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    Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
    1.
    发明授权
    Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes 失效
    表达APPK670N，M671L和突变型早老素转基因的转基因小鼠

    公开(公告)号：US5898094A

    公开(公告)日：1999-04-27

    申请号：US903518

    申请日：1997-07-30

    申请人： Karen Duff ,  John Hardy

    发明人： Karen Duff ,  John Hardy

    IPC分类号： A01K67/027 ,  A61K49/00 ,  C07K14/47 ,  C12N15/09 ,  C12N15/85 ,  C12Q1/68 ,  C12N15/00 ,  C12N5/00

    CPC分类号： C12N15/8509 ,  A61K49/0008 ,  C07K14/4711 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0312

    摘要： A method of preparing a transgenic animal model with enhanced, accelerated pathology for Alzheimer's Disease (AD) and the transgenic animal made by the method is disclosed. The method includes producing an F.sub.1 generation by crossing a first and second transgenic parent each carrying a different expressible transgene for differing aspects of the same desired phenotype associated with AD pathology. The offspring of the F.sub.1 generation are then screened and those which carry a transgene from each parental transgenic animal resulting in an enhanced pathology for Alzheimer's Disease are selected. In a preferred embodiment the AD-associated pathology is for amyloid accumulation. In an embodiment a mutant presenilin transgene and a transgene for a mutant amyloid precursor protein are used. In a further embodiment the mutant presenilin transgene is the PS1 M146L mutation and the mutant amyloid precursor protein transgene is the Swedish mutation (APP695 isoform containing a K670N,M671L mutation (APP770 numbering)).

    摘要翻译： 公开了一种制备具有阿尔茨海默氏病（AD）增强，加速病理学和通过该方法制备的转基因动物的转基因动物模型的方法。 该方法包括通过与携带不同可表达转基因的第一和第二转基因亲本杂交产生F1代，用于与AD病理学相关的相同所需表型的不同方面。 然后筛选F1代的后代，选择携带来自每个亲本转基因动物的转基因的后代，导致阿尔茨海默氏病的增强的病理学。 在优选实施方案中，AD相关病理学用于淀粉样蛋白积聚。 在一个实施方案中，使用突变型早老素转基因和用于突变淀粉样蛋白前体蛋白的转基因。 在另一个实施方案中，突变型早老素转基因是PS1 M146L突变，突变淀粉样蛋白前体蛋白转基因是瑞典突变（含有K670N，M671L突变（APP770编号）的APP695同种型）。

    Joint with application in electrochemical devices
    2.
    发明申请
    Joint with application in electrochemical devices 有权
    联合应用于电化学装置

    公开(公告)号：US20060239765A1

    公开(公告)日：2006-10-26

    申请号：US11112122

    申请日：2005-04-22

    申请人： K. Weil ,  John Hardy

    发明人： K. Weil ,  John Hardy

    IPC分类号： F16B7/10

    CPC分类号： H01M8/1253 ,  H01M8/0273 ,  H01M8/0282 ,  H01M8/0297 ,  H01M2008/1293 ,  Y02E60/525 ,  Y02P70/56 ,  Y10T403/31

    摘要： A joint for use in electrochemical devices, such as solid oxide fuel cells (SOFCs), oxygen separators, and hydrogen separators, that will maintain a hermetic seal at operating temperatures of greater than 600° C., despite repeated thermal cycling excess of 600° C. in a hostile operating environment where one side of the joint is continuously exposed to an oxidizing atmosphere and the other side is continuously exposed to a wet reducing gas. The joint is formed of a metal part, a ceramic part, and a flexible gasket. The flexible gasket is metal, but is thinner and more flexible than the metal part. As the joint is heated and cooled, the flexible gasket is configured to flex in response to changes in the relative size of the metal part and the ceramic part brought about by differences in the coefficient of thermal expansion of the metal part and the ceramic part, such that substantially all of the tension created by the differences in the expansion and contraction of the ceramic and metal parts is absorbed and dissipated by flexing the flexible gasket.

