A1

    公开(公告)日：2013-07-18

    申请号：US13822906

    申请日：2011-09-14

    申请人： Shinya Yamanaka ,  Yoshinori Yoshida ,  Hidaka Yokota

    发明人： Shinya Yamanaka ,  Yoshinori Yoshida ,  Hidaka Yokota

    IPC分类号： C12N15/01

    CPC分类号： C12N15/00 ,  C12N5/0696 ,  C12N15/01 ,  C12N2501/998

    摘要： The present invention provides a method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells by inhibiting p38 function in the step of somatic cell nuclear reprogramming. The p38 function can be inhibited by bringing an inhibitor selected from the group consisting of (1) a chemical inhibitor of p38 (2) a dominant negative mutant of p38 or a nucleic acid that encodes the same, (3) a nucleic acid selected from the group consisting of siRNAs and shRNAs targeted to p38 and DNAs that encode the same and (4) an inhibitor of p38 pathway into contact with a somatic cell and the like. The present invention also provides an agent for improving the efficiency of establishment of induced pluripotent stem cells, which contains an inhibitor of p38 function, particularly an inhibitor selected from the group consisting of (1) a chemical inhibitor of p38 (2) a dominant negative mutant of p38 or a nucleic acid that encodes the same, (3) a nucleic acid selected from the group consisting of siRNAs and shRNAs targeted to p38 and DNAs that encode the same and (4) an inhibitor of p38 pathway. Moreover, the present invention provides a production method of iPS cells, which includes bringing a nuclear reprogramming substance and an inhibitor of p38 function into contact with a somatic cell.

    摘要翻译： 本发明提供了通过在体细胞核重编程步骤中抑制p38功能来提高诱导多能干细胞（iPS）细胞建立效率的方法。 可以通过使选自下述的抑制剂来抑制p38的功能：（1）p38的化学抑制剂（2）p38的显性失活突变体或其编码的核酸，（3）选自以下的核酸： 由针对p38的siRNA和shRNA组成的组和编码该p38的DNA和（4）p38途径的抑制剂与体细胞等接触的组。 本发明还提供了用于提高诱导多能干细胞的建立效率的试剂，其含有p38功能的抑制剂，特别是选自（1）p38（2）的显性阴性的化学抑制剂 p38的突变体或编码其的核酸，（3）选自靶向p38的siRNA和shRNA的核酸和编码其的DNA，以及（4）p38途径的抑制剂。 此外，本发明提供了iPS细胞的制备方法，其包括使核重编程物质和p38功能抑制剂与体细胞接触。

    Thermally strippable double faced adhesive sheet and method of working work piece
    3.
    发明申请
    Thermally strippable double faced adhesive sheet and method of working work piece 审中-公开
    可剥离双面胶粘剂片和加工工件的方法

    公开(公告)号：US20090288763A1

    公开(公告)日：2009-11-26

    申请号：US12311980

    申请日：2007-10-29

    申请人： Kazuyuki Kiuchi ,  Yoshinori Yoshida

    发明人： Kazuyuki Kiuchi ,  Yoshinori Yoshida

    IPC分类号： B32B38/10 ,  B32B3/26

    CPC分类号： H01L21/6836 ,  C09J5/06 ,  C09J7/26 ,  C09J7/29 ,  C09J2201/128 ,  C09J2205/302 ,  C09J2400/243 ,  H01L21/6835 ,  H01L2221/68327 ,  H01L2221/68331 ,  H01L2221/6834 ,  H01L2224/16 ,  H01L2924/01004 ,  H01L2924/01019 ,  H01L2924/01057 ,  H01L2924/19041 ,  Y10T428/249953

    摘要： A thermally strippable double faced adhesive sheet comprising a substrate, a thermally strippable pressure-sensitive adhesive layer (A) arranged on one side of the substrate, and a pressure-sensitive adhesive layer (B) arranged on the other side of the substrate, in which the substrate comprises a porous substrate. The porous substrate preferably has a density of 0.9 g/cm3 or less and a tensile elastic modulus of 20 MPa or less. The substrate may comprise a laminate of the porous substrate and a non-porous substrate. Exemplary usable adhesives for the pressure-sensitive adhesive layer (B) include pressure-sensitive adhesives, ultraviolet-curable pressure-sensitive adhesives, thermally strippable pressure-sensitive adhesives, thermoplastic pressure-sensitive adhesives, and thermosetting pressure-sensitive adhesives.

