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公开(公告)号:US08343543B2
公开(公告)日:2013-01-01
申请号:US13213379
申请日:2011-08-19
申请人: Karsten Maeder , Rainer Eugen Martin , Susanne Raab , Lukas Christoph Scheibler , Thomas Schindler , Marco Schroeder
发明人: Karsten Maeder , Rainer Eugen Martin , Susanne Raab , Lukas Christoph Scheibler , Thomas Schindler , Marco Schroeder
CPC分类号: A61K47/26 , A61K9/0056 , A61K31/365
摘要: Pharmaceutical compositions that contain a lipase inhibitor having a melting point ≧37° C., a sucrose fatty acid ester wherein the sucrose fatty acid ester is a mono-, di-, tri- or tetra-ester, and optionally one or more pharmaceutically acceptable excipients, are useful for treatment of obesity.
摘要翻译: 含有熔点≥37℃的脂肪酶抑制剂的药物组合物,蔗糖脂肪酸酯,其中蔗糖脂肪酸酯是单 - ,二 - ,三 - 或四 - 酯,以及任选的一种或多种药学上可接受的 赋形剂可用于治疗肥胖症。
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公开(公告)号:US08039508B2
公开(公告)日:2011-10-18
申请号:US11019865
申请日:2004-12-23
申请人: Karsten Maeder , Rainer Eugen Martin , Susanne Raab , Lukas Christoph Scheibler , Thomas Schindler , Marco Schroeder
发明人: Karsten Maeder , Rainer Eugen Martin , Susanne Raab , Lukas Christoph Scheibler , Thomas Schindler , Marco Schroeder
IPC分类号: A61K31/335 , A61K47/00 , A61K9/48 , A61K9/20 , A61K9/46
CPC分类号: A61K47/26 , A61K9/0056 , A61K31/365
摘要: Pharmaceutical compositions that contain a lipase inhibitor having a melting point ≧37° C., a sucrose fatty acid ester wherein the sucrose fatty acid ester is a mono-, di-, tri- or tetra-ester, and optionally one or more pharmaceutically acceptable excipients, are useful for treatment of obesity.
摘要翻译: 含有熔点≥37℃的脂肪酶抑制剂的药物组合物,蔗糖脂肪酸酯,其中蔗糖脂肪酸酯是单 - ,二 - ,三 - 或四 - 酯,以及任选的一种或多种药学上可接受的 赋形剂可用于治疗肥胖症。
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公开(公告)号:US20110301231A1
公开(公告)日:2011-12-08
申请号:US13213379
申请日:2011-08-19
申请人: Karsten MAEDER , Rainer Eugen Martin , Susanne Raab , Lukas Christoph Scheibler , Thomas Schindler , Marco Shroeder
发明人: Karsten MAEDER , Rainer Eugen Martin , Susanne Raab , Lukas Christoph Scheibler , Thomas Schindler , Marco Shroeder
IPC分类号: A61K31/365 , A61P3/10 , A61P3/00
CPC分类号: A61K47/26 , A61K9/0056 , A61K31/365
摘要: Pharmaceutical compositions that contain a lipase inhibitor having a melting point ≧37° C., a sucrose fatty acid ester wherein the sucrose fatty acid ester is a mono-, di-, tri- or tetra-ester, and optionally one or more pharmaceutically acceptable excipients, are useful for treatment of obesity.
摘要翻译: 含有熔点≥37℃的脂肪酶抑制剂的药物组合物,蔗糖脂肪酸酯,其中蔗糖脂肪酸酯是单 - ,二 - ,三 - 或四 - 酯,以及任选的一种或多种药学上可接受的 赋形剂可用于治疗肥胖症。
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公开(公告)号:US20050101562A1
公开(公告)日:2005-05-12
申请号:US11019865
申请日:2004-12-23
申请人: Karsten Maeder , Rainer Martin , Susanne Raab , Lukas Scheibler , Thomas Schindler , Marco Schroeder
发明人: Karsten Maeder , Rainer Martin , Susanne Raab , Lukas Scheibler , Thomas Schindler , Marco Schroeder
IPC分类号: A61K47/02 , A61K9/00 , A61K9/20 , A61K31/337 , A61K31/365 , A61K31/7024 , A61K45/00 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/38 , A61P3/04 , A61P43/00
CPC分类号: A61K47/26 , A61K9/0056 , A61K31/365
摘要: Pharmaceutical compositions that contain a lipase inhibitor having a melting point ≧37° C., a sucrose fatty acid ester wherein the sucrose fatty acid ester is a mono-, di-, tri- or tetra-ester, and optionally one or more pharmaceutically acceptable excipients, are useful for treatment of obesity.