    摘要翻译： 用于电化学装置的接头，例如固体氧化物燃料电池（SOFC），氧气分离器和氢气分离器，其将在高于600℃的工作温度下保持气密密封，尽管重复的热循环超过600° C.在恶劣的操作环境中，接头的一侧连续暴露于氧化气氛，另一侧连续暴露于湿的还原气体。 接头由金属部件，陶瓷部件和柔性衬垫形成。 柔性垫片是金属，但比金属部件更薄，更柔韧。 当接头被加热和冷却时，柔性衬垫被配置为响应于由于金属部件和陶瓷部件的热膨胀系数的差异而导致的金属部件和陶瓷部件的相对尺寸的变化而弯曲， 使得由陶瓷和金属部件的膨胀和收缩的差异产生的基本上所有的张力通过弯曲柔性垫片被吸收和消散。

    High strength insulating metal-to-metal joints for solid oxide fuel cells and other high temperature applications and method of making
    3.
    发明申请
    High strength insulating metal-to-metal joints for solid oxide fuel cells and other high temperature applications and method of making 审中-公开
    用于固体氧化物燃料电池的高强度绝缘金属 - 金属接头和其他高温应用和制造方法

    公开(公告)号：US20060063057A1

    公开(公告)日：2006-03-23

    申请号：US10948359

    申请日：2004-09-22

    申请人： K. Weil ,  Lawrence Chick ,  Christopher Coyle ,  John Hardy ,  Guanguang Xia ,  Kerry Meinhardt ,  Vincent Sprenkle ,  Dean Paxton

    发明人： K. Weil ,  Lawrence Chick ,  Christopher Coyle ,  John Hardy ,  Guanguang Xia ,  Kerry Meinhardt ,  Vincent Sprenkle ,  Dean Paxton

    IPC分类号： H01M2/02

    CPC分类号： H01M8/0282 ,  C03C8/24 ,  C03C29/00 ,  H01M8/0286 ,  H01M8/1246 ,  Y02E60/525 ,  Y02P70/56

    摘要： A seal formed between a metal part and a second part that will remain gas tight in high temperature operating environments which experience frequent thermal cycling, which is particularly useful as an insulating joint in solid oxide fuel cells. A first metal part is attached to a reinforcing material. A glass forming material in the positioned in between the first metal part and the second part, and a seal is formed between the first metal part and the second part by heating the glass to a temperature suitable to melt the glass forming materials. The glass encapsulates and bonds at least a portion of the reinforcing material, thereby adding tremendous strength to the overall seal. A ceramic material may be added to the glass forming materials, to assist in forming an insulating barrier between the first metal part and the second part and to regulating the viscosity of the glass during the heating step.

    摘要翻译： 形成在金属部件和第二部件之间的密封件，其将在经受频繁热循环的高温操作环境中保持气密，这在固体氧化物燃料电池中作为绝缘接头特别有用。 第一金属部件附接到增强材料。 定位在第一金属部分和第二部分之间的玻璃形成材料，并且通过将玻璃加热到适于熔化玻璃形成材料的温度，在第一金属部分和第二部分之间形成密封。 玻璃封装并粘合至少一部分增强材料，从而为整个密封件增加了巨大的强度。 陶瓷材料可以添加到玻璃形成材料中，以有助于在第一金属部分和第二部分之间形成绝缘屏障，并且在加热步骤期间调节玻璃的粘度。

    Clock assembly having an adjustable configuration
    5.
    发明授权
    Clock assembly having an adjustable configuration 失效
    时钟组件具有可调配置

    公开(公告)号：US06942379B2

    公开(公告)日：2005-09-13

    申请号：US10139698

    申请日：2002-05-03

    申请人： John Hardy

    发明人： John Hardy

    IPC分类号： G04B37/14 ,  G04B37/00

    CPC分类号： G04B37/1413

    摘要： The present invention provides a modular clock assembly comprising a body portion having a clock face and an exterior surface extending peripherally around the clock face, a clock mechanism secured to the body portion, a clock magnet affixed to the exterior surface of the body portion, a moveable member having a plurality of member surfaces, and at least one member magnet affixed to a member surface so that the moveable member is attachable to the exterior surface of the body portion by aligning the member magnet with the clock magnet.

    摘要翻译： 本发明提供了一种模块化时钟组件，其包括主体部分，其具有钟表面和在钟表面周围延伸的外表面，固定到主体部分的时钟机构，固定到主体部分的外表面的时钟磁体， 具有多个构件表面的可移动构件和固定到构件表面的至少一个构件磁体，使得可移动构件可通过使构件磁体与时钟磁体对准而附接到主体部分的外表面。