    摘要翻译： 一种可热剥离的双面粘合片，包括基材，布置在基材一侧的可热剥离的压敏粘合剂层（A）和布置在基材的另一侧上的压敏粘合剂层（B）， 其中基底包括多孔基底。 多孔质基材的密度优选为0.9g / cm 3以下，拉伸弹性模量为20MPa以下。 基底可以包括多孔基底和非多孔基底的层压体。 用于粘合剂层（B）的示例性可用粘合剂包括压敏粘合剂，紫外线固化型压敏粘合剂，热剥离压敏粘合剂，热塑性压敏粘合剂和热固性压敏粘合剂。

    SEMICONDUCTOR DEVICE AND METHOD FOR MANUFACTURING THE SAME
    4.
    发明申请
    SEMICONDUCTOR DEVICE AND METHOD FOR MANUFACTURING THE SAME 有权
    半导体器件及其制造方法

    公开(公告)号：US20080099788A1

    公开(公告)日：2008-05-01

    申请号：US11933195

    申请日：2007-10-31

    申请人： Yoshinori Yoshida ,  Tatsuya Tominari ,  Toshio Ando

    发明人： Yoshinori Yoshida ,  Tatsuya Tominari ,  Toshio Ando

    IPC分类号： H01L29/737 ,  H01L21/331

    CPC分类号： H01L29/7378 ,  H01L21/8249 ,  H01L27/0623 ,  H01L29/66242

    摘要： The external base electrode has a two-layered structure where a p-type polysilicon film doped with a medium concentration of boron is laminated on a p-type polysilicon film doped with a high concentration of boron. Therefore, since the p-type polysilicon film doped with a high concentration of boron is in contact with an intrinsic base layer at a junction portion between the external base electrode and the intrinsic base layer, the resistance of the junction portion can be reduced. In addition, since the resistance of the external base electrode becomes a parallel resistance of the two layers of the p-type polysilicon films, the resistance of the p-type polysilicon film whose boron concentration is relatively lower is dominant.

    摘要翻译： 外部基极具有两层结构，其中掺杂有中等浓度硼的p型多晶硅膜层压在掺杂有高浓度硼的p型多晶硅膜上。 因此，由于掺杂高浓度的硼的p型多晶硅膜在外部基极和本征基极层之间的接合部与本征基极层接触，所以能够降低接合部的电阻。 此外，由于外部基极的电阻成为p型多晶硅膜的两层的并联电阻，所以其硼浓度相对较低的p型多晶硅膜的电阻是主要的。

    Pressure-sensitive adhesive sheet and method of processing articles
    5.
    发明申请
    Pressure-sensitive adhesive sheet and method of processing articles 审中-公开
    压敏粘合片和加工制品的方法