摘要翻译: 含有熔点> 37℃的脂肪酶抑制剂的药物组合物,蔗糖脂肪酸酯,其中蔗糖脂肪酸酯是单酯,二,三或四酯,以及任选的一种或多种药学上可接受的盐 可接受的赋形剂可用于治疗肥胖症。
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公开(公告)号:US07816342B2
公开(公告)日:2010-10-19
申请号:US11348828
申请日:2006-02-07
IPC分类号: A61K31/715 , A61K31/335 , A01N43/02
CPC分类号: A61K9/0095 , A61K9/0056 , A61K9/48 , A61K31/365 , A61K31/736 , A61K36/888 , A61K2300/00
摘要: The present invention relates to compositions and methods for treating obesity. More particularly, the invention relates to a composition comprising a lipase inhibitor such as orlistat, and glucomannan such as konjac as well as methods for utilizing such compositions and kits for carrying out this method.
摘要翻译: 本发明涉及治疗肥胖症的组合物和方法。 更具体地说,本发明涉及包含脂肪酶抑制剂例如奥利司他,和诸如魔芋的葡甘露聚糖的组合物,以及用于实施该方法的这些组合物和试剂盒的使用方法。
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公开(公告)号:US20060135471A1
公开(公告)日:2006-06-22
申请号:US11348828
申请日:2006-02-07
申请人: Jacques Bailly , Rainer Martin , Susanne Raab
发明人: Jacques Bailly , Rainer Martin , Susanne Raab
IPC分类号: A61K31/716 , A61K31/365
CPC分类号: A61K9/0095 , A61K9/0056 , A61K9/48 , A61K31/365 , A61K31/736 , A61K36/888 , A61K2300/00
摘要: The present invention relates to compositions and methods for treating obesity. More particularly, the invention relates to a composition comprising a lipase inhibitor such as orlistat, and glucomannan such as konjac as well as methods for utilizing such compositions and kits for carrying out this method.
摘要翻译: 本发明涉及治疗肥胖症的组合物和方法。 更具体地说,本发明涉及包含脂肪酶抑制剂例如奥利司他,和诸如魔芋的葡甘露聚糖的组合物,以及用于实施该方法的这些组合物和试剂盒的使用方法。
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公开(公告)号:US20050282864A1
公开(公告)日:2005-12-22
申请号:US11157093
申请日:2005-06-20
申请人: Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Susanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler , Jean Marc Plancher
发明人: Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Susanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler , Jean Marc Plancher
IPC分类号: C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/454 , C07D43/02
CPC分类号: C07D405/14 , C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要: The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译: 本发明涉及式I化合物:其中X,R 1,R 2,R 3,R 4, SUP和R 5如在说明书和权利要求书及其药学上可接受的盐中所定义,用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号:US09132136B2
公开(公告)日:2015-09-15
申请号:US13189600
申请日:2011-07-25
申请人: Marius Hoener , Susanne Raab , Celine Risterucci , Sabine Sewing
发明人: Marius Hoener , Susanne Raab , Celine Risterucci , Sabine Sewing
IPC分类号: A61K31/5513 , A61K31/422 , A61K31/4168 , A61K31/455 , A61K31/506 , A61K31/5377 , A61K31/4439 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/40 , A61K31/421 , A61K31/5375 , A61K31/551 , C07D413/12
CPC分类号: A61K31/5513 , A61K9/1623 , A61K9/2018 , A61K9/4858 , A61K31/40 , A61K31/4168 , A61K31/421 , A61K31/422 , A61K31/4439 , A61K31/455 , A61K31/506 , A61K31/5375 , A61K31/5377 , A61K31/551 , C07D413/12 , A61K2300/00
摘要: The present invention relates to a pharmaceutical combination for the treatment of schizophrenia and acute manic episodes associated with bipolar disorders, which comprises a compound which is active on a trace amine-associated receptor 1 (TAAR1 agonist) and an antipsychotic drug. This combination can reduce metabolic side effects which appear if using an antipsychotic drug alone.
摘要翻译: 本发明涉及用于治疗与双相性精神障碍相关的精神分裂症和急性躁狂发作的药物组合,其包含对微量胺相关受体1(TAAR1激动剂)和抗精神病药物具有活性的化合物。 这种组合可以减少仅在使用抗精神病药物时出现的代谢副作用。
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公开(公告)号:US07608617B2
公开(公告)日:2009-10-27
申请号:US11821263
申请日:2007-06-22
申请人: Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
发明人: Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
IPC分类号: A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D401/10 , C07D217/06 , C07D417/10 , C07D211/06 , C07D413/10
CPC分类号: C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译: 本发明涉及式I化合物及其药学上可接受的盐,用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号:US07361682B2
公开(公告)日:2008-04-22
申请号:US11157093
申请日:2005-06-20
申请人: Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler , Jean-Marc Plancher
发明人: Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler , Jean-Marc Plancher
IPC分类号: A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/454 , A61K31/4545 , A61K31/4045 , C07D209/42 , C07D401/02 , C07D413/02 , C07D417/02
CPC分类号: C07D405/14 , C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要: The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译: 本发明涉及式I化合物:其中X,R 1,R 2,R 3,R 4, SUP和R 5如在说明书和权利要求书及其药学上可接受的盐中所定义,用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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