公开(公告)号：US11135163B2

公开(公告)日：2021-10-05

申请号：US16109119

申请日：2018-08-22

Applicant: Kansas State University Research Foundation

Inventor： Xiuzhi S. Sun ,  Hongzhou Huang ,  Tiffany L. Carter ,  Mark L. Weiss

IPC: A61K9/06 ,  A61K38/00 ,  A61L24/00 ,  A61L24/10

Abstract: Peptide hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and optionally albumin. The peptide comprises (consists of) a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, hemostatic agents, as well as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.

公开(公告)号：US20180353428A1

公开(公告)日：2018-12-13

申请号：US16109119

申请日：2018-08-22

Applicant: Kansas State University Research Foundation

Inventor： Xiuzhi S. Sun ,  Hongzhou Huang ,  Tiffany L. Carter

IPC: A61K9/06 ,  A61K38/00 ,  A61L24/10 ,  A61L24/00

CPC classification number: A61K9/06 ,  A61K38/00 ,  A61L24/0031 ,  A61L24/108 ,  A61L2400/04 ,  C12N2513/00 ,  C12N2533/50

Abstract: Peptide hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and optionally albumin. The peptide comprises (consists of) a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, hemostatic agents, as well as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.

公开(公告)号：US20160030629A1

公开(公告)日：2016-02-04

申请号：US14434327

申请日：2013-12-06

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Xiuzhi S. Sun ,  Hongzhou Huang ,  Thu Annelise Nguyen

IPC: A61L26/00 ,  A61L27/52 ,  A61K47/48 ,  A61L27/26

CPC classification number: A61L26/008 ,  A61K9/06 ,  A61K9/7007 ,  A61K47/42 ,  A61K47/64 ,  A61K47/643 ,  A61K47/6903 ,  A61L26/0028 ,  A61L26/0047 ,  A61L26/0052 ,  A61L26/0061 ,  A61L26/0066 ,  A61L27/22 ,  A61L27/227 ,  A61L27/26 ,  A61L27/50 ,  A61L27/52 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/418 ,  A61L2300/602 ,  A61L2300/62 ,  A61L2400/06 ,  C07K14/76

Abstract: Peptide-albumin hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and albumin. The peptide comprises a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.

Abstract translation: 描述了具有自组装的三维纳米纤维基质的肽 - 白蛋白水凝胶。 纳米纤维基质包含两亲肽和白蛋白。 肽包含末端疏水区域，中心转移区域和末端亲水区域。 还描述了制备这种水凝胶的方法以及使用水凝胶作为组织工程的支架作为3维细胞培养物和用于药物递送，活性剂（治疗细胞，分子，药物，化合物），细胞的包封的方法 移植，细胞储存，病毒培养和储存。

公开(公告)号：US20170189334A1

公开(公告)日：2017-07-06

申请号：US15316398

申请日：2015-06-05

Applicant: Kansas State University Research Foundation

Inventor： Xiuzhi S. Sun ,  Hongzhou Huang ,  Tiffany L. Carter

IPC: A61K9/06 ,  A61L24/10 ,  A61K38/00 ,  A61L24/00

CPC classification number: A61K9/06 ,  A61K38/00 ,  A61L24/0031 ,  A61L24/108 ,  A61L2400/04 ,  C12N2513/00 ,  C12N2533/50

Abstract: Peptide hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and optionally albumin. The peptide comprises (consists of) a terminal hydrophobic region, a central turning region, and a terminal hydrophilic region. Methods of making such hydrogels are also described, along with methods of using the hydrogels as scaffolding for tissue engineering, hemostatic agents, as well as 3-dimensional cell cultures, and for drug delivery, encapsulation of active agents (therapeutic cells, molecules, drugs, compounds), cell transplantation, cell storage, virus culture and storage.

公开(公告)号：US20140357837A1

公开(公告)日：2014-12-04

申请号：US14461708

申请日：2014-08-18

Applicant: Kansas State University Research Foundation

Inventor： Xiuzhi Susan Sun ,  Hongzhou Huang

IPC: C07K1/113

CPC classification number: C07K1/1136 ,  A61K38/10 ,  A61K51/1213 ,  A61L27/22 ,  A61L27/52 ,  C07K7/00 ,  C07K14/00

Abstract: The present invention broadly provides novel peptides that can be used to form hydrogels. The peptides are short (preferably 30 amino acid residues or less) and include hydrophilic and hydrophobic segments joined by a turning segment. The hydrogels are formed by altering the pH of a solution of these peptides to an acidic level, or by introducing a source of ions into a solution of these peptides. The resulting hydrogels are shear thinning gels that have high storage moduli and high rates of recovery after destruction. They find use in medical applications, including tissue engineering.

Abstract translation: 本发明广泛地提供可用于形成水凝胶的新型肽。 肽短（优选30个氨基酸残基或更少），并且包括通过转动部分连接的亲水和疏水部分。 通过将这些肽的溶液的pH改变到酸性水平，或通过将离子源引入这些肽的溶液中而形成水凝胶。 所得水凝胶是具有高储存模量和破坏后高回收率的剪切稀化凝胶。 它们用于医疗应用，包括组织工程。