    公开(公告)号：US20070054469A1

    公开(公告)日：2007-03-08

    申请号：US11514454

    申请日：2006-09-01

    申请人： Kohei Yano ,  Kouji Akazawa ,  Yoshinori Yoshida ,  Tomohiro Kontani

    发明人： Kohei Yano ,  Kouji Akazawa ,  Yoshinori Yoshida ,  Tomohiro Kontani

    IPC分类号： H01L21/30

    CPC分类号： C09J7/29 ,  C09J2201/162 ,  C09J2203/326 ,  C09J2433/006

    摘要： To provide a pressure-sensitive adhesive sheet, which is used in processing an article such as a semiconductor wafer, the pressure-sensitive adhesive sheet has a base, an intermediate layer and a pressure-sensitive adhesive layer in this order, wherein the intermediate layer has an elastic modulus in tension at 23° C. of 10 MPa or more and 100 Mpa or less, the intermediate layer includes an acrylic-based polymer obtained by polymerization of a mixture containing 70 to 99 parts by weight of a (meth)acrylate monomer and 1 to 30 parts by weight of an unsaturated carboxylic acid based on 100 parts by weight of total monomers, and the base includes at least one film having an elastic modulus in tension at 23° C. of 0.6 GPa or more.

    摘要翻译： 为了提供用于加工诸如半导体晶片的物品的压敏粘合片，该压敏粘合片依次具有基底，中间层和压敏粘合剂层，其中中间层 在23℃下的拉伸弹性模量为10MPa以上至100Mpa以下，中间层包含通过聚合含有70〜99重量份的（甲基）丙烯酸酯的混合物而得到的丙烯酸系聚合物 单体和1〜30重量份的不饱和羧酸，基于100重量份的总单体，并且所述基材包括至少一种在23℃下的拉伸弹性模量为0.6GPa以上的膜。

    Miniaturized video camera
    6.
    发明授权
    Miniaturized video camera 失效
    小型摄像机

    公开(公告)号：US5381176A

    公开(公告)日：1995-01-10

    申请号：US971330

    申请日：1992-11-04

    申请人： Ikuo Tanabe ,  Yoshinori Yoshida ,  Kiyoshi Seitoh ,  Masanobu Morioka

    发明人： Ikuo Tanabe ,  Yoshinori Yoshida ,  Kiyoshi Seitoh ,  Masanobu Morioka

    IPC分类号： G11B31/00 ,  H04N5/225 ,  H05K7/14 ,  H05K7/20

    CPC分类号： H05K7/20445 ,  G11B31/006 ,  H04N5/2251 ,  H04N5/2253 ,  H05K7/142 ,  H05K7/20409

    摘要： In a miniature or small-sized video camera, a front block assembly including an image pick-up element and a rear block assembly are respectively secured within opposed open ends of a tubular outer casing, and a base plate assembly is disposed within the casing between the front and rear block assemblies and includes a plurality of elongated base plates arranged in longitudinally overlapped folded relation and having electronic elements or components mounted thereon and included in an electrical circuit through flexible flat cable elements which connect the base plates end-to-end to each other and to the image pick-up element and to a connector in the rear block assembly for outputting a video signal.

    摘要翻译： 在微型或小型摄像机中，包括图像拾取元件和后块组件的前块组件分别固定在管状外壳的相对的开口端内，并且底板组件设置在壳体内 前块和后块组件并且包括多个细长的基板，其以纵向重叠的折叠关系布置并且具有安装在其上的电子元件或部件，并且通过柔性扁平电缆元件包括在电路中，所述柔性扁平电缆元件将基板端对端连接到 彼此和图像拾取元件以及后块组件中的连接器输出视频信号。

    Process for producing diol
    7.
    发明授权
    Process for producing diol 失效
    二醇生产方法

    公开(公告)号：US4283579A

    公开(公告)日：1981-08-11

    申请号：US72991

    申请日：1979-09-06

    申请人： Yoshinori Yoshida ,  Hiroshi Oka

    发明人： Yoshinori Yoshida ,  Hiroshi Oka

    IPC分类号： C07C27/00 ,  C07C27/02 ,  C07C29/09 ,  C07C29/128 ,  C07C29/80 ,  C07C31/20 ,  C07C33/035 ,  C07C67/00 ,  C07C67/03

    CPC分类号： C07C29/80 ,  C07C29/095 ,  C07C29/1285 ,  C07C67/03

    摘要： A process for producing a diol by reacting an acetic ester of butanediol or butenediol with methanol, which comprises (a) continuously feeding to a first reaction-distilling column from its upper part a liquid acetic ester of butanediol or butenediol, while continuously feeding methanol to said column from its lower part, to bring both feeds into counter current gas-liquid contact in the presence of an acidic or a basic catalyst, to allow both feeds to react, and withdrawing from the bottom a bottom stream comprising a diol as major constituent, (b) continuously feeding to a hydrolyzer the distillate obtained from said first reaction-distilling column containing methyl acetate as major constituent, thus bringing said distillate into contact with water or steam in the presence of an acidic catalyst to hydrolyze the methyl acetate, (c) then continuously feeding the hydrolysis product thus obtained from the hydrolyzer to a second distilling column, withdrawing a methyl acetate-containing methanol stream from the top of said second distilling column, and recycling said stream to the lower part of the first reaction-distilling column. According to this process, it is possible to leave out the conventional complicated procedure necessary for the separation of methanol and, hence, to save the labor required therefor.

    摘要翻译： 一种通过使丁二醇或丁烯二醇的乙酸酯与甲醇反应来生产二醇的方法，该方法包括（a）从其上部连续向第一反应蒸馏塔中加入丁二醇或丁烯二醇的液体乙酸酯，同时连续地将甲醇加入到 所述柱从其下部分，在酸性或碱性催化剂的存在下将两种进料进入逆流气液接触，以允许两种进料反应，并从底部排出包含二醇作为主要成分的底部物流 ，（b）向水解器中连续地将由含有乙酸甲酯的第一反应 - 蒸馏塔获得的馏出物作为主要成分进料，由此在酸性催化剂的存在下使所述馏出物与水或蒸汽接触以水解乙酸甲酯（ c）然后将由此获得的水解产物的水解产物连续地进料到第二蒸馏塔中，抽出含乙酸甲酯 甲醇流从所述第二蒸馏塔的顶部，并将所述物流再循环到第一反应蒸馏塔的下部。 根据该方法，可以省略分离甲醇所需的常规复杂程序，从而节省了所需的劳动。

    Semiconductor device for performing photoelectric conversion
    8.
    发明授权
    Semiconductor device for performing photoelectric conversion 有权
    用于执行光电转换的半导体器件

    公开(公告)号：US08415762B2

    公开(公告)日：2013-04-09

    申请号：US11933195

    申请日：2007-10-31

    申请人： Yoshinori Yoshida ,  Tatsuya Tominari ,  Toshio Ando

    发明人： Yoshinori Yoshida ,  Tatsuya Tominari ,  Toshio Ando

    IPC分类号： H01L21/331 ,  H01L29/737

    CPC分类号： H01L29/7378 ,  H01L21/8249 ,  H01L27/0623 ,  H01L29/66242

    摘要： The external base electrode has a two-layered structure where a p-type polysilicon film doped with a medium concentration of boron is laminated on a p-type polysilicon film doped with a high concentration of boron. Therefore, since the p-type polysilicon film doped with a high concentration of boron is in contact with an intrinsic base layer at a junction portion between the external base electrode and the intrinsic base layer, the resistance of the junction portion can be reduced. In addition, since the resistance of the external base electrode becomes a parallel resistance of the two layers of the p-type polysilicon films, the resistance of the p-type polysilicon film whose boron concentration is relatively lower is dominant.

    摘要翻译： 外部基极具有两层结构，其中掺杂有中等浓度硼的p型多晶硅膜层压在掺杂有高浓度硼的p型多晶硅膜上。 因此，由于掺杂高浓度的硼的p型多晶硅膜在外部基极和本征基极层之间的接合部与本征基极层接触，所以能够降低接合部的电阻。 此外，由于外部基极的电阻成为p型多晶硅膜的两层的并联电阻，所以其硼浓度相对较低的p型多晶硅膜的电阻是主要的。